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We present a facile surface-enhanced Raman spectroscopy (SERS)-based method for the sulfite /SO2 detection with high sensitivity, high selectivity and rapid response. Spectral changes of the capture probe at 600 cm−1 and 910 cm−1 upon binding to SO2 originated from the sulfites constitutes the assay, which is demonstrated to function well in the red wine and tremella samples testing.

Until today, the clinical application of phytochemicals is still limited largely due to poor oral bioavailability. Pulmonary administration is considered as an attractive alternative to oral delivery as it can improve the pharmacokinetic properties of compounds with extensive metabolism. In this study, resveratrol was selected as a study model to evaluate the feasibility of pulmonary administration in the delivery of phytochemicals, aiming to promote their therapeutic potential. The pharmacokinetic investigation on resveratrol was conducted in rats. Compared with oral delivery, resveratrol in rats after pulmonary administration showed superior absorption and bioavailability (92.95%). Directed delivery of resveratrol to lungs also showed potential usefulness in the treatment of lung diseases as drugs rapidly accumulated in lung tissues and concentrations were more than 100 times those of oral delivery at early time points. The metabolic study was carried out using rat microsomes and showed that metabolic activity of lung was much lower than that of liver. The overall results indicate that pulmonary administration is an effective strategy for both systemic and local delivery of resveratrol.