103 results on '"Cassiano Francisco Weege NONAKA"'
Search Results
2. Assessment of the presence of interleukin 17+ macrophages and Th17 cells in situ in lip and oral tongue cancer
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Thâmara Manoela Marinho Bezerra, Bárbara Vanessa de Brito Monteiro, Cassiano Francisco Weege Nonaka, Joabe dos Santos Pereira, Márcia Cristina da Costa Miguel, Luiz Arthur Barbosa Da Silva, and Éricka Janine Dantas da Silveira
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Tumor microenvironment ,business.industry ,Immunology ,Interleukin ,Cancer ,General Medicine ,medicine.disease ,Pathogenesis ,stomatognathic diseases ,medicine.anatomical_structure ,Tumor progression ,Tongue ,Cancer research ,medicine ,Immunology and Allergy ,Immunohistochemistry ,Interleukin 17 ,business - Abstract
Increasing clinical evidence indicates that Th17 cells may promote or inhibit tumor progression, however the exact role of these cells in Oral Squamous Cell Carcinoma (OSCCs) pathogenesis and progression remains unclear. Tumor associated macrophages are highly plastic phenotype cells which can differentiate as M1 or M2. The mechanism and cellular phenotype of IL-17 expressing macrophages are unknown. 40 cases of lip and 28 of tongue SCCs were submitted to immunohistochemical analysis, and histologically graded. In tongue cases TNM was analyzed. The number of IL-17+ T cells was higher in lip SCC (p = 0.028). IL-17+ macrophages was greater in tongue SCC (p = 0.014). There were more IL-17+ macrophages in the high-grade malignancy oral tongue SCCs (p = 0.016), yet there was no significant difference in the numbers of RORγt+ lymphocytes by histopathological or TNM analysis. This study provides evidence concerning IL-17’s pleiotropic roles, being possibly dependent on its cellular sources in the tumor microenvironment.
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- 2021
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3. IMMUNOEXPRESSION OF GALECTINS-1, -3, AND -7 IN AMELOBLASTOMAS AND ADENOMATOID ODONTOGENIC TUMORS
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Pâmela De Medeiros Dantas, Walter Gleybson Antas De Morais, Luan Éverton Galdino Barnabé, Éricka Janine Dantas Da Silveira, Ricardo Alves De Mesquita, Cassiano Francisco Weege Nonaka, and Pollianna Muniz Alves
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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4. IMMUNOHISTOCHEMICAL ANALYSIS OF AUTOPHAGY-RELATED PROTEINS IN PLEOMORPHIC ADENOMAS AND ADENOID CYSTIC CARCINOMAS OF SALI
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Amanda Lira Rufino De Lucena, Emanuene Galdino Pires, Denize Núbia Souza, Roberta Barroso Cavalcante, Ricardo Alves Mesquita, Polliana Muniz Alves, and Cassiano Francisco Weege Nonaka
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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5. Myoepithelial carcinoma with rhabdoid features in the maxillary sinus: Immunohistochemical and in situ hybridization analysis of a rare case
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Heitor Albergoni Da Silveira, Cassiano Francisco Weege Nonaka, Luciana Yamamoto Almeida, Alfredo Ribeiro-Silva, Pollianna Muniz Alves, and Jorge Esquiche León
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Cancer Research ,Pathology ,medicine.medical_specialty ,IMUNOHISTOQUÍMICA ,Maxillary sinus ,business.industry ,Myoepithelial Carcinoma ,Myoepithelial cell ,In situ hybridization ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,stomatognathic system ,Oncology ,030220 oncology & carcinogenesis ,Major Salivary Gland ,Rare case ,Immunohistochemistry ,Medicine ,Oral Surgery ,SMARCB1 ,030223 otorhinolaryngology ,business - Abstract
Myoepithelial carcinomas of the head and neck are often located in the major salivary glands, notably in the parotid glands, being less frequent in the minor salivary glands. Noteworthy, myoepithelial carcinoma in the maxillary sinus is extremely rare. In fact, only five cases have been previously published to date. Here, we present, for the first time, a detailed immunohistochemical and in situ hybridization analysis of a SMARCB1 (INI-1)-intact myoepithelial carcinoma with rhabdoid features, expanding the histopathological spectrum of high-grade sinonasal carcinomas.
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- 2019
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6. IMMUNOHISTOCHEMICAL ANALYSIS OF C-X-C CHEMOKINE RECEPTOR TYPE 4 IN ODONTOGENIC KERATOCYSTS AND DENTIGEROUS CYSTS
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Allany De Oliveira Andrade, Christany Rodrigues Ferreira, Ana Luzia Araújo Batista, Ricardo Alves De Mesquita, Manuel Antonio Gordón-Núñez, Pollianna Muniz Alves, and Cassiano Francisco Weege Nonaka
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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7. IMMUNOHISTOCHEMICAL ANALYSIS OF AUTOPHAGY-RELATED PROTEINS IN ODONTOGENIC KERATOCYSTS AND DENTIGEROUS CYSTS
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Christany Rodrigues Ferreira, Allany De Oliveira Andrade, Fabianna Da Conceição Dantas De Medeiros, Bárbara Vanessa De Brito Monteiro, Ricardo Alves Mesquita, Pollianna Muniz Alves, and Cassiano Francisco Weege Nonaka
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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8. ORAL LICHEN PLANUS AND ORAL LICHENOID REACTION: A MORPHOLOGICAL STUDY
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Luan Éverton Galdino Barnabé, Walter Gleybson Antas De Morais, Pâmela De Medeiros Dantas, Ricardo Alves De Mesquita, Manuel Antônio Gordón-Núñez, Cassiano Francisco Weege Nonaka, and Pollianna Muniz Alves
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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9. PERIPHERAL DENTINOGENIC GHOST CELL TUMOR: CASE REPORT
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Christany Rodrigues Ferreira, Marjhory Fernandes De Moura, Hélder Domiciano Dantas Martins, Tácio Candeia Lyra, José Wilson Noleto Ramos, Pollianna Muniz Alves, and Cassiano Francisco Weege Nonaka
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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10. TREATMENT OF ORAL LEUKOPLASIA WITH HIGH-POWER DIODE LASER: CASE REPORT
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Anna Beatriz Barbosa Falcão, Gustavo Araújo De Freitas, Diego Filipe Bezerra Silva, Cassiano Francisco Weege Nonaka, Tiago João Da Silva Filho, Sérgio Henrique Gonçalves De Carvalho, and Daliana Queiroga De Castro Gomes
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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11. PERIPHERAL GIANT CELL LESION ASSOCIATED WITH PERIPHERAL OSSIFYING FIBROMA: A RARE CASE REPORT
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Allany De Oliveira Andrade, Vanessa Alves De Medeiros, Helen Kaysa Cabral Caitano, Thalles Moreira Suassuna, Manuel Antonio Gordón-Nuñez, Pollianna Muniz Alves, and Cassiano Francisco Weege Nonaka
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2022
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12. Intraosseous rhabdomyosarcoma of the maxilla with TFCP2 fusion: A rare aggressive subtype with predilection for the gnathic bones
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John Lennon Silva Cunha, Israel Leal Cavalcante, Caio César da Silva Barros, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka, Assis Filipe Medeiros Albuquerque, Oslei Paes de Almeida, Bruno Augusto Benevenuto de Andrade, and Roberta Barroso Cavalcante
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Cancer Research ,Oncology ,Oral Surgery - Published
- 2022
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13. Participation of hypoxia-inducible factor-1α and lymphangiogenesis in metastatic and non-metastatic lower lip squamous cell carcinoma
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Cassiano Francisco Weege Nonaka, Ana Rafaela Luz de Aquino Martins, Leão Pereira Pinto, Rodrigo Porpino Mafra, Lélia Batista de Souza, and Hellen Bandeira de Pontes Santos
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Lower lip ,Lip Neoplasm ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Lymphangiogenesis ,Stage (cooking) ,Survival analysis ,business.industry ,Hypoxia-Inducible Factor 1, alpha Subunit ,Survival Analysis ,Lip ,030104 developmental biology ,Lymphatic system ,Otorhinolaryngology ,Hypoxia-inducible factors ,030220 oncology & carcinogenesis ,Lip Neoplasms ,Carcinoma, Squamous Cell ,Immunohistochemistry ,Surgery ,Oral Surgery ,business - Abstract
This study evaluated the lymphatic density and HIF-1α immunoexpression in lower lip squamous cell carcinoma (LLSCC) and their correlation with clinicopathological (nodal metastasis, clinical stage, histological grade, recurrence and disease outcome) and survival parameters in 20 metastatic and 20 non-metastatic LLSCCs. Lymphatic density was established by counting microvessels (D2-40+) at the tumor core (intratumoral lymphatic density, ILD) and at the invasive front (peritumoral lymphatic density, PLD) and percentages of immunopositive cells for HIF-1α were established. No statistically significant differences in lymphatic densities in relation to clinicopathological parameters were observed (P > 0.05). All cases exhibited nuclear and cytoplasmic HIF-1α immunoexpression, with relatively high percentages of positivity, but this expression was not statistically different in relation to clinicopathological variables (P > 0.05). Positive correlations were observed between ILD and PLD (P = 0.002), and between nuclear HIF-1α immunoexpression at the tumor core and ILD (P = 0.001). The results suggest ILD and PLD are not directly related to the development of lymph node metastasis in LLSCC. The striking expression of HIF-1α suggests the involvement of this protein in the etiopathogenesis of LLSCCs, possibly stimulating lymphangiogenesis at the tumor core. However, this protein does not seem to exert a determining influence on the biological aggressiveness of these tumors.
