Search

Your search keyword '"Charles C Barr"' showing total 20 results
Start Over Author "Charles C Barr" Publisher elsevier bv
20 results on '"Charles C Barr"'

1. Prediction for 2-Year Vision Outcomes Using Early Morphologic and Functional Responses in the Comparison of Age-related Macular Degeneration Treatments Trials

Author

Katie Xue, Peiying Hua, Maureen G. Maguire, Ebenezer Daniel, Glenn J. Jaffe, Juan E. Grunwald, Gui-shuang Ying, David F. Williams, Sara Beardsley, Steven Bennett, Herbert Cantrill, Carmen Chan-Tram, Holly Cheshier, Kathyrn Damato, John Davies, Sundeep Dev, Julianne Enloe, Gennaro Follano, Peggy Gilbert, Jill Johnson, Tori Jones, Lisa Mayleben, Robert Mittra, Martha Moos, Ryan Neist, Neal Oestreich, Polly Quiram, Robert Ramsay, Edwin Ryan, Stephanie Schindeldecker, John Snater, Trenise Steele, Dwight Selders, Jessica Tonsfeldt, Shelly Valardi, Gary Edd Fish, Hank A. Aguado, Sally Arceneaux, Jean Arnwine, Kim Bell, Tina Bell, Bob Boleman, Patricia Bradley, David Callanan, Lori Coors, Jodi Creighton, Timothy Crew, Kimberly Cummings, Christopher Dock, Karen Duignan, Dwain Fuller, Keith Gray, Betsy Hendrix, Nicholas Hesse, Diana Jaramillo, Bradley Jost, Sandy Lash, Laura Lonsdale, Michael Mackens, Karin Mutz, Michael Potts, Brenda Sanchez, William Snyder, Wayne Solley, Carrie Tarter, Robert Wang, Patrick Williams, Stephen L. Perkins, Nicholas Anderson, Ann Arnold, Paul Blais, Joseph Googe, Tina T. Higdon, Cecile Hunt, Mary Johnson, James Miller, Misty Moore, Charity K. Morris, Christopher Morris, Sarah Oelrich, Kristina Oliver, Vicky Seitz, Jerry Whetstone, Bernard H. Doft, Jay Bedel, Robert Bergren, Ann Borthwick, Paul Conrad, Amanda Fec, Christina Fulwylie, Willia Ingram, Shawnique Latham, Gina Lester, Judy Liu, Louis Lobes, Nicole M. Lucko, Holly Mechling, Lori Merlotti, Keith McBroom, Karl Olsen, Danielle Puskas, Pamela Rath, Maria Schmucker, Lynn Schueckler, Christina Schultz, Heather Shultz, David Steinberg, Avni Vyas, Kim Whale, Kimberly Yeckel, David H. Orth, Linda S. Arredondo, Susan Brown, Barbara J. Ciscato, Joseph M. Civantos, Celeste Figliulo, Sohail Hasan, Belinda Kosinski, Dan Muir, Kiersten Nelson, Kirk Packo, John S. Pollack, Kourous Rezaei, Gina Shelton, Shannya Townsend-Patrick, Marian Walsh, H. Richard McDonald, Nina Ansari, Amanda Bye, Arthur D. Fu, Sean Grout, Chad Indermill, Robert N. Johnson, J. Michael Jumper, Silvia Linares, Brandon J. Lujan, Ames Munden, Meredith Persons, Rosa Rodriguez, Jennifer M. Rose, Brandi Teske, Yesmin Urias, Stephen Young, Richard F. Dreyer, Howard Daniel, Michele Connaughton, Irvin Handelman, Stephen Hobbs, Christine Hoerner, Dawn Hudson, Marcia Kopfer, Michael Lee, Craig Lemley, Joe Logan, Colin Ma, Christophe Mallet, Amanda Milliron, Mark Peters, Harry Wohlsein, Joel A. Pearlman, Margo Andrews, Melissa Bartlett, Nanette Carlson, Emily Cox, Robert Equi, Marta Gonzalez, Sophia Griffin, Fran Hogue, Lance Kennedy, Lana Kryuchkov, Carmen Lopez, Danny Lopez, Bertha Luevano, Erin McKenna, Arun Patel, Brian Reed, Nyla Secor, Iris R. Sison, Tony Tsai, Nina Varghis, Brooke Waller, Robert Wendel, Reina Yebra, Daniel B. Roth, Jane Deinzer, Howard Fine, Flory Green, Stuart Green, Bruce Keyser, Steven Leff, Amy Leviton, Amy Martir, Kristin Mosenthine, Starr Muscle, Linda Okoren, Sandy Parker, Jonathan Prenner, Nancy Price, Deana Rogers, Linda Rosas, Alex Schlosser, Loretta Studenko, Thea Tantum, Harold Wheatley, Michael T. Trese, Thomas Aaberg, Denis Bezaire, Craig Bridges, Doug Bryant, Antonio Capone, Michelle Coleman, Christina Consolo, Cindy Cook, Candice DuLong, Bruce Garretson, Tracy Grooten, Julie Hammersley, Tarek Hassan, Heather Jessick, Nanette Jones, Crystal Kinsman, Jennifer Krumlauf, Sandy Lewis, Heather Locke, Alan Margherio, Debra Markus, Tanya Marsh, Serena Neal, Amy Noffke, Kean Oh, Clarence Pence, Lisa Preston, Paul Raphaelian, Virginia R. Regan, Peter Roberts, Alan Ruby, Ramin Sarrafizadeh, Marissa Scherf, Sarita Scott, Scott Sneed, Lisa Staples, Brad Terry, Matthew T. Trese, Joan Videtich, George Williams, Mary Zajechowski, Daniel P. Joseph, Kevin Blinder, Lynda Boyd, Sarah Buckley, Meaghan Crow, Amanda Dinatale, Nicholas Engelbrecht, Bridget Forke, Dana Gabel, Gilbert Grand, Jennifer Grillion-Cerone, Nancy Holekamp, Charlotte Kelly, Ginny Nobel, Kelly Pepple, Matt Raeber, P. Kumar Rao, Tammy Ressel, Steven Schremp, Merrilee Sgorlon, Shantia Shears, Matthew Thomas, Cathy Timma, Annette Vaughn, Carolyn Walters, Rhonda Weeks, Jarrod Wehmeier, Tim Wright, Daniel M. Berinstein, Aida Ayyad, Mohammed K. Barazi, Erica Bickhart, Tracey Brady, Lisa Byank, Alysia Cronise, Vanessa Denny, Courtney Dunn, Michael Flory, Robert Frantz, Richard A. Garfinkel, William Gilbert, Michael M. Lai, Alexander Melamud, Janine Newgen, Shamekia Newton, Debbie Oliver, Michael Osman, Reginald Sanders, Manfred von Fricken, Pravin Dugel, Sandra Arenas, Gabe Balea, Dayna Bartoli, John Bucci, Jennifer A. Cornelius, Scheleen Dickens, Don Doherty, Heather Dunlap, David Goldenberg, Karim Jamal, Norma Jimenez, Nicole Kavanagh, Derek Kunimoto, John Martin, Jessica Miner, Sarah Mobley, Donald Park, Edward Quinlan, Jack Sipperley, Carol Slagle, Danielle Smith, Miguelina Yafchak, Rohana Yager, Christina J. Flaxel, Steven Bailey, Peter Francis, Chris Howell, Thomas Hwang, Shirley Ira, Michael Klein, Andreas Lauer, Teresa Liesegang, Ann Lundquist, Sarah Nolte, Susan K. Nolte, Scott Pickell, Susan Pope, Joseph Rossi, Mitchell Schain, Peter Steinkamp, Maureen D. Toomey, Debora Vahrenwald, Kelly West, Baker Hubbard, Stacey Andelman, Chris Bergstrom, Judy Brower, Blaine Cribbs, Linda Curtis, Jannah Dobbs, Lindreth DuBois, Jessica Gaultney, Deborah Gibbs, Debora Jordan, Donna Leef, Daniel F. Martin, Robert Myles, Timothy Olsen, Bryan Schwent, Sunil Srivastava, Rhonda Waldron, Andrew N. Antoszyk, Uma Balasubramaniam, Danielle Brooks, Justin Brown, David Browning, Loraine Clark, Sarah Ennis, Susannah Held, Jennifer V. Helms, Jenna Herby, Angie Karow, Pearl Leotaud, Caterina Massimino, Donna McClain, Michael McOwen, Jennifer Mindel, Candace Pereira, Rachel Pierce, Michele Powers, Angela Price, Jason Rohrer, Jason Sanders, Robert L. Avery, Kelly Avery, Jessica Basefsky, Liz Beckner, Alessandro Castellarin, Stephen Couvillion, Jack Giust, Matthew Giust, Maan Nasir, Dante Pieramici, Melvin Rabena, Sarah Risard, Robert See, Jerry Smith, Lisha Wan, Sophie J. Bakri, Nakhleh Abu-Yaghi, Andrew Barkmeier, Karin Berg, Jean Burrington, Albert Edwards, Shannon Goddard, Shannon Howard, Raymond Iezzi, Denise Lewison, Thomas Link, Colin A. McCannel, Joan Overend, John Pach, Margaret Ruszczyk, Ryan Shultz, Cindy Stephan, Diane Vogen, Reagan H. Bradford, Vanessa Bergman, Russ Burris, Amanda Butt, Beth Daniels, Connie Dwiggins, Stephen Fransen, Tiffany Guerrero, Darin Haivala, Amy Harris, Sonny Icks, Ronald Kingsley, Lena Redden, Rob Richmond, Brittany Ross, Kammerin White, Misty Youngberg, Trexler M. Topping, Steve Bennett, Sandy Chong, Mary Ciotti, Tina Cleary, Emily Corey, Dennis Donovan, Albert Frederick, Lesley Freese, Margaret Graham, Natalya Gud, Taneika Howard, Mike Jones, Michael Morley, Katie Moses, Jen Stone, Robin Ty, Torsten Wiegand, Lindsey Williams, Beth Winder, Carl C. Awh, Michelle Amonette, Everton Arrindell, Dena Beck, Brandon Busbee, Amy Dilback, Sara Downs, Allison Guidry, Gary Gutow, Jackey Hardin, Sarah Hines, Emily Hutchins, Kim LaCivita, Ashley Lester, Larry Malott, MaryAnn McCain, Jayme Miracle, Kenneth Moffat, Lacy Palazzotta, Kelly Robinson, Peter Sonkin, Alecia Travis, Roy Trent Wallace, Kelly J. Winters, Julia Wray, April E. Harris, Mari Bunnell, Katrina Crooks, Rebecca Fitzgerald, Cameron Javid, Corin Kew, Erica Kill, Patricia Kline, Janet Kreienkamp, Maricruz Martinez, Roy Ann Moore, Egbert Saavedra, LuAnne Taylor, Mark Walsh, Larry Wilson, Thomas A. Ciulla, Ellen Coyle, Tonya Harrington, Charlotte Harris, Cindi Hood, Ingrid Kerr, Raj Maturi, Dawn Moore, Stephanie Morrow, Jennifer Savage, Bethany Sink, Tom Steele, Neelam Thukral, Janet Wilburn, Joseph P. Walker, Jennifer Banks, Debbie Ciampaglia, Danielle Dyshanowitz, Jennifer Frederick, A. Tom Ghuman, Richard Grodin, Cheryl Kiesel, Eileen Knips, Jonathan McCue, Maria Ortiz, Crystal Peters, Paul Raskauskas, Etienne Schoeman, Ashish Sharma, Glenn Wing, Rebecca Youngblood, Suresh R. Chandra, Michael Altaweel, Barbara Blodi, Kathryn Burke, Kristine A. Dietzman, Justin Gottlieb, Gene Knutson, Denise Krolnik, T. Michael Nork, Shelly Olson, John Peterson, Sandra Reed, Barbara Soderling, Guy Somers, Thomas Stevens, Angela Wealti, Srilaxmi Bearelly, Brenda Branchaud, Joyce W. Bryant, Sara Crowell, Sharon Fekrat, Merritt Gammage, Cheala Harrison, Sarah Jones, Noreen McClain, Brooks McCuen, Prithvi Mruthyunjaya, Jeanne Queen, Neeru Sarin, Cindy Skalak, Marriner Skelly, Ivan Suner, Ronnie Tomany, Lauren Welch, Susanna S. Park, Allison Cassidy, Karishma Chandra, Idalew Good, Katrina Imson, null Sashi, null Kaur, Helen Metzler, Lawrence Morse, Ellen Redenbo, Marisa Salvador, David Telander, Mark Thomas, Cindy Wallace, Charles C. Barr, Amanda Battcher, Michelle Bottorff, Mary Chasteen, Kelly Clark, Diane Denning, Debra Schoen, Amy Schultz, Evie Tempel, Lisa Wheeler, Greg K. Whittington, Thomas W. Stone, Todd Blevins, Michelle Buck, Lynn Cruz, Wanda Heath, Diana Holcomb, Rick Isernhagen, Terri Kidd, John Kitchens, Cathy Sears, Ed Slade, Jeanne Van Arsdall, Brenda VanHoose, Jenny Wolfe, William Wood, John Zilis, Carol Crooks, Larry Disney, Mimi Liu, Stephen Petty, Sandra Sall, James C. Folk, Tracy Aly, Abby Brotherton, Douglas Critser, Connie J. Hinz, Stefani Karakas, Valerie Kirschner, Cheyanne Lester, Cindy Montague, Stephen Russell, Heather Stockman, Barbara Taylor, Randy Verdick, Jean Walshire, John T. Thompson, Barbara Connell, Maryanth Constantine, John L. Davis, null Gwen Holsapple, Lisa Hunter, C. Nicki Lenane, Robin Mitchell, Leslie Russel, Raymond Sjaarda, David M. Brown, Matthew Benz, Llewellyn Burns, JoLene G. Carranza, Richard Fish, Debra Goates, Shayla Hay, Theresa Jeffers, Eric Kegley, Dallas Kubecka, Stacy McGilvra, Beau Richter, Veronica Sneed, Cary Stoever, Isabell Tellez, Tien Wong, Ivana Kim, Christopher Andreoli, Leslie Barresi, Sarah Brett, Charlene Callahan, Karen Capaccioli, William Carli, Matthew Coppola, Nicholas Emmanuel, Claudia Evans, Anna Fagan, Marcia Grillo, John Head, Troy Kieser, Elaine Lee, Ursula Lord, Edward Miretsky, Kate Palitsch, Todd Petrin, Liz Reader, Svetlana Reznichenko, Mary Robertson, Justin Smith, Demetrios Vavvas, John Wells, Cassie Cahill, W. Lloyd Clark, Kayla Henry, David Johnson, Peggy Miller, LaDetrick Oliver, Robbin Spivey, Tiffany Swinford, Mallie Taylor, Michael Lambert, Kris Chase, Debbie Fredrickson, Joseph Khawly, Valerie Lazarte, Donald Lowd, Pam Miller, Arthur Willis, Philip J. Ferrone, Miguel Almonte, Rachel Arnott, Ingrid Aviles, Sheri Carbon, Michael Chitjian, Kristen DAmore, Christin Elliott, David Fastenberg, Barry Golub, Kenneth Graham, AnnMarie Lavorna, Laura Murphy, Amanda Palomo, Christina Puglisi, David Rhee, Juan Romero, Brett Rosenblatt, Glenda Salcedo, Marianne Schlameuss, Eric Shakin, Vasanti Sookhai, Richard Kaiser, Elizabeth Affel, Gary Brown, Christina Centinaro, Deborah Fine, Mitchell Fineman, Michele Formoso, Sunir Garg, Lisa Grande, Carolyn Herbert, Allen Ho, Jason Hsu, Maryann Jay, Lisa Lavetsky, Elaine Liebenbaum, Joseph Maguire, Julia Monsonego, Lucia O’Connor, Lisa Pierce, Carl Regillo, Maria Rosario, Marc Spirn, James Vander, Jennifer Walsh, Frederick H. Davidorf, Amanda Barnett, Susie Chang, John Christoforidis, Joy Elliott, Heather Justice, Alan Letson, Kathryne McKinney, Jeri Perry, Jill A. Salerno, Scott Savage, Stephen Shelley, Lawrence J. Singerman, Joseph Coney, John DuBois, Kimberly DuBois, Gregg Greanoff, Dianne Himmelman, Mary Ilc, Elizabeth McNamara, Michael Novak, Scott Pendergast, Susan Rath, Sheila Smith-Brewer, Vivian Tanner, Diane E. Weiss, Hernando Zegarra, Lawrence Halperin, Patricia Aramayo, Mandeep Dhalla, Brian Fernandez, Cindy Fernandez, Jaclyn Lopez, Monica Lopez, Jamie Mariano, Kellie Murphy, Clifford Sherley, Rita Veksler, Firas Rahhal, Razmig Babikian, David Boyer, Sepideh Hami, Jeff Kessinger, Janet Kurokouchi, Saba Mukarram, Sarah Pachman, Eric Protacio, Julio Sierra, Homayoun Tabandeh, Adam Zamboni, Michael Elman, Jennifer Belz, Tammy Butcher, Theresa Cain, Teresa Coffey, Dena Firestone, Nancy Gore, Pamela Singletary, Peter Sotirakos, JoAnn Starr, Travis A. Meredith, Cassandra J. Barnhart, Debra Cantrell, RonaLyn Esquejo-Leon, Odette Houghton, Harpreet Kaur, Fatoumatta NDure, Ronald Glatzer, Leonard Joffe, and Reid Schindler

