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We present the field test results on a novel model-predictive controller for HVAC systems, which minimizes the operational costs of the air-treatment unit while guaranteeing indoor comfort. Unlike traditional control systems, which usually ignore the building's physics and cannot use weather forecasts, this controller features an adaptive model of the controlled space and uses weather forecasts from a national weather forecasting service. We tested this controller on two real, occupied buildings during the summer of 2017 and compared its performance with the existing control system. The system performs at least as well as the original controller, while reducing the operational costs by about 20%.

The p53 pathway is a key tumor suppressor mechanism that stalls cell cycle progression in response to stress. It has been proposed that p53 suppresses proliferation in part by downregulating the Myc oncogene but the mechanism has remained unclear. Here, we show that p53 directly represses Myc through a long noncoding RNA expressed from the Pvt1 locus. Pvt1b, a p53-dependent RNA isoform, is rapidly induced upon genotoxic and oncogenic stress and accumulates at its site of transcription in foci that exhibit properties of liquid-phase condensates. Pvt1b uses long-range chromatin interactions between Pvt1b and Myc to locally suppress Myc in an RNA-dependent manner. Loss of p53-dependent Pvt1b induction leads to increased cellular proliferation in vitro and enhanced tumor growth in a mouse model of lung adenocarcinoma in vivo. We propose that Pvt1b-mediated Myc repression contributes to the p53 tumor suppressive network to limit cancer growth.