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- 2018
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14. JUVENILE OSSIFYING FIBROMA IN THE MANDIBLE: 2 CASE REPORTS
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LUAN ÉVERTON GALDINO BARNABÉ, LEONARDO COSTA DE ALMEIDA PAIVA, ANÍBAL HENRIQUE BARBOSA LUNA, DAVI FELIPE NEVES COSTA, DANIELA PITA DE MELO, CASSIANO FRANCISCO WEEGE NONAKA, and POLLIANNA MUNIZ ALVES
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Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2020
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15. ORAL LYMPHOEPITHELIAL CYST IN FLOOR OF MOUTH: A CASE REPORT
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Cassiano Francisco Weege Nonaka, Raelly Katharinne Lima De Meneses, Jozinete Vieira Pereira, Camila Guimarães De Sousa, Pollianna Muniz Alves, Tiago João Da Silva Filho, and Daliana Queiroga de Castro Gomes
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Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Lumen (anatomy) ,Soft tissue ,Connective tissue ,Ranula ,medicine.disease ,Epithelium ,Pathology and Forensic Medicine ,medicine.anatomical_structure ,Tongue ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Oral mucosa ,business - Abstract
Oral lymphoepithelial cyst (OLC) is a rare developmental cyst of soft tissue. Clinically, OLC exhibits as a small and asymptomatic mass, with color ranging from rose to yellowish. OLC develops manly in floor of mouth and lateral and ventral surfaces of tongue. Based on this, we aimed to report a case of OLC in a young patient. A 17-year-old male patient presented a painless nodular aspect located in floor of mouth with a history of evolution of 2 months. Clinical hypothesis was ranula. Excisional biopsy was performed, and histopathologic analysis revealed a cystic cavity lined by keratinized stratified epithelium; cystic lumen showed desquamated epithelial cells. Cystic capsule was composed of connective tissue exhibiting numerous lymphocytes, sometimes arranged in germinal centers. Superficially, epithelium of oral mucosa was observed. Based on pathologic findings, final diagnosis was OLC. After 12 months of follow-up, no sign of recurrence was observed.
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- 2020
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16. SQUAMOUS ODONTOGENIC TUMOR-LIKE PROLIFERATIONS IN RADICULAR CYST: CASE REPORT
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Pollianna Muniz Alves, Vanessa Alves de Medeiros, Allany de Oliveira Andrade, Cassiano Francisco Weege Nonaka, Daniella Lucena Morais, Thiago Lima Maia, and Denize Núbia Souza
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Pathology ,medicine.medical_specialty ,Radicular Cyst ,medicine.diagnostic_test ,business.industry ,Stratified squamous epithelium ,Hyperplasia ,medicine.disease ,Epithelium ,Pathology and Forensic Medicine ,stomatognathic diseases ,medicine.anatomical_structure ,Squamous odontogenic tumor ,Maxilla ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,Spongiosis - Abstract
Squamous odontogenic tumor-like proliferations (SOT-LPs) are an uncommon histopathological finding occurring in the fibrous capsule of odontogenic cysts, which share certain microscopic features with squamous odontogenic tumor (SOT). A 36-year-old woman presented with an 18-month history of a painless, slow-growing swelling in the maxilla. Her medical history was unremarkable. Computed tomography revealed a well-defined, unilocular hypodense lesion extending from nonvital tooth #21 to tooth #11, with expansion and rupture of vestibular cortical bone, measuring approximately 1.5 cm. Under the diagnostic hypothesis of radicular cyst, an excisional biopsy was performed. Histopathological analysis disclosed a cystic cavity lined by nonkeratinized stratified squamous epithelium exhibiting hyperplasia, exocytosis, and spongiosis. The fibrous capsule revealed conspicuous islands of well-differentiated squamous epithelium, some of them exhibiting foci of microcystic degeneration. The final diagnosis was radicular cyst with SOT-LPs. The patient remains under close follow-up.
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- 2020
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17. Pleomorphic adenoma and adenoid cystic carcinoma of salivary glands: E-cadherin immunoexpression and analysis of the CDH1 -160C/A polymorphism
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Silvia Helena Barem Rabenhorst, Márcia Cristina da Costa Miguel, Cassiano Francisco Weege Nonaka, Lélia Batista de Souza, Leão Pereira Pinto, and Roberta Barroso Cavalcante
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Genotype ,Adenoid cystic carcinoma ,Adenoma, Pleomorphic ,Biology ,Adenoid ,Polymerase Chain Reaction ,CDH1 ,Immunoenzyme Techniques ,Pleomorphic adenoma ,03 medical and health sciences ,0302 clinical medicine ,Antigens, CD ,medicine ,Humans ,General Dentistry ,Cellular localization ,Polymorphism, Genetic ,Cadherin ,Myoepithelial cell ,Cell Biology ,General Medicine ,Cadherins ,Salivary Gland Neoplasms ,medicine.disease ,Carcinoma, Adenoid Cystic ,030104 developmental biology ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,biology.protein ,Electrophoresis, Polyacrylamide Gel ,Polymorphism, Restriction Fragment Length - Abstract
Objective Despite their similar cellular origin, pleomorphic adenomas (PA) and adenoid cystic carcinomas (ACC) present distinct behaviors. This study aimed to analyze the immunoexpression of E-cadherin in PA and ACC of salivary glands, and to investigate differences in its expression in relation to E-cadherin gene ( CDH1 ) -160C/A polymorphism. Design Twenty-four PA (15 cell-rich and 9 cell-poor tumors) and 24 ACC (10 tubular, 8 cribriform and 6 solid tumors) were selected for the analysis of pattern of distribution, and cellular localization of E-cadherin. In addition, E-cadherin expression was evaluated using the H-score scoring system. The CDH1 -160C/A polymorphism was investigated by PCR-RFLP. Results No significant differences in pattern of distribution ( p = 0.181) and cellular localization ( p = 0.192) of E-cadherin were observed between PA and ACC. Comparison of PA and ACC cases revealed a higher median H-score in the latter ( p = 0.036). Cell-rich PA presented a higher H-score than cell-poor tumors ( p = 0.013), whereas no significant differences in E-cadherin expression were observed between ACC subtypes ( p = 0.254). The heterozygous genotype of the CDH1 -160C/A polymorphism was detected in only one PA and one ACC. H-scores for tumors carrying the polymorphism were below the lower quartile of their respective groups. Conclusions The results suggest that E-cadherin expression in PA and ACC is mainly related to cellular composition (epithelial cells versus myoepithelial cells) and degree of differentiation of myoepithelial cells in these tumors. The CDH1 -160C/A polymorphism does not seem to significantly influence the expression of E-cadherin in PA and ACC of salivary glands.
