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Your search keyword '"DI SCIPIO, Federica"' showing total 6 results
Start Over Author "DI SCIPIO, Federica" Publisher elsevier bv
6 results on '"DI SCIPIO, Federica"'

1. Patient-Specific iPSC-Derived Endothelial Cells Provide Long-Term Phenotypic Correction of Hemophilia A

Author

Olgasi, Cristina, primary, Talmon, Maria, additional, Merlin, Simone, additional, Cucci, Alessia, additional, Richaud-Patin, Yvonne, additional, Ranaldo, Gabriella, additional, Colangelo, Donato, additional, Di Scipio, Federica, additional, Berta, Giovanni N., additional, Borsotti, Chiara, additional, Valeri, Federica, additional, Faraldi, Francesco, additional, Prat, Maria, additional, Messina, Maria, additional, Schinco, Piercarla, additional, Lombardo, Angelo, additional, Raya, Angel, additional, and Follenzi, Antonia, additional

Published
2018
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2. Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line.

Author

Audisio, Chiara, Raimondo, Stefania, Nicolino, Silvia, Gambarotta, Giovanna, Di Scipio, Federica, Macrì, Loredana, Montarolo, Francesca, Giacobini-Robecchi, Maria Giuseppina, Porporato, Paolo, Filigheddu, Nicoletta, Graziani, Andrea, Geuna, Stefano, Perroteau, Isabelle, Audisio, Chiara, Raimondo, Stefania, Nicolino, Silvia, Gambarotta, Giovanna, Di Scipio, Federica, Macrì, Loredana, Montarolo, Francesca, Giacobini-Robecchi, Maria Giuseppina, Porporato, Paolo, Filigheddu, Nicoletta, Graziani, Andrea, Geuna, Stefano, and Perroteau, Isabelle

Abstract

Cell transplantation therapy has raised a great interest in the perspective of its employment for nerve tissue repair. Among the various cell populations proposed, olfactory ensheathing glial cells have raised great interest over recent years, especially in the perspective of their employment for neural repair because of their homing capacity in both central and peripheral nervous system. This paper is aimed to provide an in vitro characterization of the NOBEC (neonatal olfactory bulb ensheathing cell) line that was obtained from primary cells dissociated from rat neonatal olfactory bulb (OB) and immortalized by retroviral transduction of SV40 large T antigen. Light and electron microscopy investigation showed that NOBECs are a homogeneous cell population both at structural and ultrastructural level. RT-PCR, Western blotting and immunocytochemistry showed that NOBECs express the glial markers S100, GFAP (Glial Fibrillar Acid Protein) and p75NGFR as well as NRG1 (neuregulin-1) and ErbB1-2-3 receptors; while they are negative for ErbB4. Yet, NOBECs exhibit a high proliferation and migration basal activity and can be transducted with vectors carrying GFP (green fluorescent protein) and NRG1 cDNA. Functional stimulation by means of NRG1-III-beta3 overexpression through viral transduction induced a significant increase in cell proliferation rate while it had no effect on cell migration. Altogether, these results show that NOBEC cell line retain glial features both morphologically and functionally, responding to the NRG1/ErbB-mediated gliotrophic stimulus, and represents thus a good tool for in vitro assays of glial cell manipulation and for in vivo experimental studies of glial cell transplantation in the central and peripheral nervous system.

Published
2009

3. Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal

Author

Testa, Gabriella, primary, Gamba, Paola, additional, Di Scipio, Federica, additional, Sprio, Andrea Elio, additional, Salamone, Paolina, additional, Gargiulo, Simona, additional, Sottero, Barbara, additional, Biasi, Fiorella, additional, Berta, Giovanni Nicolao, additional, Poli, Giuseppe, additional, and Leonarduzzi, Gabriella, additional

Published
2012
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4. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-β-cyclodextrin

Author

Berta, Giovanni Nicolao, primary, Salamone, Paolina, additional, Sprio, Andrea Elio, additional, Di Scipio, Federica, additional, Marinos, Lucy Marcela, additional, Sapino, Simona, additional, Carlotti, Maria Eugenia, additional, Cavalli, Roberta, additional, and Di Carlo, Francesco, additional

Published
2010
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5. Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line

Author

Audisio, Chiara, primary, Raimondo, Stefania, additional, Nicolino, Silvia, additional, Gambarotta, Giovanna, additional, Di Scipio, Federica, additional, Macrì, Loredana, additional, Montarolo, Francesca, additional, Giacobini-Robecchi, Maria Giuseppina, additional, Porporato, Paolo, additional, Filigheddu, Nicoletta, additional, Graziani, Andrea, additional, Geuna, Stefano, additional, and Perroteau, Isabelle, additional

Published
2009
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6. Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats

Author

Pereira, José E., primary, Costa, Luís M., additional, Cabrita, António M., additional, Couto, Pedro A., additional, Filipe, Vítor M., additional, Magalhães, Luís G., additional, Fornaro, Michele, additional, Di Scipio, Federica, additional, Geuna, Stefano, additional, Maurício, Ana C., additional, and Varejão, Artur S.P., additional

Published
2009
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