54 results on '"Dörk, Thilo"'
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2. Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels
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Wang, Xuemin, primary, Kho, Pik Fang, additional, Ramachandran, Dhanya, additional, Bafligil, Cemsel, additional, Amant, Frederic, additional, Goode, Ellen L., additional, Scott, Rodney J., additional, Tomlinson, Ian, additional, Evans, D. Gareth, additional, Crosbie, Emma J., additional, Dörk, Thilo, additional, Spurdle, Amanda B., additional, Glubb, Dylan M., additional, and O'Mara, Tracy A., additional
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- 2023
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3. Incorporating progesterone receptor expression into the PREDICT breast prognostic model
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Grootes, Isabelle, primary, Keeman, Renske, additional, Blows, Fiona M., additional, Milne, Roger L., additional, Giles, Graham G., additional, Swerdlow, Anthony J., additional, Fasching, Peter A., additional, Abubakar, Mustapha, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Beckmann, Matthias W., additional, Blomqvist, Carl, additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Bonanni, Bernardo, additional, Briceno, Ignacio, additional, Burwinkel, Barbara, additional, Camp, Nicola J., additional, Castelao, Jose E., additional, Choi, Ji-Yeob, additional, Clarke, Christine L., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Devilee, Peter, additional, Dörk, Thilo, additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Easton, Douglas F., additional, Eccles, Diana M., additional, Eriksson, Mikael, additional, Ernst, Kristina, additional, Evans, D. Gareth, additional, Figueroa, Jonine D., additional, Fink, Visnja, additional, Floris, Giuseppe, additional, Fox, Stephen, additional, Gabrielson, Marike, additional, Gago-Dominguez, Manuela, additional, García-Sáenz, José A., additional, González-Neira, Anna, additional, Haeberle, Lothar, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hamann, Ute, additional, Harkness, Elaine F., additional, Hartman, Mikael, additional, Hein, Alexander, additional, Hooning, Maartje J., additional, Hou, Ming-Feng, additional, Howell, Sacha J., additional, Ito, Hidemi, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Jung, Audrey, additional, Kang, Daehee, additional, Kristensen, Vessela N., additional, Kwong, Ava, additional, Lambrechts, Diether, additional, Li, Jingmei, additional, Lubiński, Jan, additional, Manoochehri, Mehdi, additional, Margolin, Sara, additional, Matsuo, Keitaro, additional, Taib, Nur Aishah Mohd, additional, Mulligan, Anna Marie, additional, Nevanlinna, Heli, additional, Newman, William G., additional, Offit, Kenneth, additional, Osorio, Ana, additional, Park, Sue K., additional, Park-Simon, Tjoung-Won, additional, Patel, Alpa V., additional, Presneau, Nadege, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Radice, Paolo, additional, Rennert, Gad, additional, Romero, Atocha, additional, Saloustros, Emmanouil, additional, Sawyer, Elinor J., additional, Schneeweiss, Andreas, additional, Schochter, Fabienne, additional, Schoemaker, Minouk J., additional, Shen, Chen-Yang, additional, Shibli, Rana, additional, Sinn, Peter, additional, Tapper, William J., additional, Tawfiq, Essa, additional, Teo, Soo Hwang, additional, Teras, Lauren R., additional, Torres, Diana, additional, Vachon, Celine M., additional, van Deurzen, Carolien H.M., additional, Wendt, Camilla, additional, Williams, Justin A., additional, Winqvist, Robert, additional, Elwood, Mark, additional, Schmidt, Marjanka K., additional, García-Closas, Montserrat, additional, and Pharoah, Paul D.P., additional
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- 2022
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4. Incorporating progesterone receptor expression into the PREDICT breast prognostic model
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Grootes, Isabelle, Keeman, Renske, Blows, Fiona M, Milne, Roger L, Giles, Graham G, Swerdlow, Anthony J, Fasching, Peter A, Abubakar, Mustapha, Andrulis, Irene L, Anton-Culver, Hoda, Beckmann, Matthias W, Blomqvist, Carl, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Briceno, Ignacio, Burwinkel, Barbara, Camp, Nicola J, Castelao, Jose E, Choi, Ji-Yeob, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Easton, Douglas F, Eccles, Diana M, Eriksson, Mikael, Ernst, Kristina, Evans, D Gareth, Figueroa, Jonine D, Fink, Visnja, Floris, Giuseppe, Fox, Stephen, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Sáenz, José A, González-Neira, Anna, Haeberle, Lothar, Haiman, Christopher A, Hall, Per, Hamann, Ute, Harkness, Elaine F, Hartman, Mikael, Hein, Alexander, Hooning, Maartje J, Hou, Ming-Feng, Howell, Sacha J, ABCTB Investigators, kConFab Investigators, Ito, Hidemi, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kristensen, Vessela N, Kwong, Ava, Lambrechts, Diether, Li, Jingmei, Lubiński, Jan, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Taib, Nur Aishah Mohd, Mulligan, Anna Marie, Nevanlinna, Heli, Newman, William G, Offit, Kenneth, Osorio, Ana, Park, Sue K, Park-Simon, Tjoung-Won, Patel, Alpa V, Presneau, Nadege, Pylkäs, Katri, Rack, Brigitte, Radice, Paolo, Rennert, Gad, Romero, Atocha, Saloustros, Emmanouil, Sawyer, Elinor J, Schneeweiss, Andreas, Schochter, Fabienne, Schoemaker, Minouk J, Shen, Chen-Yang, Shibli, Rana, Sinn, Peter, Tapper, William J, Tawfiq, Essa, Teo, Soo Hwang, Teras, Lauren R, Torres, Diana, Vachon, Celine M, van Deurzen, Carolien HM, Wendt, Camilla, Williams, Justin A, Winqvist, Robert, Elwood, Mark, Schmidt, Marjanka K, García-Closas, Montserrat, Pharoah, Paul DP, Easton, Douglas [0000-0003-2444-3247], Pharoah, Paul [0000-0001-8494-732X], and Apollo - University of Cambridge Repository
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breast cancer ,Receptor, ErbB-2 ,Humans ,PREDICT Breast ,Breast Neoplasms ,Female ,Prognosis ,Receptors, Progesterone ,Progesterone ,Progesterone receptor - Abstract
BACKGROUND: Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2). METHOD: The prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium. Cox proportional hazard models were used to estimate the hazard ratio for PR status. Data from a New Zealand study of 11,365 patients with early invasive breast cancer were used for external validation. Model calibration and discrimination were used to test the model performance. RESULTS: Having a PR-positive tumour was associated with a 23% and 28% lower risk of dying from breast cancer for women with oestrogen receptor (ER)-negative and ER-positive breast cancer, respectively. The area under the ROC curve increased with the addition of PR status from 0.807 to 0.809 for patients with ER-negative tumours (p = 0.023) and from 0.898 to 0.902 for patients with ER-positive tumours (p = 2.3 × 10-6) in the New Zealand cohort. Model calibration was modest with 940 observed deaths compared to 1151 predicted. CONCLUSION: The inclusion of the prognostic effect of PR status to PREDICT Breast has led to an improvement of model performance and more accurate absolute treatment benefit predictions for individual patients. Further studies should determine whether the baseline hazard function requires recalibration.
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- 2022
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5. Exome sequencing identifies RASSF1 and KLK3 germline variants in an Iranian multiple-case breast cancer family
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Radmanesh, Hoda, primary, Liu, Di, additional, Geffers, Robert, additional, Shandiz, Fatemeh Homaei, additional, Sadr-Nabavi, Ariane, additional, Hillemanns, Peter, additional, Park-Simon, Tjoung-Won, additional, and Dörk, Thilo, additional
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- 2022
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6. Causation and causal inference in obstetrics-gynecology
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Dammann, Olaf, primary, Dörk, Thilo, additional, Hillemanns, Peter, additional, and Reydon, Thomas, additional
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- 2022
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7. Performance of a six-methylation-marker assay on self-collected cervical samples – A feasibility study
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Klischke, Lara, primary, von Ehr, Julia, additional, Kohls, Fabian, additional, Kampers, Johanna, additional, Hülse, Fabienne, additional, Schmitz, Martina, additional, Hennig, Anne, additional, Dörk, Thilo, additional, Hillemanns, Peter, additional, and Jentschke, Matthias, additional
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- 2021
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8. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element
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Baxter, Joseph S., primary, Johnson, Nichola, additional, Tomczyk, Katarzyna, additional, Gillespie, Andrea, additional, Maguire, Sarah, additional, Brough, Rachel, additional, Fachal, Laura, additional, Michailidou, Kyriaki, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Dennis, Joe, additional, Ahearn, Thomas U., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Arndt, Volker, additional, Aronson, Kristan J., additional, Augustinsson, Annelie, additional, Becher, Heiko, additional, Beckmann, Matthias W., additional, Behrens, Sabine, additional, Benitez, Javier, additional, Bermisheva, Marina, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Brenner, Hermann, additional, Brucker, Sara Y., additional, Cai, Qiuyin, additional, Campa, Daniele, additional, Canzian, Federico, additional, Castelao, Jose E., additional, Chan, Tsun L., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chenevix-Trench, Georgia, additional, Choi, Ji-Yeob, additional, Clarke, Christine L., additional, Colonna, Sarah, additional, Conroy, Don M., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Daly, Mary B., additional, Devilee, Peter, additional, Dörk, Thilo, additional, Dossus, Laure, additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Ekici, Arif B., additional, Eliassen, A. Heather, additional, Engel, Christoph, additional, Fasching, Peter A., additional, Figueroa, Jonine, additional, Flyger, Henrik, additional, Gago-Dominguez, Manuela, additional, Gao, Chi, additional, García-Closas, Montserrat, additional, García-Sáenz, José A., additional, Ghoussaini, Maya, additional, Giles, Graham G., additional, Goldberg, Mark S., additional, González-Neira, Anna, additional, Guénel, Pascal, additional, Gündert, Melanie, additional, Haeberle, Lothar, additional, Hahnen, Eric, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hamann, Ute, additional, Hartman, Mikael, additional, Hatse, Sigrid, additional, Hauke, Jan, additional, Hollestelle, Antoinette, additional, Hoppe, Reiner, additional, Hopper, John L., additional, Hou, Ming-Feng, additional, Ito, Hidemi, additional, Iwasaki, Motoki, additional, Jager, Agnes, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Joseph, Vijai, additional, Jung, Audrey, additional, Kaaks, Rudolf, additional, Kang, Daehee, additional, Keeman, Renske, additional, Khusnutdinova, Elza, additional, Kim, Sung-Won, additional, Kosma, Veli-Matti, additional, Kraft, Peter, additional, Kristensen, Vessela N., additional, Kubelka-Sabit, Katerina, additional, Kurian, Allison W., additional, Kwong, Ava, additional, Lacey, James V., additional, Lambrechts, Diether, additional, Larson, Nicole L., additional, Larsson, Susanna C., additional, Le Marchand, Loic, additional, Lejbkowicz, Flavio, additional, Li, Jingmei, additional, Long, Jirong, additional, Lophatananon, Artitaya, additional, Lubiński, Jan, additional, Mannermaa, Arto, additional, Manoochehri, Mehdi, additional, Manoukian, Siranoush, additional, Margolin, Sara, additional, Matsuo, Keitaro, additional, Mavroudis, Dimitrios, additional, Mayes, Rebecca, additional, Menon, Usha, additional, Milne, Roger L., additional, Mohd Taib, Nur Aishah, additional, Muir, Kenneth, additional, Muranen, Taru A., additional, Murphy, Rachel A., additional, Nevanlinna, Heli, additional, O’Brien, Katie M., additional, Offit, Kenneth, additional, Olson, Janet E., additional, Olsson, Håkan, additional, Park, Sue K., additional, Park-Simon, Tjoung-Won, additional, Patel, Alpa V., additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Plaseska-Karanfilska, Dijana, additional, Presneau, Nadege, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Rennert, Gad, additional, Romero, Atocha, additional, Ruebner, Matthias, additional, Rüdiger, Thomas, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schmidt, Marjanka K., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Shah, Mitul, additional, Shen, Chen-Yang, additional, Shu, Xiao-Ou, additional, Simard, Jacques, additional, Southey, Melissa C., additional, Stone, Jennifer, additional, Surowy, Harald, additional, Swerdlow, Anthony J., additional, Tamimi, Rulla M., additional, Tapper, William J., additional, Taylor, Jack A., additional, Teo, Soo Hwang, additional, Teras, Lauren R., additional, Terry, Mary Beth, additional, Toland, Amanda E., additional, Tomlinson, Ian, additional, Truong, Thérèse, additional, Tseng, Chiu-Chen, additional, Untch, Michael, additional, Vachon, Celine M., additional, van den Ouweland, Ans M.W., additional, Wang, Sophia S., additional, Weinberg, Clarice R., additional, Wendt, Camilla, additional, Winham, Stacey J., additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Wu, Anna H., additional, Yamaji, Taiki, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Pharoah, Paul D.P., additional, Dunning, Alison M., additional, Easton, Douglas F., additional, Pettitt, Stephen J., additional, Lord, Christopher J., additional, Haider, Syed, additional, Orr, Nick, additional, and Fletcher, Olivia, additional