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- 2017
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18. Immunoexpression of VEGFR-3, but not the immunoexpression of VEGF-C or lymphatic density, is correlated with metastasis in lower lip squamous cell carcinoma
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L. De Souza, Cassiano-Francisco-Weege Nonaka, A.R.L. de Aquino, Clarissa Favero Demeda, C.H.P. de Carvalho, and Leão Pereira Pinto
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Vascular Endothelial Growth Factor C ,Lower lip ,Metastasis ,Immunoenzyme Techniques ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Neoplasm Staging ,Membrane Glycoproteins ,biology ,business.industry ,Vascular Endothelial Growth Factor Receptor-3 ,medicine.disease ,Staining ,Lymphangiogenesis ,030104 developmental biology ,Lymphatic system ,Otorhinolaryngology ,Vascular endothelial growth factor C ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Lip Neoplasms ,Carcinoma, Squamous Cell ,biology.protein ,Immunohistochemistry ,Female ,Surgery ,Neoplasm Recurrence, Local ,Oral Surgery ,Antibody ,business - Abstract
The purpose of this study was to evaluate the immunoexpression of vascular endothelial growth factor C (VEGF-C) and VEGF receptor 3 (VEGFR-3) and their correlation with intratumoural lymphatic density (ILD) and peritumoural lymphatic density (PLD) in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Twenty-five LLSCC with regional nodal metastasis and 25 LLSCC without metastasis were selected. The percentages of VEGF-C and VEGFR-3 staining in each tumour core and at the deep invasive front were assessed. PLD and ILD were determined using anti-podoplanin antibody. Immunohistochemical findings were correlated with nodal metastasis, clinical staging, local recurrence, clinical outcome, and histological grade. Cytoplasmic immunoexpression of VEGFR-3 in the tumour core was associated with metastasis (P=0.009), patient death (P=0.008), and histological grade (P0.005). PLD, ILD, and VEGF-C expression showed no significant associations with clinicopathological parameters (P0.05). PLD and ILD were not significantly correlated with the immunoexpression of VEGF-C or VEGFR-3 (P0.05). There was a significant positive correlation between PLD and ILD (P=0.004), and between cytoplasmic immunoreactivity of VEGF-C and VEGFR-3 (P=0.011). These results suggest an important role for VEGFR-3 in the progression of LLSCC, and highlight the possible influence of its expression on the prognosis of these tumours. ILD and PLD may not be associated with lymph node metastasis in LLSCC.
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- 2017
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19. Immunohistochemical comparative analysis of lymphatic vessel density and VEGF-C expression in squamous cell carcinomas of the tongue between young and old patients
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Lélia Batista de Souza, Cassiano Francisco Weege Nonaka, Jamile Marinho Bezerra De Oliveira Moura, Leão Pereira Pinto, and Adriana Costa De Souza Martins Câmara
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Vascular Endothelial Growth Factor C ,Cell ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Tongue ,medicine ,Lymphatic vessel ,Humans ,Lymphangiogenesis ,Young adult ,Aged ,Lymphatic Vessels ,Neoplasm Staging ,biology ,business.industry ,Age Factors ,030206 dentistry ,Cell Biology ,Middle Aged ,Immunohistochemistry ,Tongue Neoplasms ,medicine.anatomical_structure ,Lymphatic system ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,biology.protein ,Female ,Antibody ,business - Abstract
Squamous cell carcinoma (SCC) of the oral cavity is a malignant epithelial tumor that most commonly involves the tongue, and mainly affects men between the fifth and seventh decades of life. This study compared the lymphatic vessel density and VEGF-C expression in SCCs of the tongue between young and old patients.Thirty-four SCCs of the tongue, 17 diagnosed in young patients (≤40y) and 17 diagnosed in old patients (50y), were evaluated by immunohistochemistry. Lymphatic microdensity was determined based on the number of vessels immunoreactive to anti-D2-40 antibody. The percentage of neoplastic cells exhibiting cytoplasmic staining for VEGF-C was established for each case.Assessment of intratumoral lymphatic microdensity (ILMD) disclosed a median number of 6.20 lymphatic vessels in young patients and of 6.60 in old patients (p=0.809). Analysis of peritumoral lymphatic microdensity (PLMD) revealed a median number of 3.60 lymphatic vessels in young patients and of 3.40 in old patients (p=0.769). In the tumor core, analysis of the percentage of immunopositive cells for VEGF-C revealed a median number of 95.95% in young patients and of 55.48% in old patients (p0.001). In the deep invasive front, the median number of immunopositive cells for VEGF-C was 97.93% in young patients and 66.09% in old patients (p0.001).The results of this study suggest that the more aggressive biological behavior of SCC of the tongue in young patients may be related to a higher expression of VEGF-C.
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- 2016
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20. ORAL LYMPHOEPITHELIAL CYST: A MULTICENTRIC STUDY OF 77 CASES
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Sandra Beatriz Chaves Tarquinio, Karine Duarte da Silva, Cassiano Francisco Weege Nonaka, Patrícia Carlos Caldeira, Tatiana Nayara Libório Kimura, Adriana Aparecida Silva Da Costa, and Elismauro Francisco Mendonça
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Retrospective cohort study ,Lymphoepithelial cyst ,medicine.disease ,Asymptomatic ,Dermatology ,Pathology and Forensic Medicine ,Lateral border ,medicine.anatomical_structure ,Tongue ,Oral and maxillofacial pathology ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Medical diagnosis ,medicine.symptom ,business - Abstract
Objective: To analyze the frequency and clinical and demographic features of oral lymphoepithelial cyst (OLEC) from 5 Brazilian services of oral and maxillofacial pathology. Study Design: Ethical approval (80249117.0.0000.5149). A cross-sectional retrospective study was conducted in 5 oral pathology services. The biopsy records were reviewed from 1952-2018. Cases with a microscopic diagnosis of OLEC were retrieved. Hematoxylin-eosin slides were reviewed by a single pathologist to confirm the diagnosis. Lesions of major salivary glands were excluded. Frequency and clinical and demographic data were analyzed descriptively. Results: Seventy-seven OLECs were found, representing 0.05% of the lesions submitted to diagnosis in the centers (n = 146,150). OLEC was predominantly diagnosed in females (n = 54; 70.1%). The mean age was 46.51 years (range [SD], 13-84 [14.80]). Lesions arose mainly in the tongue, lateral border (n = 31; 40.3%). The lesions measured up to 1 cm in size (n = 47; 61.0%) and were asymptomatic (n = 50; 64.9%). Twenty-four cases (31.2%) were white in color. Conclusion: OLECs are very uncommon diagnoses in oral pathology services. Lesions usually affect women, are small and asymptomatic, and located in the lateral border of the tongue. Detailed microscopic and immunohistochemical features will be accessed in the next step of this study. Support: CAPES, FAPEMIG, CNPq.
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- 2020
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21. IMMUNOHISTOCHEMICAL ANALYSIS OF AUTOPHAGY-RELATED PROTEINS IN ODONTOGENIC KERATOCYSTS
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Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Ana Luzia Araújo Batista, Fabianna da Conceiçao Dantas de Medeiros, Roberta Barroso Cavalcante, Hellen Bandeira de Pontes Santos, and Manuel Antonio Gordón-Núñez
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Pathology ,medicine.medical_specialty ,Autophagy-Related Proteins ,business.industry ,Spearman Correlation Test ,Pathology and Forensic Medicine ,Odontogenic ,stomatognathic diseases ,Cytoplasm ,Mann–Whitney U test ,Medicine ,Immunohistochemistry ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business - Abstract
Objective: To evaluate the immunoexpression of autophagy-related proteins (p62 and Atg7) in odontogenic keratocysts associated with Gorlin syndrome (SOKCs) and nonsyndromic odontogenic keratocysts (NSOKCs).Study design: The percentages of immunopositive cells (nuclear and cytoplasmic/membrane) for p62 and Atg7 in the epithelial component of 25 SOKCs and 25 NSOKCs were assessed. The results were analyzed statistically using the nonparametric Mann-Whitney U test and Spearman correlation test. Results: Expression of p62 and Atg7 was observed in all cases studied. Compared with NSOKCs, SOKCs exhibited higher nuclear expression of p62 (P
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- 2020
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22. CLINICAL AND HISTOPATHOLOGICAL CHARACTERISTICS OF GLANDULAR ODONTOGENIC CYST: A RETROSPECTIVE STUDY
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Jurema Freire Lisboa de Castro, JOSé Rodrigo Barbosa Franklin, Cassiano Francisco Weege Nonaka, Lélia Batista de Souza, Lívia Natália Sales Brito, Hellen Bandeira de Pontes Santos, and Gustavo Pina Godoy
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Cuboidal Cell ,Pathology ,medicine.medical_specialty ,business.industry ,Apocrine ,Lumen (anatomy) ,Retrospective cohort study ,medicine.disease ,Pathology and Forensic Medicine ,Eosinophilic ,Oral and maxillofacial pathology ,Glandular odontogenic cyst ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Cyst ,Oral Surgery ,business - Abstract
Objective: To analyze the determinant clinical and histologic aspects in the establishment of the diagnosis of the glandular odontogenic cyst (GOC).Study Design: A cross-sectional study was performed in 2 oral pathology services. All slides of GOCs were reviewed and clinical data were obtained from the patient records. The determination of the diagnosis followed predetermined microscopic parameters according to the World Health Organization. Statistical analysis was performed in order to identify the predictive parameters for the diagnosis of GOC. Results: From the 9 patient cases of GOCs, 55.5% were male, with a mean age of 50.6 years, and 66.6% were located in the mandible. All cases presented with intraepithelial microcysts or duct-like spaces, clear or vacuolated cells, variable thickness of the cyst lining, and papillary projections into the lumen. Multiple compartments, surface eosinophilic cuboidal cells, and epithelial spheres or plaque-like thickenings were observed in 8 (88%) cases. Apocrine snouting of hobnail cells were present in 6 (66%), mucous goblet cells in 3 (33.3%), and cilia in only 1 (11%). Conclusion: The association between the predictive clinical and histopathological aspects for the diagnosis of this rare lesion is fundamental, since GOC has the potential to mimic other potentially more aggressive lesions.
