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Background An intergenerational association between maternal depression and child emotional problems is well established. However, the underlying processes underpinning this association are still unclear, with relatively little attention paid to potential child-driven effects. This study adds to existing research by examining the bidirectional processes between maternal depression, parenting, and child internalizing symptoms. Methods A large prospective pregnancy cohort was used (N = 1992). Mothers reported on their depressive symptoms, hostile parenting, child internalizing symptoms, and child effortful control. Data was collected during pregnancy, and at 4 months, 3 years, and 5 years postpartum. Results Using a cross-lag analytical approach, results revealed that prenatal and postpartum maternal depression predicted child internalizing problems through an increase in hostile parenting. Child internalizing symptoms predicted increases in subsequent hostile parenting, but not maternal depressive symptoms. Additional moderation analyses revealed that the indirect effect of maternal depression on child internalizing problems through hostile parenting was only significant for children low in effortful control. Limitations The study relied on maternal reports of both mother and child symptomology and characteristics. The sample was predominantly white and middle- to high-income. Conclusions Hostile parenting is a potential intermediary mechanism explaining the intergenerational transmission of maternal depression to child internalizing problems. Critically, this indirect effect was only significant for children low in effortful control. There was limited support for child evocative effects, with child internalizing symptoms predicting subsequent hostile parenting but not maternal depressive symptoms. Results highlight the need for considering both maternal and child characteristics when treating maternal depression.

Objective Developmental psychopathology processes pertinent to underserved ethnically diverse youths may not always coincide with those relevant to youths from nondisadvantaged groups. This article reports on the young adulthood assessment (fourth wave; April 2013 to August 2017) of the Boricua Youth Study, which includes 2 population-based samples of children of Puerto Rican background (N = 2,491) aged 5–13 years (recruited in 2000), in the South Bronx, New York, and San Juan, Puerto Rico. Method Study procedures included intensive participant tracking and in-person interviews of young adults and, when possible, their parents. Study participation rates, measures, and weights are described. Results At Boricua Youth Study wave 4 (on average 11.3 years since last wave of participation), we reassessed 2,004 young adults (mean age = 22.9 years, range = 15–29 years; 51% women; retention rate adjusted for ineligibility = 82.7%) and available parents (n = 1,180). Nonparticipation was due to inability to locate/contact participants (8.6%); refusal (4.7%); and ineligible status (2.8%) owing to cognitive impairment, incarceration, or death. Among participants originally from Puerto Rico, 91% stayed in Puerto Rico during young adulthood. Of participants from the South Bronx, 52.4% remained in the area (85.8% within 100 miles). Most study measures had good internal consistency (Cronbach α ≥ .70). Conclusion Our results support the viability of retaining a population-based cohort of children from the same ethnic group across 2 contexts during a life stage when individuals are likely to move. Longitudinal samples that are generalizable to underserved populations can elucidate developmental processes of relevance for curtailing the risk of psychopathology in disadvantaged contexts.

Irritability is a substrate of more than one dozen clinical syndromes. Thus, identifying when it is atypical and interfering with functioning is crucial to the prevention of mental disorder in the earliest phase of the clinical sequence. Advances in developmentally based measurement of irritability have enabled differentiation of normative irritable mood and tantrums from indicators of concern, beginning in infancy. However, developmentally sensitive assessments of irritability-related impairment are lacking. We introduce the Early Childhood Irritability-Related Impairment Interview (E-CRI), which assesses impairment associated with irritable mood and tantrums across contexts. Reliability and validity are established across two independent samples varied by developmental period: the Emotional Growth preschool sample (EmoGrow; N = 151, M = 4.82 years) and the When to Worry infant/toddler sample (W2W; N = 330, M = 14 months). We generated a well-fitting two-factor E-CRI model, with tantrum- and irritable mood-related impairment factors. The E-CRI exhibited good interrater, test–retest, and longitudinal reliability. Construct and clinical validity were also demonstrated. In both samples, E-CRI factors showed association to internalizing and externalizing problems, and to caregiver-reported concern in W2W. Tantrum-related impairment demonstrated stronger and more consistent explanatory value across outcomes, while mood-related impairment added explanatory utility for internalizing problems. The E-CRI also showed incremental utility beyond variance explained by the Family Life Impairment Scale (FLIS) survey indicator of developmental impairment. The E-CRI holds promise as an indicator of impairment to inform identification of typical versus atypical patterns reflecting early emerging irritability-related syndromes in the initial phase of the clinical sequence.

OBJECTIVE: The DSM’s disruptive mood dysregulation disorder (DMDD), characterized by severe, chronic irritability, currently excludes children

Developmental research documents that anhedonia, or diminished interest in usual activities, is associated with a diverse array of emotional problems in childhood and adolescence. Meanwhile, official nosologies desginate anhedonia as a more specific characteristic of major depressive disorder. Using a quantitative model of the internalizing domain, we compared the strength of transdiagnostic versus diagnosis-specific pathways from anhedonia to major depression (and other internalizing conditions) during adolescence. We recruited 241 youth ages 14–17 who completed semistructured interviews of anxiety and depressive disorders, as well as several self-report surveys of trait anhedonia and neuroticism. Confirmatory factor analysis of diagnostic correlations revealed good fit for a unidimensional model of the 10 internalizing conditions we assessed. This overarching internalizing dimension was statistically significantly correlated with trait anhedonia (r = 0.17) and neuroticism (r = 0.59). In contrast, anhedonia was virtually unrelated to major depression (r = −0.02), net the internalizing dimension. Thus, in this sample, the connection between anhedonia and major depression was explained by a transdiagnostic dimension presumed to underlie all internalizing problems. Compared to neuroticism, however, anhedonia had a more limited association with internalizing, consistent with established personality models of anxiety and depression. We conclude that these data are consistent with conceptualizing anhedonia predominantly as a transdiagnostic correlate of internalizing conditions, rather than a specific marker of major depression, in developmental psychopathology research and clinical interventions for young people.

Contains fulltext : 197100.pdf (Publisher’s version ) (Closed access) Information is scarce on the distinct techniques delivered by the practitioner to promote positive outcomes (practice elements) and aspects of the intervention design and service delivery system (program elements) that make part of interventions for families with multiple problems (FMP). The aim of this study was to (1) develop a taxonomy to identify practice and program elements of interventions targeting FMP and (2) examine the interrater reliability of this taxonomy. The development procedure of the taxonomy consisted of five steps, in which different data sources were used (e.g., existing taxonomies, national guidelines for FMP, intervention manuals and field experts) to ensure the comprehensiveness of the taxonomy. The taxonomy of interventions for FMP (TIFMP) was developed and tested on eight FMP interventions that had at least moderate effect sizes (>0.5) in the Dutch context. It consisted of 53 practice elements in eight main categories (e.g., working on behavioral change and relieve tasks) and six program elements (e.g., duration and intensity). Raters had an average agreement for practice elements of 84.9%, ranging from 73.6% to 90.6% for the eight FMP interventions. A wide range of FMP interventions can be described reliably with the TIFMP that comprises practice and program elements of interventions. Using this taxonomy can provide more insight into the actual content of interventions and enables optimisation of care for FMP. 7 p.

