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The Society of Powder Technology Japan In pharmaceutical development, it is very useful to exploit the knowledge of the causal relationship between product quality and critical material attributes (CMA) in developing new formulations and products, and optimizing manufacturing processes. With the big data captured in the pharmaceutical industry, computational intelligence (CI) models could potentially be used to identify critical quality attributes (CQA), CMA and critical process parameters (CPP). The objective of this study was to develop computational intelligence models for pharmaceutical tabletting processes, for which bio-inspired feature selection algorithms were developed and implemented for optimisation while artificial neural network (ANN) was employed to predict the tablet characteristics such as porosity and tensile strength. Various pharmaceutical excipients (MCC PH 101, MCC PH 102, MCC DG, Mannitol Pearlitol 200SD, Lactose, and binary mixtures) were considered. Granules were also produced with dry granulation using roll compaction. The feed powders and granules were then compressed at various compression pressures to produce tablets with different porosities, and the corresponding tensile strengths were measured. For the CI modelling, the efficiency of seven bio-inspired optimization algorithms were explored: grey wolf optimization (GWO), bat optimization (BAT), cuckoo search (CS), flower pollination algorithm (FPA), genetic algorithm (GA), particle swarm optimization (PSO), and social spider optimization (SSO). Two-thirds of the experimental dataset was randomly chosen as the training set, and the remaining was used to validate the model prediction. The model efficiency was evaluated in terms of the average reduction (representing the fraction of selected input variables) and the mean square error (MSE). It was found that the CI models can well predict the tablet characteristics (i.e. porosity and tensile strength). It was also shown that the GWO algorithm was the most accurate in predicting porosity. While the most accurate prediction for the tensile strength was achieved using the SSO algorithm. In terms of the average reduction, the GA algorithm resulted in the highest reduction of inputs (i.e. 60%) for predicting both the porosity and the tensile strength. This work was supported by the IPROCOM Marie Curie initial training network, funded through the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7/2007-2013/under REA grant agreement No. 316555.

Tele-rehabilitation is an alternative to the conventional rehabilitation service that helps patients in remote areas to access a service that is practical in terms of logistics and cost, in a controlled environment. It includes the usage of mobile phones or other wireless devices that are applied to rehabilitation exercises. Such applications or software include exercises in the form of virtual games, treatment monitoring based on the rehabilitation progress and data analysis. However, nowadays, physiotherapists use a default profiling setting for patients carrying out rehabilitation, due to lack of information. Medical Interactive Rehabilitation Assistant (MIRA) is a computer-based (virtual reality) rehabilitation platform. The profile setting includes: a level of difficulty, percentage of tolerance and maximum range. To the best of our knowledge, there is a lack of optimization in the parameter values setting of MIRA exergames that could enhance patients' performance. Generally, non-optimal profile setting leads to reduced effectiveness. Therefore, this study aims to develop a method that optimizes the profile setting of each patient according to the estimated (desired) optimal results. The proposed method is developed using unsupervised and supervised machine learning techniques. We use Self-Organizing Map (SOM) to cluster patient records into several distinct clusters. K-fold cross validation is applied to construct the prediction models. Classification And Regression Tree (CART) is utilized to predict the patient's optimal input setting for playing the MIRA games. The combination of these techniques seems to improve the efficiency of the standard (default) way in predicting the optimal settings for exergames. To evaluate the proposed method, we conduct an experiment with data collected from a rehabilitation center. We use three metrics to quantify the quality of the results: R-squared (R2), Mean Absolute Error (MAE) and Root Mean Square Error (RMSE). The results of experimental analysis demonstrate that the proposed method is effective in predicting the adequate parameter setting in MIRA platform. The method has potential to be implemented as an intelligent system for MIRA prediction in healthcare. Moreover, the method could be extended to similar platforms for which data is available to train our method on.

The research in this paper presents a new approach for the modeling of epidemic spread by using a set of connected social networks. The purpose of this work is to simulate the spreading of the well know A/H1N1 pandemic virus. The case study analyzed in this paper refers to the spreading of A/H1N1 in Romania. The epidemic is followed from its beginning throughout its evolution in Romania, i.e. between May 2009 and February 2010. The evolution is performed in a hierarchical way, taking into account the state divisions, the influences among them, national level as well as influences from abroad (from other infected countries). Numerical experiments performed analyze the monthly evolution of the infection in each county and at the country level and compare the results with the real ones (collected during and at the end of the epidemic spread). The simulations results are closer to the reality than the ones provided by the Health Ministry in Romania. The Romanian National Authority for Scientific Research, CNDI–UEFISCDI, project number PN-II-PT-PCCA-2011-3.2-0917.

This is the post-print version of the final paper published in Information Sciences. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2010 Elsevier B.V. The aggregation of objectives in multiple criteria programming is one of the simplest and widely used approach. But it is well known that this technique sometimes fail in different aspects for determining the Pareto frontier. This paper proposes a new approach for multicriteria optimization, which aggregates the objective functions and uses a line search method in order to locate an approximate efficient point. Once the first Pareto solution is obtained, a simplified version of the former one is used in the context of Pareto dominance to obtain a set of efficient points, which will assure a thorough distribution of solutions on the Pareto frontier. In the current form, the proposed technique is well suitable for problems having multiple objectives (it is not limited to bi-objective problems) and require the functions to be continuous twice differentiable. In order to assess the effectiveness of this approach, some experiments were performed and compared with two recent well known population-based metaheuristics namely ParEGO and NSGA II. When compared to ParEGO and NSGA II, the proposed approach not only assures a better convergence to the Pareto frontier but also illustrates a good distribution of solutions. From a computational point of view, both stages of the line search converge within a short time (average about 150 ms for the first stage and about 20 ms for the second stage). Apart from this, the proposed technique is very simple, easy to implement and use to solve multiobjective problems. CNCSIS IDEI 2412, Romania

This paper deals with a special case of multicriteria optimization problems. The problems studied come from the medical domain and are of a very important practical relevance. One of the problems refers to the ranking of treatments for the Trigeminal Neuralgia. The second problem refers to a hierarchy of risk factors for Bronchial Asthma. The most common way to deal with a multiobjective optimization problem is to apply Pareto dominance relationship between solutions. But in the cases studied here, a decision cannot be made just by using Pareto dominance. In one of the experiments, all the potential solutions are nondominated (and we need to clearly find a hierarchy of these solutions) and in the second experiment most of the solutions are nondominated between them. We propose a novel multiple criteria procedure and then an evolutionary scheme is applied for solving the problems. Results obtained by the proposed approach in a very simple way are same as the results (or even better) obtained by applying weighted-sum method. The advantage of the proposed technique is that it does not require any additional information about the problem (like weights for each criteria in the case of weighted-sumapproach).

The process of monitoring the events occurring in a computer system or network and analyzing them for sign of intrusions is known as intrusion detection system (IDS). This paper presents two hybrid approaches for modeling IDS. Decision trees (DT) and support vector machines (SVM) are combined as a hierarchical hybrid intelligent system model (DT-SVM) and an ensemble approach combining the base classifiers. The hybrid intrusion detection model combines the individual base classifiers and other hybrid machine learning paradigms to maximize detection accuracy and minimize computational complexity. Empirical results illustrate that the proposed hybrid systems provide more accurate intrusion detection systems.