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- 2020
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23. IMMUNOEXPRESSION OF DNA BER AND NER PROTEINS IN BENIGN EPITHELIAL ODONTOGENIC LESIONS
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Cassiano Francisco Weege Nonaka, Renato Luiz Maia Nogueira, Roseana de Almeida Freitas, Hellen Bandeira de Pontes Santos, Everton Freitas de Morais, and Roberta Barroso Cavalcante
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Pathology ,medicine.medical_specialty ,business.industry ,DNA Base Excision Repair ,Pathology and Forensic Medicine ,Odontogenic ,stomatognathic diseases ,chemistry.chemical_compound ,XRCC1 ,chemistry ,medicine ,Immunohistochemistry ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,DNA ,Nucleotide excision repair - Abstract
Objective: To evaluate DNA base excision repair (BER) in APE-1 and XRCC1; and nucleotide excision repair (NER) in XPF proteins in benign epithelial odontogenic lesions with different biological behaviors. Study design: Thirty solid ameloblastomas (AMEs), 30 isolated odontogenic keratocysts (NSOKCs), 29 syndromic odontogenic keratocysts (SKOCs), 30 dentigerous cysts (DCs; n = 30), and 20 dental follicles (DFs) were evaluated quantitatively for APE-1, XRCC1 and XPF through immunohistochemistry. Results: All the odontogenic lesions studied revealed a statistically significant expression of APE-1 (nuclear), XRCC1 (nuclear), and XPF (nuclear and cytoplasmic) compared with DFs (P
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- 2020
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24. HIGH-POWER LASER REMOVAL OF A VASCULAR LESION THAT MIMICKED A CUTANEOUS HORN
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Tiago João Da Silva Filho, Wliana Pontes De Lima, Cassiano Francisco Weege Nonaka, Daliana Queiroga de Castro Gomes, Pollianna Muniz Alves, Manuel Antonio Gordón-Núñez, and Robéria Lúcia De Queiroz Figueiredo
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Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Pyogenic granuloma ,Nodule (medicine) ,Physical examination ,medicine.disease ,Pathology and Forensic Medicine ,Lesion ,medicine.anatomical_structure ,Cutaneous horn ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,medicine.symptom ,business ,Wound healing ,Vascular tissue ,Blood vessel - Abstract
Pyogenic granuloma (PG) is a non-neoplastic vascular tissue growth, which occurs in response to several stimuli. A 15-year-old nonwhite male patient presented with a nonsymptomatic lesion in the lower lip, which was noted for the first time 4 months before. Clinical examination revealed a rigid, brownish, well-delimited, and pediculated nodule, features that led to the clinical diagnosis of cutaneous horn. In an attempt to promote a better wound healing, total removal of the lesional area using the high-power diode laser (808 nm; 1.5 W; continuous mode) was decided. Microscopic examination revealed intense endothelial cells proliferation and new blood vessel formation, besides extensive ulceration areas. Based on these morphologic features, the final diagnosis of PG was established. The patient had very good healing of the incised area on the postsurgical examination and underwent long-term follow-up.
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- 2020
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25. SIMULTANEOUS ORAL SQUAMOUS CELL CARCINOMA: A CASE REPORT
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Pollianna Muniz Alves, Rafael Grotta Grempel, Cassiano Francisco Weege Nonaka, Camila Guimarães De Sousa, Luan Éverton Galdino Barnabé, and Raelly Katharinne Lima De Meneses
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Pathology ,medicine.medical_specialty ,Incisional biopsy ,business.industry ,medicine.medical_treatment ,Atypical Squamous Cells ,Oral cavity ,Pathology and Forensic Medicine ,Radiation therapy ,Lesion ,stomatognathic diseases ,Female patient ,Alveolar ridge ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Basal cell ,Oral Surgery ,medicine.symptom ,business - Abstract
Oral squamous cell carcinoma (OSCC) is a more common malignant neoplasm in the oral cavity, being rare as simultaneous primary tumors. Based on this, we aimed to report a rare case of simultaneous OSCC. A 76-year-old female patient presented in intraoral examination 2 lesions, one localized in palate and the other localized in alveolar ridge, with history of evolution of 4 months. Both lesions had a tumoral aspect and corrugated and whitish surface. For lesion in palate was observed area of ulcerations. Incisional biopsy was performed for both lesions, and histopathologic analysis revealed a proliferation of atypical squamous cells in nests and sheets exhibiting atypical mitosis, moderate hyperchromatic nuclei, and nuclear pleomorphism. Final diagnosis was simultaneous differentiated moderate OSCC. Treatment indicated was surgery and radiotherapy, and after 12 months of follow-up, no sign of recurrence was observed.
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- 2020
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26. CALCIFYING ODONTOGENIC CYST IN THE MAXILLA: A CASE REPORT
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Cassiano Francisco Weege Nonaka, Márcio Menezes Novaes, Amanda Lira Rufino De Lucena, Denize Núbia Souza, Manuel Antonio Gordón-Núñez, Tiago João Da Silva Filho, and Pollianna Muniz Alves
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Incisional biopsy ,business.industry ,Ghost cell ,Anatomy ,medicine.disease ,Anterior region ,Pathology and Forensic Medicine ,Nasal ala ,Calcifying odontogenic cyst ,Odontogenic cyst ,Maxilla ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,Facial symmetry - Abstract
Calcifying odontogenic cyst (COC) is a rare, developmental odontogenic cyst that usually arises in the anterior region of the jaws. An 18-year-old, dark-skinned man was referred for evaluation of a painless, slow-growing swelling in the maxilla, extending from tooth #21 to tooth #25. Extraoral examination revealed slight elevation of the left nasal ala, producing discrete facial asymmetry. Computed tomography showed an expansive, unilocular hypodense lesion with small hyperdense foci, measuring approximately 3.0 cm in diameter. Under the diagnostic hypothesis of COC, an incisional biopsy was performed. Histopathological analysis disclosed a cystic cavity lined by ameloblastoma-like epithelium, with focal accumulation of ghost cells. Calcifications within the ghost cells could also be observed. The definitive diagnosis was COC. The patient was referred for surgical treatment and remains under close follow-up.
