1. Integrity of 111In-radiolabeled superparamagnetic iron oxide nanoparticles in the mouse
- Author
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Srinivas Sridhar, Richard I. Duclos, Samuel J. Gatley, Haotian Wang, Dattatri Nagesha, and Rajiv Kumar
- Subjects
Male ,Cancer Research ,Chemistry, Pharmaceutical ,Iron oxide ,Nanoparticle ,Ligands ,Ferric Compounds ,Polyethylene Glycols ,Mice ,chemistry.chemical_compound ,In vivo ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Magnetite Nanoparticles ,Phospholipids ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,Indium Radioisotopes ,Radiochemistry ,Mononuclear phagocyte system ,Oleic acid ,chemistry ,Positron emission tomography ,Isotope Labeling ,Positron-Emission Tomography ,Molecular Medicine ,Emission computed tomography ,Iron oxide nanoparticles ,Oleic Acid - Abstract
Introduction Iron-oxide nanoparticles can act as contrast agents in magnetic resonance imaging (MRI), while radiolabeling the same platform with nuclear medicine isotopes allows imaging with positron emission tomography (PET) or single-photon emission computed tomography (SPECT), modalities that offer better quantification. For successful translation of these multifunctional imaging platforms to clinical use, it is imperative to evaluate the degree to which the association between radioactive label and iron oxide core remains intact in vivo. Methods We prepared iron oxide nanoparticles stabilized by oleic acid and phospholipids which were further radiolabeled with 59 Fe, 14 C-oleic acid, and 111 In. Results Mouse biodistributions showed 111 In preferentially localized in reticuloendothelial organs, liver, spleen and bone. However, there were greater levels of 59 Fe than 111 In in liver and spleen, but lower levels of 14 C. Conclusions While there is some degree of dissociation between the 111 In labeled component of the nanoparticle and the iron oxide core, there is extensive dissociation of the oleic acid component.
- Published
- 2015