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Existing animal and human research support the causal role of stress in the emergence of anhedonia, and in turn, the influence of anhedonia in social functioning. However, this model has not been tested in relation to psychosis-risk; this literature gap is notable given that both anhedonia and declining social functioning represent key markers of risk of developing a psychotic disorder such as schizophrenia. The current research tested the evidence for this model using structural equation modeling in 240 individuals selected based on a range of psychosis-risk symptomatology from the general community. Results supported this model in comparison with alternative models, and additionally emphasized the direct role of perceived stress in social functioning outcomes. Findings suggest the clinical relevance of targeting early perceptions of stress in individuals meeting psychosis-risk self-report criteria in an effort to prevent subsequent anhedonia and declines in social functioning.

Individuals at risk for schizophrenia-spectrum disorders tend to make atypical attributions of significance to unimportant stimuli. This experience of heightened significance, known as aberrant salience, is thought to contribute to psychotic symptoms. The Aberrant Salience Inventory (ASI) was designed to capture subclinical and clinical manifestations of the construct, and scores on the scale are associated with schizophrenia-like symptoms and behaviors in laboratory studies. Experience sampling methodology (ESM) studies have assessed momentary experiences of aberrant salience in daily life, but to our knowledge no study has examined real-world outcomes using the ASI as a trait measure of aberrant salience. The current study assessed the expression of aberrant salience in undergraduates oversampled for positive and negative schizotypy using ESM. Overall, findings of the expression of aberrant salience in daily life were similar to previous findings with positive schizotypy. Aberrant salience was associated with psychotic-like and disorganized symptoms, suspiciousness, and social impairment in daily life. It was unassociated with negative symptoms, stress, or affect in the moment. Aberrant salience did not moderate daily life associations of stress with schizotypic symptoms. The ASI subscales showed differential patterns of associations in daily life. These findings support the construct validity of the ASI and suggest that aberrant salience traits are relevant for real-world outcomes in schizotypy-spectrum psychopathology.

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.