1. Reperfusion injury after temporary coronary occlusion
- Author
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Jakob Vinten-Johansen, Kirk B. Faust, DeMasi Rj, A. R. Cordell, Stephen A. Mills, Kim R. Geisinger, and William E. Johnston
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Diastole ,Hemodynamics ,Anterior Descending Coronary Artery ,medicine.disease ,Surgery ,Sonomicrometry ,medicine.anatomical_structure ,Coronary occlusion ,Internal medicine ,Occlusion ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Reperfusion injury ,Artery - Abstract
In 24 anesthetized open-chest dogs, we examined the time course of changes in contractile function, diastolic muscle stiffness (sonomicrometry), tissue water content, and ultrastructure after 1 hour of occlusion of the left anterior descending coronary artery and after 2 hours of unmodified reperfusion. One hour of occlusion of the left anterior descending artery replaced active shortening with passive bulging (21.4% ± 2.9% versus -5.9% ± 0.9%, p
- Published
- 1988
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