Search

Your search keyword '"Custers J"' showing total 18 results
Start Over Author "Custers J" Publisher elsevier bv
18 results on '"Custers J"'

6. Hall effect of

Author

Kriegisch, M., primary, Custers, J., additional, Geibel, C., additional, Hilscher, G., additional, Krellner, C., additional, Müller, M., additional, Steglich, F., additional, and Paschen, S., additional

Published
2008
Full Text
View/download PDF

8. First order phase transitions in

Author

Custers, J., primary, Kriegisch, M., additional, Müller, M., additional, Thamizhavel, A., additional, Strydom, A.M., additional, and Paschen, S., additional

Published
2008
Full Text
View/download PDF

9. Quantum critical behaviour in Ce3Pd20Si6?

Author

Paschen, S., primary, Müller, M., additional, Custers, J., additional, Kriegisch, M., additional, Prokofiev, A., additional, Hilscher, G., additional, Steiner, W., additional, Pikul, A., additional, Steglich, F., additional, and Strydom, A.M., additional

Published
2007
Full Text
View/download PDF

10. A replication-competent adenovirus assay for E1-deleted Ad35 vectors produced in PER.C6 cells

Author

Marzio, G., primary, Kerkvliet, E., additional, Bogaards, J.A., additional, Koelewijn, S., additional, De Groot, A., additional, Gijsbers, L., additional, Weverling, G.J., additional, Vogels, R., additional, Havenga, M., additional, Custers, J., additional, Pau, M.G., additional, Guichoux, J.Y., additional, Lewis, J., additional, and Goudsmit, J., additional

Published
2007
Full Text
View/download PDF

16. Low-energy excitations of the semimetallic one-dimensional S=1/2 antiferromagnet Yb4As3

Author

Schmidt, B., primary, Aoki, H., additional, Cichorek, T., additional, Custers, J., additional, Gegenwart, P., additional, Kohgi, M., additional, Lang, M., additional, Langhammer, C., additional, Ochiai, A., additional, Paschen, S., additional, Steglich, F., additional, Suzuki, T., additional, Thalmeier, P., additional, Wand, B., additional, and Yaresko, A., additional

Published
2001
Full Text
View/download PDF

18. Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

Author

Nico van Rooijen, Dan H. Barouch, John H. McVey, Laura Denby, Andrew H. Baker, David Bhella, Jenny A. Greig, R. Pink, Takashi Morita, Alan L. Parker, Kristeen Barker, Ivo M.B. Francischetti, Suzanne M. K. Buckley, Menzo J. E. Havenga, Simon N. Waddington, Stuart A. Nicklin, Claudio Napoli, Hideko Atoda, Jerome Custers, Robson Q. Monteiro, Waddington, S., Mcvey, J., Bhella, D., Parker, A., Barker, K., Atoda, H., Pink, R., Buckley, S., Greig, J., Denby, L., Custers, J., Morita, T., Francischetti, I., Monteiro, R., Barouch, D., VAN ROOIJEN, N., Napoli, Claudio, Havenga, M., Nicklin, S., Baker, A., Molecular cell biology and Immunology, and CCA - Immuno-pathogenesis

Subjects
Models, Molecular, MICROBIO, Transgene, viruses, HUMDISEASE, Mice, Transgenic, Plasma protein binding, Coxsackievirus, Liver Gene Transfer, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Transduction (genetics), Mice, Imaging, Three-Dimensional, Transduction, Genetic, Adenovirus serotype 5, Animals, Humans, Protein Interaction Domains and Motifs, Phylogeny, Gla domain, Serine protease, Liver infection, biology, Biochemistry, Genetics and Molecular Biology(all), Factor X, Adenoviruses, Human, Cryoelectron Microscopy, Surface Plasmon Resonance, Virus Internalization, biology.organism_classification, Virology, Molecular biology, chemistry, Liver, biology.protein, Hepatocytes, Capsid Proteins, Warfarin, Carrier Proteins, Protein Binding
Abstract

SummaryAdenoviruses are used extensively as gene transfer agents, both experimentally and clinically. However, targeting of liver cells by adenoviruses compromises their potential efficacy. In cell culture, the adenovirus serotype 5 fiber protein engages the coxsackievirus and adenovirus receptor (CAR) to bind cells. Paradoxically, following intravascular delivery, CAR is not used for liver transduction, implicating alternate pathways. Recently, we demonstrated that coagulation factor (F)X directly binds adenovirus leading to liver infection. Here, we show that FX binds to the Ad5 hexon, not fiber, via an interaction between the FX Gla domain and hypervariable regions of the hexon surface. Binding occurs in multiple human adenovirus serotypes. Liver infection by the FX-Ad5 complex is mediated through a heparin-binding exosite in the FX serine protease domain. This study reveals an unanticipated function for hexon in mediating liver gene transfer in vivo.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results