Contains fulltext : 242206.pdf (Publisher’s version ) (Open Access) Adolescents and young adults with mild intellectual disabilities or borderline intellectual functioning (MID-BIF) are a high-risk group for developing substance use disorders. The aim of this study was to gain a better understanding of the mechanisms that underlie substance use in this particular population. We tested the mediating role of substance use motives in the relationship between personality dimensions and substance use-related outcomes. Self-reported data on substance use risk personality dimensions (i.e., sensation seeking, impulsivity, anxiety sensitivity, and negative thinking), substance use motives (i.e., social, enhancement, coping, and conformity motives), and substance use were obtained from 163 individuals with MID-BIF (mean age 18.9 years). Results show that coping motives played a main role in the associations between personality dimensions and substance use in adolescents and young adults with MID-BIF, with significant relationships between impulsivity and negative thinking and severity of alcohol use or drug use via coping motives. Moreover, findings indicated a relatively high risk for several substance use motives and associated substance use (disorder) in individuals high on impulsivity. Results show significant relationships between impulsivity and severity of alcohol use or drug use via social, enhancement, and coping motives. No mediating associations were found for conformity motives, nor did we find any mediation associations in individuals with high levels of anxiety sensitivity. These insights provide the possibility of tailoring interventions to specific motives that underlie substance use in different types of users with MID-BIF based on personality dimensions. 9 p.

In the past 35 years, developmental psychopathology has grown into a flourishing discipline that shares a scientific agenda with contemporary psychiatry. In this editorial, which introduces the special issue, we describe the history of developmental psychopathology, including core principles that bridge allied disciplines. These include (1) emphasis on interdisciplinary research, (2) elucidation of multicausal pathways to seemingly single disorders (phenocopies), (3) description of divergent multifinal outcomes from common etiological start points (pathoplasticity), and (4) research conducted across multiple levels of analysis spanning genes to environments. Next, we discuss neurodevelopmental models of psychopathology, and provide selected examples. We emphasize differential neuromaturation of subcortical and cortical neural networks and connectivity, and how both acute and protracted environmental insults can compromise neural structure and function. To date, developmental psychopathology has placed greater emphasis than psychiatry on neuromaturational models of mental illness. However, this gap is closing rapidly as advances in technology render etiopathophysiologies of psychopathology more interrogable. We end with suggestions for future interdisciplinary research, including the need to evaluate measurement invariance across development, and to construct more valid assessment methods where indicated. Keywords: Psychiatry, Developmental psychopathology, Multifinality, Equifinality, Neurodevelopment, Interdisciplinary

Parental risk for perpetrating child abuse is frequently associated with intergenerational patterns of abuse: being abused increases the risk for future abuse. Yet, the mechanisms of intergenerational abuse are unclear, and the risk factors for perpetrating child abuse are interrelated. Research suggests that history of childhood abuse, psychiatric distress, and exposure to intimate partner violence (IPV) are all related risk factors for perpetrating child abuse. We investigated these three risk factors using the developmental psychopathology framework in a racially diverse sample of high-risk women: women residing in domestic violence shelters. 211 mothers residing in domestic violence shelters completed measures of their own childhood abuse (defined narrowly in a 10-item self-report survey), exposure to and severity of IPV victimization, and structured interviews to diagnose psychiatric disorders. We utilized a hierarchical regression model to predict child abuse potential, accounting for risk factors in blocks roughly representing theorized temporal relationships: childhood abuse followed by psychiatric diagnoses, and then recency of exposure to IPV. Consistent with hypotheses, the strongest predictor of current child abuse potential was the psychiatric diagnosis of PTSD. Mediation tests further explicated that the relationship between maternal history of childhood sexual abuse and current potential for perpetrating child abuse is mediated by IPV-related PTSD symptoms. Results suggest that IPV-related PTSD symptoms, rather than exposure to abuse (i.e., childhood abuse or IPV), is most strongly associated with child abuse potential in recent IPV survivors. Interventions which can ameliorate maternal psychopathology and provide resources are recommended for these vulnerable families.

Anxiety disorders are among the most prevalent psychiatric disorders in youth; however, progress in treatment for childhood anxiety has stalled over the past decade. The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) project represents a shift toward a dimensional and interdisciplinary approach to psychiatric disorders; this shift can reframe developmental psychopathology for childhood anxiety and facilitate novel advances in its classification and treatment. Here we highlight constructs in the Systems for Social Processes and the Negative Valence System domains of RDoC, as they relate to childhood anxiety disorders. Childhood anxiety relates to both RDoC domains. In terms of social processes, through natural reliance on parents to reduce children's fear, attachment represents one particular social process, which plays a central role in anxiety among youth. In terms of negative valence, considerable research links threat conditioning to pediatric anxiety. Finally, fronto-amygdala circuitry relates to all three entities, as it has been shown to underly both attachment processes and threat learning, while it also has been consistently implicated in anxiety disorders across development. Through integrative and translational approaches, RDoC provides unique opportunities and simultaneous challenges for advancing the understanding and treatment of childhood anxiety disorders.

The Research Domain Criteria (RDoC) propose a much-needed change in approach to the study of vulnerability factors implicated in mental disorders, shifting away from a categorical, disease-oriented model to a dimensional approach that focuses on underlying systems implicated in psychopathology. In this paper we illustrate this approach with a focus on the emergence of depression in childhood and adolescence. Based on evolutionary biological and developmental psychopathology considerations, we present an integrative developmental cascade model of depression that essentially suggests that depression emerges out of a three-pronged series of interacting impairments in the domains of stress regulation, reward, and mentalizing. We discuss the relation of these impairments to the five domains proposed by RDoC. We also focus on how this model may explain in large part the marked comorbidity of depression with other psychiatric disorders, as well as with functional somatic and somatic disorders. Limitations of this theoretical approach are discussed, as well as implications for the development, evaluation, and dissemination of interventions aimed at preventing or treating depression. ispartof: Clinical Psychology Review vol:64 pages:87-98 ispartof: location:United States status: published

Available treatment methods have shown little effect on the burden associated with mental health disorders. We review promising universal, selective, and indicated preventive mental health strategies that might reduce the incidence of mental health disorders, or shift expected trajectories to less debilitating outcomes. Some of these interventions also seem to be cost-effective. In the transition to mental illness, the cumulative lifetime effect of multiple small effect size risk factors progressively increases vulnerability to mental health disorders. This process might inform different levels and stages of tailored interventions to lessen risk, or increase protective factors and resilience, especially during sensitive developmental periods. Gaps between knowledge, policy, and practice need to be bridged. Future steps should emphasise mental health promotion, and improvement of early detection and interventions in clinical settings, schools, and the community, with essential support from society and policy makers.

The present study took a developmental psychopathology approach to examine the longitudinal association between parents’ emotional expressiveness and children’s self-regulation. Data collection spanned from 2004 to 2008. Ninety-two physically abusive parents completed yearly assessments of their emotional expressiveness, as well as their children’s self-regulation abilities. Observational and behavioral measures were also obtained yearly to capture both parents’ emotional expressiveness and children’s self-regulation. Specifically, parents participated in a parent-child interaction task, which provided insight into their levels of flat affect. A puzzle box task was completed by each child to assess self-regulation. Results indicated, first, that greater parental expression of negative emotions predicted poorer self-regulation in children, both concurrently and across time. Second, parental expressions of positive emotions and parents’ flat affect were unrelated to children’s self-regulation. Findings inform our understanding of parental socialization of self-regulation and provide insight into the roles of distinct components of emotional expressiveness. Moreover, findings have crucial implications for understanding emotional expressiveness in high-risk samples and increase our understanding of within-group functioning among maltreating families that may serve as a means to direct intervention efforts.

