1. Oligoblastic leukaemia with (8;21) translocation and haemophagocytic syndrome and granulocytic cannibalism
- Author
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A. Aventin, A. Domingo-Claros, J. Petit, Esther Alonso, A Grañena, C. Ponce, and N. Crespo
- Subjects
Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Histiocytosis, Non-Langerhans-Cell ,Chromosomes, Human, Pair 21 ,Granulocytic cells ,Chromosomal translocation ,Intensive chemotherapy ,Biology ,Translocation, Genetic ,hemic and lymphatic diseases ,medicine ,Humans ,Histiocyte ,Cannibalism ,Cytogenetics ,Hematology ,Middle Aged ,medicine.disease ,Leukemia, Myeloid, Acute ,Leukemia ,Histiocytosis ,Oncology ,Immunology ,Chromosomes, Human, Pair 8 ,Granulocytes - Abstract
We report a 47-year-old man with oligoblastic leukaemia (8;21) translocation, phenomenon of cannibalism by granulocytic cells and haemophagocytic syndrome. The patient responded to intensive chemotherapy with disappearance of haemophagocytosis, granulocytic and histiocytic. We conclude that: (1) granulocytic cannibalism and haemophagocytic syndrome can be unusual myelodysplastic features; (2) the oligoblastic leukaemia with presence of cytogenetic abnormalities related to AML in young patients are probably more close to acute leukaemia than to myelodysplastic syndrome.
- Published
- 1996
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