Subjects
Ophthalmology
Published
2023
Full Text
View/download PDF

2. Vitamin Analysis Comparison Study

Author

Efrat Fleissig, Eddie Apenbrinck, Charles C. Barr, and Xiang Zhang

Subjects
Vitamin, Dose, National brand, medicine.medical_treatment, Ascorbic Acid, Gas Chromatography-Mass Spectrometry, Macular Degeneration, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Humans, Vitamin E, Medicine, Prospective Studies, Food science, 030304 developmental biology, 0303 health sciences, Vitamin C, business.industry, Spectrophotometry, Atomic, Reproducibility of Results, Vitamins, Zinc, Ophthalmology, Cross-Sectional Studies, Systemic toxicity, chemistry, 030221 ophthalmology & optometry, Comparison study, Multivitamin, business, Biomarkers
Abstract

Purpose We compared and analyzed the concentrations of vitamin C, vitamin E, zinc, and copper in both national and regional brands of dietary supplements recommended for patients who are at risk for macular degeneration. Design Prospective cross-sectional study. Methods National brand name and generic multivitamin formulations for age-related macular degeneration were obtained. Comparative analysis of the vitamin C and vitamin E content was performed by gas chromatography-mass spectrometry and the zinc and copper content was analyzed by atomic absorption spectroscopy in an institutional chemistry laboratory. Results All national brand name vitamins, both tablet and gel capsule formulations, and generic brands in tablet form were relatively accurate in their product labeling. For most of the samples tested, the measured quantities of vitamin C, vitamin E, zinc, and copper were slightly higher than labeled but not to an amount that would cause any systemic toxicity if taken at the recommended dosages. Conclusions Physicians may recommend national brand name vitamins and generic brands in tablet form to their patients with some confidence; however, the content may have some inaccuracies regarding labeling.