Contains fulltext : 197928.pdf (Publisher’s version ) (Closed access) In response to calls for further research into the phenomenology of Internet gaming disorder (IGD), we used a community-engaged consensus development approach to evaluate how members of the "gamer culture" describe problematic gaming and the relationship of these descriptions to the proposed IGD criteria. Two focus groups of garners were recruited at a video game convention. Participants were asked to submit suggestions for signs of game "addiction". Participants discussed and ranked the criteria in order of conceptual importance. The rankings were analyzed quantitatively, and then a multidisciplinary team compared the ranked criteria to the DSM-5 IGD proposed criteria. The strongest agreement between participants' rankings and IGD symptomatology was found for harms/functional impairment due to gaming, continued use despite problems, unsuccessful attempts to control gaming, and loss of interest in previous hobbies and entertainment. There was less support for other IGD criteria. Participants also offered new content domains. These findings suggest that collaborative knowledge-building approaches may help researchers and policymakers understand the characteristics and processes specific to problematic video game play and improve content validity of IGD criteria. Future efforts may benefit from multi-stakeholder approaches to refine IGD criteria and inform theory, measurement and intervention. 9 p.

Contains fulltext : 178759pub.pdf (Publisher’s version ) (Closed access) Although numerous studies have examined the neuroendocrinology of aggression, the findings are mixed and focused on cortisol and testosterone. We argue that past findings remain inconclusive partly because the key roles of oxytocin and trauma have not been systematically integrated yet. Oxytocin is associated with social behavior and interacts with cortisol and testosterone, whereas trauma is a crucial risk factor of aggression that strongly affects hormonal activity. In this review, we investigate the role of trauma in the hormonal interplay of cortisol, testosterone, and oxytocin in aggression during adolescence. We first discuss how these hormones interact with each other and how trauma influences these interactions and then we propose a model that highlights the role of trauma in the hormonal interplay in aggression. We suggest that the timing of trauma has a distinct effect on hormonal activity and it should be integrated into any comprehensive model. Current trauma is linked to different levels of oxytocin, cortisol, testosterone, and testosterone/cortisol ratio than childhood trauma, but this distinction is also influenced by gender and type of aggression. We conclude that in order to better understand the neuroendocrinology of aggression, it is crucial to incorporate the investigation of oxytocin and trauma in future research. 14 p.

A history of childhood maltreatment has a well-established association with clinical sleep disturbances in adulthood, which is a transdiagnostic contributor to many chronic diseases.Determine whether actigraphy-measured indices of dysregulated arousal during sleep explain associations between abuse or neglect in childhood and clinical sleep disturbances in adulthood.Participants were 646 individuals, ages 25-83 (59.3% female) from the MIDUS II Biomarker, Refresher studies.Participants completed the Childhood Trauma Questionnaire, wore an actigraph for seven days, and rated sleep quality using the Pittsburgh Sleep Quality Index (PSQI).Both neglect (b = 0.66, SE = 0.33, p = .04) and abuse (b = 1.09, SE = 0.32, p .001) were associated with clinical sleep disturbance. Actigraphy-measured sleep efficiency mediated the link between neglect and clinical sleep disturbances (ab = 0.33, SE = 0.12, 95%CI [0.12, 0.57]). However, no such link between abuse and clinical sleep disturbances was mediated by actigraphy-measured indices. Sleep onset latency did not mediate the link between neglect or abuse and sleep disturbance. Models covaried for other maltreatment, gender, and age.While the unique associations between abuse or neglect and clinical sleep disturbances were robust in this sample, only sleep efficiency emerged as a mediator linking maltreatment and clinical sleep disturbances. Critically, this mediation was specific to neglect. Abuse and neglect may lead to disease through distinct pathways. Moreover, potential dysregulation in arousal that leads to sleep inefficiency may be a specific pathway through which experiences of neglect in childhood contribute to chronic disease.

Fear and safety learning are necessary adaptive behaviors that develop over the course of maturation. While there is a large body of literature regarding the neurobiology of fear and safety learning in adults, less is known regarding safety learning during development. Given developmental changes in the brain, there are corresponding changes in safety learning that are quantifiable; these may serve to predict risk and point to treatment targets for fear and anxiety-related disorders in children and adolescents. For healthy, typically developing youth, the main developmental variation observed is reduced discrimination between threat and safety cues in children compared to adolescents and adults, while lower expression of extinction learning is exhibited in adolescents compared to adults. Such distinctions may be related to faster maturation of the amygdala relative to the prefrontal cortex, as well as incompletely developed functional circuits between the two. Fear and anxiety-related disorders, childhood maltreatment, and behavioral problems are all associated with alterations in safety learning for youth, and this dysfunction may proceed into adulthood with corresponding abnormalities in brain structure and function—including amygdala hypertrophy and hyperreactivity. As impaired inhibition of fear to safety may reflect abnormalities in the developing brain and subsequent psychopathology, impaired safety learning may be considered as both a predictor of risk and a treatment target. Longitudinal neuroimaging studies over the course of development, and studies that query change with interventions are needed in order to improve outcomes for individuals and reduce long-term impact of developmental psychopathology.

Contains fulltext : 169208.pdf (Publisher’s version ) (Open Access) Adolescents are generally characterized as impulsive. However, impulsivity is a multi-dimensional construct that involves multiple component processes. Which of these components contribute to adolescent impulsivity is currently unclear. This study focused on the neural mechanisms underlying individual differences in distinct components of temporal discounting (TD), i.e., the preference for smaller immediate rewards over larger delayed rewards. Participants were 58 adolescents (12-16 years-old) who performed an fMRI TD task with both monetary and snack rewards. Using mixed-effects modeling, we determined participants’ average impatience, and further decomposed TD choices into: 1) amount sensitivity (unique contribution of the magnitude of the immediate reward); and 2) delay sensitivity (unique contribution of delay duration). Adolescents' average impatience was positively correlated with frontoparietal and ventral striatal activity during delayed reward choices, and with ventromedial prefrontal cortex activity during immediate reward choices. Adolescents’ amount sensitivity was positively associated with ventral striatal and dorsal anterior cingulate cortex activity during immediate reward choices. Delay sensitivity was positively correlated with inferior parietal cortex activity during delayed reward choices. As expected, snacks were discounted more steeply than money, and TD of both reward types was associated with overlapping activation in the inferior parietal cortex. Exploring whether testosterone or estradiol were associated with TD and its neural correlates revealed no significant associations. These findings indicate that distinct components contribute uniquely to TD choice and that individual differences in amount sensitivity are uniquely associated with activation of reward valuation areas, while individual differences in delay sensitivity are uniquely associated with activation of cognitive control areas. 13 p.