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- 2020
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27. LIPOMA OF THE TONGUE IN AN ELDERLY PATIENT: A CASE REPORT
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Ana Vitória Leite Luna, Pollianna Muniz Alves, Fabianna da Conceiçao Dantas de Medeiros, Allany de Oliveira Andrade, Cassiano Francisco Weege Nonaka, Joabe dos Santos Pereira, and Tiago João Da Silva Filho
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Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Mesenchymal stem cell ,Connective tissue ,Nodule (medicine) ,Lipoma ,medicine.disease ,Pathology and Forensic Medicine ,stomatognathic diseases ,medicine.anatomical_structure ,Tongue ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Medical history ,Oral Surgery ,medicine.symptom ,Elderly patient ,business - Abstract
Lipomas are mesenchymal neoplasms consisting of mature adipocytes, which account for only 1% to 5% of all oral benign tumors. These lesions are occasionally altered by an admixture of other mesenchymal elements that comprise an intrinsic part of the tumor. A 76-year-old white woman was referred for evaluation of a painless, slow-growing swelling on the tongue that had been identified 3 years earlier. Her medical history was unremarkable. Intraoral examination revealed a yellowish, soft, sessile nodule on the right lateral border and ventral surface of the tongue, measuring approximately 2 cm. Under the diagnostic hypothesis of lipoma, an excisional biopsy was performed. Histopathologic analysis revealed a well-delimited proliferation of mature adipocytes arranged in lobules and separated by thin septa of fibrovascular connective tissue. The final diagnosis was lipoma. Eight months after surgical excision, clinical signs of recurrence were not detected. The patient remains under clinical follow-up.
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- 2020
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28. CENTRAL ODONTOGENIC FIBROMA IN THE MANDIBLE: A CASE REPORT
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Amanda Lira Rufino De Lucena, Cassiano Francisco Weege Nonaka, Manuel Antonio Gordón-Núñez, Ilky Pollansky Silva e Farias, Ana Luzia Araújo Batista, Pollianna Muniz Alves, and Maria LETíCIA Oliveira Xavier
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business.industry ,medicine.medical_treatment ,Enucleation ,Mandible ,Connective tissue ,Anatomy ,Unerupted tooth ,medicine.disease ,Curettage ,Calcifying epithelial odontogenic tumor ,Pathology and Forensic Medicine ,stomatognathic diseases ,medicine.anatomical_structure ,Maxilla ,Central odontogenic fibroma ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business - Abstract
Central odontogenic fibroma (COF) is a rare, benign mesenchymal odontogenic neoplasm that has a wide patient age range and a relatively similar distribution in the maxilla and mandible. A 60-year-old woman was referred for evaluation of a painless, slow-growing swelling in the mandible, extending from the left ramus to the distal root of tooth #36, covered by normal mucosa. Computed tomography showed an expansive, unilocular hypodense lesion with hyperdense foci, associated with unerupted tooth #38, measuring approximately 4.5 cm in diameter. Under the diagnostic hypothesis of calcifying epithelial odontogenic tumor, an incisional biopsy was performed. Histopathological analysis disclosed a moderately cellular, fibroblastic connective tissue intermixed with inactive-looking odontogenic epithelial islands and strands. The definitive diagnosis was COF. The treatment consisted of enucleation, curettage, and extraction of the associated tooth. No signs of recurrence were observed after 14 months of surgical excision. The patient remains under clinical and radiographic follow-up.
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- 2020
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29. PHOTODYNAMIC THERAPY FOR THE TREATMENT OF RECURRENT HERPES: CASE REPORT
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Isabella Jardelino Dias, Gabriella de Vasconcelos Neves, Cassiano Francisco Weege Nonaka, Diego Filipe Bezerra Silva, Sandro Roberto de Araújo, Daliana Queiroga de Castro Gomes, and Rodrigo Queiroga de Moura
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Lower lip ,Photodynamic therapy ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,chemistry ,Clinical diagnosis ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Photosensitizer ,Radiology ,Oral Surgery ,Total energy ,business ,Methylene blue - Abstract
The aim of the present study was to describe a case report on the treatment of recurrent herpes using photodynamic therapy as a therapy of choice. A 21-year-old white man presented for evaluation of vesicles arranged in a skin region just below the transition zone between mucosa and skin of lower lip. The clinical diagnosis was of recurrent herpes and, for treatment, photodynamic therapy was applied, with application of 0.1% methylene blue as photosensitizer and a pre-irradiation time of 5 minutes. The low power device used was Therapy XT, with wavelength of 660 nm, power of 100 mW, in a spot area of 0.028 cm2, using the total energy of 4.0 J. It was possible to observe total repair after 10 days of treatment and the patient remained in follow-up for 8 months without recurrences.
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- 2020
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30. ORAL CONDYLOMA ACUMINATUM IN CHILDREN: A CASE REPORT
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Pollianna Muniz Alves, Jozinete Vieira Pereira, Cassiano Francisco Weege Nonaka, Camila Guimarães De Sousa, Daliana Queiroga de Castro Gomes, Raelly Katharinne Lima De Meneses, and Tiago João Da Silva Filho
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Acanthosis ,Hyperplasia ,Condyloma Acuminatum ,medicine.disease ,Asymptomatic ,Dermatology ,Koilocyte ,Pathology and Forensic Medicine ,medicine.anatomical_structure ,Sexual abuse ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,medicine.symptom ,Oral mucosa ,business - Abstract
Condyloma acuminatum is induced disease by human papillomavirus that commonly affects the genital region and is rarely observed on oral mucosa. Pathogenesis is associated with sexual contact or trauma, and when it develops in children it can indicate sexual abuse. Based on this, we aimed to report a case of condyloma acuminatum in a child. A 9-year-old male patient clinically presented verrucous nodule, asymptomatic, with history of evolution of 18 months, measuring 1 cm, and localized in left side of lower lip. No signs of other lesions in the skin were present. Clinical hypothesis was squamous papilloma or condyloma acuminatum. Excisional biopsy was performed, and histopathologic analysis revealed hyperplasia of parakeratinized squamous epithelium, with exophytic projections exhibiting acanthosis and exocytosis. Clear cytoplasm cells, suggestive of koilocytosis, were also observed. Subjacent fibrovascular connective tissue was also seen. Based on histopathologic findings, final diagnosis was condyloma acuminatum. After 12 months of follow-up, no sign of recurrence was observed.
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- 2020
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31. Analyses of VEGFC/VEGF-D expressions, density and endothelial lymphatic proliferation in salivary gland neoplasms
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Cassiano Francisco Weege Nonaka, Leorik Pereira da Silva, Aquiles Sales Craveiro Sarmento, Keila Martha Amorim Barroso, Leão Pereira Pinto, Lélia Batista de Souza, and Pedro Paulo de Andrade Santos
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,VEGF receptors ,Vascular Endothelial Growth Factor C ,Clinical Biochemistry ,Vascular Endothelial Growth Factor D ,Adenoid ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Molecular Biology ,Cell Proliferation ,Lymphatic Vessels ,Salivary gland ,biology ,business.industry ,Endothelial Cells ,Salivary Gland Neoplasms ,Blot ,030104 developmental biology ,Lymphatic system ,medicine.anatomical_structure ,Vascular endothelial growth factor C ,030220 oncology & carcinogenesis ,biology.protein ,Immunohistochemistry ,Salivary gland neoplasm ,business - Abstract
Objective The aim of this study was to assess vascular endothelial growth factor C (VEGF-C) and VEGF-D expressions, tumor lymphatic density (D2–40) and endothelial lymphatic proliferation (D2–40/Ki-67 double labeling) in a series of salivary gland neoplasm cases. Materials and methods Twenty pleomorphic adenomas (PA), 20 adenoid cystic carcinomas (ACC) and 20 mucoepidermoid carcinomas (MEC) were assessed, as well as 10 normal minor salivary gland (SG) tissues for comparison. Results All cases presented positive VEGF-C expression in the peritumoral and intratumoral regions, and no differences in immunoexpression were detected between groups. However, the ACC group presented a significant difference in VEGF-C immunoexpression according to the predominant histological pattern. Most cases presented poor VEGF-D labeling in the peritumoral and intratumoral regions. Concerning peritumoral, intratumoral and total lymphatic endothelial density, the assessed groups revealed an increasing gradient, with lower values for PA, followed by MEC and ACC. Conclusion No correlation was detected between VEGF-C and VEGF-D immunoexpression in relation to lymphatic tumor density and endothelial lymphatic proliferation. Western blotting (WB) revealed no difference between VEGF-C and VEGF-D expression among the lesions, corroborating the immunohistochemistry findings.