Published
2021
Full Text
View/download PDF

3. Bilateral neuroretinits and exudative retinal detachment with multifocal subretinal deposits secondary to Bartonella henselae infection

Author

Efrat Fleissig, Charles C. Barr, Douglas K. Sigford, and Fiona Kim

Subjects
medicine.medical_specialty, Visual acuity, Reduced vision, Case Report, Subretinal deposits, Neuroretinitis, Systemic antibiotics, Ophthalmology, medicine, Doxycycline, Bartonella henselae, biology, business.industry, Retinal detachment, Exudative retinal detachment, RE1-994, biology.organism_classification, medicine.disease, eye diseases, Bartonella henselae neuroretinitis, medicine.symptom, business, medicine.drug
Abstract

Purpose to describe a case of bilateral neuroretinitis with bullous retinal detachment and multiple subretinal lesions, in a 10-year-old immunocompetent girl. Observations A broad workup for infectious, inflammatory and masquerade etiologies was done for the patient, resulting in positive IgM and IgG for Bartonella henselae. The patient demonstrated improvement in the visual acuity, and rapid resolution of the retinal detachment and subretinal lesions in both eyes in response to systemic rifampin, doxycycline and corticosteroids. Conclusions and Importance Bartonella henselae neuroretinitis may present as an acute form of bullous retinal detachment with multiple subretinal lesions and markedly reduced vision. Significant visual improvement may occur with prompt treatment with a combination of systemic antibiotics and corticosteroids.

Published
2021
Full Text
View/download PDF

4. Single grading vs double grading with adjudication in the telemedicine approaches to evaluating acute-phase retinopathy of prematurity (e-ROP) study

Author

Ebenezer Daniel, Wei Pan, Graham E. Quinn, Eli Smith, Agnieshka Baumritter, Gui-Shuang Ying, Kelly Wade, Trang B. Duros, Lisa Erbring, Michael X. Repka, Jennifer A. Shepard, David Emmert, C. Mark Herring, Deborah VanderVeen, Suzanne Johnston, Carolyn Wu, Jason Mantagos, Danielle Ledoux, Tamar Winter, Frank Weng, Theresa Mansfield, Don L. Bremer, Mary Lou McGregor, Catherine Olson Jordan, David L. Rogers, Rae R. Fellows, Suzanne Brandt, Brenda Mann, David Wallace, Sharon Freedman, Sarah K. Jones, Du Tran-Viet, Rhonda 'Michelle' Young, Charles C. Barr, Rahul Bhola, Craig Douglas, Peggy Fishman, Michelle Bottorff, Brandi Hubbuch, Rachel Keith, Erick D. Bothun, Inge DeBecker, Jill Anderson, Ann Marie Holleschau, Nichole E. Miller, Darla N. Nyquist, R. Michael Siatkowski, Lucas Trigler, Marilyn Escobedo, Karen Corff, Michelle Huynh, Kelli Satnes, Monte D. Mills, Will Anninger, Gil Binenbaum, Graham Quinn, Karen A. Karp, Denise Pearson, Alice Gong, John Stokes, Clio Armitage Harper, Laurie Weaver, Carmen McHenry, Kathryn Conner, Rosalind Heemer, Elnora Cokley, Robert Hoffman, David Dries, Katie Jo Farnsworth, Deborah Harrison, Bonnie Carlstrom, Cyrie Ann Frye, David Morrison, Sean Donahue, Nancy Benegas, Sandy Owings, Sandra Phillips, Scott Ruark, Anna Ells, Patrick Mitchell, April Ingram, Rosie Sorbie, Maureen Maguire, Mary Brightwell-Arnold, Max Pistilli, Kathleen McWilliams, Sandra Harris, Claressa Whearry, E. Revell Martin, Candace R. Parker Ostroff, Krista Sepielli, Antonio Capone, G. Baker Hubbard, Peter Lloyd, Kerry Davis, G. Carl Gibson, Regina Hansen, Alex R. Kemper, Lisa Prosser, David C. Musch, Stephen P. Christiansen, Ditte J. Hess, Steven M. Kymes, SriniVas R. Sadda, Ryan Spaulding, and Eleanor B. Schron

Subjects
medicine.medical_specialty, Telemedicine, business.industry, Infant, Newborn, Infant, Retinopathy of prematurity, medicine.disease, Sensitivity and Specificity, Article, Ophthalmoscopy, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Image Processing, Computer-Assisted, 030221 ophthalmology & optometry, medicine, Humans, Infant, Very Low Birth Weight, Retinopathy of Prematurity, Grading (education), business
Abstract

To evaluate the sensitivity and specificity of single, independent, nonphysician trained reader (TR) gradings in the Telemedicine Approaches to Evaluating Acute-phase Retinopathy of Prematurity (e-ROP) study.Secondary analyses of image grading results from 1,235 infants of birth weights1251 g. Two of three TRs independently graded image sets; discrepancies were adjudicated by the reading center director (an ophthalmologist) to reach final grading. Sensitivity and specificity of each TR grading and final grading was calculated by comparing gradings to clinical examination results.Of 7,808 double graded image sets, TR1 graded 5,165; TR2, 3,787; and TR3, 6,664. Compared to final grading for referral warranted retinopathy of prematurity (RW-ROP), two TRs had relatively lower sensitivity (TR1, 75% vs 79% [P = 0.03]; TR2, 73% vs 77% [P = 0.02]) and specificity (TR1, 80% vs 83% [P 0.001]; TR2, 82% vs 83% [P = 0.09]). TR3 had similar sensitivity (83% vs 83% [P = 0.78]) and specificity (83% vs 84% [P = 0.02]). Compared to final grading, TR1 had lower sensitivity for zone I ROP (47% vs 56% [P = 0.04]) and stage ≥3 ROP (71% vs 77% [P = 0.002]); TR2 had lower sensitivity for stage ≥3 ROP (69% vs 77% [P 0.001]) and lower specificity for all three components (P 0.001); TR3 had lower sensitivity for detecting plus disease (23% vs 35% [P 0.001]) and similar sensitivity for zone I ROP and stage ≥3 ROP.There is a small but significant decrease in the sensitivity and specificity for RW-ROP when single-reader grading is compared to double adjudicated grading.

Published
2018
Full Text
View/download PDF

5. Disseminated Nocardiosis with retinal abscess in a patient treated for bullous pemphigoid

Author

Andrea Breaux, Charles C. Barr, Sidharth Puri, and Amir Hadayer

Subjects
medicine.medical_specialty, Nocardia, Retina, Nocardiosis, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Ophthalmology, Medicine, Abscess, Nocardia farcinica, Brief report, integumentary system, medicine.diagnostic_test, biology, business.industry, Brain biopsy, Retinal, medicine.disease, biology.organism_classification, Dermatology, eye diseases, Ophthalmology, chemistry, lcsh:RE1-994, 030221 ophthalmology & optometry, sense organs, Bullous pemphigoid, business, Rare disease
Abstract

Purpose: To report a case of disseminated Nocardiosis with retinal and intracranial lesions. Observations: A 49-year-old woman immunosuppressed because of treatment given for bullous pemphigoid presented with altered mental status and multiple intracranial lesions on imaging. The patient was found to have multiple retinal lesions in both eyes, including a subretinal abscess in the right eye. The patient underwent brain biopsy, confirming Nocardia farcinica histopathologically and in culture. Conclusions and Importance: Ocular Nocardiosis is a rare disease with varying prognosis that requires prompt diagnosis to ensure appropriate medical therapy. Keywords: Abscess, Nocardia, Nocardiosis, Retina

Published
2018
Full Text
View/download PDF

6. Changes in Course of Retinopathy of Prematurity from 1986 to 2013

Author

Charles C. Barr, Michael X. Repka, R. Michael Siatkowski, Gui-Shuang Ying, Robert O. Hoffman, Don L. Bremer, Alice K Gong, Jennifer Shepard, Kelly C. Wade, Rae R. Fellows, and Graham E. Quinn

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Neonatal intensive care unit, business.industry, medicine.medical_treatment, Birth weight, Outcome measures, Gestational age, Cryotherapy, Retinopathy of prematurity, medicine.disease, eye diseases, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, 030225 pediatrics, Secondary analysis, Time course, 030221 ophthalmology & optometry, medicine, business
Abstract

Purpose To compare infant and retinopathy of prematurity (ROP) characteristics from 3 clinical studies conducted over a 27-year period in the United States. Design Secondary analysis of results of 3 clinical studies. Participants Infants with birth weight (BW) Methods Analysis of data from the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) and Early Treatment for Retinopathy of Prematurity (ETROP) trials and the primary data from the Telemedicine Approaches for the Evaluation of Acute-Phase Retinopathy of Prematurity (e-ROP) study. Main Outcome Measures Infant characteristics and onset, severity, and time course of ROP. Results Across the 3 studies, mean (standard deviation) BW and mean gestational age (GA) decreased over time from CRYO-ROP (954 g [185 g], 27.9 weeks [2.2 weeks]) to ETROP (907 g [205 g], 27.4 weeks [2.2 weeks]) to e-ROP (864 g [212 g], 27.0 weeks [2.2 weeks]), with an increase in the percentage of infants enrolled weighing P P = 0.003). Moderately severe ROP (defined as prethreshold or referral warranted) varied (17.8% CRYO, 12.3% ETROP, 19.4% e-ROP; P Conclusions The BW and GA of infants enrolled in ROP studies in the United States have decreased over the past 27 years, whereas ROP prevalence and onset of disease are stable.