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- 2021
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9. Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer
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Kar, Siddhartha P., primary, Considine, Daniel P.C., additional, Tyrer, Jonathan P., additional, Plummer, Jasmine T., additional, Chen, Stephanie, additional, Dezem, Felipe S., additional, Barbeira, Alvaro N., additional, Rajagopal, Padma S., additional, Rosenow, Will T., additional, Moreno, Fernando, additional, Bodelon, Clara, additional, Chang-Claude, Jenny, additional, Chenevix-Trench, Georgia, additional, deFazio, Anna, additional, Dörk, Thilo, additional, Ekici, Arif B., additional, Ewing, Ailith, additional, Fountzilas, George, additional, Goode, Ellen L., additional, Hartman, Mikael, additional, Heitz, Florian, additional, Hillemanns, Peter, additional, Høgdall, Estrid, additional, Høgdall, Claus K., additional, Huzarski, Tomasz, additional, Jensen, Allan, additional, Karlan, Beth Y., additional, Khusnutdinova, Elza, additional, Kiemeney, Lambertus A., additional, Kjaer, Susanne K., additional, Klapdor, Rüdiger, additional, Köbel, Martin, additional, Li, Jingmei, additional, Liebrich, Clemens, additional, May, Taymaa, additional, Olsson, Håkan, additional, Permuth, Jennifer B., additional, Peterlongo, Paolo, additional, Radice, Paolo, additional, Ramus, Susan J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Saloustros, Emmanouil, additional, Simard, Jacques, additional, Szafron, Lukasz M., additional, Titus, Linda, additional, Thompson, Cheryl L., additional, Vierkant, Robert A., additional, Winham, Stacey J., additional, Zheng, Wei, additional, Doherty, Jennifer A., additional, Berchuck, Andrew, additional, Lawrenson, Kate, additional, Im, Hae Kyung, additional, Manichaikul, Ani W., additional, Pharoah, Paul D.P., additional, Gayther, Simon A., additional, and Schildkraut, Joellen M., additional
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- 2021
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10. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk
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Kramer, Iris, Hooning, Maartje J, Mavaddat, Nasim, Hauptmann, Michael, Keeman, Renske, Steyerberg, Ewout W, Giardiello, Daniele, Antoniou, Antonis C, Pharoah, Paul DP, Canisius, Sander, Abu-Ful, Zumuruda, Andrulis, Irene L, Anton-Culver, Hoda, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Brauch, Hiltrud, Bremer, Michael, Brucker, Sara Y, Burwinkel, Barbara, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, NBCS Collaborators, Collée, J Margriet, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hartman, Mikael, Heemskerk-Gerritsen, Bernadette AM, Hollestelle, Antoinette, Hopper, John L, Hou, Ming-Feng, Howell, Anthony, ABCTB Investigators, kConFab Investigators, Ito, Hidemi, Jakimovska, Milena, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kets, C Marleen, Khusnutdinova, Elza, Ko, Yon-Dschun, Kristensen, Vessela N, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Muranen, Taru A, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Park-Simon, Tjoung-Won, Peto, Julian, Petridis, Christos, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Pylkäs, Katri, Radice, Paolo, Rennert, Gad, Romero, Atocha, Roylance, Rebecca, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, See, Mee-Hoong, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Siesling, Sabine, Slager, Susan, Sohn, Christof, Southey, Melissa C, Spinelli, John J, Stone, Jennifer, Tapper, William J, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Tollenaar, Rob AEM, Tomlinson, Ian, Troester, Melissa A, Vachon, Celine M, van Ongeval, Chantal, van Veen, Elke M, Winqvist, Robert, Wolk, Alicja, Zheng, Wei, Ziogas, Argyrios, Easton, Douglas F, Hall, Per, Schmidt, Marjanka K, Mavaddat, Nasim [0000-0003-0307-055X], Antoniou, Antonis [0000-0001-9223-3116], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], Easton, Douglas [0000-0003-2444-3247], and Apollo - University of Cambridge Repository
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Adult ,Multifactorial Inheritance ,Receptor, ErbB-2 ,Gene Expression ,Breast Neoplasms ,Risk Assessment ,White People ,Cohort Studies ,Asian People ,parasitic diseases ,Humans ,Genetic Predisposition to Disease ,Aged ,Proportional Hazards Models ,Genome, Human ,Estrogen Receptor alpha ,Neoplasms, Second Primary ,Middle Aged ,Prognosis ,Neoadjuvant Therapy ,polygenic risk score ,contralateral breast cancer ,epidemiology ,Female ,genetic ,Receptors, Progesterone ,Genome-Wide Association Study - Abstract
Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies.
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- 2020
11. Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry
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Yang, Yaohua, primary, Shu, Xiang, additional, Shu, Xiao-ou, additional, Bolla, Manjeet K., additional, Kweon, Sun-Seog, additional, Cai, Qiuyin, additional, Michailidou, Kyriaki, additional, Wang, Qin, additional, Dennis, Joe, additional, Park, Boyoung, additional, Matsuo, Keitaro, additional, Kwong, Ava, additional, Park, Sue Kyung, additional, Wu, Anna H., additional, Teo, Soo Hwang, additional, Iwasaki, Motoki, additional, Choi, Ji-Yeob, additional, Li, Jingmei, additional, Hartman, Mikael, additional, Shen, Chen-Yang, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Li, Bingshan, additional, Wen, Wanqing, additional, Gao, Yu-Tang, additional, Xiang, Yong-Bing, additional, Aronson, Kristan J., additional, Spinell, John J., additional, Gago-Dominguez, Manuela, additional, John, Esther M., additional, Kurian, Allison W., additional, Chang-Claude, Jenny, additional, Chen, Shou-Tung, additional, Dörk, Thilo, additional, Evans, D. Gareth R., additional, Schmidt, Marjanka K., additional, Shin, Min-Ho, additional, Giles, Graham G., additional, Milne, Roger L., additional, Simard, Jacques, additional, Kubo, Michiaki, additional, Kraft, Peter, additional, Kang, Daehee, additional, Easton, Douglas F., additional, Zheng, Wei, additional, and Long, Jirong, additional
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- 2019
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12. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
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Mavaddat, Nasim, primary, Michailidou, Kyriaki, additional, Dennis, Joe, additional, Lush, Michael, additional, Fachal, Laura, additional, Lee, Andrew, additional, Tyrer, Jonathan P., additional, Chen, Ting-Huei, additional, Wang, Qin, additional, Bolla, Manjeet K., additional, Yang, Xin, additional, Adank, Muriel A., additional, Ahearn, Thomas, additional, Aittomäki, Kristiina, additional, Allen, Jamie, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Arndt, Volker, additional, Aronson, Kristan J., additional, Auer, Paul L., additional, Auvinen, Päivi, additional, Barrdahl, Myrto, additional, Beane Freeman, Laura E., additional, Beckmann, Matthias W., additional, Behrens, Sabine, additional, Benitez, Javier, additional, Bermisheva, Marina, additional, Bernstein, Leslie, additional, Blomqvist, Carl, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bonanni, Bernardo, additional, Børresen-Dale, Anne-Lise, additional, Brauch, Hiltrud, additional, Bremer, Michael, additional, Brenner, Hermann, additional, Brentnall, Adam, additional, Brock, Ian W., additional, Brooks-Wilson, Angela, additional, Brucker, Sara Y., additional, Brüning, Thomas, additional, Burwinkel, Barbara, additional, Campa, Daniele, additional, Carter, Brian D., additional, Castelao, Jose E., additional, Chanock, Stephen J., additional, Chlebowski, Rowan, additional, Christiansen, Hans, additional, Clarke, Christine L., additional, Collée, J. Margriet, additional, Cordina-Duverger, Emilie, additional, Cornelissen, Sten, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Daly, Mary B., additional, Devilee, Peter, additional, Dörk, Thilo, additional, dos-Santos-Silva, Isabel, additional, Dumont, Martine, additional, Durcan, Lorraine, additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Ekici, Arif B., additional, Eliassen, A. Heather, additional, Ellberg, Carolina, additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Figueroa, Jonine, additional, Fletcher, Olivia, additional, Flyger, Henrik, additional, Försti, Asta, additional, Fritschi, Lin, additional, Gabrielson, Marike, additional, Gago-Dominguez, Manuela, additional, Gapstur, Susan M., additional, García-Sáenz, José A., additional, Gaudet, Mia M., additional, Georgoulias, Vassilios, additional, Giles, Graham G., additional, Gilyazova, Irina R., additional, Glendon, Gord, additional, Goldberg, Mark S., additional, Goldgar, David E., additional, González-Neira, Anna, additional, Grenaker Alnæs, Grethe I., additional, Grip, Mervi, additional, Gronwald, Jacek, additional, Grundy, Anne, additional, Guénel, Pascal, additional, Haeberle, Lothar, additional, Hahnen, Eric, additional, Haiman, Christopher A., additional, Håkansson, Niclas, additional, Hamann, Ute, additional, Hankinson, Susan E., additional, Harkness, Elaine F., additional, Hart, Steven N., additional, He, Wei, additional, Hein, Alexander, additional, Heyworth, Jane, additional, Hillemanns, Peter, additional, Hollestelle, Antoinette, additional, Hooning, Maartje J., additional, Hoover, Robert N., additional, Hopper, John L., additional, Howell, Anthony, additional, Huang, Guanmengqian, additional, Humphreys, Keith, additional, Hunter, David J., additional, Jakimovska, Milena, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Johnson, Nichola, additional, Jones, Michael E., additional, Jukkola-Vuorinen, Arja, additional, Jung, Audrey, additional, Kaaks, Rudolf, additional, Kaczmarek, Katarzyna, additional, Kataja, Vesa, additional, Keeman, Renske, additional, Kerin, Michael J., additional, Khusnutdinova, Elza, additional, Kiiski, Johanna I., additional, Knight, Julia A., additional, Ko, Yon-Dschun, additional, Kosma, Veli-Matti, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Krüger, Ute, additional, Kühl, Tabea, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lilyquist, Jenna, additional, Lindblom, Annika, additional, Lindström, Sara, additional, Lissowska, Jolanta, additional, Lo, Wing-Yee, additional, Loibl, Sibylle, additional, Long, Jirong, additional, Lubiński, Jan, additional, Lux, Michael P., additional, MacInnis, Robert J., additional, Maishman, Tom, additional, Makalic, Enes, additional, Maleva Kostovska, Ivana, additional, Mannermaa, Arto, additional, Manoukian, Siranoush, additional, Margolin, Sara, additional, Martens, John W.M., additional, Martinez, Maria Elena, additional, Mavroudis, Dimitrios, additional, McLean, Catriona, additional, Meindl, Alfons, additional, Menon, Usha, additional, Middha, Pooja, additional, Miller, Nicola, additional, Moreno, Fernando, additional, Mulligan, Anna Marie, additional, Mulot, Claire, additional, Muñoz-Garzon, Victor M., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Neven, Patrick, additional, Newman, William G., additional, Nielsen, Sune F., additional, Nordestgaard, Børge G., additional, Norman, Aaron, additional, Offit, Kenneth, additional, Olson, Janet E., additional, Olsson, Håkan, additional, Orr, Nick, additional, Pankratz, V. Shane, additional, Park-Simon, Tjoung-Won, additional, Perez, Jose I.A., additional, Pérez-Barrios, Clara, additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Pinchev, Mila, additional, Plaseska-Karanfilska, Dijana, additional, Polley, Eric C., additional, Prentice, Ross, additional, Presneau, Nadege, additional, Prokofyeva, Darya, additional, Purrington, Kristen, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Radice, Paolo, additional, Rau-Murthy, Rohini, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, Rhenius, Valerie, additional, Robson, Mark, additional, Romero, Atocha, additional, Ruddy, Kathryn J., additional, Ruebner, Matthias, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schmidt, Daniel F., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Schumacher, Fredrick, additional, Schürmann, Peter, additional, Schwentner, Lukas, additional, Scott, Christopher, additional, Scott, Rodney J., additional, Seynaeve, Caroline, additional, Shah, Mitul, additional, Sherman, Mark E., additional, Shrubsole, Martha J., additional, Shu, Xiao-Ou, additional, Slager, Susan, additional, Smeets, Ann, additional, Sohn, Christof, additional, Soucy, Penny, additional, Southey, Melissa C., additional, Spinelli, John J., additional, Stegmaier, Christa, additional, Stone, Jennifer, additional, Swerdlow, Anthony J., additional, Tamimi, Rulla M., additional, Tapper, William J., additional, Taylor, Jack A., additional, Terry, Mary Beth, additional, Thöne, Kathrin, additional, Tollenaar, Rob A.E.M., additional, Tomlinson, Ian, additional, Truong, Thérèse, additional, Tzardi, Maria, additional, Ulmer, Hans-Ulrich, additional, Untch, Michael, additional, Vachon, Celine M., additional, van Veen, Elke M., additional, Vijai, Joseph, additional, Weinberg, Clarice R., additional, Wendt, Camilla, additional, Whittemore, Alice S., additional, Wildiers, Hans, additional, Willett, Walter, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Yang, Xiaohong R., additional, Yannoukakos, Drakoulis, additional, Zhang, Yan, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Dunning, Alison M., additional, Thompson, Deborah J., additional, Chenevix-Trench, Georgia, additional, Chang-Claude, Jenny, additional, Schmidt, Marjanka K., additional, Hall, Per, additional, Milne, Roger L., additional, Pharoah, Paul D.P., additional, Antoniou, Antonis C., additional, Chatterjee, Nilanjan, additional, Kraft, Peter, additional, García-Closas, Montserrat, additional, Simard, Jacques, additional, and Easton, Douglas F., additional