Autism spectrum disorder (ASD), a condition defined along a continuum of socio-communicative difficulties, is associated with unique patterns of memory functioning including difficulties with autobiographical memory (AM). AM refers to memory for information related to the self and personally experienced events and has a strong social function. The current paper reviews empirical studies assessing AM among individuals with ASD across the lifespan. Results support that both children and adults with ASD manifest AM difficulties characterized by (a) reduced specificity, (b) less elaborated and detailed AM narratives, (c) lower AM coherence, and (d) increased reliance on scaffolding for retrieval. Individuals with ASD also demonstrate intact AM for certain memory indices and show evidence of using compensatory strategies to facilitate retrieval. Results are interpreted in relation to models of typically developing AM and broad memory theory, as well as models of information processing specific to ASD. To advance knowledge of how AM develops within the context of ASD, a developmental psychopathology perspective is applied to the consideration of candidate processes underlying developing AM among individuals with ASD. Future research should consider support for mechanisms that promote AM performance at multiple ecological levels. Limitations, clinical implications for intervention, and future directions are discussed.

Objective Although most people will experience a traumatic event at some point in their life, only some will develop significant psychological symptoms in the aftermath. In the current study, we use a preexisting longitudinal study located in Long Island to examine the impact of Hurricane Sandy on internalizing symptoms in a large sample of children. We focused on temperamental fear and a biomarker of risk for anxiety, the error-related negativity (ERN). The ERN is a negative deflection in the event-related potential (ERP) occurring when individuals make mistakes and is increased in anxious individuals. Method The final sample consisted of 223 children who had undergone an observational assessment of fear at age 3 years and an electroencephalogram assessment of the ERN at age 6 years. At the age 9 year assessment, internalizing symptoms were assessed, and then again after the hurricane (∼65 weeks later). Results A significant three-way interaction among fearfulness, hurricane stressors, and the ERN in predicting posthurricane increases in internalizing symptoms suggested that children who were high in fear at age 3 years and experienced elevated hurricane stressors were characterized by subsequent increases in internalizing symptoms, but only when they were also characterized by an increased ERN at age 6 years. Conclusion These findings support a diathesis–stress model, suggesting that early temperament and prestressor biological markers confer risk for increased psychological symptoms following environmental stressors.

Item does not contain fulltext Background and aim: Previous studies have shown a relationship between schizophrenia and cannabis use. As both traits are substantially heritable, a shared genetic liability could explain the association. We use two recently developed genomics methods to investigate the genetic overlap between schizophrenia and cannabis use. Methods: Firstly, polygenic risk scores for schizophrenia were created based on summary statistics from the largest schizophrenia genome-wide association (GWA) meta-analysis to date. We analysed the association between these schizophrenia polygenic scores and multiple cannabis use phenotypes (lifetime use, regular use, age at initiation, and quantity and frequency of use) in a sample of 6,931 individuals. Secondly, we applied LD-score regression to the GWA summary statistics of schizophrenia and lifetime cannabis use to calculate the genome-wide genetic correlation. Results: Polygenic risk scores for schizophrenia were significantly (alpha

There is little extant empirical literature examining the associations between life history strategies and symptoms of psychopathology. The current study (N = 138) investigated the associations between life history strategies, symptoms of psychopathology, aggression, incidence of self-harm behaviour, and attachment (perceived parental support) in sample drawn from the general population and community mental health service providers. The results from the study indicate those with a faster life strategy report greater levels of aggression and symptoms of psychopathology. Further, perceptions of poorer parental support were associated with a faster life history strategy. Implications for life history theory, conceptualising psychopathology, and future research directions are discussed. Refereed/Peer-reviewed

Background Child maltreatment poses substantial risk for compromised mental health in children. Further, child abuse and neglect are potentiated within a cascade of intergenerational and current familial risk processes that require clarification to inform understanding of adverse outcomes and direct prevention and intervention efforts. Objective Using a multi-informant design, the current study applied an intergenerational cascades approach to examine the interconnected pathways among several familial risk factors associated with child maltreatment and its consequences. Participants Participants were 378 children (aged 10−12) and their mothers from economically disadvantaged, ethnically diverse backgrounds. The sample included maltreated children recruited via CPS records and demographically comparable non-maltreated children. Methods Structural equation modeling (SEM) was conducted to test sequential mediation pathways examining the independent and cascading effects of maternal history of childhood maltreatment, maternal adolescent childbearing, current maternal depression, and the child’s lifetime history of maltreatment on the child’s internalizing and externalizing symptoms. Results Multigenerational developmental cascades were identified. Maternal history of maltreatment predicted chronic maltreatment for offspring, which in turn predicted greater internalizing (β = .167, p = .03) and externalizing symptoms (β = .236, p = .005) in late childhood. Similarly, children born to mothers who began childbearing in adolescence were more likely to experience chronic maltreatment during childhood and develop subsequent symptoms. Effects were found over and above a parallel cascade from maternal maltreatment to offspring psychopathology via a maternal depression pathway. Conclusion Findings reveal targets to prevent or ameliorate progressions of intergenerational risk pathways.

Contains fulltext : 157753pub.pdf (Publisher’s version ) (Closed access) Background Childhood anxiety is a global mental health concern. Interventions are needed that are effective, but also cost less, are more accessible and engage children long enough to build emotional resilience skills through practice. Methods The present randomized controlled study aimed to examine the prevention effects of a neurofeedback video game, MindLight, developed based on evidence-based practices with anxious youth. Over 750 children (7-13 years old) in elementary schools were screened for elevated anxiety; 136 selected children were randomly assigned to play Mindlight or a control game. Self- and parent-reported anxiety was assessed at pre-, post-intervention and 3-month follow up. Results/conclusions Intent-to-treat analyses revealed an overall significant reduction in child- and parent-reported anxiety, but the magnitude of improvements did not differ between conditions. Future research comparing MindLight to cognitive-behavioral interventions is suggested, as well as testing a range of specific (e.g., exposure) and non-specific (e.g., expectations, motivation) therapeutic factors as mediators of outcomes. 13 p.

Item does not contain fulltext While much is known about alcohol use in adolescence and beyond, factors leading to such behaviors are rooted much earlier in life. To investigate what preschoolers (aged three to six) know about alcohol and adult alcohol use, we developed an electronic version (eABT) of the Appropriate Beverage Task (Zucker, Kincaid, Fitzgerald, & Bingham, 1995). Drawings of adults and children in 11 everyday scenarios and 12 photos of different beverages were shown on a touchscreen computer to 301 three- to six-year-olds (49.5% girls) from 37 preschools and seven nurseries in French-speaking Switzerland. First, the children assigned a beverage to each individual in each drawing, and then were asked if the beverage contained alcohol and if they knew its name. The results revealed that 68.1% correctly classified beer, white wine, red wine and champagne as alcoholic beverages, while 46.4% knew the drinks by name, compared to 83.2% and 73.1% for non-alcoholic beverages. Alcoholic beverages were assigned more often to men (42.2%) than to women (28.7%) or to children (12.7%), and more often to adults at a party (39.4%) than to those playing outdoors (34.7%). In conclusion, children as young as three often have some beverage-specific knowledge. From the age of four onwards, they begin to know that alcoholic beverages contain alcohol. Children aged six and over tend to have some knowledge of adult drinking norms, i.e. who is drinking and in what circumstances. 6 p.

