1. A PC-based graphical simulator for physiological pharmacokinetic models
- Author
-
Wada Dr, Ebling Wf, and Stanski Dr
- Subjects
Drug disposition ,Physiology ,Computer science ,Pharmacokinetic modeling ,Health Informatics ,Models, Biological ,Computer Science Applications ,Microcomputers ,Pharmacokinetics ,Computer Graphics ,Animals ,Humans ,Computer Simulation ,Tissue Distribution ,Software ,Simulation ,Anesthetics - Abstract
Since many intravenous anesthetic drugs alter blood flows, physiologically-based pharmacokinetic models describing drug disposition may be time-varying. Using the commercially available programming software MATLAB, a platform to simulate time-varying physiological pharmacokinetic models was developed. The platform is based upon a library of pharmacokinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs. Because of MATLAB's additional numerical capabilities (e.g. non-linear optimization), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.
- Published
- 1995
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