1. A New Urinary Metabolite of Pantothenate in Dogs
- Author
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D. E. Hathway, H. Partington, Hawkins Dr, and T Taylor
- Subjects
Vitamin ,Carbon Isotopes ,medicine.medical_specialty ,General Veterinary ,Urinary system ,Metabolite ,Glucuronates ,Urine ,Pharmacology ,Pantothenic Acid ,Rats ,Excretion ,chemistry.chemical_compound ,Metabolic pathway ,Dogs ,Endocrinology ,chemistry ,Internal medicine ,Pantothenic acid ,medicine ,Animals ,Chromatography, Thin Layer ,Glucuronide - Abstract
SUMMARY In dogs treated intravenously or orally with sodium pantothenate, the principal urinary metabolite has been identified provisionally as the vitamin ester β-glucuronide; 0-5 per cent of an oral dose is excreted in the urine as unchanged pantothenic acid, all in the first 24 h, and up to 40 per cent as the ester β-glucuronide in 7 days. Small amounts of the ester β-glucuronide are detectable in the urine, voided 2 months after dosing. In comparison, rats excrete 25 per cent of the dose in the 7-day urine as unchanged pantothenic acid, but no ester glucuronide was detected. Thus, dogs and rats show a species difference both in the metabolic pathway of pantothenic acid and in the rate of excretion of the vitamin and its metabolites. Excretion of pantothen [ 14 C]ic acid in the urine of dogs, treated 2 months earlier with pantothen [ 14 C]ate, was brought about by the administration of a massive dose of unlabelled pantothenate.
- Published
- 1972