Published
2016
Full Text
View/download PDF

7. Endogenous aspergillus endophthalmitis

Author

Charles C. Barr, Harry W. Flynn, Timothy G. Murray, Jeffrey G. Gross, Walter C. McLean, John H. Killian, Janet L. Davis, Paul D. Weishaar, and Calvin E. Mein

Subjects
Pars plana, medicine.medical_specialty, Visual acuity, genetic structures, business.industry, medicine.medical_treatment, Eye disease, Retinal detachment, Vitrectomy, Eye infection, Aspergillosis, medicine.disease, eye diseases, Surgery, Ophthalmology, medicine.anatomical_structure, Amphotericin B, Medicine, sense organs, medicine.symptom, business, medicine.drug
Abstract

Objective: This study evaluated the clinical features and treatment outcomes in patients with endogenous Aspergillus endophthalmitis. Design: The study design was a multicenter retrospective chart review. Participants: Ten patients (12 eyes) with culture-proven endogenous Aspergillus endophthalmitis treated by 1 of the authors were studied. Intervention: Intravitreous amphotericin B injection, pars plana vitrectomy, systemic amphotericin B therapy, and oral anti-fungal therapy were performed. Main Outcome Measures: Elimination of endogenous Aspergillus endophthalmitis and Snellen visual acuity, best corrected, were measured. Results: All patients had a 1- to 3-day history of pain and marked loss of visual acuity in the involved eyes. Varying degrees of vitritis was present in all 12 eyes. In 8 of 12 eyes, a central macular chorioretinal inflammatory lesion was present. Four patients (six eyes) had associated pulmonary diseases and were receiving concurrent steroid therapy. One of these patients with chronic asthma also was abusing intravenous drugs. Overall, six patients (six eyes) had a history of intravenous drug abuse, whereas a seventh patient (one eye) was suspected of abusing intravenous drugs. Blood cultures and echocardiograms were negative for systemic aspergillosis. Management consisted of a pars plana vitrectomy in 10 of 12 eyes. Intravitreous amphotericin B was administered in 11 of 12 eyes. Systemic amphotericin B therapy was used in eight patients. One patient was treated with oral antifungal agents. In three eyes without central macular involvement, final visual acuities were 20/25 to 20/200. In eight eyes with initial central macular involvement, final visual acuities were 20/400 in three eyes and 5/200 or less in four eyes. Two painful eyes with marked inflammation, hypotony, and retinal detachment were enucleated. Conclusions: Endogenous Aspergillus endophthalmitis usually has an acute onset of intraocular inflammation and often has a characteristic chorioretinal lesion located in the macula. Although treatment with pars plana vitrectomy and intravitreous amphotericin B is capable of eliminating the ocular infection, the visual outcome generally is poor, especially when there is direct macular involvement.

Published
1998
Full Text
View/download PDF

8. The Endophthalmitis Vitrectomy Study

Author

Mark W. Johnson, Bernard H. Doft, Sheryl F. Kelsey, Michael Barza, Louis A. Wilson, Charles C. Barr, Stephen R. Wisniewski, Andrew K. Vine, Barbara A. Blodi, Susan G. Elner, Laurie M. Jessup, Sharad Khanderia, Carl L. Pierson, Julie Willis, Frances McIver, Sally Stanley, Scott R. Sneed, Antonio Capone, Thomas M. Aaberg, Jennifer I. Lim, Paul Sternberg, Diana S. Coffman, Cameile N. Moore, Susanne K. Gardner, Frederick S. Nolte, Ann Fremstad, Deborah Gibbs, James Gilman, Ray Swords, H.Edith Aguilar, Travis A. Meredith, Vinod Lakhanpal, Faith D. Christian, A. Hood, Richard S. Schwalbe, Emery E. Billings, William Buie, James J. Mallonee, Mary Ann Millar, Sharon Verbeek, Peter A. Campochiaro, Carol B. Palardy, Lois Reynolds, James D. Dick, Dennis Cain, Donald J. D'Amico, Albert R. Frederick, Michael G. Morley, Richard D. Pesavento, Carmen A. Puliafito, Trexler M. Topping, Susan M. Finn, Laura A. Raymond, Ann Sullivan Baker, Barbara Paton, Claudia Evans, Jeffrey Napoli, Christine Kierman, Kathryn Makris, Tom McInnes, Wini T. Reidy, Ruth White, Richard A. Garfinkel, A.Raymond Pilkerton, Robert A. Frantz, Gill B. Abernathy, Jay G. Barbaccia, H.Russell Ensey, Carol A. Ormes, Choong H. Park, Joel Caplan, Kathryn Russell, Robert Toma, Kirk H. Packo, Serge de Bustros, Timothy P. Flood, Louis Glazer, Maggie DeAlba, Evangeline Evanich, Michael A. Montwill, Jeri J. Rothman, Gail Ruderman, Melodie Beard, William Landau, Min H. Shen, Martha Gordon, Sharon Graff, Kathy Kwiatkowski, Loreen Pappas, Douglas Bryant, Don Doherty, Frank Morini, Linda Arredondo, Bruce R. Garretson, Carlos Gerena, Maureen Hunt, Sharon M. Kinnaird, Toni Neri, Thomas A. Rice, Michael A. Novak, Pamela S. Rowe, Scott Jamieson, Deborah Newberry, Glenn R. Rech, Michael J. Dul, Livia Kinser, Krystyna Strozewski, Susan Clark-Rath, Marty DeLisio, David L. Dempsey, Donna Kukula, Anne Pinter-Smith, Sheila Smith-Brewer, Tracey Ludwig, Robert B. Chambers, Frederick H. Davidorf, Cindy S. Taylor, Karen N. Hale, William J. Buesching, Chhanda Chaudhuri, Nanci J. Cover, Gail R. Shortlidge, Michael J. Keating, Scott J. Savage, Paula Andrzejewska, Susan Cometet, Jill D. Milliron, Rob Richmond, Lori Schneider, Debra Weisenberger, Herbert L. Cantrill, Robert C. Ramsay, Amy B. Brallier, Timothy P. Johnson, Edith E. Rossing, Kathleen A. Knauth, Martha M. Monahan, Neal W. Oestreich, Kenneth F. Clark, Anita M. Glennen, David L. Yarian, Stuart N. Green, Steven R. Leff, Leo Masciulli, Margaret M. Lucido, Edward J. Ludwig, Charlotte L. Marano, Linda Peters, Kim Joho, Doris C. Volkert, Finn Andersen, Donna Coffey, Alex Schlosser, Ann Honeywell, Robert N. Mames, William T. Driebe, George A. Stern, Amye Francis, Z.Suzanne Zam, Rhonda Cooper, Darla Gaskins, Diana J. Shamis, Melinda Willingham, Kay Barker, Harry Rosa, Scott M. Friedman, Thomas W. Gardner, George W. Blankenship, Carole J. Coyle, Christopher J. Bero, Cindy Halas, Suzanne Schick, Jean Walker, Denise Cunningham, H.Michael Lambert, Pamela S. Clogston, Pamela M. Frady, S.Neal Gardner, Michael S. Osato, Louise Carr, James Shigley, Pedro F. Lopez, Lawrence P. Chong, Donald A. Frambach, Lupe CisnerosMargaret^Padilla, Edmond Ming Yee, Tamako Nakamura, A.Frances Walonker, Ronald Morales, Tracy Nichols, Maria E. Huete, Peter E. Liggett, Richard R. Ober, Beth Quillen-Thomas, Mark Williams, Steven M. Bloom, Pamela J. Greene, Greg K. Whittington, Mark E. Martin, Glen Watson, Betty Jenkins-Curry, Leigh A. Gilkey, Steven Huelsman, Dennis P. Han, Thomas C. Burton, William F. Mieler, Jose S. Pulido, Frederick H. Reeser, Janet L. Newman, Kathy A. Werner, Paul J. Pisarzewicz, Nina A. Reinerio, Mary Lee K. Walloch, Zuzana Wilmer, Jan Laabs, Ruth Picchiottino, Jim Phillips, Walter Wipplinger, Gary W. Abrams, Dale T. Jurkiewicz, Margaret L. Leet, Paul Mandel, Kim Metzger, Lori Suchla, Denise Zarling, Mark W. Balles, Edwin H. Ryan, William H. Knobloch, Sally M. Cook, Darlette G. Luke, Patricia Ferrieri, Norynne M. Schiminsky, Anne Genia, David A. Philiph, Elizabeth K. Stinson, Linda M. Wright, William C. McMichael, Sandy J. Mielke, Lisa J. Ponwith, Peter Reed Pavan, Scott E. Pautler, Marion L. Coats, Nancy M. Kirk, Sharon M. Millard, Frank C. Castellano, Charlotte R. Edwards, Angela Marquardt, Amy J. McCormack, Michael T. McCormick, Bernard Renshaw, Angela Restuccia, Monica Campbell, Nell Christopher, L.Scott Garrett, Demetrios G. Halkias, Kim Hothersall, Karen Mickler, Thomas S. Minnick, Cheryl Burr, Wyatt Saxon, Miguel A. Arcacha, Steve Carlton, Sonya K. Edison, Marc J. Mallis, Tamre L. Sayers, Thomas W. Sudds, Robert J. Tiberia, Sherry Wolabaugh, Reagan H. Bradford, David W. Parke, Thomas C. Wolf, Janie M. Shofner, Lee E. Tobey, Harold G. Jensen, Dinah Sanchez, Janie Shofner, Russell Burris, Kellie K. Drake, Kay R. Grissom, J.James Rowsey, Charles P. Wilkinson, Gary C. Brown, William E. Benson, Jay L. Federman, Alfred C. Lucier, Joseph I. Maguire, Lov K. Sarin, Eric P. Shakin, Arunan Sivalingam, William Tasman, James F. Vander, Nancy Ward, Clement A. Weisbecker, Caroline L. Agnew, Richard Lambert, Terrance Torner, Kathy Carlson, Gerrie Franchine, Michelle S. Serfass, Robert L. Bergren, Louis A. Lobes, Karl R. Olsen, Jeffrey S. Rinkoff, Donna J. Metz, Margaret N. Leonard, Lisa M. Karenchak, Regis P. Kowalski, Lynn A. Wellman, Linda A. Wilcox, Alan F. Campbell, David R. Steinberg, Gary L. Vagstad, Kimberly A. Flook, Mary M. Good, Beverly J. Keenen, Kim A. Mellinger, Raymond R. Margherio, Morton S. Cox, Patrick L. Murphy, Michael T. Trese, Jane C. Werner, George A. Williams, Patricia E. Manatrey, Janet L. Prote, Richard Lucarotti, Susan Martin, Jeff Band, Grace Bostic, Kristi Gumming, Beth Mitchell, Virginia S. Regan, Craig Bridges, Sam Cox, Gary Houston, John Johnson, Pat Streasik, Betty Wood, Mark S. Blumenkranz, Lisa Cayo, Virginia Kaye, Carmen Luz Valenzuela, Ira K. Orgel, Lon S. Poliner, Paul E. Tornambe, Sarah V. Cannon, Janet L. Nielsen, Anne Carlson, Pauline Chan, Lynne Drake, Martha Grim, Corky Peterson, Lynn A. Borg, Joann Gillyatt, Conny Beyer, Mark E. Hammer, W.Sanderson Grizzard, Theresa L. Shannon, Janet R. Traynom, Melinda J. Collado, Dennis W. McManus, Daniel E. Sweeney, Donald H. Adams, Thomas T. Watson, Michael V. Antworth, Johanna Glacy Araos, Mark A. Greenwald, Mohsen Habib, Sandra K. Myers, Karen M. Ockers, Judy-Ann Thibodeau, Brett Watkins, Philip T. Nelsen, J.Gregory Rosenthal, Fay V. Mintz, Michael Biedenbach, Nicholas J. Leonardy, Sue M. Lawniczak, Chuck Bork, George Hageage, Evelyn B. Hunter, MarLynn J. Marshall, Patricia Roman, Rick Hill, Thomas Hofbauer, Jack Lemanowicz, Howard P. Cupples, Gladys I. Guzman, Richard J. Brodeur, Donald Yee, Edward C. Delaha, Stanley L. Geyer, Stacey Slovis, William J. Shields, Susan Lauber, Karl Michelitsch, Aaron Kassoff, Sharon Watling, JoAnne C. Buehler, Jeffrey McVay, Gale K. Podobinski, Robert L. Sillett, Shirley Groer, Brian Avery, Steven H. Belle, James Boles, Linda Henry, Sarah J. Shema, Linda Titus-Emstoff, Matthew Davis, Yvonne L. Magli, Larry Hubbard, Suzanne Thomas, Donald F. Everett, Richard Mowery, Donald Everett, Kathryn Davis, Stanley Azen, Preston Covey, Brooks McCuen, Andrew Packer, and Jeffrey Robin

