1. Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis
- Author
-
Andrea Párniczky, Ágnes Rita Martonosi, V. Izsak, Orsolya Varannai, Szabolcs Kiss, Péter Hegyi, Dávid Németh, Zsolt Szakács, and Márk Félix Juhász
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Cystic Fibrosis ,Bone disease ,Parathyroid hormone ,Placebo ,Cystic fibrosis ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Vitamin D ,Randomized Controlled Trials as Topic ,business.industry ,medicine.disease ,030104 developmental biology ,030228 respiratory system ,chemistry ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Cholecalciferol ,business - Abstract
Despite routine supplementation, vitamin D insufficiency is often seen in cystic fibrosis (CF) patients on account of pancreatic insufficiency. Vitamin D is a crucial component of bone health and affects nearly all cells of the immune system. However, clinical benefits or harms associated with supplementation are poorly documented. In this systematic review, we included randomized controlled trials (RCTs) that compared vitamin D supplementation with placebo (i.e. 'non-increased dose') in CF patients. Analysing the 8 included RCTs, the intervention group had significantly higher serum 25-hydroxyvitamin D (se25OHD) levels, but there were no significant differences found in the quantitative synthesis of clinical outcomes, including bone disease-, respiratory status- and immunological status-related outcomes. Based on our current results, while a higher vitamin D dose elevates se25OHD, it does not seem to influence clinical outcomes. Future RCTs should include outcomes of past studies and apply longer follow-up periods to document long-term patient-important outcomes.
- Published
- 2021
- Full Text
- View/download PDF