1. Emerging Knowledge of the Neurobiology of COVID-19
- Author
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Timothy R Nicholson, Mao Fong Lim, Hamilton Morrin, Thomas A Pollak, Benjamin Cross, Emma Rachel Rengasamy, Matthew Butler, Danish Hafeez, Nicholson, Timothy R [0000-0002-2350-2332], and Apollo - University of Cambridge Repository
- Subjects
Long COVID ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,COVID-19 ,Delirium ,Neuropsychiatry ,Article ,Psychiatry and Mental health ,Post-Acute COVID-19 Syndrome ,Neurobiology ,Humans ,Nervous System Diseases ,Psychology ,Neuroscience - Abstract
Synopsis Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge, however the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into two broad categories: neuropsychiatric deficits occurring after severe (hospitalised) COVID-19, and ‘long COVID’, which occurs in many patients with a milder acute COVID-19 illness.
- Published
- 2022
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