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- 2019
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13. Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central Europe
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Wang, Jing, primary, Bogdanova, Natalia, additional, Schürmann, Peter, additional, Park-Simon, Tjoung-Won, additional, Geffers, Robert, additional, and Dörk, Thilo, additional
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- 2018
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14. Limited role of interferon-kappa ( IFNK ) truncating mutations in common variable immunodeficiency
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Atschekzei, Faranaz, primary, Dörk, Thilo, additional, Schürmann, Peter, additional, Geffers, Robert, additional, Witte, Torsten, additional, and Schmidt, Reinhold E., additional
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- 2017
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15. Evaluation of RAG1 mutations in an adult with combined immunodeficiency and progressive multifocal leukoencephalopathy
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Schröder, Claudia, primary, Baerlecken, Niklas Thomas, additional, Pannicke, Ulrich, additional, Dörk, Thilo, additional, Witte, Torsten, additional, Jacobs, Roland, additional, Stoll, Matthias, additional, Schwarz, Klaus, additional, Grimbacher, Bodo, additional, Schmidt, Reinhold E., additional, and Atschekzei, Faranaz, additional
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- 2017
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16. Genetic modifiers of CHEK2*1100delC-associated breast cancer risk
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Muranen, Taru A., primary, Greco, Dario, additional, Blomqvist, Carl, additional, Aittomäki, Kristiina, additional, Khan, Sofia, additional, Hogervorst, Frans, additional, Verhoef, Senno, additional, Pharoah, Paul D.P., additional, Dunning, Alison M., additional, Shah, Mitul, additional, Luben, Robert, additional, Bojesen, Stig E., additional, Nordestgaard, Børge G., additional, Schoemaker, Minouk, additional, Swerdlow, Anthony, additional, García-Closas, Montserrat, additional, Figueroa, Jonine, additional, Dörk, Thilo, additional, Bogdanova, Natalia V., additional, Hall, Per, additional, Li, Jingmei, additional, Khusnutdinova, Elza, additional, Bermisheva, Marina, additional, Kristensen, Vessela, additional, Borresen-Dale, Anne-Lise, additional, Peto, Julian, additional, dos Santos Silva, Isabel, additional, Couch, Fergus J., additional, Olson, Janet E., additional, Hillemans, Peter, additional, Park-Simon, Tjoung-Won, additional, Brauch, Hiltrud, additional, Hamann, Ute, additional, Burwinkel, Barbara, additional, Marme, Frederik, additional, Meindl, Alfons, additional, Schmutzler, Rita K., additional, Cox, Angela, additional, Cross, Simon S., additional, Sawyer, Elinor J., additional, Tomlinson, Ian, additional, Lambrechts, Diether, additional, Moisse, Matthieu, additional, Lindblom, Annika, additional, Margolin, Sara, additional, Hollestelle, Antoinette, additional, Martens, John W.M., additional, Fasching, Peter A., additional, Beckmann, Matthias W., additional, Andrulis, Irene L., additional, Knight, Julia A., additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Giles, Graham G., additional, Milne, Roger L., additional, Brenner, Hermann, additional, Arndt, Volker, additional, Mannermaa, Arto, additional, Kosma, Veli-Matti, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Devilee, Peter, additional, Seynaeve, Caroline, additional, Hopper, John L., additional, Southey, Melissa C., additional, John, Esther M., additional, Whittemore, Alice S., additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Michailidou, Kyriaki, additional, Dennis, Joe, additional, Easton, Douglas F., additional, Schmidt, Marjanka K., additional, and Nevanlinna, Heli, additional
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- 2017
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17. Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation
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Ghoussaini, Maya, primary, French, Juliet D., additional, Michailidou, Kyriaki, additional, Nord, Silje, additional, Beesley, Jonathan, additional, Canisus, Sander, additional, Hillman, Kristine M., additional, Kaufmann, Susanne, additional, Sivakumaran, Haran, additional, Moradi Marjaneh, Mahdi, additional, Lee, Jason S., additional, Dennis, Joe, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Dicks, Ed, additional, Milne, Roger L., additional, Hopper, John L., additional, Southey, Melissa C., additional, Schmidt, Marjanka K., additional, Broeks, Annegien, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Fasching, Peter A., additional, Beckmann, Matthias W., additional, Fletcher, Olivia, additional, Johnson, Nichola, additional, Sawyer, Elinor J., additional, Tomlinson, Ian, additional, Burwinkel, Barbara, additional, Marme, Frederik, additional, Guénel, Pascal, additional, Truong, Thérèse, additional, Bojesen, Stig E., additional, Flyger, Henrik, additional, Benitez, Javier, additional, González-Neira, Anna, additional, Alonso, M. Rosario, additional, Pita, Guillermo, additional, Neuhausen, Susan L., additional, Anton-Culver, Hoda, additional, Brenner, Hermann, additional, Arndt, Volker, additional, Meindl, Alfons, additional, Schmutzler, Rita K., additional, Brauch, Hiltrud, additional, Hamann, Ute, additional, Tessier, Daniel C., additional, Vincent, Daniel, additional, Nevanlinna, Heli, additional, Khan, Sofia, additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Dörk, Thilo, additional, Bogdanova, Natalia V., additional, Lindblom, Annika, additional, Margolin, Sara, additional, Mannermaa, Arto, additional, Kosma, Veli-Matti, additional, Wu, Anna H., additional, Van Den Berg, David, additional, Lambrechts, Diether, additional, Floris, Giuseppe, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Radice, Paolo, additional, Barile, Monica, additional, Couch, Fergus J., additional, Hallberg, Emily, additional, Giles, Graham G., additional, Haiman, Christopher A., additional, Le Marchand, Loic, additional, Goldberg, Mark S., additional, Teo, Soo H., additional, Yip, Cheng Har, additional, Borresen-Dale, Anne-Lise, additional, Zheng, Wei, additional, Cai, Qiuyin, additional, Winqvist, Robert, additional, Pylkäs, Katri, additional, Andrulis, Irene L., additional, Devilee, Peter, additional, Tollenaar, Rob A.E.M., additional, García-Closas, Montserrat, additional, Figueroa, Jonine, additional, Hall, Per, additional, Czene, Kamila, additional, Brand, Judith S., additional, Darabi, Hatef, additional, Eriksson, Mikael, additional, Hooning, Maartje J., additional, Koppert, Linetta B., additional, Li, Jingmei, additional, Shu, Xiao-Ou, additional, Zheng, Ying, additional, Cox, Angela, additional, Cross, Simon S., additional, Shah, Mitul, additional, Rhenius, Valerie, additional, Choi, Ji-Yeob, additional, Kang, Daehee, additional, Hartman, Mikael, additional, Chia, Kee Seng, additional, Kabisch, Maria, additional, Torres, Diana, additional, Luccarini, Craig, additional, Conroy, Don M., additional, Jakubowska, Anna, additional, Lubinski, Jan, additional, Sangrajrang, Suleeporn, additional, Brennan, Paul, additional, Olswold, Curtis, additional, Slager, Susan, additional, Shen, Chen-Yang, additional, Hou, Ming-Feng, additional, Swerdlow, Anthony, additional, Schoemaker, Minouk J., additional, Simard, Jacques, additional, Pharoah, Paul D.P., additional, Kristensen, Vessela, additional, Chenevix-Trench, Georgia, additional, Easton, Douglas F., additional, Dunning, Alison M., additional, and Edwards, Stacey L., additional
- Published
- 2016
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18. Rare ATAD5 missense variants in breast and ovarian cancer patients
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Maleva Kostovska, Ivana, primary, Wang, Jing, additional, Bogdanova, Natalia, additional, Schürmann, Peter, additional, Bhuju, Sabin, additional, Geffers, Robert, additional, Dürst, Matthias, additional, Liebrich, Clemens, additional, Klapdor, Rüdiger, additional, Christiansen, Hans, additional, Park-Simon, Tjoung-Won, additional, Hillemanns, Peter, additional, Plaseska-Karanfilska, Dijana, additional, and Dörk, Thilo, additional
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- 2016
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19. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
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Hollestelle, Antoinette, primary, van der Baan, Frederieke H., additional, Berchuck, Andrew, additional, Johnatty, Sharon E., additional, Aben, Katja K., additional, Agnarsson, Bjarni A., additional, Aittomäki, Kristiina, additional, Alducci, Elisa, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Antoniou, Antonis C., additional, Apicella, Carmel, additional, Arndt, Volker, additional, Arnold, Norbert, additional, Arun, Banu K., additional, Arver, Brita, additional, Ashworth, Alan, additional, Baglietto, Laura, additional, Balleine, Rosemary, additional, Bandera, Elisa V., additional, Barrowdale, Daniel, additional, Bean, Yukie T., additional, Beckmann, Lars, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Berger, Andreas, additional, Berger, Raanan, additional, Beuselinck, Benoit, additional, Bisogna, Maria, additional, Bjorge, Line, additional, Blomqvist, Carl, additional, Bogdanova, Natalia V., additional, Bojesen, Anders, additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Bonanni, Bernardo, additional, Brand, Judith S., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brinton, Louise, additional, Brooks-Wilson, Angela, additional, Bruinsma, Fiona, additional, Brunet, Joan, additional, Brüning, Thomas, additional, Budzilowska, Agnieszka, additional, Bunker, Clareann H., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Buys, Saundra S., additional, Caligo, Maria A., additional, Campbell, Ian, additional, Carter, Jonathan, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Claes, Kathleen B.M., additional, Collée, J. Margriet, additional, Cook, Linda S., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cramer, Daniel, additional, Cross, Simon S., additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Damiola, Francesca, additional, Dansonka-Mieszkowska, Agnieszka, additional, Darabi, Hatef, additional, de la Hoya, Miguel, additional, deFazio, Anna, additional, Dennis, Joseph, additional, Devilee, Peter, additional, Dicks, Ed M., additional, Diez, Orland, additional, Doherty, Jennifer A., additional, Domchek, Susan M., additional, Dorfling, Cecilia M., additional, Dörk, Thilo, additional, Silva, Isabel Dos Santos, additional, du Bois, Andreas, additional, Dumont, Martine, additional, Dunning, Alison M., additional, Duran, Mercedes, additional, Easton, Douglas F., additional, Eccles, Diana, additional, Edwards, Robert P., additional, Ehrencrona, Hans, additional, Ejlertsen, Bent, additional, Ekici, Arif B., additional, Ellis, Steve D., additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Fasching, Peter A., additional, Feliubadalo, Lidia, additional, Figueroa, Jonine, additional, Flesch-Janys, Dieter, additional, Fletcher, Olivia, additional, Fontaine, Annette, additional, Fortuzzi, Stefano, additional, Fostira, Florentia, additional, Fridley, Brooke L., additional, Friebel, Tara, additional, Friedman, Eitan, additional, Friel, Grace, additional, Frost, Debra, additional, Garber, Judy, additional, García-Closas, Montserrat, additional, Gayther, Simon