Item does not contain fulltext Psychometric intelligence correlates with performance on a wide range of sensory and motor tasks that involve processing of temporal information in the millisecond-second range. For some timing tasks, e.g. reaction time and discrimination of temporal stimuli in working memory, the associations with intelligence are likely to involve top-down mechanisms such as attention. However, studies on repetitive, automatic motor timing tasks indicate that correlations between intelligence and timing also may reflect bottom-up mechanisms, i.e. basic neural properties that influence both the temporal accuracy of behavior and cognitive processes. Here, we study the genetic architecture of the associations between intelligence, perceptual timing (auditory rhythm discrimination) and motor timing (finger tapping) in a large twin cohort. Specifically, we hypothesized that the associations between these tasks on the phenotypic level involve broad pleiotropic genetic effects that influence all three tasks, as well as additional genetic effects on the covariation between perceptual and motor timing. Phenotypic associations between the variables were low to moderate, with Pearson's correlations in the range 0.17-0.32. Trivariate twin modeling showed that the associations between the three variables were essentially due to shared genetic influences. In support of the hypotheses, we found evidence for pleiotropic effects on motor timing, perceptual timing, and intelligence, as well as additional genetic covariation between the two timing tasks that was not shared with intelligence. We conclude, first, that genetic factors underlying intelligence may involve genes which influence brain properties of importance for the temporal accuracy of neural processing. We discuss possible neural substrates of such effects. Secondly, the correlation between motor and perceptual timing also partly explained by genetic influences that are unrelated to intelligence. 8 p.

Does changing context play a role in the decline in ADHD symptoms in adulthood? Insufficient research has explored the functioning of adults with ADHD. As adults, individuals with ADHD have significantly more latitude to control aspects of their day-to-day environments. Do the new contexts young adults find themselves in alter their experience of ADHD? Are there particular occupational or educational contexts in which young adults report functioning better than others? To examine this issue, we conducted semi-structured interviews at four North American sites in 2010-11 with 125 young adults, originally diagnosed with ADHD as children, regarding their work and post-secondary educational environments. Many subjects describe their symptoms as context-dependent. In some contexts, participants report feeling better able to focus; in others, their symptoms-such as high energy levels-become strengths rather than liabilities. Modal descriptions included tasks that were stressful and challenging, novel and required multitasking, busy and fast-paced, physically demanding or hands-on, and/or intrinsically interesting. Consistent with a developmental psychopathology framework, ADHD is experienced as arising from an interaction between our subjects and their environments. These findings demonstrate the need to account for the role of context in our understanding of ADHD as a psychiatric disorder, especially as it manifests in young adulthood.

The aim of this study is to develop and test the effectiveness of a drinking-motive-tailored intervention for adolescents hospitalized due to alcohol intoxication in eight cities in Germany between December 2011 and May 2012 against a similar, non-motive-tailored intervention. In a randomized controlled trial, 254 adolescents received a psychosocial intervention plus motive-tailored (intervention group; IG) or general exercises (control group; CG). Adolescents in the IG received exercises in accordance with their drinking motives as indicated at baseline (e.g. alternative ways of spending leisure time or dealing with stress). Exercises for the CG contained alcohol-related information in general (e.g. legal issues). The data of 81 adolescents (age: M = 15.6, SD = 1.0; 42.0% female) who participated in both the baseline and the follow-up were compared using ANOVA with repeated measurements and effect sizes (available case analyses). Adolescents reported lower alcohol use at the four-week follow-up independently of the kind of intervention. Significant interaction effects between time and IG were found for girls in terms of drinking frequency (F = 7.770, p, Highlights • Adolescents hospitalized for alcohol intoxication reported lower alcohol use 4 weeks after the psychosocial intervention. • For girls, the intervention was even more effective when motive-tailored. • For boys, there was no significant effect of the motive-tailored intervention additional to HaLT.

Contains fulltext : 157507.pdf (Publisher’s version ) (Closed access) Spontaneous dizygotic (DZ) twinning occurs in 1%–4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association across a broad range of fertility traits in women. Two SNPs were identified (rs11031006 near FSHB, p = 1.54 × 10−9, and rs17293443 in SMAD3, p = 1.57 × 10−8) and replicated (p = 3 × 10−3 and p = 1.44 × 10−4, respectively). Based on ∼90,000 births in Iceland, the risk of a mother delivering twins increased by 18% for each copy of allele rs11031006-G and 9% for rs17293443-C. A higher polygenic risk score (PRS) for DZ twinning, calculated based on the results of the DZ twinning GWAS, was significantly associated with DZ twinning in Iceland (p = 0.001). A higher PRS was also associated with having children (p = 0.01), greater lifetime parity (p = 0.03), and earlier age at first child (p = 0.02). Allele rs11031006-G was associated with higher serum FSH levels, earlier age at menarche, earlier age at first child, higher lifetime parity, lower PCOS risk, and earlier age at menopause. Conversely, rs17293443-C was associated with later age at last child. We identified robust genetic risk variants for DZ twinning: one near FSHB and a second within SMAD3, the product of which plays an important role in gonadal responsiveness to FSH. These loci contribute to crucial aspects of reproductive capacity and health. 11 p.

The assessment of externalizing behavior (EB) in preschoolers is crucial in developmental psychopathology. In the absence of any gold standard measure, new tools contribute to a multi-method and multi-informant approach. The aim of the current study is to present and validate a new observational paradigm, the Unfair Card Game (UCG), intentionally structured to increase the likelihood that negative affect, agitation and inattention will emerge during a video-recorded task. It was administered to 268 young children, and the results were validated by means of factorial analysis, reliability analyses, inter-rater agreement, test–retest, discriminant analyses and external validation with the Child Behavior Checklist (Achenbach & Rescorla, 2004). The validity of the UCG is supported by the findings.

Evolutionary approaches to psychopathology have made considerable progress over the last years. In this paper, I review recent advances in the field focusing on three core themes: the role of trade-offs and conflicts in the origins mental disorders, the evolution of developmental mechanisms, and the emergence of alternative classification systems based on life history theory. I situate these advances in the context of current research in psychopathology, and highlight their connections with other innovative approaches such as developmental psychopathology and computational psychiatry. In total, I argue that evolutionary psychopathology offers an integrative framework for the study of mental disorders, and allows complementary approaches to connect and cross-fertilize.

Psychopathology as the investigation and classification of experience, behavior and symptoms in psychiatric patients is an old discipline that ranges back to the end of the 19th century. Since then different approaches to psychopathology have been suggested. Recent investigations showing abnormalities in the brain on different levels raise the question how the gap between brain and psyche, between neural abnormalities and alteration in experience and behavior can be bridged. Historical approaches like descriptive (Jaspers) and structural (Minkoswki) psychopathology as well as the more current phenomenological psychopathology (Paarnas, Fuchs, Sass, Stanghellini) remain on the side of the psyche giving detailed description of the phenomenal level of experience while leaving open the link to the brain. In contrast, the recently introduced Research Domain Classification (RDoC) aims at explicitly linking brain and psyche by starting from so-called 'neuro-behavioral constructs'. How does Spatiotemporal Psychopathology, as demonstrated in the first paper on depression, stand in relation to these approaches? In a nutshell, Spatiotemporal Psychopathology aims to bridge the gap between brain and psyche. Specifically, as demonstrated in depression in the first paper, the focus is on the spatiotemporal features of the brain's intrinsic activity and how they are transformed into corresponding spatiotemporal features in experience on the phenomenal level and behavioral changes, which can well account for the symptoms in these patients. This second paper focuses on some of the theoretical background assumptions in Spatiotemporal Psychopathology by directly comparing it to descriptive, structural, and phenomenological psychopathology as well as to RDoC.

