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167 results on '"Cravatt, Benjamin"'

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1. Proteomic discovery of chemical probes that perturb protein complexes in human cells

2. Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling

3. In situ identification of cellular drug targets in mammalian tissue

6. Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

7. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

8. GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration

10. Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

12. Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex

17. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

18. Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator

19. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice

21. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

23. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

26. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human Immune Cells

27. Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

28. Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer’s disease

29. Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis

32. Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex

34. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

35. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

37. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

39. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure

40. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice

41. Ligand and Target Discovery by Fragment-Based Screening in Human Cells

42. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

43. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

44. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

45. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

46. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex

48. Endocannabinoid regulation of amyloid-induced neuroinflammation

50. Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action

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