A., additional, Gentry-Maharaj, Aleksandra, additional, Gerdes, Anne-Marie, additional, Giles, Graham G., additional, Glasspool, Rosalind, additional, Glendon, Gord, additional, Godwin, Andrew K., additional, Goodman, Marc T., additional, Gore, Martin, additional, Greene, Mark H., additional, Grip, Mervi, additional, Gronwald, Jacek, additional, Gschwantler Kaulich, Daphne, additional, Guénel, Pascal, additional, Guzman, Starr R., additional, Haeberle, Lothar, additional, Haiman, Christopher A., additional, Hall, Per, additional, Halverson, Sandra L., additional, Hamann, Ute, additional, Hansen, Thomas V.O., additional, Harter, Philipp, additional, Hartikainen, Jaana M., additional, Healey, Sue, additional, Hein, Alexander, additional, Heitz, Florian, additional, Henderson, Brian E., additional, Herzog, Josef, additional, T Hildebrandt, Michelle A., additional, Høgdall, Claus K., additional, Høgdall, Estrid, additional, Hogervorst, Frans B.L., additional, Hopper, John L., additional, Humphreys, Keith, additional, Huzarski, Tomasz, additional, Imyanitov, Evgeny N., additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, Janavicius, Ramunas, additional, Jaworska, Katarzyna, additional, Jensen, Allan, additional, Jensen, Uffe Birk, additional, Johnson, Nichola, additional, Jukkola-Vuorinen, Arja, additional, Kabisch, Maria, additional, Karlan, Beth Y., additional, Kataja, Vesa, additional, Kauff, Noah, additional, Kelemen, Linda E., additional, Kerin, Michael J., additional, Kiemeney, Lambertus A., additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Knol-Bout, Jacoba P., additional, Konstantopoulou, Irene, additional, Kosma, Veli-Matti, additional, Krakstad, Camilla, additional, Kristensen, Vessela, additional, Kuchenbaecker, Karoline B., additional, Kupryjanczyk, Jolanta, additional, Laitman, Yael, additional, Lambrechts, Diether, additional, Lambrechts, Sandrina, additional, Larson, Melissa C., additional, Lasa, Adriana, additional, Laurent-Puig, Pierre, additional, Lazaro, Conxi, additional, Le, Nhu D., additional, Le Marchand, Loic, additional, Leminen, Arto, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Jingmei, additional, Liang, Dong, additional, Lindblom, Annika, additional, Lindor, Noralane, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Karen H., additional, Lubinski, Jan, additional, Lundvall, Lene, additional, Lurie, Galina, additional, Mai, Phuong L., additional, Mannermaa, Arto, additional, Margolin, Sara, additional, Mariette, Frederique, additional, Marme, Frederik, additional, Martens, John W.M., additional, Massuger, Leon F.A.G., additional, Maugard, Christine, additional, Mazoyer, Sylvie, additional, McGuffog, Lesley, additional, McGuire, Valerie, additional, McLean, Catriona, additional, McNeish, Iain, additional, Meindl, Alfons, additional, Menegaux, Florence, additional, Menéndez, Primitiva, additional, Menkiszak, Janusz, additional, Menon, Usha, additional, Mensenkamp, Arjen R., additional, Miller, Nicola, additional, Milne, Roger L., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moysich, Kirsten B., additional, Müller, Heiko, additional, Mulligan, Anna Marie, additional, Muranen, Taru A., additional, Narod, Steven A., additional, Nathanson, Katherine L., additional, Ness, Roberta B., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Neven, Patrick, additional, Nielsen, Finn C., additional, Nielsen, Sune F., additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Odunsi, Kunle, additional, Offit, Kenneth, additional, Olah, Edith, additional, Olopade, Olufunmilayo I., additional, Olson, Janet E., additional, Olson, Sara H., additional, Oosterwijk, Jan C., additional, Orlow, Irene, additional, Orr, Nick, additional, Orsulic, Sandra, additional, Osorio, Ana, additional, Ottini, Laura, additional, Paul, James, additional, Pearce, Celeste L., additional, Pedersen, Inge Sokilde, additional, Peissel, Bernard, additional, Pejovic, Tanja, additional, Pelttari, Liisa M., additional, Perkins, Jo, additional, Permuth-Wey, Jenny, additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Phelan, Catherine M., additional, Phillips, Kelly-Anne, additional, Piedmonte, Marion, additional, Pike, Malcolm C., additional, Platte, Radka, additional, Plisiecka-Halasa, Joanna, additional, Poole, Elizabeth M., additional, Poppe, Bruce, additional, Pylkäs, Katri, additional, Radice, Paolo, additional, Ramus, Susan J., additional, Rebbeck, Timothy R., additional, Reed, Malcolm W.R., additional, Rennert, Gad, additional, Risch, Harvey A., additional, Robson, Mark, additional, Rodriguez, Gustavo C., additional, Romero, Atocha, additional, Rossing, Mary Anne, additional, Rothstein, Joseph H., additional, Rudolph, Anja, additional, Runnebaum, Ingo, additional, Salani, Ritu, additional, Salvesen, Helga B., additional, Sawyer, Elinor J., additional, Schildkraut, Joellen M., additional, Schmidt, Marjanka K., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Schrauder, Michael G., additional, Schumacher, Fredrick, additional, Schwaab, Ira, additional, Scuvera, Giulietta, additional, Sellers, Thomas A., additional, Severi, Gianluca, additional, Seynaeve, Caroline M., additional, Shah, Mitul, additional, Shrubsole, Martha, additional, Siddiqui, Nadeem, additional, Sieh, Weiva, additional, Simard, Jacques, additional, Singer, Christian F., additional, Sinilnikova, Olga M., additional, Smeets, Dominiek, additional, Sohn, Christof, additional, Soller, Maria, additional, Song, Honglin, additional, Soucy, Penny, additional, Southey, Melissa C., additional, Stegmaier, Christa, additional, Stoppa-Lyonnet, Dominique, additional, Sucheston, Lara, additional, Swerdlow, Anthony, additional, Tangen, Ingvild L., additional, Tea, Muy-Kheng, additional, Teixeira, Manuel R., additional, Terry, Kathryn L., additional, Terry, Mary Beth, additional, Thomassen, Mads, additional, Thompson, Pamela J., additional, Tihomirova, Laima, additional, Tischkowitz, Marc, additional, Toland, Amanda Ewart, additional, Tollenaar, Rob A.E.M., additional, Tomlinson, Ian, additional, Torres, Diana, additional, Truong, Thérèse, additional, Tsimiklis, Helen, additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Tyrer, Jonathan P., additional, Vachon, Celine M., additional, Van 't Veer, Laura J., additional, van Altena, Anne M., additional, Van Asperen, C.J., additional, van den Berg, David, additional, van den Ouweland, Ans M.W., additional, van Doorn, Helena C., additional, Van Nieuwenhuysen, Els, additional, van Rensburg, Elizabeth J., additional, Vergote, Ignace, additional, Verhoef, Senno, additional, Vierkant, Robert A., additional, Vijai, Joseph, additional, Vitonis, Allison F., additional, von Wachenfeldt, Anna, additional, Walsh, Christine, additional, Wang, Qin, additional, Wang-Gohrke, Shan, additional, Wappenschmidt, Barbara, additional, Weischer, Maren, additional, Weitzel, Jeffrey N., additional, Weltens, Caroline, additional, Wentzensen, Nicolas, additional, Whittemore, Alice S., additional, Wilkens, Lynne R., additional, Winqvist, Robert, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yang, Hannah P., additional, Zaffaroni, Daniela, additional, Pilar Zamora, M., additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Chenevix-Trench, Georgia, additional, Pharoah, Paul D.P., additional, Rookus, Matti A., additional, Hooning, Maartje J., additional, and Goode, Ellen L., additional
- Published
- 2016
- Full Text
- View/download PDF
20. Evidence of a genetic link between endometriosis and ovarian cancer
- Author
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Lee, Alice W., primary, Templeman, Claire, additional, Stram, Douglas A., additional, Beesley, Jonathan, additional, Tyrer, Jonathan, additional, Berchuck, Andrew, additional, Pharoah, Paul P., additional, Chenevix-Trench, Georgia, additional, Pearce, Celeste Leigh, additional, Ness, Roberta B., additional, Dansonka-Mieszkowska, Agnieszka, additional, Gentry-Maharaj, Aleksandra, additional, Hein, Alexander, additional, Whittemore, Alice S., additional, Jensen, Allan, additional, du Bois, Andreas, additional, Brooks-Wilson, Angela, additional, Rudolph, Anja, additional, Jakubowska, Anna, additional, Wu, Anna H., additional, Ziogas, Argyrios, additional, Ekici, Arif B., additional, Leminen, Arto, additional, Rosen, Barry, additional, Spiewankiewicz, Beata, additional, Karlan, Beth Y., additional, Trabert, Britton, additional, Fridley, Brooke L., additional, Gilks, C. Blake, additional, Krakstad, Camilla, additional, Phelan, Catherine M., additional, Cybulski, Cezary, additional, Walsh, Christine, additional, Hogdall, Claus, additional, Cramer, Daniel W., additional, Huntsman, David G., additional, Eccles, Diana, additional, Lambrechts, Diether, additional, Liang, Dong, additional, Levine, Douglas A., additional, Iversen, Edwin S., additional, Bandera, Elisa V., additional, Poole, Elizabeth M., additional, Goode, Ellen L., additional, Van Nieuwenhuysen, Els, additional, Hogdall, Estrid, additional, Bruinsma, Fiona, additional, Heitz, Florian, additional, Modugno, Francesmary, additional, Giles, Graham G., additional, Risch, Harvey A., additional, Baker, Helen, additional, Salvesen, Helga B., additional, Nevanlinna, Heli, additional, Anton-Culver, Hoda, additional, Song, Honglin, additional, McNeish, Iain, additional, Campbell, Ian G., additional, Vergote, Ignace, additional, Runnebaum, Ingo B., additional, Tangen, Ingvild L., additional, Schwaab, Ira, additional, Gronwald, Jacek, additional, Paul, James, additional, Lubinski, Jan, additional, Doherty, Jennifer A., additional, Chang-Claude, Jenny, additional, Lester, Jenny, additional, Schildkraut, Joellen M., additional, McLaughlin, John R., additional, Lissowska, Jolanta, additional, Kupryjanczyk, Jolanta, additional, Kelley, Joseph L., additional, Rothstein, Joseph H., additional, Cunningham, Julie M., additional, Lu, Karen, additional, Carty, Karen, additional, Terry, Kathryn L., additional, Aben, Katja K.H., additional, Moysich, Kirsten B., additional, Wicklund, Kristine G., additional, Odunsi, Kunle, additional, Kiemeney, Lambertus A., additional, Sucheston-Campbell, Lara, additional, Lundvall, Lene, additional, Massuger, Leon F.A.G., additional, Pelttari, Liisa M., additional, Kelemen, Linda E., additional, Cook, Linda S., additional, Bjorge, Line, additional, Nedergaard, Lotte, additional, Brinton, Louise A., additional, Wilkens, Lynne R., additional, Pike, Malcolm C., additional, Goodman, Marc T., additional, Bisogna, Maria, additional, Rossing, Mary Anne, additional, Beckmann, Matthias W., additional, Dürst, Matthias, additional, Southey, Melissa C., additional, Kellar, Melissa, additional, Hildebrandt, Michelle A.T., additional, Siddiqui, Nadeem, additional, Antonenkova, Natalia, additional, Bogdanova, Natalia, additional, Le, Nhu D., additional, Wentzensen, Nicolas, additional, Thompson, Pamela J., additional, Harrington, Patricia, additional, Webb, Penelope M., additional, Fasching, Peter A., additional, Hillemanns, Peter, additional, Harter, Philipp, additional, Sobiczewski, Piotr, additional, Weber, Rachel Palmieri, additional, Butzow, Ralf, additional, Edwards, Robert P., additional, Vierkant, Robert A., additional, Glasspool, Rosalind, additional, Orsulic, Sandra, additional, Lambrechts, Sandrina, additional, Olson, Sara H., additional, Wang-Gohrke, Shan, additional, Lele, Shashi, additional, Tworoger, Shelley S., additional, Gayther, Simon A., additional, Missmer, Stacey A., additional, Narod, Steven A., additional, Ramus, Susan J., additional, Kjaer, Susanne K., additional, Pejovic, Tanja, additional, Dörk, Thilo, additional, Eilber, Ursula, additional, Menon, Usha, additional, McGuire, Valerie, additional, Sieh, Weiva, additional, Wu, Xifeng, additional, Bean, Yukie, additional, and Shvetsov, Yurii B., additional
- Published
- 2016
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21. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