The adoption of a useful theoretical framework is a fundamental component of any research study, whether the investigator is using a deductive theory-verifying approach or an inductive theory-generating approach. In an attempt to encourage the use of valid and reliable theoretical frameworks in both research and clinical practice with children exposed to intimate partner violence (IPV), the main purpose of the present paper was to present a critical review of four of the most widely used theoretical frameworks used to explain the mechanisms accounting for the adverse developmental outcomes observed in children exposed to IPV. First, we described the main propositions of these frameworks, which include developmental psychopathology, social learning theory, attachment theory, and trauma theory. Next we provided a critical review of the main empirical findings related to the study of children's adjustment following exposure to IPV within each of these frameworks, as well as a critical comparison of the four frameworks that takes into account their explanatory power concerning the development of adjustment difficulties observed in this population. We concluded our review by recommending the most suitable and useful frameworks with regard to elucidating the mechanisms involved in the development of adjustment difficulties in children following exposure to IPV.

Backgrounds Despite multiple studies demonstrating no relationship between childhood vaccination and increasing Autism Spectrum Disorder (ASD) prevalence, parental fear for vaccination and subsequent refusal to vaccinate their children continue, resulting in recent outbreaks of childhood infections such as measles in the US. We examine the relationship between the completion of 6 recommended vaccinations in childhood and the likelihood for having developmental psychopathology. Methods Two large-scale South Korean epidemiologic samples were used to examine whether completion of childhood vaccinations decrease likelihood of having ASD as assessed by Autism Spectrum Screening Questionnaire (ASSQ) and behavioral problems scores. Parental reports on vaccination completion were categorized in groups: Results 84.3 % of DS and 80.1 % of RS participants were fully vaccinated. In the DS, after adjusting for demographics and confounders, children with incomplete-vaccinations were at greater risk for ASD when compared to those fully vaccinated (adjusted odds ratio [aOR] = 1.42, 95 % Confidence Interval [CI] 1.17−1.73 with 4−5 vaccinations; aOR = 2.33, CI 1.53−3.56 with vaccination Conclusions We replicate our own and prior findings that vaccination does not increase ASD risk. Further, completing recommended vaccinations may offer protection against the risk of having ASD and other developmental psychopathology.

Anxiety disorders are common and impairing throughout the life course. Propensity to anxiety disorders manifests as distress and avoidance of novel stimuli (called behavioural inhibition) as early as in infancy. Already in preschool children, anxiety disorders impact emotional development and school readiness. Anxiety disorders and behavioural inhibition are prospectively associated with increased risk of mood disorders, substance use, and suicide. Therefore, early targeted prevention and treatment need to be considered. Cognitive-behavioural interventions are effective for anxiety in older age group but their efficacy for preschool children remains to be established.We searched PsycINFO, PubMed, and Embase until September 19th, 2019 using terms describing anxiety, behavioural inhibition, intervention, and young children. We included studies with young children participating in a cognitive-behavioural intervention for anxiety disorders, anxiety symptoms, or behavioural inhibition. We completed random-effects robust meta-analyses to (1) compare anxiety measures before and after intervention and to (2) compare intervention and control groups.We identified 43 samples including 2656 participants with a mean age of 5.45 (SD = 1.00) years. Anxiety decreased after cognitive-behavioural intervention (standardized mean difference [SMD] = -1.34, 95%CI -1.59 to -1.09, p 0.0001). Anxiety decreased more in children who received intervention than in children in control conditions (SMD = -0.81, 95%CI -1.00 to -0.63, p 0.0001). The difference remained significant after correcting for potential publication bias and outliers (SMD = -0.89, 95% CI -1.13 to -0.66, p 0.0001). The improvement was maintained over follow-up.Cognitive-behavioural interventions are effective for prevention and treatment of anxiety in young children.

Summary Behavioral sleep problems in early childhood are common, affecting about 25% of children, and include symptoms such as problems going to sleep and staying asleep. This review employed the developmental psychopathology framework and 4P model (Predisposing, Precipitating, Perpetuating, Protective) to organize the diverse risk/protective factors (distal variables experienced indirectly by the child) and processes (proximal variables experienced directly by the child) for child sleep problems among preschool (1–5 y) and school-age (6–10 y) children. Variables were categorized into biological, psychological, and environmental factors/processes at the individual, family/parent, and community levels. The quality of evidence was assessed using GRADE. A literature search identified 98 articles meeting inclusion criteria. Older child age, difficult temperament, previous sleep problems, externalizing psychopathology, internalizing psychopathology, and electronics use (e.g., bedtime TV viewing) were identified as child risk variables predicting sleep problems. Parental presence at bedtime (risk), negative parenting style (e.g., lax or permissive parenting; risk), consistent bedtime routines (protective), and lower composite socioeconomic status (risk) were identified as family/parent variables predicting child sleep problems. No well-established predictors were found at the community level. Future research should employ advanced research designs more frequently and investigate: 1) risk pathways across development; and 2) nightly fluctuations in sleep problems.

Prenatal testosterone is considered to be a possible factor contributing to the development of attention-deficit/hyperactivity disorder (ADHD) symptomatology, but findings regarding the connection between individual variations in prenatal testosterone exposure as (indirectly) indexed by the second-to-fourth digit (2D:4D) ratio and ADHD remain inconsistent. To clarify the inconsistent findings and to facilitate generalization on the association between subclinical variations in ADHD tendencies and lower 2D:4D ratios the current study applied a cross-cultural replication approach employing independent healthy adult cohorts from Germany and China. Samples from Germany and China were matched for gender and age (in each sample nmales = 96, nfemales = 96; ageGermany: M = 21.47, SD = 2.55; ageChina: M = 21.36, SD = 2.28). All participants filled in the Adult ADHD Self-Report Scale Symptom Checklist (ASRS) and provided hand scans to measure 2D:4D ratios. The German sample had significantly higher 2D:4D ratios than the Chinese sample but in both samples males had significantly lower 2D:4D ratios than females. The hypothesised negative association between 2D:4D ratios and ADHD tendencies was observed on a descriptive level in German and Chinese males and with one exception in Chinese females. But only in German males correlations gained significance (range: r = −0.198 to r = −0.177). The observed effect sizes are in line with former research that was conducted in samples from different cultures. In future research on the connection between testosterone and ADHD not only prenatal but also postnatal testosterone as well as possible moderators like childhood maltreatment should be taken into account.

Rumination has been conceptualized as a stable, trait-level response style involving repetitive and passive focus on the symptoms of distress and the possible causes and consequences of those symptoms. This theoretical review examines developmental risk factors of ruminative response style, incorporating a developmental psychopathology perspective. A model integrating these developmental factors within a conceptual framework is proposed, wherein risk factors for distress (i.e., temperamental negative affectivity, stressful environments, parenting, and genetic vulnerability) lead to engagement in rumination. We propose that when rumination is well-practiced, it will consolidate into a trait-like response style, especially among adolescents who experience cognitive control deficits. Reciprocal relationships and moderators that may contribute to the formation of a ruminative response style are also included. To understand how these factors converge and influence the formation of ruminative response styles, we review patterns of stability and change in physical and cognitive development to demonstrate that individual differences in rumination may emerge and consolidate into enduring, trait-level response styles during early adolescence.

