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30 results on '"Comai, Stefano"'

1. THU-285 Lownonpsychedelic dosed of psilocybin for the therapy of MASLD

Author

Colognesi, Martina, primary, Gabbia, Daniela, additional, Rinaldi, Andrea, additional, Cascione, Luciano, additional, Zanotto, Ilaria, additional, Comai, Stefano, additional, Sayaf, Katia, additional, Mattarei, Andrea, additional, Banzato, Marco, additional, Pasut, Gianfranco, additional, Folli, Franco, additional, Centofanti, Lucia, additional, Traversa, Sergio, additional, Pappagallo, Marco, additional, Manfredi, Paolo, additional, and De Martin, Sara, additional

Published
2024
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2. Melatonin MT1 receptors as a target for the psychopharmacology of bipolar disorder: a translational study

Author

Mazzocco, Margherita Tassan, primary, Pisanu, Claudia, additional, Russo, Luigi, additional, Acconcia, Clementina, additional, Cambiaghi, Marco, additional, De Girolamo, Sofia, additional, Squassina, Alessio, additional, Cherchi, Laura, additional, Monzani, Elena, additional, Scebba, Francesca, additional, Angeloni, Debora, additional, De Gregorio, Danilo, additional, Nasini, Sofia, additional, Dall’Acqua, Stefano, additional, Sut, Stefania, additional, Suprani, Federico, additional, Garzilli, Mario, additional, Guiso, Beatrice, additional, Pulcinelli, Vittoria, additional, Iaselli, Maria Novella, additional, Pinna, Ilaria, additional, Somaini, Giulia, additional, Arru, Laura, additional, Corrias, Carolina, additional, Paribello, Pasquale, additional, Pinna, Federica, additional, Gobbi, Gabriella, additional, Valtorta, Flavia, additional, Carpiniello, Bernardo, additional, Manchia, Mirko, additional, and Comai, Stefano, additional

Published
2023
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3. Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression

Author

Comai, Stefano, primary, Melloni, Elisa, additional, Lorenzi, Cristina, additional, Bollettini, Irene, additional, Vai, Benedetta, additional, Zanardi, Raffaella, additional, Colombo, Cristina, additional, Valtorta, Flavia, additional, Benedetti, Francesco, additional, and Poletti, Sara, additional

Published
2022
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28. Melatonin, selective and non-selective MT1/MT2 receptors agonists: Differential effects on the 24-h vigilance states

Author

Gilberto Spadoni, Gabriella Gobbi, Annalida Bedini, Giorgio Tarzia, Stefano Comai, Rafael Ochoa-Sanchez, Ochoa Sanchez, Rafael, Comai, Stefano, Spadoni, Gilberto, Bedini, Annalida, Tarzia, Giorgio, and Gobbi, Gabriella

Subjects
Male, Agonist, medicine.medical_specialty, medicine.drug_class, receptor, media_common.quotation_subject, Sleep, REM, UCM793, Non-rapid eye movement sleep, Partial agonist, Rats, Sprague-Dawley, Melatonin, Sleep-wake cycle, UCM924, Internal medicine, Acetamides, medicine, Animals, Circadian rhythm, Wakefulness, media_common, First episode, Aniline Compounds, Receptor, Melatonin, MT2, Receptor, Melatonin, MT1, General Neuroscience, MT, 1, 2, Electroencephalography, Drug Partial Agonism, Endocrinology, Anesthesia, Sleep Stages, Psychology, psychological phenomena and processes, medicine.drug, Vigilance (psychology)
Abstract

Melatonin (MLT) is a neurohormone implicated in several physiological processes such as sleep. Contrasting results have been produced on whether or not it may act as a hypnotic agent, and the neurobiological mechanism through which it controls the vigilance states has not yet been elucidated. In this study we investigated the effect of MLT (40 mg/kg), a non-selective MT1/MT2 receptor agonist (UCM793, 40 mg/kg), and a selective MT2 partial agonist (UCM924, 40 mg/kg) on the 24-h vigilance states. EEG and EMG sleep-wake patterns were registered across the 24-h light-dark cycle in adult Sprague-Dawley male rats. MLT decreased (-37%) the latency to the first episode of non rapid eye movement sleep (NREMS), enhanced the power of NREMS delta band (+33%), but did not alter the duration of any of the three vigilance states. Differently, UCM793 increased the number of episodes (+52%) and decreased the length of the episodes (-38%) of wakefulness but did not alter the 24-h duration of wakefulness, NREMS and REMS. UCM924 instead reduced the latency (-56%) and increased (+31%) the duration of NREMS. Moreover, it raised the number of REMS episodes (+57%) but did not affect REMS duration. Taken together, these findings show that MLT and non-selective MT1/MT2 receptor agonists do not increase the quantity of sleep but differently influence the three vigilance states. In addition, they support the evidence that selective MT2 receptor agonists increase NREMS duration compared to MLT and non-selective MT1/MT2 agonists.

