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In response to the role of opioid prescribing in the U.S. opioid crisis, states have enacted laws intended to curb high risk opioid prescribing practices. This study assessed the effects of state prescribing cap laws that limit the dose and/or duration of dispensed opioid prescriptions on opioid prescribing patterns and opioid overdose.We identified 1,414,908 adults from a large U.S. administrative insurance claims database. Treatment states included 32 states that implemented a prescribing cap law between 2017 and 2019. Comparison states included 16 states and DC without a prescribing cap law by 2019. A difference-in-differences approach with staggered policy adoption was used to assess effects of these laws on opioid analgesic prescribing and opioid overdose.State opioid prescribing cap laws were not associated with changes in the proportion of people receiving opioid analgesic prescriptions, the dose or duration of opioid prescriptions, or opioid overdose. States with laws that imposed days' supply limits only versus days' supply and dosage limits, as well as with specific law provisions also showed no association with opioid prescribing or opioid overdose outcomes.State opioid prescribing cap laws did not appear to impact outcomes related to opioid analgesic prescribing or opioid overdose. These findings are potentially due to the limited scope of these laws, which often apply only to a subset of opioid prescriptions and include professional judgment exemptions.

Additive manufacturing (AM) of tissue scaffolds provides medical professionals and patients with personalized treatment options, which align with patients’ specific physiology and provide a more efficient and precise manufacturing process. Vat photopolymerization (VP) AM affords biocompatible, degradable, and high-resolution scaffolds capable of achieving specific pore sizes necessary for tissue regeneration. Earlier biodegradable, photoactive polymers for the VP platform usually require dissolution in a solvent or water, which often results in anisotropic shrinkage upon drying and inconsistencies in the final part geometry. This work describes a photoactive oligomeric precursor that eliminates the requirement for water or solvent during VP. Poly(lactide-co-glycolide) (PLGA) diacrylates with low number-average molecular weights (