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Darabi, Hatef, primary, McCue, Karen, additional, Beesley, Jonathan, additional, Michailidou, Kyriaki, additional, Nord, Silje, additional, Kar, Siddhartha, additional, Humphreys, Keith, additional, Thompson, Deborah, additional, Ghoussaini, Maya, additional, Bolla, Manjeet K., additional, Dennis, Joe, additional, Wang, Qin, additional, Canisius, Sander, additional, Scott, Christopher G., additional, Apicella, Carmel, additional, Hopper, John L., additional, Southey, Melissa C., additional, Stone, Jennifer, additional, Broeks, Annegien, additional, Schmidt, Marjanka K., additional, Scott, Rodney J., additional, Lophatananon, Artitaya, additional, Muir, Kenneth, additional, Beckmann, Matthias W., additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Heusinger, Katharina, additional, dos-Santos-Silva, Isabel, additional, Peto, Julian, additional, Tomlinson, Ian, additional, Sawyer, Elinor J., additional, Burwinkel, Barbara, additional, Marme, Frederik, additional, Guénel, Pascal, additional, Truong, Thérèse, additional, Bojesen, Stig E., additional, Flyger, Henrik, additional, Benitez, Javier, additional, González-Neira, Anna, additional, Anton-Culver, Hoda, additional, Neuhausen, Susan L., additional, Arndt, Volker, additional, Brenner, Hermann, additional, Engel, Christoph, additional, Meindl, Alfons, additional, Schmutzler, Rita K., additional, Arnold, Norbert, additional, Brauch, Hiltrud, additional, Hamann, Ute, additional, Chang-Claude, Jenny, additional, Khan, Sofia, additional, Nevanlinna, Heli, additional, Ito, Hidemi, additional, Matsuo, Keitaro, additional, Bogdanova, Natalia V., additional, Dörk, Thilo, additional, Lindblom, Annika, additional, Margolin, Sara, additional, Kosma, Veli-Matti, additional, Mannermaa, Arto, additional, Tseng, Chiu-chen, additional, Wu, Anna H., additional, Floris, Giuseppe, additional, Lambrechts, Diether, additional, Rudolph, Anja, additional, Peterlongo, Paolo, additional, Radice, Paolo, additional, Couch, Fergus J., additional, Vachon, Celine, additional, Giles, Graham G., additional, McLean, Catriona, additional, Milne, Roger L., additional, Dugué, Pierre-Antoine, additional, Haiman, Christopher A., additional, Maskarinec, Gertraud, additional, Woolcott, Christy, additional, Henderson, Brian E., additional, Goldberg, Mark S., additional, Simard, Jacques, additional, Teo, Soo H., additional, Mariapun, Shivaani, additional, Helland, Åslaug, additional, Haakensen, Vilde, additional, Zheng, Wei, additional, Beeghly-Fadiel, Alicia, additional, Tamimi, Rulla, additional, Jukkola-Vuorinen, Arja, additional, Winqvist, Robert, additional, Andrulis, Irene L., additional, Knight, Julia A., additional, Devilee, Peter, additional, Tollenaar, Robert A.E.M., additional, Figueroa, Jonine, additional, García-Closas, Montserrat, additional, Czene, Kamila, additional, Hooning, Maartje J., additional, Tilanus-Linthorst, Madeleine, additional, Li, Jingmei, additional, Gao, Yu-Tang, additional, Shu, Xiao-Ou, additional, Cox, Angela, additional, Cross, Simon S., additional, Luben, Robert, additional, Khaw, Kay-Tee, additional, Choi, Ji-Yeob, additional, Kang, Daehee, additional, Hartman, Mikael, additional, Lim, Wei Yen, additional, Kabisch, Maria, additional, Torres, Diana, additional, Jakubowska, Anna, additional, Lubinski, Jan, additional, McKay, James, additional, Sangrajrang, Suleeporn, additional, Toland, Amanda E., additional, Yannoukakos, Drakoulis, additional, Shen, Chen-Yang, additional, Yu, Jyh-Cherng, additional, Ziogas, Argyrios, additional, Schoemaker, Minouk J., additional, Swerdlow, Anthony, additional, Borresen-Dale, Anne-Lise, additional, Kristensen, Vessela, additional, French, Juliet D., additional, Edwards, Stacey L., additional, Dunning, Alison M., additional, Easton, Douglas F., additional, Hall, Per, additional, and Chenevix-Trench, Georgia, additional
- Published
- 2015
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22. Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study
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Lee, Alice W., primary, Tyrer, Jonathan P., additional, Doherty, Jennifer A., additional, Stram, Douglas A., additional, Kupryjanczyk, Jolanta, additional, Dansonka-Mieszkowska, Agnieszka, additional, Plisiecka-Halasa, Joanna, additional, Spiewankiewicz, Beata, additional, Myers, Emily J., additional, Chenevix-Trench, Georgia, additional, Fasching, Peter A., additional, Beckmann, Matthias W., additional, Ekici, Arif B., additional, Hein, Alexander, additional, Vergote, Ignace, additional, Van Nieuwenhuysen, Els, additional, Lambrechts, Diether, additional, Wicklund, Kristine G., additional, Eilber, Ursula, additional, Wang-Gohrke, Shan, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Sucheston-Campbell, Lara, additional, Odunsi, Kunle, additional, Moysich, Kirsten B., additional, Shvetsov, Yurii B., additional, Thompson, Pamela J., additional, Goodman, Marc T., additional, Wilkens, Lynne R., additional, Dörk, Thilo, additional, Hillemanns, Peter, additional, Dürst, Matthias, additional, Runnebaum, Ingo B., additional, Bogdanova, Natalia, additional, Pelttari, Liisa M., additional, Nevanlinna, Heli, additional, Leminen, Arto, additional, Edwards, Robert P., additional, Kelley, Joseph L., additional, Harter, Philipp, additional, Schwaab, Ira, additional, Heitz, Florian, additional, du Bois, Andreas, additional, Orsulic, Sandra, additional, Lester, Jenny, additional, Walsh, Christine, additional, Karlan, Beth Y., additional, Hogdall, Estrid, additional, Kjaer, Susanne K., additional, Jensen, Allan, additional, Vierkant, Robert A., additional, Cunningham, Julie M., additional, Goode, Ellen L., additional, Fridley, Brooke L., additional, Southey, Melissa C., additional, Giles, Graham G., additional, Bruinsma, Fiona, additional, Wu, Xifeng, additional, Hildebrandt, Michelle A.T., additional, Lu, Karen, additional, Liang, Dong, additional, Bisogna, Maria, additional, Levine, Douglas A., additional, Weber, Rachel Palmieri, additional, Schildkraut, Joellen M., additional, Iversen, Edwin S., additional, Berchuck, Andrew, additional, Terry, Kathryn L., additional, Cramer, Daniel W., additional, Tworoger, Shelley S., additional, Poole, Elizabeth M., additional, Olson, Sara H., additional, Orlow, Irene, additional, Bandera, Elisa V., additional, Bjorge, Line, additional, Tangen, Ingvild L., additional, Salvesen, Helga B., additional, Krakstad, Camilla, additional, Massuger, Leon F.A.G., additional, Kiemeney, Lambertus A., additional, Aben, Katja K.H., additional, van Altena, Anne M., additional, Bean, Yukie, additional, Pejovic, Tanja, additional, Kellar, Melissa, additional, Le, Nhu D., additional, Cook, Linda S., additional, Kelemen, Linda E., additional, Brooks-Wilson, Angela, additional, Lubinski, Jan, additional, Gronwald, Jacek, additional, Cybulski, Cezary, additional, Jakubowska, Anna, additional, Wentzensen, Nicolas, additional, Brinton, Louise A., additional, Lissowska, Jolanta, additional, Yang, Hannah, additional, Nedergaard, Lotte, additional, Lundvall, Lene, additional, Hogdall, Claus, additional, Song, Honglin, additional, Campbell, Ian G., additional, Eccles, Diana, additional, Glasspool, Rosalind, additional, Siddiqui, Nadeem, additional, Carty, Karen, additional, Paul, James, additional, McNeish, Iain A., additional, Sieh, Weiva, additional, McGuire, Valerie, additional, Rothstein, Joseph H., additional, Whittemore, Alice S., additional, McLaughlin, John R., additional, Risch, Harvey A., additional, Phelan, Catherine M., additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Menon, Usha, additional, Ramus, Susan J., additional, Gentry-Maharaj, Aleksandra, additional, Harrington, Patricia, additional, Pike, Malcolm C., additional, Modugno, Francesmary, additional, Rossing, Mary Anne, additional, Ness, Roberta B., additional, Pharoah, Paul D.P., additional, Stram, Daniel O., additional, Wu, Anna H., additional, and Pearce, Celeste Leigh, additional
- Published
- 2015
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23. Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1
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Glubb, Dylan M., primary, Maranian, Mel J., additional, Michailidou, Kyriaki, additional, Pooley, Karen A., additional, Meyer, Kerstin B., additional, Kar, Siddhartha, additional, Carlebur, Saskia, additional, O’Reilly, Martin, additional, Betts, Joshua A., additional, Hillman, Kristine M., additional, Kaufmann, Susanne, additional, Beesley, Jonathan, additional, Canisius, Sander, additional, Hopper, John L., additional, Southey, Melissa C., additional, Tsimiklis, Helen, additional, Apicella, Carmel, additional, Schmidt, Marjanka K., additional, Broeks, Annegien, additional, Hogervorst, Frans B., additional, van der Schoot, C. Ellen, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Stewart-Brown, Sarah, additional, Siriwanarangsan, Pornthep, additional, Fasching, Peter A., additional, Ruebner, Matthias, additional, Ekici, Arif B., additional, Beckmann, Matthias W., additional, Peto, Julian, additional, dos-Santos-Silva, Isabel, additional, Fletcher, Olivia, additional, Johnson, Nichola, additional, Pharoah, Paul D.P., additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Dennis, Joe, additional, Sawyer, Elinor J., additional, Tomlinson, Ian, additional, Kerin, Michael J., additional, Miller, Nicola, additional, Burwinkel, Barbara, additional, Marme, Frederik, additional, Yang, Rongxi, additional, Surowy, Harald, additional, Guénel, Pascal, additional, Truong, Thérèse, additional, Menegaux, Florence, additional, Sanchez, Marie, additional, Bojesen, Stig E., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Flyger, Henrik, additional, González-Neira, Anna, additional, Benitez, Javier, additional, Zamora, M. Pilar, additional, Arias Perez, Jose Ignacio, additional, Anton-Culver, Hoda, additional, Neuhausen, Susan L., additional, Brenner, Hermann, additional, Dieffenbach, Aida Karina, additional, Arndt, Volker, additional, Stegmaier, Christa, additional, Meindl, Alfons, additional, Schmutzler, Rita K., additional, Brauch, Hiltrud, additional, Ko, Yon-Dschun, additional, Brüning, Thomas, additional, Nevanlinna, Heli, additional, Muranen, Taru A., additional, Aittomäki, Kristiina, additional, Blomqvist, Carl, additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Iwata, Hiroji, additional, Tanaka, Hideo, additional, Dörk, Thilo, additional, Bogdanova, Natalia V., additional, Helbig, Sonja, additional, Lindblom, Annika, additional, Margolin, Sara, additional, Mannermaa, Arto, additional, Kataja, Vesa, additional, Kosma, Veli-Matti, additional, Hartikainen, Jaana M., additional, Wu, Anna H., additional, Tseng, Chiu-chen, additional, Van Den Berg, David, additional, Stram, Daniel O., additional, Lambrechts, Diether, additional, Zhao, Hui, additional, Weltens, Caroline, additional, van Limbergen, Erik, additional, Chang-Claude, Jenny, additional, Flesch-Janys, Dieter, additional, Rudolph, Anja, additional, Seibold, Petra, additional, Radice, Paolo, additional, Peterlongo, Paolo, additional, Barile, Monica, additional, Capra, Fabio, additional, Couch, Fergus J., additional, Olson, Janet E., additional, Hallberg, Emily, additional, Vachon, Celine, additional, Giles, Graham G., additional, Milne, Roger L., additional, McLean, Catriona, additional, Haiman, Christopher A., additional, Henderson, Brian E., additional, Schumacher, Fredrick, additional, Le Marchand, Loic, additional, Simard, Jacques, additional, Goldberg, Mark S., additional, Labrèche, France, additional, Dumont, Martine, additional, Teo, Soo Hwang, additional, Yip, Cheng Har, additional, See, Mee-Hoong, additional, Cornes, Belinda, additional, Cheng, Ching-Yu, additional, Ikram, M. Kamran, additional, Kristensen, Vessela, additional, Zheng, Wei, additional, Halverson, Sandra L., additional, Shrubsole, Martha, additional, Long, Jirong, additional, Winqvist, Robert, additional, Pylkäs, Katri, additional, Jukkola-Vuorinen, Arja, additional, Kauppila, Saila, additional, Andrulis, Irene L., additional, Knight, Julia A., additional, Glendon, Gord, additional, Tchatchou, Sandrine, additional, Devilee, Peter, additional, Tollenaar, Robert A.E.M., additional, Seynaeve, Caroline, additional, Van Asperen, Christi J., additional, García-Closas, Montserrat, additional, Figueroa, Jonine, additional, Chanock, Stephen J., additional, Lissowska, Jolanta, additional, Czene, Kamila, additional, Klevebring, Daniel, additional, Darabi, Hatef, additional, Eriksson, Mikael, additional, Hooning, Maartje J., additional, Hollestelle, Antoinette, additional, Martens, John W.M., additional, Collée, J. Margriet, additional, Hall, Per, additional, Li, Jingmei, additional, Humphreys, Keith, additional, Shu, Xiao-Ou, additional, Lu, Wei, additional, Gao, Yu-Tang, additional, Cai, Hui, additional, Cox, Angela, additional, Cross, Simon S., additional, Reed, Malcolm W.R., additional, Blot, William, additional, Signorello, Lisa B., additional, Cai, Qiuyin, additional, Shah, Mitul, additional, Ghoussaini, Maya, additional, Kang, Daehee, additional, Choi, Ji-Yeob, additional, Park, Sue K., additional, Noh, Dong-Young, additional, Hartman, Mikael, additional, Miao, Hui, additional, Lim, Wei Yen, additional, Tang, Anthony, additional, Hamann, Ute, additional, Torres, Diana, additional, Jakubowska, Anna, additional, Lubinski, Jan, additional, Jaworska, Katarzyna, additional, Durda, Katarzyna, additional, Sangrajrang, Suleeporn, additional, Gaborieau, Valerie, additional, Brennan, Paul, additional, McKay, James, additional, Olswold, Curtis, additional, Slager, Susan, additional, Toland, Amanda E., additional, Yannoukakos, Drakoulis, additional, Shen, Chen-Yang, additional, Wu, Pei-Ei, additional, Yu, Jyh-Cherng, additional, Hou, Ming-Feng, additional, Swerdlow, Anthony, additional, Ashworth, Alan, additional, Orr, Nick, additional, Jones, Michael, additional, Pita, Guillermo, additional, Alonso, M. Rosario, additional, Álvarez, Nuria, additional, Herrero, Daniel, additional, Tessier, Daniel C., additional, Vincent, Daniel, additional, Bacot, Francois, additional, Luccarini, Craig, additional, Baynes, Caroline, additional, Ahmed, Shahana, additional, Healey, Catherine S., additional, Brown, Melissa A., additional, Ponder, Bruce A.J., additional, Chenevix-Trench, Georgia, additional, Thompson, Deborah J., additional, Edwards, Stacey L., additional, Easton, Douglas F., additional, Dunning, Alison M., additional, and French, Juliet D., additional
