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16 results on '"Debette S"'

1. Clonal hematopoiesis of indeterminate potential do not highly increase the risk of myocardial infarction even when associated with mosaic loss of Y chromosome

Author

Fawaz, S., primary, Marti, S., additional, Dufossée, M., additional, Pucheu, Y., additional, Gaufroy, A., additional, Broitman, J., additional, Bidet, A., additional, Soumaré, A., additional, Munsch, G., additional, Tzourio, C., additional, Debette, S., additional, Trégouët, D.-A., additional, James, C., additional, Mansier, O., additional, and Couffinhal, T., additional

Published
2024
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2. Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases

Author

Georges, A., primary, Yang, M.L., additional, Berrandou, T.E., additional, Mengyao, Y., additional, Dikilitas, O., additional, Ma, L., additional, Kyryachenko, S., additional, Liu, L., additional, Amar, L., additional, Lorthioir, A., additional, Debette, S., additional, Gornik, H.L., additional, Azizi, M., additional, Jeunemaitre, X., additional, Januszewicz, A., additional, Kullo, I., additional, Persu, A., additional, Kovacic, J., additional, Ganesh, S., additional, and Bouatia-Naji, N., additional

Published
2021
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4. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies.

Author

Ding, J, Davis-Plourde, KL, Sedaghat, S, Tully, PJ, Wang, W, Phillips, C, Pase, MP, Himali, JJ, Gwen Windham, B, Griswold, M, Gottesman, R, Mosley, TH, White, L, Guðnason, V, Debette, S, Beiser, AS, Seshadri, S, Ikram, MA, Meirelles, O, Tzourio, C, Launer, LJ, Ding, J, Davis-Plourde, KL, Sedaghat, S, Tully, PJ, Wang, W, Phillips, C, Pase, MP, Himali, JJ, Gwen Windham, B, Griswold, M, Gottesman, R, Mosley, TH, White, L, Guðnason, V, Debette, S, Beiser, AS, Seshadri, S, Ikram, MA, Meirelles, O, Tzourio, C, and Launer, LJ

Abstract

BACKGROUND: Dementia is a major health concern for which prevention and treatment strategies remain elusive. Lowering high blood pressure with specific antihypertensive medications (AHMs) could reduce the burden of disease. We investigated whether specific AHM classes reduced the risk for dementia. METHODS: We did a meta-analysis of individual participant data from eligible observational studies published between Jan 1, 1980, and Jan 1, 2019. Cohorts were eligible for inclusion if they prospectively recruited community-dwelling adults; included more than 2000 participants; collected data for dementia events over at least 5 years; had measured blood pressure and verified use of AHMs; included in-person exams, supplemented with additional data, to capture dementia events; and had followed up cases for mortality. We assessed the association of incident dementia and clinical Alzheimer's disease with use of five AHM classes, within strata of baseline high (systolic blood pressure [SBP] ≥140 mm Hg or diastolic blood pressure [DBP] ≥90 mm Hg) and normal (SBP <140 mm Hg and DBP <90 mm Hg) blood pressure. We used a propensity score to control for confounding factors related to the probability of receiving AHM. Study-specific effect estimates were pooled using random-effects meta-analyses. RESULTS: Six prospective community-based studies (n=31 090 well phenotyped dementia-free adults older than 55 years) with median follow-ups across cohorts of 7-22 years were eligible for analysis. There were 3728 incident cases of dementia and 1741 incident Alzheimer's disease diagnoses. In the high blood pressure stratum (n=15 537), those using any AHM had a reduced risk for developing dementia (hazard ratio [HR] 0·88, 95% CI 0·79-0·98; p=0·019) and Alzheimer's disease (HR 0·84, 0·73-0·97; p=0·021) compared with those not using AHM. We did not find any significant differences between one drug class versus all others on risk of dementia. In the normal blood pressure stratum (n=15 553), ther

Published
2020

7. Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study

Author

Olson, N.C., primary, Butenas, S., additional, Lange, L.A., additional, Lange, E.M., additional, Cushman, M., additional, Jenny, N.S., additional, Walston, J., additional, Souto, J.C., additional, Soria, J.M., additional, Chauhan, G., additional, Debette, S., additional, Longstreth, W.T., additional, Seshadri, S., additional, Reiner, A.P., additional, and Tracy, R.P., additional

Published
2015
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