Published
2014

29. Changes in serum tryptophan during antiviral therapy with recombinant α-interferon in chronic hepatitis C

Author

C. V. L. Costa, Antonella Bertazzo, S Luise, Stefano Comai, Liliana Chemello, Luisa Cavalletto, A., Bertazzo, Comai, Stefano, L., Cavalletto, L., Chemello, S., Luise, and C. V. L., Costa

Subjects
medicine.medical_specialty, business.industry, Ribavirin, Hepatitis C virus, Beck Depression Inventory, General Medicine, Hepatitis C, medicine.disease, medicine.disease_cause, Hospital Anxiety and Depression Scale, Gastroenterology, chemistry.chemical_compound, chemistry, Internal medicine, Immunology, Medicine, Serotonin, business, Adverse effect, Depression (differential diagnoses)
Abstract

The most effective treatment of chronic hepatitis C (HCV) available to date is represented by interferon-α (IFN-α), alone or in combination with ribavirin. However, the therapy presents adverse effects, including depressive symptoms. As IFN-α can cause an alteration of the tryptophan metabolism and a consequent reduced synthesis of serotonin, we have designed a study aimed to investigate the effect of IFN-α therapy on the serum levels of tryptophan and on the development of depression in patients affected by the hepatitis C virus. Nine patients with HCV were enrolled while treated with IFN-α2a (3 MU thrice/week) plus ribavirin (15 mg/kg/day) for six months. All patients were evaluated by a hepatologist and received two self-administered scales [Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS)]. Blood samples were collected before treatment and at one month and six months of therapy. Tryptophan, 5-hydroxytryptophan and serotonin were analysed by HPLC with a spectrofluorometric detector. In all cases, a significant decrease of serum tryptophan concentrations from baseline (17.60 ± 1.08 mg/ml) to one month (13.94 ± 1.18 mg/ml) and six months (12.68 ± 0.64 mg/ml) with an increase of symptoms of depression was obtained, whereas 5-hydroxytryptophan and serotonin levels did not show any variation during the therapy from baseline values. The preliminary results suggest that IFN-α plays a role in serum tryptophan reduction and the development of depressive symptoms.

Published
2007

30. Protein and non-protein (free and protein-bound) tryptophan in legume seeds

Author

Graziella Allegri, Antonella Bertazzo, Lucia Bailoni, Mirella Zancato, Carlo Virgilio Luigi Costa, Stefano Comai, Comai, Stefano, Bertazzo, A., Bailoni, L, Zancato, M, Costa, Cvl, and Allegri, G.

Subjects
Biochemistry, Broad beans, Protein free, Free tryptophan, Tryptophan, food and beverages, A protein, General Medicine, Biology, Legume, Food Science, Analytical Chemistry
Abstract

The contents of protein and non-protein (free and protein-bound) tryptophan and of proteins in the flours of nine legume seeds were determined. Lupins and soybeans showed the highest protein concentrations, followed by groundnuts, beans, broad beans, lentils, vetches, chick-peas, and peas. Protein tryptophan content is higher in soybeans and lower in peas (502 and 192 mg/100 g of dry flour, respectively) than in the other legumes, which also contain non-protein tryptophan. Chick-peas show the highest value of free tryptophan and groundnuts the lowest (58.2 and 2.24 mg/100 g of dry flour, respectively). Tryptophan appears to be bound to water-soluble proteins and to proteins soluble at pH 8.9. In particular, chick-peas contain a high amount of tryptophan bound to water-soluble proteins, followed by beans. The results are evaluated, considering the importance, not only of protein, but also non-protein tryptophan, for assessing the nutritive value of a protein in foods.

Published
2007

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