1. Telomeres: New players in immune-mediated inflammatory diseases?
- Author
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Laurent Peyrin-Biroulet, Anne-Charlotte Heba, Simon Toupance, Ndeye Coumba Ndiaye, Anthanase Benetos, Djésia Arnone, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHRU-Nancy, Pôle 'Maladies du Vieillissement, Gérontologie et Soins Palliatif, Doctoral Fellowship from 'Reseau Lorrain des Maladies inflammatoires chroniques intestinales' MICILOR and Association des chefs de service from CHRU de Nancy to ACH. Research award 2020 from 'Societe Francophone de Nutrition Clinique et Métabolisme' SFNCM [GRANT_NUMBER: SFNCM2020] to DA. This work was supported by the French PIA project « Lorraine Université d’Excellence », reference ANR-15-IDEX-04-LUE and the Investments for the Future program under grant agreement No. ANR-15-RHU-0004., IMPACT GEENAGE, ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), and ANR-15-IDEX-0004,LUE,Isite LUE(2015)
- Subjects
Immune-mediated inflammatory diseases ,[SDV]Life Sciences [q-bio] ,Immunology ,Inflammation ,Biology ,Bioinformatics ,medicine.disease_cause ,Inflammatory bowel disease ,Arthritis, Rheumatoid ,Uveitis ,03 medical and health sciences ,0302 clinical medicine ,Chromosome instability ,Psoriasis ,Spondylarthritis ,medicine ,Humans ,Immunology and Allergy ,030304 developmental biology ,0303 health sciences ,Telomere ,Inflammatory Bowel Diseases ,medicine.disease ,Dynamics ,3. Good health ,Rheumatoid arthritis ,medicine.symptom ,030217 neurology & neurosurgery ,Oxidative stress - Abstract
International audience; Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that preserve the integrity and stability of the genome. Telomere dysfunctions due to short telomeres or altered telomere structures can ultimately lead to replicative cellular senescence and chromosomal instability, both mechanisms being hallmarks of ageing. Chronic inflammation, oxidative stress and finally telomere length (TL) dynamics have been shown to be involved in various age-related non-communicable diseases (NCDs). Immune-mediated inflammatory diseases (IMIDs), including affections such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, spondyloarthritis and uveitis belong to this group of age-related NCDs. Although in recent years, we have witnessed the emergence of studies in the literature linking these IMIDs to TL dynamics, the causality between these diseases and telomere attrition is still unclear and controversial. In this review, we provide an overview of available studies on telomere dynamics and discuss the utility of TL measurements in immune-mediated inflammatory diseases.
- Published
- 2021