Bridging advances in neurodevelopmental assessment and the established onset of common psychopathologies in early childhood with epidemiological data science and computational methods holds much promise for identifying risk for mental disorders as early as infancy. In particular, we propose the development of a mental health risk algorithm for the early detection of mental disorders with the potential for high public health impact that applies and adapts methods innovated in and successfully applied to early detection of cardiovascular risk. Specifically, we propose methods to advance risk prediction of early developmental psychopathology by creating synthetic cohorts that contain complete behavioral and neural data in the first years of life, as the basis for a robust and generalizable risk algorithm. The application of computational approaches within synthetic cohorts, an approach increasingly applied in psychiatry, may be particularly well suited to advancing risk prediction in early childhood mental health. We propose new research directions using these methods to generate an early childhood mental health risk calculator that could significantly advance early mental health risk detection to direct preventive intervention and/or need for more intensive assessment within a pragmatic framework for maximal clinical utility. The availability of such a tool in early childhood, a period of high neuroplasticity, holds promise to reduce the burden of mental disorder by identifying risk early in the clinical sequence and delivering prevention that targets the neurodevelopmental vulnerability phase.

Bipolar disorder and schizophrenia share phenotypic and genotypic features, but might differ in aspects of abnormal neurodevelopmental trajectories. We studied gyrification, a marker of early developmental pathology, in high-resolution MRI scans of 34 patients with schizophrenia, 17 euthymic bipolar I disorder patients with previous psychotic symptoms, and 34 matched healthy controls in order to test the hypothesis of overlapping and diverging prefrontal gyrification abnormalities. We applied a novel, validated method for measuring local gyrification in each vertex point of the reconstructed cortical surface. Psychotic bipolar I patients had higher gyrification in dorsal anterior and infragenual cingulate cortex compared to either schizophrenia or healthy controls, while schizophrenia patients had higher gyrification than controls in anterior medial (BA 10) and orbitofrontal areas, altogether indicating disease-specific alterations in the prefrontal cortex. Our findings indicate gyrification changes in a specific subgroup of bipolar I disorder to affect an area relevant to emotion regulation, and distinct from changes seen in schizophrenia.

Objective Impairments in cognitive emotion regulation (CER) have been linked to functional neural abnormalities and the pathogenesis of major depressive disorder (MDD). Few functional magnetic resonance imaging (fMRI) studies have investigated the neural underpinnings of CER in samples with depression. As CER develops in childhood, understanding dysfunctional CER-related alterations in brain function during this period could advance knowledge of the developmental psychopathology of MDD. Method This study tested whether neural activity in brain regions known to support cognitive reappraisal differed between healthy 7- to 15-year-old children and same-age peers with a history of MDD (MDD-ever). A total of 64 children participated in this event-related fMRI study, which used a developmentally appropriate and validated fMRI reappraisal task. Children were instructed to passively view sad or neutral images and to decrease negative emotions using cognitive reappraisal. Results MDD-ever and healthy children showed similar patterns of cortical activation during reappraisal, but with a significant difference found in 1 key CER region, the left inferior frontal gyrus (IFG). In addition, individual differences in CER were associated with left IFG activity during reappraisal. Conclusion Alterations in the neurocircuitry of reappraisal are evident in children with a depression history compared to healthy controls. The finding that MDD-ever children showed reappraisal-related neural responses in many regions similar to healthy controls has clinical implications. Findings suggest that identification of alterations in reappraisal in children with remitted depression, for whom much, although not all, of the neural circuitry remains intact, may be an important window of opportunity for intervention.

Purpose Leading criminologists have observed that criminology has much to learn from the developmental psychopathology literature which traces the temperamental and developmental factors that give rise to conduct problems early in life. Methods This article reviewed and applied what is arguably the dominant biosocial theory in developmental psychopathology relevant to crime and delinquency — the Beauchaine Ontogenic Process Model of externalizing psychopathology. Results The model is based on the finding from numerous studies that early-starting male antisocial behavior that tends to be life course persistent begins with temperamental trait impulsivity as the core predisposing biological vulnerability which is first manifested in preschool in its most extreme expression in Attention-Deficit/Hyperactivity Disorder; followed by Oppositional Defiant Disorder in elementary school, development of Conduct Disorder in middle school, Substance Use Disorder in high school, and criminality in adulthood. Conclusions Prevention of the development of the antisocial trajectory begins with the identification and treatment of preschool ADHD.

Irritability is an aspect of the negative affectivity domain of temperament, but in severe and dysregulated forms is a symptom of a range of psychopathologies. Better understanding of the neural underpinnings of irritability, outside the context of specific disorders, can help to understand normative variation but also characterize its clinical salience in psychopathology diagnosis. This study assessed brain activation during reward and frustration, domains of behavioral deficits in childhood irritability. Children (age 6–9) presenting in mental health clinics for extreme and impairing irritability ( n = 26) were compared to healthy children ( n = 28). Using developmentally sensitive methods, neural activation was measured via a negative mood induction paradigm during fMRI scanning. The clinical group displayed more activation of the anterior cingulate and middle frontal gyrus during reward, but less activation during frustration, than healthy comparison children. The opposite pattern was found in the posterior cingulate. Further, in clinical subjects, parent report of irritability was dimensionally related to decreased activation of the anterior cingulate and striatum during frustration. The results of this study indicate neural dysfunction within brain regions related to reward processing, error monitoring, and emotion regulation underlying clinically impairing irritability. Results are discussed in the context of a growing field of neuroimaging research investigating irritable children.

Objective The importance of dimensional approaches is widely recognized, but an empirical base for clinical application is lacking. This is particularly true for irritability, a dimensional phenotype that cuts across many areas of psychopathology and manifests early in life. We examine longitudinal, dimensional patterns of irritability and their clinical import in early childhood. Method Irritability was assessed longitudinally over an average of 16 months in a clinically enriched, diverse community sample of preschoolers (N = 497; mean = 4.2 years; SD = 0.8). Using the Temper Loss scale of the Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB) as a developmentally sensitive indicator of early childhood irritability, we examined its convergent/divergent, clinical, and incremental predictive validity, and modeled its linear and nonlinear associations with clinical risk. Results The Temper Loss scale demonstrated convergent and divergent validity to child and maternal factors. In multivariate analyses, Temper Loss predicted mood (separation anxiety disorder [SAD], generalized anxiety disorder [GAD], and depression/dysthymia), disruptive (oppositional defiant disorder [ODD], attention-deficit/hyperactivity disorder [ADHD], and conduct disorder [CD]) symptoms. Preschoolers with even mildly elevated Temper Loss scale scores showed substantially increased risk of symptoms and disorders. For ODD, GAD, SAD, and depression, increases in Temper Loss scale scores at the higher end of the dimension had a greater impact on symptoms relative to increases at the lower end. Temper Loss scale scores also showed incremental validity over DSM-IV disorders in predicting subsequent impairment. Finally, accounting for the substantial heterogeneity in longitudinal patterns of Temper Loss significantly improved prediction of mood and disruptive symptoms. Conclusion Dimensional, longitudinal characterization of irritability informs clinical prediction. A vital next step will be empirically generating parameters for the incorporation of dimensional information into clinical decision-making with reasonable certainty.

