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Background: Aberrant fatty acid (FA) metabolism is a unique vulnerability of cancer cells and may present a promising target for cancer therapy. Our study aims to elucidate the molecular mechanisms by which NKX2-8 deletion reprogrammed FA metabolism-induced chemoresistance in epithelial ovarian cancer (EOC). Methods: The deletion frequency and expression of NKX2-8 in 144 EOC specimens were assayed using Fluorescence in situ hybridization and immunochemical assays. The effects of NKX2-8 deletion and the fatty acid oxidation (FAO) antagonist Perhexiline on chemoresistance were examined by Annexin V and colony formation in vitro, and via an intraperitoneal tumor model in vivo. The mechanisms of NKX2-8 deletion in reprogrammed FA metabolism was determined using Chip-seq, metabolomic analysis, FAO assays and immunoprecipitation assays. Findings: NKX2-8 deletion was correlated with the overall and relapse-free survival of EOC patients. NKX2-8 inhibited the FAO pathway by epigenetically suppressing multiple key components of the FAO cascade, including CPT1A and CPT2. Loss of NKX2-8 resulted in reprogramming of FA metabolism of EOC cells in an adipose microenvironment and leading to platinum resistance. Importantly, pharmacological inhibition of FAO pathway using Perhexiline significantly counteracted NKX2-8 deletion-induced chemoresistance and enhanced platinum's therapeutic efficacy in EOC. Interpretation: Our results demonstrate that NKX2-8 deletion-reprogrammed FA metabolism contributes to chemoresistance and Perhexiline might serve as a potential tailored treatment for patients with NKX2-8-deleted EOC. Funding Statement: This work was supported by Natural Science Foundation of China (No. 81830082, 91740119, 91529301, 81621004, 91740118, 81773106 and 81530082); Guangzhou Science and Technology Plan Projects (201803010098); Natural Science Foundation of Guangdong Province (2018B030311009 and 2016A030308002); The Fundamental Research Funds for the Central Universities [No. 17ykjc02]. Declaration of Interests: The authors declare no conflicts of interest. Ethics Approval Statement: Prior donor consent and approval were obtained from the Institutional Research Ethics Committee. All experimental procedures were approved by the Institutional Animal Care and Use Committee of Sun Yat-sen University

Glass–ceramic foams were produced by using blast furnace slag (BFS) and waste glass as raw materials, choosing TiO 2 , ZrO 2 , and CaF 2 as nucleating agents, and adding CaCO 3 , Na 3 PO 4 ·12H 2 O, and Na 2 B 4 O 7 ·5H 2 O as a foaming agent, a foaming stabilizer and a flux agent, respectively. The effects of different BFS contents on the microstructure, bulk density, water absorption, and bending strength of the glass–ceramic foams were investigated. The results showed that glass–ceramic foams with 50 wt% BFS exhibited excellent comprehensive properties (bulk density 0.79 g/cm 3 , water absorption 2.71%, and bending strength 14.34 MPa). The new development for preparation of glass–ceramic foams is a good way to recycle BFS and waste glass, so that it could create huge economic and environmental benefits.