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- 2020
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32. SQUAMOUS CELL CARCINOMA WITH A RHABDOID PHENOTYPE AFFECTING THE MAXILLA: CASE REPORT AND IMMUNOHISTOCHEMICAL ANALYSIS
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Xiomara Beatriz Jimenez Polanco, Rodrigo Neves Silva, Pollianna Muniz Alves, Manuel Antonio Gordón-Núñez, Jorge Esquiche León, Cassiano Francisco Weege Nonaka, and Lucas Ribeiro Teixeira
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Pathology ,medicine.medical_specialty ,Maxillary sinus ,biology ,business.industry ,Cytoplasmic inclusion ,CD68 ,Vimentin ,Pathology and Forensic Medicine ,stomatognathic diseases ,medicine.anatomical_structure ,Maxilla ,biology.protein ,Immunohistochemistry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Differential diagnosis ,business ,Hyaline - Abstract
Squamous cell carcinoma (SCC) with a rhabdoid phenotype (SCCRP) is an extremely rare entity in the maxillofacial region. To date, only 2 oral SCCRP cases have been reported. The presence of this phenotype is associated with a worse prognosis than conventional SCC. A 44-year-old man was referred presenting painful facial asymmetry evidenced by increase of volume in the left maxilla with several months of evolution. Computerized tomography examination showed extensive osteolytic lesion on the left maxilla and maxillary sinus. The histopathologic analysis showed typical morphologic features of SCCRP constituted by polygonal and discohesive cells with large hyaline cytoplasmic inclusions and eccentric nuclei with single prominent nucleoli. Immunohistochemistry revealed positivity for CK AE1/AE3, epithelial membrane antigen (EMA), vimentin, CD138, INI-1, focally for α–smooth muscle actin, and CD68. Ki-67 was > 40%. Although rare, SCCRP should be considered in the differential diagnosis when assessing malignant neoplasms affecting the maxilla. FAPESP (2016/11419-0 and 2017/02502-4).
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- 2020
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33. IMMUNOHISTOCHEMICAL ANALYSIS OF HUMAN LEUKOCYTE ANTIGEN-DR (HLA-DR) IN LIP CARCINOGENESIS
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Cassiano Francisco Weege Nonaka, Emanuene Galdino Pires, Pollianna Muniz Alves, Luana Samara Balduino de Sena, Manuel Antonio Gordón-Núñez, Marina Gonçalves do Amaral, and Hellen Bandeira de Pontes Santos
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Pathology ,medicine.medical_specialty ,business.industry ,Actinic cheilitis ,medicine.disease_cause ,medicine.disease ,Malignancy ,Pathology and Forensic Medicine ,Malignant transformation ,Metastasis ,HLA-DR ,Medicine ,Immunohistochemistry ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Stage (cooking) ,business ,Carcinogenesis - Abstract
Objective To evaluate the immunoexpression of human leukocyte antigen-DR (HLA-DR) in actinic cheilitis (AC) and lower-lip squamous cell carcinomas (LLSCCs), and to correlate the findings with clinicopathologic parameters (tumor size and extent, regional lymph node metastasis, clinical stage, risk of malignant transformation for AC and histopathologic grade of malignancy for LLSCCs). Study Design The percentage of HLA-DR–positive cells in the epithelial component of 24 cases of AC and 48 LLSCCs (24 with regional nodal metastasis and 24 without metastasis) were assessed. The results were analyzed statistically using the nonparametric Mann-Whitney test. Results Only 5 (20.8%) cases of AC (2 low risk and 3 high risk) exhibited expression of HLA-DR, with a very low mean percentage of immunopositivity. Most LLSCCs (97.7%) presented with expression of HLA-DR, with a relatively high mean of immunopositivity. The percentage of HLA-DR–positive cells tended to be higher in tumors with regional metastasis, and tumors in advanced clinical stages (P > .05). There was a tendency for higher expression of HLA-DR in low-grade LLSCCs, and in highly or moderately keratinized tumors (P > .05). Conclusions The results suggest a potential role for HLA-DR in lip carcinogenesis, particularly in the progression of LLSCCs. The expression of this protein can be related to the degree of cell differentiation in these tumors.
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- 2020
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34. CLINICOPATHOLOGIC PROFILE OF 60 CASES OF ACTINIC CHEILITIS
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Ana Luiza De Araújo Batista, Pollianna Muniz Alves, Ingrid Morgana Fernandes Gonçalves, Iuska Cyntia Mariz Galvão, Luan Éverton Galdino Barnabé, and Cassiano Francisco Weege Nonaka
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medicine.medical_specialty ,Incisional biopsy ,medicine.diagnostic_test ,business.industry ,Actinic cheilitis ,medicine.disease ,Asymptomatic ,Dermatology ,World health ,Pathology and Forensic Medicine ,Biopsy ,Medicine ,Referral center ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,Oral Diagnosis ,medicine.symptom ,business ,Lip Squamous Cell Carcinoma - Abstract
Objective Actinic cheilitis (AC), a potentially malignant disorder, exhibits unpredictable progression to lip squamous cell carcinoma. Therefore, this study describes clinical and pathologic findings of cases of AC. Study Design Observational and cross-sectional study. Sample was composed of 60 cases of AC diagnosed in the period from 2011 to 2017 in an oral diagnosis referral center. Clinical data of patients (age, sex, and race) and lesions (anatomic site, size, symptomatology, and type of biopsy) were obtained from records. Morphologic analysis was graded according to the World Health Organization (WHO) (2017). Results Mean age of patients was 57.9 ± 12.9 years old; male were most affected (n = 45; 75%), with ratio of 3:1. White individuals were most affected (n = 30; 50.0%). Lower lip was the anatomic site more affected (n = 58; 96.7%). In relation to clinical aspect, AC showed predominance of white lesions (n = 30; 50.0%), aspect of plaque (n = 25; 41.7%), size ≤ 1 cm (n = 29; 48.3%) and asymptomatic (n = 37; 61.7%). Incisional biopsy was the most performed (n = 29; 48.3%). Histopathologically, most AC cases were classified as mild epithelial dysplasia (n = 26; 43.3%). Conclusions The results showed that clinical aspects of AC can reflect morphologic findings, so it is important to make a more accurate diagnosis.
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- 2020
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35. LASER PHOTOCOAGULATION FOR THE TREATMENT OF VASCULAR LESION IN OROFACIAL REGION
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Robéria Lúcia De Queiroz Figueiredo, Jozinete Vieira Pereira, Isabella Jardelino Dias, Cassiano Francisco Weege Nonaka, Daliana Queiroga de Castro Gomes, Daniella Lucena Morais, and Gustavo Gomes Agripino
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Physical examination ,medicine.disease ,Asymptomatic ,Stain ,Diascopy ,Pathology and Forensic Medicine ,Surgery ,Fibrosis ,Blood blister ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Local anesthesia ,Oral Surgery ,medicine.symptom ,business ,Alveolar mucosa - Abstract
A 53-year-old male patient presented with an approximately 8-year history of an asymptomatic "blood blister" on the lower lip. Extraoral examination revealed a soft, purplish, lobulated swelling on the left side of the lower lip skin. Intraoral examination showed a well-defined, purplish stain and papules on the left lower lip and alveolar mucosa, measuring approximately 1.5 × 1.0 cm. The diagnostic hypothesis was vascular lesion, which was later confirmed by a positive diascopy result. Under local anesthesia, the patient was submitted to 2 clinical sessions of photocoagulation with high-intensity diode laser (Thera Lase Surgery; 808∼830 nm ± 20 nm, 2.5 W, defocused 2 mm beam in continuous mode). The postoperative course was uneventful. After 6 months of follow-up, the patient reported only mild sensitivity in the region. Clinical examination revealed fibrosis compatible with the tissue repair process without aesthetic or functional impairment.