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Eye disease, Vitrectomy, Intraocular lens, Eye infection, medicine.disease, Surgery, law.invention, Clinical trial, Ophthalmology, Endophthalmitis, Randomized controlled trial, law, medicine, Complication, business
Abstract

Purpose: The authors determine if specific features of the clinical presentation of acute postoperative endophthalmitis correlate with the microbiologic culture results. Methods: A total of 420 patients who had clinical evidence of endophthalmitis within 6 weeks after cataract surgery or secondary intraocular lens implantation were evaluated as part of a randomized clinical trial. Results of cultures performed on aqueous and vitreous specimens obtained at presentation were categorized as follows: gram-positive coagulase-negative micrococci, "other" gram-positive, gram-negative, and equivocal/no growth. Results: Eleven features of the initial clinical presentation were associated with significant differences in the microbiologic spectrum ( P Conclusions: The presenting characteristics of acute endophthalmitis after cataract surgery may be helpful in predicting the most likely culture results. Such predictions do not appear sufficiently strong to guide the initial empiric choice of intravitreal antibiotics.

Published
1997
Full Text
View/download PDF

9. Macular Pucker after Successful Surgery for Proliferative Vitreoretinopathy

Author

Alexander R. Irvine, Morton S. Cox, Kenneth R. Diddie, Stanley P. Azen, Mei Ying Lai, Hal M. Freeman, Kathryn L.P. Linton, and Charles C. Barr

Subjects
medicine.medical_specialty, Proliferative vitreoretinopathy, Visual acuity, genetic structures, business.industry, medicine.medical_treatment, Eye disease, Vitrectomy, medicine.disease, eye diseases, Surgery, Ophthalmology, medicine, sense organs, Tamponade, medicine.symptom, business, Complication, Vitreous base, Retinopathy
Abstract

Background: The prevalence of postoperative macular pucker and the factors associated with its development after successful surgery for proliferative vitreoretinopathy (PVR) using silicone oil or gas tamponade are unknown. Methods: The postoperative status of the macula was determined by reviewing the photographs of 336 eyes taken 6 months after randomization. Two hundred eleven eyes with attached maculas were identified and analyzed to determine the prevalence of macular pucker after silicone oil and gas tamponades in eyes without (group 1) and with (group 2) previous vitrectomy surgery. Data obtained at baseline, from the primary study surgery, and from subsequent examinations and repeat surgeries during a follow-up period of 6 months were analyzed for factors associated with postoperative macular pucker. Results: The 6-month-point prevalence rate of postoperative macular pucker was 15% (32 of 211 eyes). Ten of the 32 eyes were new cases of macular pucker. The authors were unable to document a difference in the 6-month-point prevalence of postoperative macular pucker between group 1 and group 2 eyes (13% versus 18%) or between eyes randomized to gas versus silicone oil (19% versus 12%). Postoperative pucker was three times as likely to develop in aphakic/pseudophakic eyes compared with phakic eyes ( P = 0.02). Focal contraction posteriorly causing starfolds, and intravitreal contraction involving the vitreous base or vitreous cavity, were significantly less prevalent in eyes with postoperative macular pucker ( P P = 0.04) were associated significantly with postoperative macular pucker ( P = 0.04). The authors were unable to document an association between postoperative macular pucker and the type of adhesive modality used or the extent of its application. Postoperative visual acuity was significantly better if the macula was not puckered ( P Conclusions: The occurrence of macular pucker after successful surgery for retinal detachments complicated by severe PVR is not influenced by the choice of intraocular tamponade. Certain preoperative factors may be associated with postoperative macular pucker.

Published
1995
Full Text
View/download PDF

10. Postoperative Intraocular Pressure Abnormalities in the Silicone Study

Author

Mei Ying Lai, Stanley P. Azen, Kathryn L.P. Linton, John S. Lean, Gary W. Abrams, Stephen J. Ryan, Charles C. Barr, and Michael T. Trese

Subjects
Intraocular pressure, Proliferative vitreoretinopathy, medicine.medical_specialty, genetic structures, business.industry, medicine.medical_treatment, Retinal detachment, Postoperative complication, Vitrectomy, medicine.disease, eye diseases, Surgery, Ophthalmology, chemistry.chemical_compound, Silicone, chemistry, medicine, sense organs, Tamponade, business, Retinopathy
Abstract

Background: Chronically abnormal intraocular pressure (IOP) may follow surgery for proliferative vitreoretinopathy (PVR), using either long-acting gas or silicone oil tamponade. Its prevalence and clinical significance are unclear. Methods: In the Silicone Study, 241 eyes with severe (≥_C-3) PVR were treated with vitrectomy, randomized to perfluoropropane gas (C 3 F 8 ) or silicone oil, and followed for 6 months or longer. Chronic IOP abnormalities, based on findings at two consecutive or any three postoperative visits, were defined as (1) low lOP (hypotony), 5 mmHg or less, or (2) elevated IOP, more than 25 mmHg. Results: Eleven (5%) eyes had chronically elevated IOP and 58 (24%) had chronic hypotony. Chronically elevated IOP was more prevalent in eyes randomized to silicone oil than in those randomized to C 3 F 8 gas (8% versus 2%; P 0.05). Chronic hypotony was (1) more prevalent in eyes randomized to C 3 F 8 gas than in those randomized to silicone oil (31% versus 18%; P 0.05); (2) more prevalent in eyes with anatomic failure (48% versus 16%; P 0.01); and (3) correlated with poor postoperative vision (P 0.0001), corneal opacity (P 0.001), and retinal detachment (P 0.001). Factors prognostic of chronic hypotony included preoperative hypotony (P 0.01), diffuse contraction of the retina anterior to the equator (P 0.01), rubeosis (P = 0.02), and large retinal breaks (P = 0.02). In a multivariate analysis, diffuse contraction of the retina anterior to the equator remained an independent factor prognostic of chronic hypotony (odds ratio=4.2), regardless of whether the retina was attached postoperatively. Conclusion: Intraocular pressure abnormalities are a common postoperative complication in eyes with PVR, and may occur with either C 3 F 8 gas or with silicone oil. The presence of diffuse contraction of the retina anterior to the equator should alert the vitrectomy surgeon that the eye is likely to be hypotonus postoperatively.

Published
1993
Full Text
View/download PDF

11. Visual Loss Complicating OKT3 Monoclonal Antibody Therapy

Author

Charles C. Barr and Omar Dukar

Subjects
Adult, Graft Rejection, Pathology, medicine.medical_specialty, Visual acuity, genetic structures, Fundus Oculi, Interstitial nephritis, Visual Acuity, chemical and pharmacologic phenomena, Blindness, Retina, Ophthalmoscopy, Atrophy, Electroretinography, Humans, Medicine, Fluorescein Angiography, Pigment Epithelium of Eye, Monoclonal antibody therapy, Retinal pigment epithelium, medicine.diagnostic_test, business.industry, medicine.disease, Kidney Transplantation, eye diseases, Transplantation, Ophthalmology, medicine.anatomical_structure, Female, sense organs, medicine.symptom, business, Muromonab-CD3
Abstract

OKT3 is a murine monoclonal antibody used for immunosuppression of solid-organ transplant rejection. We studied severe visual loss after administration of OKT3 in two patients who received renal transplants (one 25-year-old woman with interstitial nephritis and severe hypertension and one 27-year-old woman with diabetic nephropathy). Both patients lost visual acuity to the level of light perception after a second or third dose of OKT3. Ophthalmoscopy disclosed arteriolar constriction, but there was no evidence of optic atrophy. The electroretinogram was extinguished in one patient, indicating an effect on the outer retina or retinal pigment epithelium. Ophthalmologists should be aware that OKT3 may cause profound visual loss in patients who receive organ transplants.

Published
1993
Full Text
View/download PDF

12. Ophthalmic Aspects Of Orbital Injury

Author

M. Douglas Gossman, Charles C. Barr, and Dale M Roberts

Subjects
medicine.medical_specialty, genetic structures, business.industry, Ocular motility, eye diseases, Surgery, Optic nerve injury, Optic nerve, Medicine, sense organs, Approaches of management, business, Intensive care medicine
Abstract

This article provides information essential to early diagnosis and insight into vision-threatening ocular injuries that commonly accompany facial fractures. It also suggests management of these injuries as it relates to facial fracture repair. The primary focus is on pure ocular and optic nerve injuries. Minor attention is given to ocular motility disturbances and adnexal injuries.