- Published
- 2015
- Full Text
- View/download PDF
24. Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1
- Author
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Meyer, Kerstin B., primary, O’Reilly, Martin, additional, Michailidou, Kyriaki, additional, Carlebur, Saskia, additional, Edwards, Stacey L., additional, French, Juliet D., additional, Prathalingham, Radhika, additional, Dennis, Joe, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, de Santiago, Ines, additional, Hopper, John L., additional, Tsimiklis, Helen, additional, Apicella, Carmel, additional, Southey, Melissa C., additional, Schmidt, Marjanka K., additional, Broeks, Annegien, additional, Van ’t Veer, Laura J., additional, Hogervorst, Frans B., additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Stewart-Brown, Sarah, additional, Siriwanarangsan, Pornthep, additional, Fasching, Peter A., additional, Lux, Michael P., additional, Ekici, Arif B., additional, Beckmann, Matthias W., additional, Peto, Julian, additional, dos Santos Silva, Isabel, additional, Fletcher, Olivia, additional, Johnson, Nichola, additional, Sawyer, Elinor J., additional, Tomlinson, Ian, additional, Kerin, Michael J., additional, Miller, Nicola, additional, Marme, Federick, additional, Schneeweiss, Andreas, additional, Sohn, Christof, additional, Burwinkel, Barbara, additional, Guénel, Pascal, additional, Truong, Thérèse, additional, Laurent-Puig, Pierre, additional, Menegaux, Florence, additional, Bojesen, Stig E., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Flyger, Henrik, additional, Milne, Roger L., additional, Zamora, M. Pilar, additional, Arias, Jose I., additional, Benitez, Javier, additional, Neuhausen, Susan, additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Dur, Christina C., additional, Brenner, Hermann, additional, Müller, Heiko, additional, Arndt, Volker, additional, Stegmaier, Christa, additional, Meindl, Alfons, additional, Schmutzler, Rita K., additional, Engel, Christoph, additional, Ditsch, Nina, additional, Brauch, Hiltrud, additional, Brüning, Thomas, additional, Ko, Yon-Dschun, additional, Nevanlinna, Heli, additional, Muranen, Taru A., additional, Aittomäki, Kristiina, additional, Blomqvist, Carl, additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Iwata, Hiroji, additional, Yatabe, Yasushi, additional, Dörk, Thilo, additional, Helbig, Sonja, additional, Bogdanova, Natalia V., additional, Lindblom, Annika, additional, Margolin, Sara, additional, Mannermaa, Arto, additional, Kataja, Vesa, additional, Kosma, Veli-Matti, additional, Hartikainen, Jaana M., additional, Chenevix-Trench, Georgia, additional, Wu, Anna H., additional, Tseng, Chiu-chen, additional, Van Den Berg, David, additional, Stram, Daniel O., additional, Lambrechts, Diether, additional, Thienpont, Bernard, additional, Christiaens, Marie-Rose, additional, Smeets, Ann, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Seibold, Petra, additional, Flesch-Janys, Dieter, additional, Radice, Paolo, additional, Peterlongo, Paolo, additional, Bonanni, Bernardo, additional, Bernard, Loris, additional, Couch, Fergus J., additional, Olson, Janet E., additional, Wang, Xianshu, additional, Purrington, Kristen, additional, Giles, Graham G., additional, Severi, Gianluca, additional, Baglietto, Laura, additional, McLean, Catriona, additional, Haiman, Christopher A., additional, Henderson, Brian E., additional, Schumacher, Fredrick, additional, Le Marchand, Loic, additional, Simard, Jacques, additional, Goldberg, Mark S., additional, Labrèche, France, additional, Dumont, Martine, additional, Teo, Soo-Hwang, additional, Yip, Cheng-Har, additional, Phuah, Sze-Yee, additional, Kristensen, Vessela, additional, Grenaker Alnæs, Grethe, additional, Børresen-Dale, Anne-Lise, additional, Zheng, Wei, additional, Deming-Halverson, Sandra, additional, Shrubsole, Martha, additional, Long, Jirong, additional, Winqvist, Robert, additional, Pylkäs, Katri, additional, Jukkola-Vuorinen, Arja, additional, Kauppila, Saila, additional, Andrulis, Irene L., additional, Knight, Julia A., additional, Glendon, Gord, additional, Tchatchou, Sandrine, additional, Devilee, Peter, additional, Tollenaar, Robert A.E.M., additional, Seynaeve, Caroline M., additional, García-Closas, Montserrat, additional, Figueroa, Jonine, additional, Chanock, Stephen J., additional, Lissowska, Jolanta, additional, Czene, Kamila, additional, Darabi, Hartef, additional, Eriksson, Kimael, additional, Hooning, Maartje J., additional, Martens, John W.M., additional, van den Ouweland, Ans M.W., additional, van Deurzen, Carolien H.M., additional, Hall, Per, additional, Li, Jingmei, additional, Liu, Jianjun, additional, Humphreys, Keith, additional, Shu, Xiao-Ou, additional, Lu, Wei, additional, Gao, Yu-Tang, additional, Cai, Hui, additional, Cox, Angela, additional, Reed, Malcolm W.R., additional, Blot, William, additional, Signorello, Lisa B., additional, Cai, Qiuyin, additional, Pharoah, Paul D.P., additional, Ghoussaini, Maya, additional, Harrington, Patricia, additional, Tyrer, Jonathan, additional, Kang, Daehee, additional, Choi, Ji-Yeob, additional, Park, Sue K., additional, Noh, Dong-Young, additional, Hartman, Mikael, additional, Hui, Miao, additional, Lim, Wei-Yen, additional, Buhari, Shaik A., additional, Hamann, Ute, additional, Försti, Asta, additional, Rüdiger, Thomas, additional, Ulmer, Hans-Ulrich, additional, Jakubowska, Anna, additional, Lubinski, Jan, additional, Jaworska, Katarzyna, additional, Durda, Katarzyna, additional, Sangrajrang, Suleeporn, additional, Gaborieau, Valerie, additional, Brennan, Paul, additional, McKay, James, additional, Vachon, Celine, additional, Slager, Susan, additional, Fostira, Florentia, additional, Pilarski, Robert, additional, Shen, Chen-Yang, additional, Hsiung, Chia-Ni, additional, Wu, Pei-Ei, additional, Hou, Ming-Feng, additional, Swerdlow, Anthony, additional, Ashworth, Alan, additional, Orr, Nick, additional, Schoemaker, Minouk J., additional, Ponder, Bruce A.J., additional, Dunning, Alison M., additional, and Easton, Douglas F., additional
- Published
- 2013
- Full Text
- View/download PDF
25. Mitochondrial dysfunction in a novel form of autosomal recessive ataxia
- Author
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Murad, Nor Azian Abdul, primary, Cullen, Jason K., additional, McKenzie, Matthew, additional, Ryan, Michael T., additional, Thorburn, David, additional, Gueven, Nuri, additional, Kobayashi, Junya, additional, Birrell, Geoff, additional, Yang, Jian, additional, Dörk, Thilo, additional, Becherel, Olivier, additional, Grattan-Smith, Padraic, additional, and Lavin, Martin F., additional
- Published
- 2013
- Full Text
- View/download PDF
26. Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers
- Author
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French, Juliet D., primary, Ghoussaini, Maya, additional, Edwards, Stacey L., additional, Meyer, Kerstin B., additional, Michailidou, Kyriaki, additional, Ahmed, Shahana, additional, Khan, Sofia, additional, Maranian, Mel J., additional, O’Reilly, Martin, additional, Hillman, Kristine M., additional, Betts, Joshua A., additional, Carroll, Thomas, additional, Bailey, Peter J., additional, Dicks, Ed, additional, Beesley, Jonathan, additional, Tyrer, Jonathan, additional, Maia, Ana-Teresa, additional, Beck, Andrew, additional, Knoblauch, Nicholas W., additional, Chen, Constance, additional, Kraft, Peter, additional, Barnes, Daniel, additional, González-Neira, Anna, additional, Alonso, M. Rosario, additional, Herrero, Daniel, additional, Tessier, Daniel C., additional, Vincent, Daniel, additional, Bacot, Francois, additional, Luccarini, Craig, additional, Baynes, Caroline, additional, Conroy, Don, additional, Dennis, Joe, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Hopper, John L., additional, Southey, Melissa C., additional, Schmidt, Marjanka K., additional, Broeks, Annegien, additional, Verhoef, Senno, additional, Cornelissen, Sten, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Stewart-Brown, Sarah, additional, Siriwanarangsan, Pornthep, additional, Fasching, Peter A., additional, Loehberg, Christian R., additional, Ekici, Arif B., additional, Beckmann, Matthias W., additional, Peto, Julian, additional, dos Santos Silva, Isabel, additional, Johnson, Nichola, additional, Aitken, Zoe, additional, Sawyer, Elinor J., additional, Tomlinson, Ian, additional, Kerin, Michael J., additional, Miller, Nicola, additional, Marme, Frederik, additional, Schneeweiss, Andreas, additional, Sohn, Christof, additional, Burwinkel, Barbara, additional, Guénel, Pascal, additional, Truong, Thérèse, additional, Laurent-Puig, Pierre, additional, Menegaux, Florence, additional, Bojesen, Stig E., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Flyger, Henrik, additional, Milne, Roger L., additional, Zamora, M. Pilar, additional, Arias Perez, Jose Ignacio, additional, Benitez, Javier, additional, Anton-Culver, Hoda, additional, Brenner, Hermann, additional, Müller, Heiko, additional, Arndt, Volker, additional, Stegmaier, Christa, additional, Meindl, Alfons, additional, Lichtner, Peter, additional, Schmutzler, Rita K., additional, Engel, Christoph, additional, Brauch, Hiltrud, additional, Hamann, Ute, additional, Justenhoven, Christina, additional, Aaltonen, Kirsimari, additional, Heikkilä, Päivi, additional, Aittomäki, Kristiina, additional, Blomqvist, Carl, additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Iwata, Hiroji, additional, Sueta, Aiko, additional, Bogdanova, Natalia V., additional, Antonenkova, Natalia N., additional, Dörk, Thilo, additional, Lindblom, Annika, additional, Margolin, Sara, additional, Mannermaa, Arto, additional, Kataja, Vesa, additional, Kosma, Veli-Matti, additional, Hartikainen, Jaana M., additional, Wu, Anna H., additional, Tseng, Chiu-chen, additional, Van Den Berg, David, additional, Stram, Daniel O., additional, Lambrechts, Diether, additional, Peeters, Stephanie, additional, Smeets, Ann, additional, Floris, Giuseppe, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Nickels, Stefan, additional, Flesch-Janys, Dieter, additional, Radice, Paolo, additional, Peterlongo, Paolo, additional, Bonanni, Bernardo, additional, Sardella, Domenico, additional, Couch, Fergus J., additional, Wang, Xianshu, additional, Pankratz, Vernon S., additional, Lee, Adam, additional, Giles, Graham G., additional, Severi, Gianluca, additional, Baglietto, Laura, additional, Haiman, Christopher A., additional, Henderson, Brian E., additional, Schumacher, Fredrick, additional, Le Marchand, Loic, additional, Simard, Jacques, additional, Goldberg, Mark S., additional, Labrèche, France, additional, Dumont, Martine, additional, Teo, Soo Hwang, additional, Yip, Cheng Har, additional, Ng, Char-Hong, additional, Vithana, Eranga Nishanthie, additional, Kristensen, Vessela, additional, Zheng, Wei, additional, Deming-Halverson, Sandra, additional, Shrubsole, Martha, additional, Long, Jirong, additional, Winqvist, Robert, additional, Pylkäs, Katri, additional, Jukkola-Vuorinen, Arja, additional, Grip, Mervi, additional, Andrulis, Irene L., additional, Knight, Julia A., additional, Glendon, Gord, additional, Mulligan, Anna Marie, additional, Devilee, Peter, additional, Seynaeve, Caroline, additional, García-Closas, Montserrat, additional, Figueroa, Jonine, additional, Chanock, Stephen J., additional, Lissowska, Jolanta, additional, Czene, Kamila, additional, Klevebring, Daniel, additional, Schoof, Nils, additional, Hooning, Maartje J., additional, Martens, John W.M., additional, Collée, J. Margriet, additional, Tilanus-Linthorst, Madeleine, additional, Hall, Per, additional, Li, Jingmei, additional, Liu, Jianjun, additional, Humphreys, Keith, additional, Shu, Xiao-Ou, additional, Lu, Wei, additional, Gao, Yu-Tang, additional, Cai, Hui, additional, Cox, Angela, additional, Balasubramanian, Sabapathy P., additional, Blot, William, additional, Signorello, Lisa B., additional, Cai, Qiuyin, additional, Pharoah, Paul D.P., additional, Healey, Catherine S., additional, Shah, Mitul, additional, Pooley, Karen A., additional, Kang, Daehee, additional, Yoo, Keun-Young, additional, Noh, Dong-Young, additional, Hartman, Mikael, additional, Miao, Hui, additional, Sng, Jen-Hwei, additional, Sim, Xueling, additional, Jakubowska, Anna, additional, Lubinski, Jan, additional, Jaworska-Bieniek, Katarzyna, additional, Durda, Katarzyna, additional, Sangrajrang, Suleeporn, additional, Gaborieau, Valerie, additional, McKay, James, additional, Toland, Amanda E., additional, Ambrosone, Christine B., additional, Yannoukakos, Drakoulis, additional, Godwin, Andrew K., additional, Shen, Chen-Yang, additional, Hsiung, Chia-Ni, additional, Wu, Pei-Ei, additional, Chen, Shou-Tung, additional, Swerdlow, Anthony, additional, Ashworth, Alan, additional, Orr, Nick, additional, Schoemaker, Minouk J., additional, Ponder, Bruce A.J., additional, Nevanlinna, Heli, additional, Brown, Melissa A., additional, Chenevix-Trench, Georgia, additional, Easton, Douglas F., additional, and Dunning, Alison M., additional