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- 2020
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36. COMPARISON OF PROGNOSTIC FACTORS OF ORAL SQUAMOUS CELL CARCINOMA BETWEEN YOUNG AND OLDER PATIENTS: A SYSTEMATIC REVIEW
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Robeci Alves Macedo Filho, Cassiano Francisco Weege Nonaka, Ingrid Morgana Fernandes Gonçalves, and Pollianna Muniz Alves
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medicine.medical_specialty ,Web of science ,business.industry ,Cochrane Library ,Pathology and Forensic Medicine ,medicine.anatomical_structure ,Age groups ,Older patients ,Tongue ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Basal cell ,Oral Surgery ,business ,Grading (tumors) ,Cohort study - Abstract
Objective Biological behavior of oral squamous cell carcinoma (OSCC) in young patients is controversial. Therefore, this study compared prognostic factors of OSCC between young and older patients, through a systemic review. Study Design Electronic search in the databases Pubmed/Scopus/Ovid/Proquest/Cochrane Library/Web of Science/Lilacs was performed until April 2018, without filters by language or year of publication. Only cohort studies were included and evaluated by Newcastle-Ottawa scale for risk of bias. Analysis of titles and abstracts was made by 2 calibrated researchers (kappa = 0.94). Results A total of 5370 articles were reviewed, and 10 of the most relevant articles that are suitable to the criteria were selected. All included studies had a low risk of bias. Independent of age group, male was more affected, and tongue was anatomic site more frequent. Main risk factors were smoking and alcoholism in both age groups. Most patients in both age groups were diagnosed in early clinical stages (I/II). Regarding to histologic grading, majority of OSCC was classified as moderately differentiated in both age groups. Lower survival was observed in older patients. Conclusions Among all prognostic factors evaluated, survival showed difference in age groups, suggesting, then, that OSCC in older patients could exhibit more aggressive biologic behavior.
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- 2020
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37. USE OF THERMOGRAPHY FOR DIAGNOSIS OF ACTINIC CHEILITS AND LOWER LIP SQUAMOUS CELL CARCINOMA
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Cassiano Francisco Weege Nonaka, Robson Pequeno de Sousa, Daniela Pita de Melo, Pollianna Muniz Alves, Ingrid Morgana Fernandes Gonçalves, Alanne Vandreia da Silva Alves, and Kátia Elizabete Galdino
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Pathology ,medicine.medical_specialty ,Epithelial dysplasia ,business.industry ,Actinic cheilitis ,Lower lip ,Thermal distribution ,Context (language use) ,medicine.disease ,Pathology and Forensic Medicine ,Thermography ,medicine ,Mild epithelial dysplasia ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Basal cell ,Oral Surgery ,business - Abstract
Lower lip squamous cell carcinoma (LLSCC) represents frequent lip malignant neoplasms, and the majority is preceded by actinic cheilitis (AC), a potentially malignant disorder. In this context, we report 3 cases of AC and 1 of LLSCC, emphasizing the importance of thermography as an auxiliary tool in diagnosis. In AC and LLSCC, thermography showed, respectively, whitish areas with higher heat emission and reddish circular area of irregular thermal distribution. After acquisition of thermography images, incisional biopsies were performed to evaluate microscopic alterations according to the criteria described by the World Health Organization (2017). Of the AC cases, 1 was diagnosed as mild epithelial dysplasia and 2 were moderate epithelial dysplasia. LLSCC was confirmed on anatomopathologic examination. As a result, we observed that thermography is not able to distinguish the different degrees of epithelial dysplasia found in AC, but it is a new imaging method useful in distinguishing AC from LLSCC.
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- 2020
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38. AMELOBLASTOMA OF THE POSTERIOR MANDIBLE: DELAYED DIAGNOSIS DURING ORTHODONTIC TREATMENT
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Cassiano Francisco Weege Nonaka, Daniela Pita de Melo, Rafael Grotta Grempel, Tiago João Da Silva Filho, Daniella Lucena Morais, Pollianna Muniz Alves, and Ana Luzia Araújo Batista
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Orthodontics ,Panoramic radiograph ,business.industry ,medicine.medical_treatment ,Mandible ,Unerupted tooth ,medicine.disease ,Crown (dentistry) ,Pathology and Forensic Medicine ,stomatognathic diseases ,stomatognathic system ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Medical history ,Oral Surgery ,Keratocyst ,medicine.symptom ,Radiation treatment planning ,business ,Ameloblastoma - Abstract
Ameloblastoma is a benign epithelial odontogenic neoplasm characterized by locally aggressive behavior. This lesion is often asymptomatic, and some cases are detected during routine radiographic examination. A 33-year-old female patient undergoing orthodontic treatment presented with a 1-month history of a painful swelling in the posterior mandible. Her medical history was noncontributory. Panoramic radiograph showed a well-defined, multilocular radiolucency on the left side of the mandible extending from tooth #37 to the mandibular ramus. A panoramic radiograph obtained for orthodontic documentation 7 years earlier revealed a well-defined, unilocular radiolucency associated with the crown of unerupted tooth #38. Under the diagnostic hypothesis of odontogenic keratocyst, an incisional biopsy was performed. Histopathologic findings confirmed the diagnosis of ameloblastoma. The patient was referred for surgical treatment and remains under close follow-up. This case emphasizes the importance of a detailed analysis of patient images, irrespective of the diagnostic goal, before any dental treatment planning.
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- 2020
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39. Intraoral Blue Nevus: Report of an Uncommon Entity
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Jozinete Vieira Pereira, Cassiano Francisco Weege Nonaka, Rodrigo Porpino Mafra, Maria Luiza Diniz de Sousa Lopes, Daliana Queiroga de Castro Gomes, Leão Pereira Pinto, and Ernani Canuto Figueirêdo Júnior
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medicine.medical_specialty ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,medicine.symptom ,business ,Dermatology ,Blue nevus ,Pathology and Forensic Medicine - Published
- 2018
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40. Hyaline Ring Granulomas Associated with Oroantral Fistula in A Patient with Neurofibromatosis Type 1
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Robéria Lúcia De Queiroz Figueiredo, Márcio Menezes Novaes, Maria Luiza Diniz de Sousa Lopes, Gustavo Pina Godoy, Pollianna Muniz Alves, Leonardo Henrique De Araujo Cavalcante, and Cassiano Francisco Weege Nonaka
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medicine.medical_specialty ,business.industry ,Ring (chemistry) ,medicine.disease ,Pathology and Forensic Medicine ,Surgery ,Oroantral fistula ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Oral Surgery ,Neurofibromatosis ,business ,Hyaline - Published
- 2018
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41. Oral Melanoacanthoma: a Case Report of Diffuse Oral Pigmentation
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Jozinete Vieira Pereira, Robéria Lúcia De Queiroz Figueiredo, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka, Bárbara Vanessa De Brito Monteiro, Daliana Queiroga de Castro Gomes, and Robeci Alves Macêdo-Filho
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medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,medicine.disease ,Oral pigmentation ,Dermatology ,Melanoacanthoma ,Pathology and Forensic Medicine - Published
- 2018
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42. Myofibroblasts and their relationship with oral squamous cell carcinoma
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Alessandro Leite Cavalcanti, Gustavo Pina Godoy, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, and Priscilla Suassuna Carneiro Lúcio
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stomatognathic diseases ,Cell Transformation, Neoplastic ,Otorhinolaryngology ,carcinoma, squamous cell ,immunohistochemistry ,myofibroblasts ,Humans ,Mouth Neoplasms ,Basal cell ,Biology ,Molecular biology - Abstract
Os miofibroblastos sao celulas especializadas que exibem um fenotipo hibrido, com caracteristicas de fibroblastos e celulas musculares lisas. Devido sua habilidade contratil e capacidade de sintese de componentes da matriz extracelular, citocinas, proteases e fatores pro-angiogenicos, os miofibroblastos tem sido implicados na patogenese de doencas fibrocontrateis e na progressao de diversos tumores, incluindo o carcinoma de celulas escamosas (CCE) oral. OBJETIVO: Fazer uma revisao da literatura sobre a origem dos miofibroblastos, seus principais aspectos morfofisiologicos e imuno-histoquimicos, assim como discutir sua relacao com o CCE oral. METODO: Realizou-se uma busca eletronica na base de dados PubMed, selecionando os principais artigos da literatura em lingua inglesa relacionados ao tema, publicados entre janeiro de 1991 e dezembro de 2011. CONCLUSAO: Os miofibroblastos representam um componente importante do estroma de CCE orais, embora nao estejam presentes em todos os casos desta neoplasia. A presenca abundante destas celulas pode estar associada com a recorrencia local da doenca e diminuicao da sobrevida dos pacientes. No entanto, em virtude do numero relativamente limitado de estudos sobre o assunto, pesquisas ainda sao necessarias para esclarecer os mecanismos moleculares pelos quais os miofibroblastos sao capazes de influenciar no comportamento biologico do CCE oral.