Published
1992
Full Text
View/download PDF

13. Incidence and Early Course of Retlnonathy of Prematurity

Author

Earl A. Palmer, John T. Flynn, Robert J. Hardy, Dale L. Phelps, Cynthia L. Phillips, David B. Schaffer, Betty Tung, Frederick J. Elsas, Jan M. Botsford, Karen W. Braune, George Cassady, John A. Jones, James A. Kimble, Lanning Kline, Douglas Witherspoon, Malinda Young, Alan M. Roth, Byron H. Demorest, Roberta Erickson, William S. Gilbert, Georgia A. Chrousos, David S. Friendly, Mohammad Jaafar, Marshall P. Keys, Martin P. Kolsky, Patricia Ann Mercer, Donna O'Neill, John F. O'Neill, Edward S. Parelhoff, Ed Perraut, A. Raymond Pilkerton, David Plotsky, John Clarkson, Gabrielle Lopez, Marilyn T. Miller, Rama Bhat, Steven B. Cohen, Cathleen Cronin, Mark Daily, Donald A. Gagliano, Richard Gieser, Betty Anne Haldi, Kristine McCulloch, David Mittelman, Tonse N. Raju, David Sheftel, Kathleen Skuran, Daniel B. Sobel, Peggy Squires, Charles Vygantas, Forrest D. Ellis, Steve Archer, Eugene M. Helveston, Ken Julian, Gayle Reed, Richard Schreiner, Charles C. Barr, David N. Adamkin, Craig H. Douglas, Gregory K. Whittington, Shirley Wilkerson, Robert A. Gordon, Carolyn Bushaw, W. Michael DeVoe, James G. Diamond, William L. Gill, Donald R. May, Jane E. Reynolds, Thomas G. Storch, Serge de Bustros, Alethia Alford, Janet Graeber, Michael X. Repka, Michael T. Trese, John D. Baker, Ghaleb F. Hatem, Patricia Manatrey, Doreen Medalis, Robert C. Ramsay, C. Gail Summers, J. Douglas Cameron, Kim Chisholm, Rebecca Heikenen, Donna K. Irlbeck, Alvina M. Janda, Leslie A. Kopietz, Robin Kriedeman, Jane D. Lavoie, Molly Maxwell, Ted R. Pier, William P. Rodman, Patty Witt, Amy Woody, Paul Torrisi, Thaddeus Zak, Kathy Cohen, Rajesh J. Dave, Ernest Guillet, David Hakanson, Robert Hampton, Walter Merriam, Henry S. Metz, Ellen Pronobis, Richard Simon, Robert E. Vanderlinde, Nancy E. Wood, Donald N. Zehl, Edward Buckley, Malcolm M. Anderson, Grace Valentine, Susie Wong, Miles J. Burke, Judith C. Johnson, Gary L. Rogers, Don L. Bremer, Leandro Cordero, Rae R. Fellows, Nancy B. Hansen, Richard E. McClead, Arthur A. Aaby, Raul Banagale, Gerda I. Benda, Nancy D. Binder, William J. Brown, Joseph T. Gilhooly, Shawn Goodman, Robert K. Huston, Susan B. LaFrance, Patrick K. Lewallen, John V. McDonald, David L. Murphy, John W. Reynolds, Joseph Robertson, Andrea C. Tongue, Frank W. Bowen, Maria Delivoria-Papadopoulos, Hemant J. Desai, Gary R. Diamond, Joan M. Giannetta, Michael A. Naidoff, George J. Peckham, Jeanette R. Pleasure, Rachael Porat, Graham E. Quinn, Albert W. Biglan, David R. Brown, Bernard H. Doft, Andrew W. Eller, Louis A. Lobes, Richard A. Saunders, Linda M. Christmann, Tom L. Austin, Lesley Berkeley, James G. Ferguson, Wilson G. McWilliams, Karen W. Miller, Sharada Pai, V. Al Pakalnis, Dilip M. Purohit, Stephen S. Feman, Robert Cotton, James H. Elliott, Amy B. Law, Steven D. Steele, Rand Spencer, Priscilla M. Berry, Gary E. Fish, Dwain G. Fuller, William L. Hutton, Joel Lefer, Jean R. Manning, George E. Sanborn, William B. Snyder, David R. Stager, W.A.J. van Heuven, Marilyn B. Escobedo, Maria G. Montez, James W. Speights, Jane D. Kivlin, Susan Bracken, John Carver, Jack Dolcourt, Robert O. Hoffman, Michael Teske, and A. Thomas Williams

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, genetic structures, business.industry, medicine.medical_treatment, Birth weight, Incidence (epidemiology), Gestational age, Retinopathy of prematurity, Cryotherapy, medicine.disease, eye diseases, Ophthalmology, Postnatal age, Multicenter trial, Medicine, business, Retinopathy
Abstract

In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.