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27. Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma
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Mansour, Wael Y., primary, Bogdanova, Natalia V., additional, Kasten-Pisula, Ulla, additional, Rieckmann, Thorsten, additional, Köcher, Sabrina, additional, Borgmann, Kerstin, additional, Baumann, Michael, additional, Krause, Mechtild, additional, Petersen, Cordula, additional, Hu, Hailiang, additional, Gatti, Richard A., additional, Dikomey, Ekkehard, additional, Dörk, Thilo, additional, and Dahm-Daphi, Jochen, additional
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- 2013
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28. Apoptosis gene polymorphisms and risk of prostate cancer: A hospital-based study of German patients treated with brachytherapy
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Meyer, Andreas, primary, Coinac, Irina, additional, Bogdanova, Natalia, additional, Dubrowinskaja, Natalia, additional, Turmanov, Nurzhan, additional, Haubold, Sabine, additional, Schürmann, Peter, additional, Imkamp, Florian, additional, von Klot, Christoph, additional, Merseburger, Axel S., additional, Machtens, Stefan, additional, Bremer, Michael, additional, Hillemanns, Peter, additional, Kuczyk, Markus A., additional, Karstens, Johann H., additional, Serth, Jürgen, additional, and Dörk, Thilo, additional
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- 2013
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29. ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control
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Gatei, Magtouf, primary, Jakob, Burkhard, additional, Chen, Philip, additional, Kijas, Amanda W., additional, Becherel, Olivier J., additional, Gueven, Nuri, additional, Birrell, Geoff, additional, Lee, Ji-Hoon, additional, Paull, Tanya T., additional, Lerenthal, Yaniv, additional, Fazry, Shazrul, additional, Taucher-Scholz, Gisela, additional, Kalb, Reinhard, additional, Schindler, Detlev, additional, Waltes, Regina, additional, Dörk, Thilo, additional, and Lavin, Martin F., additional
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- 2011
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30. Corrigendum to “Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns” [Brain Behav. Immun. 24 (2010) 784–791]
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Hoffmann, Insa, primary, Bueter, Wolfgang, additional, Zscheppang, Katja, additional, Brinkhaus, Maria-Jantje, additional, Liese, Andrea, additional, Riemke, Stefan, additional, Dörk, Thilo, additional, Dammann, Olaf, additional, and Dammann, Christiane E.L., additional
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- 2011
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31. Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns
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Hoffmann, Insa, primary, Bueter, Wolfgang, additional, Zscheppang, Katja, additional, Brinkhaus, Maria-Jantje, additional, Liese, Andrea, additional, Riemke, Stefan, additional, Dörk, Thilo, additional, Dammann, Olaf, additional, and Dammann, Christiane E.L., additional
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- 2010
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32. Neuregulin-1 high-producer genotype is associated with a decreased risk of admission to the neonatal intensive care unit
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Pleickhardt, Elizabeth P., primary, Celandine, Andrew, additional, Davis, Jonathan M., additional, Chen, Minghua, additional, Schürmann, Peter, additional, Dörk, Thilo, additional, Dammann, Christiane E.L., additional, and Dammann, Olaf, additional
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- 2010
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33. Association of chromosomal locus 8q24 and risk of prostate cancer: A hospital-based study of German patients treated with brachytherapy
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Meyer, Andreas, primary, Schürmann, Peter, additional, Ghahremani, Maryam, additional, Kocak, Ertan, additional, Brinkhaus, Maria-Jantje, additional, Bremer, Michael, additional, Karstens, Johann H., additional, Hagemann, Jörn, additional, Machtens, Stefan, additional, and Dörk, Thilo, additional
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- 2009
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34. Immaturity, perinatal inflammation, and retinopathy of prematurity: A multi-hit hypothesis
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Dammann, Olaf, primary, Brinkhaus, Maria-Jantje, additional, Bartels, Dorothee B., additional, Dördelmann, Michael, additional, Dressler, Frank, additional, Kerk, Julia, additional, Dörk, Thilo, additional, and Dammann, Christiane E.L., additional
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- 2009
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35. Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder
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Waltes, Regina, primary, Kalb, Reinhard, additional, Gatei, Magtouf, additional, Kijas, Amanda W., additional, Stumm, Markus, additional, Sobeck, Alexandra, additional, Wieland, Britta, additional, Varon, Raymonda, additional, Lerenthal, Yaniv, additional, Lavin, Martin F., additional, Schindler, Detlev, additional, and Dörk, Thilo, additional
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- 2009
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36. ATM missense variant P1054R predisposes to prostate cancer
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Meyer, Andreas, primary, Wilhelm, Bettina, additional, Dörk, Thilo, additional, Bremer, Michael, additional, Baumann, Rolf, additional, Karstens, Johann Hinrich, additional, and Machtens, Stefan, additional
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- 2007
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37. Breast cancer in patients carrying a germ-line CHEK2 mutation: Outcome after breast conserving surgery and adjuvant radiotherapy
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Meyer, Andreas, primary, Dörk, Thilo, additional, Sohn, Christof, additional, Karstens, Johann H., additional, and Bremer, Michael, additional
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- 2007
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38. Breast cancer in female carriers of ATM gene alterations: outcome of adjuvant radiotherapy
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Meyer, Andreas, primary, John, Esther, additional, Dörk, Thilo, additional, Sohn, Christof, additional, Karstens, Johann H., additional, and Bremer, Michael, additional
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- 2004
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39. Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects
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Bremer, Michael, primary, Klöpper, Karin, additional, Yamini, Paria, additional, Bendix-Waltes, Regina, additional, Dörk, Thilo, additional, and Karstens, Johann H., additional
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- 2003
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40. Frequency of BRCA1 Mutation 5382insC in German Breast Cancer Patients
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Backe, Jael, primary, Hofferbert, Sigrun, additional, Skawran, Britta, additional, Dörk, Thilo, additional, Stuhrmann, Manfred, additional, Karstens, Johann H., additional, Untch, Michael, additional, Meindl, Alfons, additional, Burgemeister, Renate, additional, Chang-Claude, Jenny, additional, and Weber, Bernhard H.F., additional
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- 1999
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41. Evidence for a Common Ethnic Origin of Cystic Fibrosis Mutation 3120+1G→A in Diverse Populations
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Dörk, Thilo, primary, El-Harith, El-Harith A., additional, Stuhrmann, Manfred, additional, Macek, Milan, additional, Egan, Michelle, additional, Cutting, Garry R., additional, Tzetis, Maria, additional, Kanavakis, Emmanuel, additional, Carles, Soukeyna, additional, Claustres, Mireille, additional, Padoa, Carolyn, additional, Ramsay, Michèle, additional, and Schmidtke, Jörg, additional
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- 1998
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42. Polymorphisms of the humanβ-defensin-1gene
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Dörk, Thilo, primary and Stuhrmann, Manfred, additional
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- 1998
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43. Severity of disease in cystic fibrosis
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Dörk, Thilo, primary and Stuhrmann, Manfred, additional
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- 1995
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44. Cystic fibrosis: the impact of analytical technology for genotype-phenotype studies
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Tümmler, Burkhard, primary, Dörk, Thilo, additional, Kubesch, Peter, additional, Fislage, Rainer, additional, Kälin, Nanette, additional, Neumann, Thomas, additional, Wulbrand, Ulrich, additional, Wulf, Brigitte, additional, Steinkamp, Gratiana, additional, and von der Hardt, Horst, additional
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- 1993
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45. Four Novel Cystic Fibrosis Mutations in Splice Junction Sequences Affecting the CFTR Nucleotide Binding Folds
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Dörk, Thilo, primary, Wulbrand, Ulrich, additional, and Tümmler, Burkhard, additional
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- 1993
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46. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element
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Baxter, Joseph S, Johnson, Nichola, Tomczyk, Katarzyna, Gillespie, Andrea, Maguire, Sarah, Brough, Rachel, Fachal, Laura, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Brucker, Sara Y, Cai, Qiuyin, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, NBCS Collaborators, Colonna, Sarah, Conroy, Don M, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Chi, García-Closas, Montserrat, García-Sáenz, José A, Ghoussaini, Maya, Giles, Graham G, Goldberg, Mark S, González-Neira, Anna, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hartman, Mikael, Hatse, Sigrid, Hauke, Jan, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Hou, Ming-Feng, KConFab Investigators, ABCTB Investigators, Ito, Hidemi, Iwasaki, Motoki, Jager, Agnes, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Joseph, Vijai, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Keeman, Renske, Khusnutdinova, Elza, Kim, Sung-Won, Kosma, Veli-Matti, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, Lacey, James V, Lambrechts, Diether, Larson, Nicole L, Larsson, Susanna C, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Jingmei, Long, Jirong, Lophatananon, Artitaya, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Mayes, Rebecca, Menon, Usha, Milne, Roger L, Mohd Taib, Nur Aishah, Muir, Kenneth, Muranen, Taru A, Murphy, Rachel A, Nevanlinna, Heli, O'Brien, Katie M, Offit, Kenneth, Olson, Janet E, Olsson, Håkan, Park, Sue K, Park-Simon, Tjoung-Won, Patel, Alpa V, Peterlongo, Paolo, Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Pylkäs, Katri, Rack, Brigitte, Rennert, Gad, Romero, Atocha, Ruebner, Matthias, Rüdiger, Thomas, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Schneeweiss, Andreas, Schoemaker, Minouk J, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C, Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Tapper, William J, Taylor, Jack A, Teo, Soo Hwang, Teras, Lauren R, Terry, Mary Beth, Toland, Amanda E, Tomlinson, Ian, Truong, Thérèse, Tseng, Chiu-Chen, Untch, Michael, Vachon, Celine M, Van Den Ouweland, Ans MW, Wang, Sophia S, Weinberg, Clarice R, Wendt, Camilla, Winham, Stacey J, Winqvist, Robert, Wolk, Alicja, Wu, Anna H, Yamaji, Taiki, Zheng, Wei, Ziogas, Argyrios, Pharoah, Paul DP, Dunning, Alison M, Easton, Douglas F, Pettitt, Stephen J, Lord, Christopher J, Haider, Syed, Orr, Nick, and Fletcher, Olivia
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Chromosome Mapping ,Genetic Variation ,Breast Neoplasms ,Molecular Sequence Annotation ,functional annotation ,3. Good health ,Cell Line ,breast cancer risk ,risk locus ,Risk Factors ,Chromosomes, Human, Pair 2 ,Humans ,Female ,CRISPR-Cas Systems ,Insulin-Like Growth Factor Binding Protein 5 ,Promoter Regions, Genetic ,Genetic Association Studies ,Sequence Deletion - Abstract
A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74-0.81, p = 3.1 × 10-31).
47. Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry
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Yang, Yaohua, Shu, Xiang, Shu, Xiao-Ou, Bolla, Manjeet K, Kweon, Sun-Seog, Cai, Qiuyin, Michailidou, Kyriaki, Wang, Qin, Dennis, Joe, Park, Boyoung, Matsuo, Keitaro, Kwong, Ava, Park, Sue Kyung, Wu, Anna H, Teo, Soo Hwang, Iwasaki, Motoki, Choi, Ji-Yeob, Li, Jingmei, Hartman, Mikael, Shen, Chen-Yang, Muir, Kenneth, Lophatananon, Artitaya, Li, Bingshan, Wen, Wanqing, Gao, Yu-Tang, Xiang, Yong-Bing, Aronson, Kristan J, Spinell, John J, Gago-Dominguez, Manuela, John, Esther M, Kurian, Allison W, Chang-Claude, Jenny, Chen, Shou-Tung, Dörk, Thilo, Evans, D Gareth R, Schmidt, Marjanka K, Shin, Min-Ho, Giles, Graham G, Milne, Roger L, Simard, Jacques, Kubo, Michiaki, Kraft, Peter, Kang, Daehee, Easton, Douglas F, Zheng, Wei, and Long, Jirong
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Risk ,Genetic variants ,Re-evaluation ,Caspase 8 ,Genotype ,Genetic Variation ,Breast Neoplasms ,Polymorphism, Single Nucleotide ,Candidate gene studies ,White People ,3. Good health ,Asian People ,Population Surveillance ,Odds Ratio ,Humans ,Female ,Genetic Predisposition to Disease ,Breast cancer risk ,Alleles - Abstract
BACKGROUND: We previously conducted a systematic field synopsis of 1059 breast cancer candidate gene studies and investigated 279 genetic variants, 51 of which showed associations. The major limitation of this work was the small sample size, even pooling data from all 1059 studies. Thereafter, genome-wide association studies (GWAS) have accumulated data for hundreds of thousands of subjects. It's necessary to re-evaluate these variants in large GWAS datasets. METHODS: Of these 279 variants, data were obtained for 228 from GWAS conducted within the Asian Breast Cancer Consortium (24,206 cases and 24,775 controls) and the Breast Cancer Association Consortium (122,977 cases and 105,974 controls of European ancestry). Meta-analyses were conducted to combine the results from these two datasets. FINDINGS: Of those 228 variants, an association was observed for 12 variants in 10 genes at a Bonferroni-corrected threshold of P < 2·19 × 10-4. The associations for four variants reached P < 5 × 10-8 and have been reported by previous GWAS, including rs6435074 and rs6723097 (CASP8), rs17879961 (CHEK2) and rs2853669 (TERT). The remaining eight variants were rs676387 (HSD17B1), rs762551 (CYP1A2), rs1045485 (CASP8), rs9340799 (ESR1), rs7931342 (CHR11), rs1050450 (GPX1), rs13010627 (CASP10) and rs9344 (CCND1). Further investigating these 10 genes identified associations for two additional variants at P < 5 × 10-8, including rs4793090 (near HSD17B1), and rs9210 (near CYP1A2), which have not been identified by previous GWAS. INTERPRETATION: Though most candidate gene variants were not associated with breast cancer risk, we found 14 variants showing an association. Our findings warrant further functional investigation of these variants. FUND: National Institutes of Health.
48. Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer
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Kar, Siddhartha P, Considine, Daniel PC, Tyrer, Jonathan P, Plummer, Jasmine T, Chen, Stephanie, Dezem, Felipe S, Barbeira, Alvaro N, Rajagopal, Padma S, Rosenow, Will T, Moreno, Fernando, Bodelon, Clara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, DeFazio, Anna, Dörk, Thilo, Ekici, Arif B, Ewing, Ailith, Fountzilas, George, Goode, Ellen L, Hartman, Mikael, Heitz, Florian, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K, Huzarski, Tomasz, Jensen, Allan, Karlan, Beth Y, Khusnutdinova, Elza, Kiemeney, Lambertus A, Kjaer, Susanne K, Klapdor, Rüdiger, Köbel, Martin, Li, Jingmei, Liebrich, Clemens, May, Taymaa, Olsson, Håkan, Permuth, Jennifer B, Peterlongo, Paolo, Radice, Paolo, Ramus, Susan J, Riggan, Marjorie J, Risch, Harvey A, Saloustros, Emmanouil, Simard, Jacques, Szafron, Lukasz M, Titus, Linda, Thompson, Cheryl L, Vierkant, Robert A, Winham, Stacey J, Zheng, Wei, Doherty, Jennifer A, Berchuck, Andrew, Lawrenson, Kate, Im, Hae Kyung, Manichaikul, Ani W, Pharoah, Paul DP, Gayther, Simon A, and Schildkraut, Joellen M
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2 Aetiology ,Prevention ,Human Genome ,3105 Genetics ,3. Good health ,Ovarian Cancer ,Rare Diseases ,FOS: Biological sciences ,Breast Cancer ,Genetics ,2.1 Biological and endogenous factors ,31 Biological Sciences ,Cancer ,Biotechnology - Abstract
Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germline genetics to improve the power of transcriptome-wide association studies (TWASs) to identify candidate breast cancer and ovarian cancer susceptibility genes. We built gene expression prediction models using the PrediXcan method in 681 breast and 295 ovarian tumors from The Cancer Genome Atlas and 211 breast and 99 ovarian normal tissue samples from the Genotype-Tissue Expression project and integrated these with GWAS meta-analysis data from the Breast Cancer Association Consortium (122,977 cases/105,974 controls) and the Ovarian Cancer Association Consortium (22,406 cases/40,941 controls). The integration was achieved through application of a pleiotropy-guided conditional/conjunction false discovery rate (FDR) approach in the setting of a TWASs. This identified 14 candidate breast cancer susceptibility genes spanning 11 genomic regions and 8 candidate ovarian cancer susceptibility genes spanning 5 genomic regions at conjunction FDR < 0.05 that were >1 Mb away from known breast and/or ovarian cancer susceptibility loci. We also identified 38 candidate breast cancer susceptibility genes and 17 candidate ovarian cancer susceptibility genes at conjunction FDR < 0.05 at known breast and/or ovarian susceptibility loci. The 22 genes identified by our cross-cancer analysis represent promising candidates that further elucidate the role of the transcriptome in mediating germline breast and ovarian cancer risk.
49. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk
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Kramer, Iris, Hooning, Maartje J, Mavaddat, Nasim, Hauptmann, Michael, Keeman, Renske, Steyerberg, Ewout W, Giardiello, Daniele, Antoniou, Antonis C, Pharoah, Paul DP, Canisius, Sander, Abu-Ful, Zumuruda, Andrulis, Irene L, Anton-Culver, Hoda, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Brauch, Hiltrud, Bremer, Michael, Brucker, Sara Y, Burwinkel, Barbara, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, NBCS Collaborators, Collée, J Margriet, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hartman, Mikael, Heemskerk-Gerritsen, Bernadette AM, Hollestelle, Antoinette, Hopper, John L, Hou, Ming-Feng, Howell, Anthony, ABCTB Investigators, KConFab Investigators, Ito, Hidemi, Jakimovska, Milena, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kets, C Marleen, Khusnutdinova, Elza, Ko, Yon-Dschun, Kristensen, Vessela N, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Muranen, Taru A, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Park-Simon, Tjoung-Won, Peto, Julian, Petridis, Christos, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Pylkäs, Katri, Radice, Paolo, Rennert, Gad, Romero, Atocha, Roylance, Rebecca, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, See, Mee-Hoong, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Siesling, Sabine, Slager, Susan, Sohn, Christof, Southey, Melissa C, Spinelli, John J, Stone, Jennifer, Tapper, William J, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Tollenaar, Rob AEM, Tomlinson, Ian, Troester, Melissa A, Vachon, Celine M, Van Ongeval, Chantal, Van Veen, Elke M, Winqvist, Robert, Wolk, Alicja, Zheng, Wei, Ziogas, Argyrios, Easton, Douglas F, Hall, Per, and Schmidt, Marjanka K
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Adult ,Multifactorial Inheritance ,Receptor, ErbB-2 ,Gene Expression ,Breast Neoplasms ,Risk Assessment ,White People ,Cohort Studies ,Asian People ,parasitic diseases ,Humans ,Genetic Predisposition to Disease ,Aged ,Proportional Hazards Models ,Genome, Human ,Estrogen Receptor alpha ,Neoplasms, Second Primary ,Middle Aged ,Prognosis ,Neoadjuvant Therapy ,3. Good health ,polygenic risk score ,contralateral breast cancer ,epidemiology ,Female ,genetic ,Receptors, Progesterone ,Genome-Wide Association Study - Abstract
Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies.
50. Genetic modifiers of CHEK2*1100delC-associated breast cancer risk
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Muranen, Taru A, Greco, Dario, Blomqvist, Carl, Aittomäki, Kristiina, Khan, Sofia, Hogervorst, Frans, Verhoef, Senno, Pharoah, Paul DP, Dunning, Alison M, Shah, Mitul, Luben, Robert, Bojesen, Stig E, Nordestgaard, Børge G, Schoemaker, Minouk, Swerdlow, Anthony, García-Closas, Montserrat, Figueroa, Jonine, Dörk, Thilo, Bogdanova, Natalia V, Hall, Per, Li, Jingmei, Khusnutdinova, Elza, Bermisheva, Marina, Kristensen, Vessela, Borresen-Dale, Anne-Lise, NBCS Investigators, Peto, Julian, Dos Santos Silva, Isabel, Couch, Fergus J, Olson, Janet E, Hillemans, Peter, Park-Simon, Tjoung-Won, Brauch, Hiltrud, Hamann, Ute, Burwinkel, Barbara, Marme, Frederik, Meindl, Alfons, Schmutzler, Rita K, Cox, Angela, Cross, Simon S, Sawyer, Elinor J, Tomlinson, Ian, Lambrechts, Diether, Moisse, Matthieu, Lindblom, Annika, Margolin, Sara, Hollestelle, Antoinette, Martens, John WM, Fasching, Peter A, Beckmann, Matthias W, Andrulis, Irene L, Knight, Julia A, KConFab/AOCS Investigators, Anton-Culver, Hoda, Ziogas, Argyrios, Giles, Graham G, Milne, Roger L, Brenner, Hermann, Arndt, Volker, Mannermaa, Arto, Kosma, Veli-Matti, Chang-Claude, Jenny, Rudolph, Anja, Devilee, Peter, Seynaeve, Caroline, Hopper, John L, Southey, Melissa C, John, Esther M, Whittemore, Alice S, Bolla, Manjeet K, Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Easton, Douglas F, Schmidt, Marjanka K, and Nevanlinna, Heli
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Checkpoint Kinase 2 ,Genes, Modifier ,Odds Ratio ,Humans ,Breast Neoplasms ,Female ,Genetic Predisposition to Disease ,Penetrance ,skin and connective tissue diseases ,3. Good health ,Sequence Deletion - Abstract
PURPOSE: CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have investigated this empirically using data from the Breast Cancer Association Consortium (BCAC). METHODS: Using genotype data from 39,139 (624 1100delC carriers) BC patients and 40,063 (224) healthy controls from 32 BCAC studies, we analyzed the combined risk effects of CHEK2*1100delC and 77 common variants in terms of a polygenic risk score (PRS) and pairwise interaction. RESULTS: The PRS conferred odds ratios (OR) of 1.59 (95% CI: 1.21-2.09) per standard deviation for BC for CHEK2*1100delC carriers and 1.58 (1.55-1.62) for noncarriers. No evidence of deviation from the multiplicative model was found. The OR for the highest quintile of the PRS was 2.03 (0.86-4.78) for CHEK2*1100delC carriers, placing them in the high risk category according to UK NICE guidelines. The OR for the lowest quintile was 0.52 (0.16-1.74), indicating a lifetime risk close to the population average. CONCLUSION: Our results confirm the multiplicative nature of risk effects conferred by CHEK2*1100delC and the common susceptibility variants. Furthermore, the PRS could identify carriers at a high lifetime risk for clinical actions.Genet Med advance online publication 06 October 2016.
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