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- 2013
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43. Immunohistochemical analysis of FoxP3+ cells in periapical granulomas and radicular cysts
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Cassiano Francisco Weege Nonaka, Joabe dos Santos Pereira, Márcia Cristina da Costa Miguel, Raniel Fernandes Peixoto, and Éricka Janine Dantas da Silveira
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Pathology ,medicine.medical_specialty ,Forkhead box P3 ,Inflammatory response ,Periapical Granuloma ,Cell Count ,macromolecular substances ,Biology ,T-Lymphocytes, Regulatory ,Epithelium ,Lesion ,Periapical granuloma ,medicine ,Humans ,General Dentistry ,Radicular cyst ,Inflammation ,Radicular Cyst ,Hyperplasia ,Dentistry(all) ,Mean value ,FOXP3 ,Forkhead Transcription Factors ,Regulatory T cells ,Cell Biology ,General Medicine ,Immunohistochemistry ,Otorhinolaryngology ,Atrophy ,Inflammation Mediators ,medicine.symptom - Abstract
Objectives To compare the number of FoxP3 + cells between periapical granulomas (PGs) and radicular cysts (RCs), and to correlate this number with the intensity of the inflammatory infiltrate in these lesions and with epithelial thickness of RCs. Study design Thirty PGs and 30 RCs were submitted to immunohistochemical analysis using an anti-FoxP3 polyclonal antibody. FoxP3 + cells were counted under a light microscope (×400 magnification) in five fields and the mean value was calculated for each specimen. Statistical tests were used to evaluate differences in the number of FoxP3 + cells according to type of lesion (PG vs. RC), intensity of the inflammatory infiltrate (grade I/II vs. grade III), and epithelial thickness of RCs (atrophic vs. hyperplastic). Results FoxP3 + cells were detected in most PGs (93.3%) and RCs (93.3%). The median number of FoxP3 + cells was 2.40 in PGs and 1.00 in RCs, with this difference being statistically significant ( P = 0.005). No significant differences in the number of FoxP3 + cells were observed in terms of the intensity of the inflammatory infiltrate ( P = 0.465) or epithelial thickness of RCs ( P = 0.737). Conclusions The present results suggest a greater participation of regulatory T cells in the modulation of the inflammatory response in PGs. In addition, the presence of a less effective regulatory environment in RCs, together with the high levels of inflammatory mediators as reported in the literature, may contribute to the greater growth potential of these lesions.
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- 2012
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44. Immunohistochemical analysis of bone resorption regulators (RANKL and OPG), angiogenic index, and myofibroblasts in syndrome and non-syndrome odontogenic keratocysts
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Renato Luiz Maia Nogueira, Lélia Batista de Souza, Leão Pereira Pinto, Roberta Barroso Cavalcante, and Cassiano Francisco Weege Nonaka
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musculoskeletal diseases ,Pathology ,medicine.medical_specialty ,CD34 ,Antigens, CD34 ,Bone resorption ,Neovascularization ,Osteoprotegerin ,Receptor activator of nuclear factor kappa B ligand ,Medicine ,Humans ,Bone Resorption ,Myofibroblasts ,General Dentistry ,Microvessel ,Myofibroblast ,biology ,Neovascularization, Pathologic ,business.industry ,Dentistry(all) ,RANK Ligand ,Basal Cell Nevus Syndrome ,Epithelial Cells ,General Medicine ,Cell Biology ,Odontogenic keratocyst ,Immunohistochemistry ,Otorhinolaryngology ,RANKL ,Odontogenic Cysts ,biology.protein ,medicine.symptom ,business - Abstract
Objective The aim of this study was to immunohistochemically analyse bone resorption regulators (receptor activator of nuclear factor kappa B ligand [RANKL] and osteoprotegerin [OPG]), angiogenic index, and myofibroblasts in Gorlin syndrome-related odontogenic keratocysts (SOKCs) and non-syndrome odontogenic keratocysts (NSOKCs). Study design Twenty-two SOKCs, 22 primary NSOKCs, and eight recurrent NSOKCs were evaluated by immunohistochemistry using anti-RANKL and anti-OPG antibodies. The angiogenic index was determined by microvessel count (MVC) using anti-CD34 antibody. Anti-α-smooth muscle actin (α-SMA) antibody was used for the identification of myofibroblasts. Results Analysis of the expression of RANKL and OPG in the epithelial lining and fibrous capsule did not reveal significant differences between groups (P > 0.05). In the epithelial lining, the RANKL/OPG ratio was RANKL < OPG and RANKL = OPG in most primary NSOCKs (54.5%) and SOKCs (59.1%), respectively (P > 0.05). In the fibrous capsule, the ratio was RANKL = OPG in most primary (81.8%) and recurrent NSOKCs (75.0%) and in most SOKCs (45.5%) (P > 0.05). No significant differences in the angiogenic index or number of myofibroblasts were observed between primary NSOKCs, recurrent NSOKCs, and SOKCs (P > 0.05). Conclusions The present results suggest that differences in the biological behaviour of SOKCs and NSOKCs may not be related to the expression of RANKL and OPG, to the RANKL/OPG ratio, to the angiogenic index, or to the number of myofibroblasts in these lesions.
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- 2012
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45. Large Myoepithelioma with Unusual Histopathologic Findings: A Case Report
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Tony Santos Peixoto, Marcela Pessoa de Melo, Cassiano Francisco Weege Nonaka, Bárbara Vanessa De Brito Monteiro, Daliana Queiroga de Castro Gomes, Pollianna Muniz Alves, and Diego Filipe Bezerra Silva
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medicine.medical_specialty ,Myoepithelioma ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,Dermatology ,Pathology and Forensic Medicine - Published
- 2018
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46. The Role of Galectin-7 in Endothelial Cells of Periapical Granulomas, Radicular Cysts, and Residual Radicular Cysts
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Gustavo Pina Godoy, Arlley De Sousa Leitão, Cassiano Francisco Weege Nonaka, Lélia Batista de Souza, Pollianna Muniz Alves, Éricka Janine Dantas da Silveira, and Lívia Natália Sales Brito
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Radicular Cyst ,Pathology ,medicine.medical_specialty ,business.industry ,medicine ,Periapical Granuloma ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business ,Pathology and Forensic Medicine ,Galectin - Published
- 2018
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47. Parry-Romberg Syndrome: an Unusual Case Report
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João Augusto Vianna Goulart Filho, Rodolpho Ferreira Lima Vilela, Ana Cláudia Ramos Pinto, Cassiano Francisco Weege Nonaka, and José de Amorim Lisboa Neto
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medicine.medical_specialty ,Unusual case ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Parry–Romberg syndrome ,Oral Surgery ,medicine.disease ,business ,Dermatology ,Pathology and Forensic Medicine - Published
- 2018
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48. Granular Cell Tumor of the Tongue: Report of an Uncommon Neoplasm
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Robeci Alves Macêdo-Filho, Pollianna Muniz Alves, Maria Luiza Diniz de Sousa Lopes, Cassiano Francisco Weege Nonaka, Daliana Queiroga de Castro Gomes, Robéria Lúcia De Queiroz Figueiredo, and Éricka Janine Dantas da Silveira
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Granular cell tumor ,Pathology ,medicine.medical_specialty ,business.industry ,medicine.disease ,Pathology and Forensic Medicine ,medicine.anatomical_structure ,Tongue ,Medicine ,Neoplasm ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,business - Published
- 2018
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49. CLIC4 and CLIC4-Associated Proteins in Actinic Cheilitis and Squamous Cell Carcinoma of the Lower Lip
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Márcia Cristina da Costa Miguel, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas da Silveira, Lélia Maria Guedes Queiroz, Francisco Jadson Lima, and Maria Luiza Diniz de Sousa Lopes
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medicine.medical_specialty ,business.industry ,Actinic cheilitis ,Lower lip ,medicine.disease ,Dermatology ,Pathology and Forensic Medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Basal cell ,Oral Surgery ,business - Published
- 2018
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50. Peripheral Odontogenic Fibroma in the Mandibular Gingiva: a Case Report
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Márcia Cristina da Costa Miguel, Cassiano Francisco Weege Nonaka, Bárbara Vanessa De Brito Monteiro, Jozinete Vieira Pereira, Daliana Queiroga de Castro Gomes, Pollianna Muniz Alves, and Luana Samara Balduino de Sena
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Mandibular gingiva ,business.industry ,medicine ,Peripheral odontogenic fibroma ,Dentistry ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,medicine.disease ,business ,Pathology and Forensic Medicine - Published
- 2018
- Full Text
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