Published
1991
Full Text
View/download PDF

14. Outcomes of Eyes with Lesions Composed of >50% Blood in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT)

Author

Michael M. Altaweel, Ebenezer Daniel, Daniel F. Martin, Robert A. Mittra, Juan E. Grunwald, Michael M. Lai, Alexander Melamud, Lawrence S. Morse, Jiayan Huang, Frederick L. Ferris, Stuart L. Fine, Maureen G. Maguire, David F. Williams, Sara Beardsley, Steven Bennett, Herbert Cantrill, Carmen Chan- Tram, Holly Cheshier, Kathyrn Damato, John Davies, Sundeep Dev, Julianne Enloe, Gennaro Follano, Peggy Gilbert, Jill Johnson, Tori Jones, Lisa Mayleben, Robert Mittra, Martha Moos, Ryan Neist, Neal Oestreich, Polly Quiram, Robert Ramsay, Edwin Ryan, Stephanie Schindeldecker, John Snater, Trenise Steele, Dwight Selders, Jessica Tonsfeldt, Shelly Valardi, Gary Edd Fish, Hank A. Aguado, Sally Arceneaux, Jean Arnwine, Kim Bell, Tina Bell, Bob Boleman, Patricia Bradley, David Callanan, Lori Coors, Jodi Creighton, Timothy Crew, Kimberly Cummings, Christopher Dock, Karen Duignan, Dwain Fuller, Keith Gray, Betsy Hendrix, Nicholas Hesse, Diana Jaramillo, Bradley Jost, Sandy Lash, Laura Lonsdale, Michael Mackens, Karin Mutz, Michael Potts, Brenda Sanchez, William Snyder, Wayne Solley, Carrie Tarter, Robert Wang, Patrick Williams, Stephen L. Perkins, Nicholas Anderson, Ann Arnold, Paul Blais, Joseph Googe, Tina T. Higdon, Cecile Hunt, Mary Johnson, James Miller, Misty Moore, Charity K. Morris, Christopher Morris, Sarah Oelrich, Kristina Oliver, Vicky Seitz, Jerry Whetstone, Bernard H. Doft, Jay Bedel, Robert Bergren, Ann Borthwick, Paul Conrad, Amanda Fec, Christina Fulwylie, Willia Ingram, Shawnique Latham, Gina Lester, Judy Liu, Louis Lobes, Nicole M. Lucko, Holly Mechling, Lori Merlotti, Keith McBroom, Karl Olsen, Danielle Puskas, Pamela Rath, Maria Schmucker, Lynn Schueckler, Christina Schultz, Heather Shultz, David Steinberg, Avni Vyas, Kim Whale, Kimberly Yeckel, David H. Orth, Linda S. Arredondo, Susan Brown, Barbara J. Ciscato, Joseph M. Civantos, Celeste Figliulo, Sohail Hasan, Belinda Kosinski, Dan Muir, Kiersten Nelson, Kirk Packo, John S. Pollack, Kourous Rezaei, Gina Shelton, Shannya Townsend-Patrick, Marian Walsh, H. Richard McDonald, Nina Ansari, Amanda Bye, Arthur D. Fu, Sean Grout, Chad Indermill, Robert N. Johnson, J. Michael Jumper, Silvia Linares, Brandon J. Lujan, Ames Munden, Meredith Persons, Rosa Rodriguez, Jennifer M. Rose, Brandi Teske, Yesmin Urias, Stephen Young, Richard F. Dreyer, Howard Daniel, Michele Connaughton, Irvin Handelman, Stephen Hobbs, Christine Hoerner, Dawn Hudson, Marcia Kopfer, Michael Lee, Craig Lemley, Joe Logan, Colin Ma, Christophe Mallet, Amanda Milliron, Mark Peters, Harry Wohlsein, Joel A. Pearlman, Margo Andrews, Melissa Bartlett, Nanette Carlson, Emily Cox, Robert Equi, Marta Gonzalez, Sophia Griffin, Fran Hogue, Lance Kennedy, Lana Kryuchkov, Carmen Lopez, Danny Lopez, Bertha Luevano, Erin McKenna, Arun Patel, Brian Reed, Nyla Secor, Iris R. Sison, Tony Tsai, Nina Varghis, Brooke Waller, Robert Wendel, Reina Yebra, Daniel B. Roth, Jane Deinzer, Howard Fine, Flory Green, Stuart Green, Bruce Keyser, Steven Leff, Amy Leviton, Amy Martir, Kristin Mosenthine, Starr Muscle, Linda Okoren, Sandy Parker, Jonathan Prenner, Nancy Price, Deana Rogers, Linda Rosas, Alex Schlosser, Loretta Studenko, Thea Tantum, Harold Wheatley, Michael T. Trese, Thomas Aaberg, Denis Bezaire, Craig Bridges, Doug Bryant, Antonio Capone, Michelle Coleman, Christina Consolo, Cindy Cook, Candice DuLong, Bruce Garretson, Tracy Grooten, Julie Hammersley, Tarek Hassan, Heather Jessick, Nanette Jones, Crystal Kinsman, Jennifer Krumlauf, Sandy Lewis, Heather Locke, Alan Margherio, Debra Markus, Tanya Marsh, Serena Neal, Amy Noffke, Kean Oh, Clarence Pence, Lisa Preston, Paul Raphaelian, Virginia R. Regan, Peter Roberts, Alan Ruby, Ramin Sarrafizadeh, Marissa Scherf, Sarita Scott, Scott Sneed, Lisa Staples, Brad Terry, Matthew T. Trese, Joan Videtich, George Williams, Mary Zajechowski, Daniel P. Joseph, Kevin Blinder, Lynda Boyd, Sarah Buckley, Meaghan Crow, Amanda Dinatale, Nicholas Engelbrecht, Bridget Forke, Dana Gabel, Gilbert Grand, Jennifer Grillion-Cerone, Nancy Holekamp, Charlotte Kelly, Ginny Nobel, Kelly Pepple, Matt Raeber, P. Kumar Rao, Tammy Ressel, Steven Schremp, Merrilee Sgorlon, Shantia Shears, Matthew Thomas, Cathy Timma, Annette Vaughn, Carolyn Walters, Rhonda Weeks, Jarrod Wehmeier, Tim Wright, Daniel M. Berinstein, Aida Ayyad, Mohammed K. Barazi, Erica Bickhart, Tracey Brady, Lisa Byank, Alysia Cronise, Vanessa Denny, Courtney Dunn, Michael Flory, Robert Frantz, Richard A. Garfinkel, William Gilbert, Janine Newgen, Shamekia Newton, Debbie Oliver, Michael Osman, Reginald Sanders, Manfred von Fricken, Pravin Dugel, Sandra Arenas, Gabe Balea, Dayna Bartoli, John Bucci, Jennifer A. Cornelius, Scheleen Dickens, Don Doherty, Heather Dunlap, David Goldenberg, Karim Jamal, Norma Jimenez, Nicole Kavanagh, Derek Kunimoto, John Martin, Jessica Miner, Sarah Mobley, Donald Park, Edward Quinlan, Jack Sipperley, Carol Slagle, Danielle Smith, Miguelina Yafchak, Rohana Yager, Christina J. Flaxel, Steven Bailey, Peter Francis, Chris Howell, Thomas Hwang, Shirley Ira, Michael Klein, Andreas Lauer, Teresa Liesegang, Ann Lundquist, Sarah Nolte, Susan K. Nolte, Scott Pickell, Susan Pope, Joseph Rossi, Mitchell Schain, Peter Steinkamp, Maureen D. Toomey, Debora Vahrenwald, Kelly West, Baker Hubbard, Stacey Andelman, Chris Bergstrom, Judy Brower, Blaine Cribbs, Linda Curtis, Jannah Dobbs, Lindreth DuBois, Jessica Gaultney, Deborah Gibbs, Debora Jordan, Donna Leef, Robert Myles, Timothy Olsen, Bryan Schwent, Sunil Srivastava, Rhonda Waldron, Andrew N. Antoszyk, Uma Balasubramaniam, Danielle Brooks, Justin Brown, David Browning, Loraine Clark, Sarah Ennis, Susannah Held, Jennifer V. Helms, Jenna Herby, Angie Karow, Pearl Leotaud, Caterina Massimino, Donna McClain, Michael McOwen, Jennifer Mindel, Candace Pereira, Rachel Pierce, Michele Powers, Angela Price, Jason Rohrer, Jason Sanders, Robert L. Avery, Kelly Avery, Jessica Basefsky, Liz Beckner, Alessandro Castellarin, Stephen Couvillion, Jack Giust, Matthew Giust, Maan Nasir, Dante Pieramici, Melvin Rabena, Sarah Risard, Robert See, Jerry Smith, Lisha Wan, Sophie J. Bakri, Nakhleh Abu-Yaghi, Andrew Barkmeier, Karin Berg, Jean Burrington, Albert Edwards, Shannon Goddard, Shannon Howard, Raymond Iezzi, Denise Lewison, Thomas Link, Colin A. McCannel, Joan Overend, John Pach, Margaret Ruszczyk, Ryan Shultz, Cindy Stephan, Diane Vogen, Reagan H. Bradford, Vanessa Bergman, Russ Burris, Amanda Butt, Beth Daniels, Connie Dwiggins, Stephen Fransen, Tiffany Guerrero, Darin Haivala, Amy Harris, Sonny Icks, Ronald Kingsley, Lena Redden, Rob Richmond, Brittany Ross, Kammerin White, Misty Youngberg, Trexler M. Topping, Steve Bennett, Sandy Chong, Mary Ciotti, Tina Cleary, Emily Corey, Dennis Donovan, Albert Frederick, Lesley Freese, Margaret Graham, Natalya Gud, Taneika Howard, Mike Jones, Michael Morley, Katie Moses, Jen Stone, Robin Ty, Torsten Wiegand, Lindsey Williams, Beth Winder, Carl C. Awh, Michelle Amonette, Everton Arrindell, Dena Beck, Brandon Busbee, Amy Dilback, Sara Downs, Allison Guidry, Gary Gutow, Jackey Hardin, Sarah Hines, Emily Hutchins, Kim LaCivita, Ashley Lester, Larry Malott, MaryAnn McCain, Jayme Miracle, Kenneth Moffat, Lacy Palazzotta, Kelly Robinson, Peter Sonkin, Alecia Travis, Roy Trent Wallace, Kelly J. Winters, Julia Wray, April E. Harris, Mari Bunnell, Katrina Crooks, Rebecca Fitzgerald, Cameron Javid, Corin Kew, Erica Kill, Patricia Kline, Janet Kreienkamp, Maricruz Martinez, Roy Ann Moore, Egbert Saavedra, LuAnne Taylor, Mark Walsh, Larry Wilson, Thomas A. Ciulla, Ellen Coyle, Tonya Harrington, Charlotte Harris, Cindi Hood, Ingrid Kerr, Raj Maturi, Dawn Moore, Stephanie Morrow, Jennifer Savage, Bethany Sink, Tom Steele, Neelam Thukral, Janet Wilburn, Joseph P. Walker, Jennifer Banks, Debbie Ciampaglia, Danielle Dyshanowitz, Jennifer Frederick, A. Tom Ghuman, Richard Grodin, Cheryl Kiesel, Eileen Knips, Jonathan McCue, Maria Ortiz, Crystal Peters, Paul Raskauskas, Etienne Schoeman, Ashish Sharma, Glenn Wing, Rebecca Youngblood, Suresh R. Chandra, Michael Altaweel, Barbara Blodi, Kathryn Burke, Kristine A. Dietzman, Justin Gottlieb, Gene Knutson, Denise Krolnik, T. Michael Nork, Shelly Olson, John Peterson, Sandra Reed, Barbara Soderling, Guy Somers, Thomas Stevens, Angela Wealti, Srilaxmi Bearelly, Brenda Branchaud, Joyce W. Bryant, Sara Crowell, Sharon Fekrat, Merritt Gammage, Cheala Harrison, Sarah Jones, Noreen McClain, Brooks McCuen, Prithvi Mruthyunjaya, Jeanne Queen, Neeru Sarin, Cindy Skalak, Marriner Skelly, Ivan Suner, Ronnie Tomany, Lauren Welch, Susanna S. Park, Allison Cassidy, Karishma Chandra, Idalew Good, Katrina Imson, Sashi Kaur, Helen Metzler, Lawrence Morse, Ellen Redenbo, Marisa Salvador, David Telander, Mark Thomas, Cindy Wallace, Charles C. Barr, Amanda Battcher, Michelle Bottorff, Mary Chasteen, Kelly Clark, Diane Denning, Debra Schoen, Amy Schultz, Evie Tempel, Lisa Wheeler, Greg K. Whittington, Thomas W. Stone, Todd Blevins, Michelle Buck, Lynn Cruz, Wanda Heath, Diana Holcomb, Rick Isernhagen, Terri Kidd, John Kitchens, Cathy Sears, Ed Slade, Jeanne Van Arsdall, Brenda VanHoose, Jenny Wolfe, William Wood, John Zilis, Carol Crooks, Larry Disney, Mimi Liu, Stephen Petty, Sandra Sall, James C. Folk, Tracy Aly, Abby Brotherton, Douglas Critser, Connie J. Hinz, Stefani Karakas, Valerie Kirschner, Cheyanne Lester, Cindy Montague, Stephen Russell, Heather Stockman, Barbara Taylor, Randy Verdick, Jean Walshire, John T. Thompson, Barbara Connell, Maryanth Constantine, John L. Davis, Gwen Holsapple, Lisa Hunter, C. Nicki Lenane, Robin Mitchell, Leslie Russel, Raymond Sjaarda, David M. Brown, Matthew Benz, Llewellyn Burns, JoLene G. Carranza, Richard Fish, Debra Goates, Shayla Hay, Theresa Jeffers, Eric Kegley, Dallas Kubecka, Stacy McGilvra, Beau Richter, Veronica Sneed, Cary Stoever, Isabell Tellez, Tien Wong, Ivana Kim, Christopher Andreoli, Leslie Barresi, Sarah Brett, Charlene Callahan, Karen Capaccioli, William Carli, Matthew Coppola, Nicholas Emmanuel, Claudia Evans, Anna Fagan, Marcia Grillo, John Head, Troy Kieser, Elaine Lee, Ursula Lord, Edward Miretsky, Kate Palitsch, Todd Petrin, Liz Reader, Svetlana Reznichenko, Mary Robertson, Justin Smith, Demetrios Vavvas, John Wells, Cassie Cahill, W. Lloyd Clark, Kayla Henry, David Johnson, Peggy Miller, LaDetrick Oliver, Robbin Spivey, Tiffany Swinford, Mallie Taylor, Michael Lambert, Kris Chase, Debbie Fredrickson, Joseph Khawly, Valerie Lazarte, Donald Lowd, Pam Miller, Arthur Willis, Philip J. Ferrone, Miguel Almonte, Rachel Arnott, Ingrid Aviles, Sheri Carbon, Michael Chitjian, Kristen D’Amore, Christin Elliott, David Fastenberg, Barry Golub, Kenneth Graham, AnnMarie Lavorna, Laura Murphy, Amanda Palomo, Christina Puglisi, David Rhee, Juan Romero, Brett Rosenblatt, Glenda Salcedo, Marianne Schlameuss, Eric Shakin, Vasanti Sookhai, Richard Kaiser, Elizabeth Affel, Gary Brown, Christina Centinaro, Deborah Fine, Mitchell Fineman, Michele Formoso, Sunir Garg, Lisa Grande, Carolyn Herbert, Allen Ho, Jason Hsu, Maryann Jay, Lisa Lavetsky, Elaine Liebenbaum, Joseph Maguire, Julia Monsonego, Lucia O’Connor, Lisa Pierce, Carl Regillo, Maria Rosario, Marc Spirn, James Vander, Jennifer Walsh, Frederick H. Davidorf, Amanda Barnett, Susie Chang, John Christoforidis, Joy Elliott, Heather Justice, Alan Letson, Kathryne McKinney, Jeri Perry, Jill A. Salerno, Scott Savage, Stephen Shelley, Lawrence J. Singerman, Joseph Coney, John DuBois, Kimberly DuBois, Gregg Greanoff, Dianne Himmelman, Mary Ilc, Elizabeth McNamara, Michael Novak, Scott Pendergast, Susan Rath, Sheila Smith-Brewer, Vivian Tanner, Diane E. Weiss, Hernando Zegarra, null Lawrence Halperin, Patricia Aramayo, Mandeep Dhalla, Brian Fernandez, Cindy Fernandez, Jaclyn Lopez, Monica Lopez, Jamie Mariano, Kellie Murphy, Clifford Sherley, Rita Veksler, Firas Rahhal, Razmig Babikian, David Boyer, Sepideh Hami, Jeff Kessinger, Janet Kurokouchi, Saba Mukarram, Sarah Pachman, Eric Protacio, Julio Sierra, Homayoun Tabandeh, Adam Zamboni, Michael Elman, Jennifer Belz, Tammy Butcher, Theresa Cain, Teresa Coffey, Dena Firestone, Nancy Gore, Pamela Singletary, Peter Sotirakos, JoAnn Starr, Travis A. Meredith, Cassandra J. Barnhart, Debra Cantrell, RonaLyn Esquejo-Leon, Odette Houghton, Harpreet Kaur, Fatoumatta N’Dure, Ronald Glatzer, Leonard Joffe, Reid Schindler, Marilyn Katz, Mary Brightwell-Arnold, Ruchira Glaser, Judith Hall, Sandra Harkins, Alexander Khvatov, Kathy McWilliams, Ellen Peskin, Maxwell Pistilli, Susan Ryan, Allison Schnader, Gui-Shuang Ying, Glenn Jaffe, Jennifer Afrani-Sakyi, Brannon Balsley, Linda S. Bennett, Adam Brooks, Adrienne Brower-Lingsch, Lori Bruce, Russell Burns, Dee Busian, John Choong, Lindsey Cloaninger, Francis Char DeCroos, Emily DuBois, Mays El-Dairi, Sarah Gach, Katelyn Hall, Terry Hawks, ChengChenh Huang, Cindy Heydary, Alexander Ho, Shashi Kini, Michelle McCall, Daaimah Muhammad, Jayne Nicholson, Pamela Rieves, Kelly Shields, Adam Specker, Sandra Stinnett, Sujatha Subramaniam, Patrick Tenbrink, Cynthia Toth, Aaron Towe, Kimberly Welch, Natasha Williams, Katrina Winter, Ellen Young, Judith Alexander, Elisabeth Flannagan, E. Revell Martin, Candace Parker, Krista Sepielli, Tom Shannon, Claressa Whearry, Maryann Redford, Marcia R. Kopfer, Joan DuPont, Lawrence M. Friedman, Susan B. Bressler, David L. DeMets, Martin Friedlander, Mark W. Johnson, Anne Lindblad, Douglas W. Losordo, and Franklin G. Miller