We propose that role-confusion or role reversal between parent and child is a major risk factor for a child's development, yet one that has gone largely unnoticed. In the context of an evolutionary tension between parental reproductive needs and child needs for nurturing, parental history and current stressors may affect the ability to invest in parenting a particular child. When adult relationships do not provide adequate emotional and instrumental support to the parent, he or she may look to a child to provide that support. A growing empirical literature across clinical, family systems and developmental disciplines has pointed to the potential for the child to take on the role of parent, spouse, or peer in relation to the parent, such that traditional parent–child roles become confused or reversed and generational boundaries blurred. From a developmental psychopathology perspective, this change in parent–child role relations may adversely affect the child's socio-emotional development if demands placed on the child exceed the capacity to comply, thus increasing the risk for psychopathology. Conversely, shouldering family responsibilities that are within the developmental capacities of the child may lead to increased self-efficacy and competence. This paper critically reviews the growing literature, proposes a model for precursors to, and sequelae of, role-confusion, examines resilience, and points to directions for future research and preventive interventions.

AimTo assess the effectiveness of the Healthy School and Drugs (HSD) program for secondary schools on the development of substance use among Dutch early adolescents and to explore whether boys, adolescents of lower educational backgrounds, or adolescents high on personality risk traits, would benefit more from the HSD program than others.DesignRandomized clustered trial with two intervention conditions (i.e., lessons and integral) among a general population of adolescents in the Netherlands.ParticipantsA total of 3784 students of 23 Dutch secondary schools.MeasurementsStructured digital questionnaires were administered pre-intervention and at 8, 20, and 32 months follow-ups. The outcome measure was the rate of change in substance use across follow-ups. Differential effectiveness of the HSD program was examined for sex, educational level, and personality traits.FindingsOur results show no HSD intervention effects on the development of substance use. Sex, education level, and personality characteristics of the participants did not moderate the intervention effects.ConclusionThe absence of effects of the Healthy School and Drugs program on the development of substance use indicates that the program should be renewed and redeveloped.KeywordsSubstance use; Randomized clustered trial; Early adolescents; Prevention; Latent growth curve modeling

BACKGROUND: Depression is the most common psychiatric disorder in adolescence, and is characterised by an inability to down-regulate negative emotional responses to stress. Adult studies suggest this may be associated with reduced functional connectivity between prefrontal and subcortical regions, yet the neurological mechanisms in adolescence remain unclear. METHODS: We developed a novel, age-appropriate, reappraisal paradigm to investigate functional connectivity during reappraisal of a real-life source of stress in 15 depressed and 15 non-depressed adolescents. During fMRI, participants i) attended to, and ii) implemented reappraisal techniques (learnt prior to fMRI) in response to, rejection. RESULTS: Reappraisal reduced negative mood and belief in negative thoughts in both groups alike, however during reappraisal (versus attend) trials, depressed adolescents showed greater connectivity between the right frontal pole and numerous subcortical and cortical regions than non-depressed adolescents. CONCLUSIONS: These findings tentatively suggest that, when instructed, depressed adolescents do have the ability to engage neural networks involved in emotion regulation, possibly because adolescence reflects a period of heightened plasticity. These data support the value of cognitive reappraisal as a treatment tool, identify neural markers that could be used to optimise current therapies, and lay the foundations for developing novel neuroscientific techniques for the treatment of adolescent depression. Language: en

Overweight is associated with a range of negative health consequences, such as type 2 diabetes, cardiovascular disease, gastrointestinal disorders, and premature mortality.1 One means to combat overweight is through encouraging people to eat more slowly.2 People who eat quickly tend to consume more3, 4 and 5 and have a higher body mass index,6, 7, 8 and 9 whereas people who eat more slowly feel sated earlier and eat less.10, 11, 12 and 13. Unfortunately, eating rate is difficult to modify, because of its highly automatic nature.14 In clinical settings, researchers have had some success changing behavior by using devices that deliver feedback in real time.15, 16 and 17 However, existing technologies are either too cumbersome18 or not engaging enough19 for use in daily life contexts. Training people to eat more slowly in everyday eating contexts, therefore, requires creative and engaging solutions. This article presents a qualitative evaluation of the feasibility of a smart fork to decelerate eating rate in daily life contexts. Furthermore, we outline the planned research to test the efficacy of this device in both laboratory and community settings

Item does not contain fulltext Objective: The present study examined the longitudinal relations between illness perceptions and asthma control and emotional problems (i.e., anxiety, depression, stress), respectively, in adolescents with asthma. Furthermore, the mediating effects of asthma-specific coping strategies on these relations were examined, as specified in the Common Sense Model (CSM). Methods: In 2011, 2012, and 2013, adolescents (aged 10-15) with asthma were visited at home (N = 253) and completed questionnaires about their illness perceptions, asthma-specific coping strategies, asthma control, symptoms of anxiety and depression, and perceived stress. Path analyses were used to examine the direct relations of illness perceptions with asthma control and emotional problems and the mediating effects of coping strategies cross-sectionally and longitudinally. Results: Perceptions of less perceived control and attributing more complaints to asthma were associated with better asthma control. Perceptions of more concern, less coherence, and increased influence of asthma on emotional well-being were associated with more emotional problems. Longitudinally, perceptions of more treatment control and fewer concerns predicted less emotional problems over time. More worrying mediated the cross-sectional relation between perceiving more concern about asthma and less asthma control and the longitudinal relation between perceiving more concern about asthma and more emotional problems. Conclusion: Illness perceptions were associated with asthma control and emotional problems; however, over time, illness perceptions only predicted changes in emotional problems. Most coping strategies did not mediate the relation between illness perceptions and outcomes. Interventions aimed to change illness perceptions in adolescents with asthma could decrease emotional problems.

Research implicates prenatal maternal stress (PNMS) as a risk factor for neurodevelopmental disorders; however few studies report PNMS effects on autism risk in offspring. We examined, prospectively, the degree to which objective and subjective elements of PNMS explained variance in autism-like traits among offspring, and tested moderating effects of sex and PNMS timing in utero. Subjects were 89 (46F/43M) children who were in utero during the 1998 Quebec Ice Storm. Soon after the storm, mothers completed questionnaires on objective exposure and subjective distress, and completed the Autism Spectrum Screening Questionnaire (ASSQ) for their children at age 6½. ASSQ scores were higher among boys than girls. Greater objective and subjective PNMS predicted higher ASSQ independent of potential confounds. An objective-by-subjective interaction suggested that when subjective PNMS was high, objective PNMS had little effect; whereas when subjective PNMS was low, objective PNMS strongly affected ASSQ scores. A timing-by-objective stress interaction suggested objective stress significantly affected ASSQ in first-trimester exposed children, though less so with later exposure. The final regression explained 43% of variance in ASSQ scores; the main effect of sex and the sex-by-PNMS interactions were not significant. Findings may help elucidate neurodevelopmental origins of non-clinical autism-like traits from a dimensional perspective.