1. Advanced glycation end products in the skin are enhanced in COPD
- Author
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Jorine E. Hartman, H. Marike Boezen, Adèle T. Lo Tam Loi, Eef D. Telenga, Leo Koenderman, Jan Willem J. Lammers, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Maarten van den Berge, Dirkje S. Postma, Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), and Lifestyle Medicine (LM)
- Subjects
Adult ,Glycation End Products, Advanced ,Male ,Chronic Obstructive ,Vital capacity ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Glycosylation End Products, Advanced ,Severity of Illness Index ,Pulmonary Disease ,Pulmonary Disease, Chronic Obstructive ,Young Adult ,chemistry.chemical_compound ,FEV1/FVC ratio ,Endocrinology ,Glycation ,Internal medicine ,Severity of illness ,Glycosylation End Products ,Humans ,Medicine ,Lung volumes ,Young adult ,Lung ,Aged ,Netherlands ,Skin ,COPD ,business.industry ,Smoking ,Age Factors ,Middle Aged ,medicine.disease ,Up-Regulation ,respiratory tract diseases ,Oxidative Stress ,Cross-Sectional Studies ,chemistry ,Advanced glycation end-product ,Advanced ,Biological Markers ,Female ,business ,Biomarkers - Abstract
Background. Cigarette smoking is the main cause of chronic obstructive pulmonary disease (COPD) inducing oxidative stress and local tissue injury, resulting in pulmonary inflammation. Advanced glycation end products (AGEs) are produced by glycation and oxidation processes and their formation is accelerated in inflammatory conditions. In this study we assessed whether AGE accumulation in the skin is elevated in COPD and associates with disease severity.Methods. 202 mild-to-very-severe COPD patients and 83 old (40-75 years) and 110 young (18-40 years) healthy smokers and never-smokers were included. AGEs were measured by skin autofluorescence (SAF). Demographic variables, smoking habits, co-morbidities and lung function values were obtained.Results. COPD patients (FEV1 = 55% predicted) had significantly higher SAF values than old and young healthy controls: 2.5 vs. 1.8 and 1.2 (arbitrary units, p Conclusions. SAF is increased in mild-to-very severe COPD patients compared with healthy controls. Interestingly, SAF was not associated with disease severity as values were comparable between different GOLD stages (stage I-IV) of COPD. This may suggest that AGEs play a role in the induction phase of COPD in susceptible smokers. Future studies should further investigate the mechanisms underlying AGEs formation and accumulation in COPD. (C) 2014 Elsevier Inc. All rights reserved.
- Published
- 2014
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