Subjects
Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Visual acuity, genetic structures, Visual Acuity, Angiogenesis Inhibitors, Fundus (eye), Antibodies, Monoclonal, Humanized, Article, Cohort Studies, Lesion, Pro re nata, Ranibizumab, Ophthalmology, medicine, Humans, Prospective Studies, Fluorescein Angiography, Prospective cohort study, Aged, Aged, 80 and over, business.industry, Retinal Hemorrhage, Macular degeneration, medicine.disease, Choroidal Neovascularization, eye diseases, Bevacizumab, Treatment Outcome, Choroidal neovascularization, Intravitreal Injections, Wet Macular Degeneration, Female, sense organs, medicine.symptom, business, Tomography, Optical Coherence, Follow-Up Studies, medicine.drug
Abstract

To compare baseline characteristics, treatment frequency, visual acuity (VA), and morphologic outcomes of eyes with50% of the lesion composed of blood (B50 group) versus all other eyes (Other group) enrolled in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).Prospective cohort study within a multicenter randomized clinical trial.CATT patients with neovascular age-related macular degeneration (AMD).Treatment for the study eye was assigned randomly to either ranibizumab or bevacizumab and to 3 different dosing regimens over a 2-year period. Reading center graders evaluated baseline and follow-up morphology in color fundus photographs, fluorescein angiography (FA), and optical coherence tomography (OCT). Masked examiners tested VA.Morphologic features and VA at 1 and 2 years.The B50 group consisted of 84 of 1185 (7.1%) patients enrolled in CATT. Baseline lesion characteristics differed between groups. In the B50 group, choroidal neovascularization size was smaller (0.73 vs 1.83 disc areas [DA]; P0.001), total lesion size was greater (4.55 vs 2.31 DA; P0.001), total retinal thickness was greater (524 vs 455 μm; P = 0.02), and mean VA was worse (56.0 vs 60.9 letters; P = 0.002). Increases in mean VA were similar in the B50 and Other groups at 1 year (+9.3 vs +7.2 letters; P = 0.22) and at 2 years (9.0 vs 6.1 letters; P = 0.17). Eyes treated PRN received a similar number of injections in the 2 groups (12.2 vs 13.4; P = 0.27). Mean lesion size in the B50 group decreased by 1.2 DA at both 1 and 2 years (primarily owing to resolution of hemorrhage) and increased in the Other group by 0.33 DA at 1 year and 0.91 DA at 2 years (P 0.001). Leakage on FA and fluid on OCT were similar between groups at 1 and 2 years.In CATT, the B50 group had a visual prognosis similar to the Other group. Lesion size decreased markedly through 2 years. Eyes like those enrolled in CATT with neovascular AMD lesions composed of50% blood can be managed similarly to those with less or no blood.

Published
2015
Full Text
View/download PDF

17. Authors' reply

Author

Graham E. Quinn, Velma Dobson, Charles C. Barr, Barry R. Davis, Earl A. Palmer, Joseph Robertson, C. Gail Summers, Michael T. Trese, and Betty Tung

Subjects
Ophthalmology
Published
1996
Full Text
View/download PDF

18. On the value of human resources

Author

Charles C. Barr, Manfred Kochen, and Yufei Yuan

Subjects
Value (ethics), Structure (mathematical logic), Knowledge management, Opportunity cost, business.industry, Net worth, Information technology, Environmental economics, Strategic human resource planning, Management of Technology and Innovation, Human resource management, Economics, Business and International Management, Human resources, business, Applied Psychology
Abstract

One challenge for planners is to discover conditions under which a society has a positive and growing “net worth” in terms of its human resources and to bring about and maintain those conditions. We discuss the utility and validity of the concept of people as “assets” or “liabilities”, the structure and cultural contexts for a proposed model of the dynamics of value that account for opportunity costs; and links between information technologies and human resources management, including planned development of these resources.

Published
1986
Full Text
View/download PDF

19. Estimation of the Maximum Number of Argon Laser Burns Possible in Panretinal Photocoagulation

Author

Charles C. Barr

Subjects
medicine.medical_specialty, Contact Lenses, chemistry.chemical_element, Panretinal photocoagulation, Models, Biological, Retina, law.invention, Optics, Retinal Diseases, Laser therapy, law, Ophthalmology, medicine, Humans, Argon, Mean diameter, business.industry, Lasers, Peripheral retina, Laser, Contact lens, chemistry, Laser Therapy, business, Mathematics
Abstract

I measured the area of the retina in ten autopsy eyes and the area of 500 mu argon laser burns placed with both Goldmann and Rodenstock contact lenses in two eyes that were subsequently enucleated. The mean area of the retina available for panretinal photocoagulation is 1,050 mm2. The mean diameter of 500 mu argon laser burns is 490 mu when placed with a Goldmann contact lens and 810 mu when placed with a Rodenstock contact lens. The maximum number of 500 mu burns that can be used to treat the entire extramacular retina in the normal sized eye is approximately 5,500 when a Goldmann contact lens is used, and approximately 2,050 when a Rodenstock contact lens is used.

Published
1984
Full Text
View/download PDF

20. Unexplained heterochromia. Intraocular foreign body demonstrated by computed tomography

Author

Andrew K. Vine, Csaba L. Martonyi, and Charles C. Barr

Subjects
Adult, Male, Intraocular foreign body, medicine.medical_specialty, Eye Color, medicine.diagnostic_test, business.industry, Radiography, Eye disease, Computed tomography, medicine.disease, eye diseases, Ophthalmology, Heterochromia iridis, Eye Foreign Bodies, Iris Diseases, Axial tomography, medicine, Humans, sense organs, Siderosis, Foreign body, Tomography, X-Ray Computed, business
Abstract

Standard radiographic techniques are often inadequate in demonstrating the presence and location of intraocular foreign bodies. Computerized axial tomography was used to confirm the presence of a metallic foreign body in a patient with heterochromia iridis and suspected ocular siderosis in whom no foreign material was found by conventional examination methods.

Published
1984
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results