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Your search keyword '"Caragounis, A"' showing total 15 results
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15 results on '"Caragounis, A"'

4. International registry on aortic balloon occlusion in major trauma: Partial inflation does not improve outcomes in abdominal trauma

Author

Paran, Maya, primary, McGreevy, David, additional, Hörer, Tal M., additional, Khan, Mansoor, additional, Dudkiewicz, Mickey, additional, Kessel, Boris, additional, Sadeghi, M., additional, Pirouzram, A., additional, Toivola, A., additional, Skoog, P., additional, Idoguchi, K., additional, Kon, Y., additional, Ishida, T., additional, Matsumura, Y., additional, Matsumoto, J., additional, Maszkowski, M., additional, Bersztel, A., additional, Caragounis, E.C., additional, Bachmann, T., additional, Falkenberg, M., additional, Handolin, L., additional, Chang, S.W., additional, Hecht, A., additional, Hebron, D., additional, Shaked, G., additional, Bala, M., additional, Coccolini, F., additional, Ansaloni, L., additional, Hoencamp, R., additional, Özlüer, Y.E., additional, Hilbert-Carius, Peter, additional, Reva, V., additional, Oosthuizen, G., additional, Szarka, E., additional, Manchev, V., additional, Wannatoop, T., additional, Ordoñez, C.A., additional, Larzon, T., additional, and Nilsson, K.F., additional

Published
2023
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6. CT-lung volume estimates in trauma patients undergoing stabilizing surgery for flail chest

Author

Rauni Rossi Norrlund, Monika Fagevik Olsén, Hans Granhed, and Eva-Corina Caragounis

Subjects
Adult, Male, Thorax, medicine.medical_specialty, Flail chest, Vital capacity, Rib Fractures, Thoracic Injuries, Pulmonary function testing, Fracture Fixation, Internal, Young Adult, 03 medical and health sciences, FEV1/FVC ratio, Injury Severity Score, 0302 clinical medicine, Forced Expiratory Volume, Preoperative Care, Flail Chest, medicine, Humans, Lung volumes, Aged, General Environmental Science, Aged, 80 and over, Postoperative Care, 030222 orthopedics, Lung, business.industry, Total Lung Capacity, 030208 emergency & critical care medicine, Cone-Beam Computed Tomography, Middle Aged, respiratory system, medicine.disease, respiratory tract diseases, Surgery, Cross-Sectional Studies, Treatment Outcome, medicine.anatomical_structure, Respiratory Mechanics, General Earth and Planetary Sciences, Female, business, Follow-Up Studies
Abstract

To estimate and compare lung volumes from pre- and post-operative computed tomography (CT) images and correlate findings with post-operative lung function tests in trauma patients with flail chest undergoing stabilizing surgery.Pre- and post-operative CT images of the thorax were used to estimate lung volumes in 37 patients who had undergone rib plate fixation at least 6 months before inclusion for flail chest due to blunt thoracic trauma. Computed tomography lung volumes were estimated from airway distal to each lung hilum by outlining air-filled lung tissue either manually in images of 5 mm slice thickness or automatically in images of 0.6 mm slice thickness. Demographics, pain, range of motion in the thorax, breathing movements and Forced Vital Capacity (FVC) were assessed. Total Lung Capacity (TLC) measurements were also made in a subgroup of patients (n = 17) who had not been intubated at time of the initial CT. Post-operative CT lung volumes were correlated to FVC and TLC.Patients with a median age of 62 (19-90) years, a median Injury Severity Score (ISS) of 20 (9-54), and a median New Injury Severity Score (NISS) of 27 (17-66) were enrolled in the study. Median follow-up time was 3.9 (0.5-5.6) years. Two patients complained of pain at rest and when breathing. Pre-operative CT lung volumes were significantly different (p 0.0001) from post-operative CT lung volumes, 3.51 l (1.50-6.05) vs. 5.59 l (2.18-7.78), respectively. At follow-up, median FVC was 3.76 l (1.48-5.84) and median TLC was 6.93 l (4.21-8.42). Post-operative CT lung volumes correlated highly with both FVC [rPost-operative CT-lung volume estimates improve compared to pre-operative values in trauma patients undergoing stabilizing surgery for flail chest, and can be used as a marker for lung function when deciding which patient with chest wall injuries can benefit from surgery.

Published
2019

7. Feasibility and Clinical Outcome Of REBOA in Patients With Impending Traumatic Cardiac Arrest

Author

McGreevy, David, primary, Abu-Zidan, F., additional, Sadeghi, M., additional, Pirouzram, A., additional, Toivola, A., additional, Skoog, P., additional, Idoguchi, K., additional, Kon, Y., additional, Ishida, T., additional, Matsumura, Y., additional, Matsumoto, J., additional, Reva, V., additional, Maszkowski, M., additional, Bersztel, A., additional, Caragounis, E., additional, Falkenberg, M., additional, Handolin, L., additional, Oosthuizen, G., additional, Szarka, E., additional, Manchev, V., additional, Wannatoop, T., additional, Chang, S., additional, Kessel, B., additional, Hebron, D., additional, Shaked, G., additional, Bala, M., additional, Coccolini, F., additional, Ansaloni, L., additional, Dogan, E., additional, Manning, J., additional, Hibert-Carius, P., additional, Larzon, T., additional, Nilsson, K., additional, and Hörer, T., additional

Published
2019
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8. Feasibility and Clinical Outcome Of REBOA in Patients With Impending Traumatic Cardiac Arrest

Author

Tokiya Ishida, Junichi Matsumoto, Federico Coccolini, Sung Wook Chang, James E. Manning, Kristofer F. Nilsson, Mariusz Maszkowski, Mårten Falkenberg, Yuri Kon, George Oosthuizen, Luca Ansaloni, David T. McGreevy, Asko Toivola, Tal M. Hörer, Fikri M. Abu-Zidan, Peter Hibert-Carius, Gad Shaked, Thomas Larzon, Dan Hebron, M. Bala, Eva-Corina Caragounis, Emanuel M. Dogan, Per Skoog, Koji Idoguchi, Lauri Handolin, Artai Pirouzram, V. Manchev, Yosuke Matsumura, Adam Bersztel, Endre Szarka, Tongporn Wannatoop, Boris Kessel, Mitra Sadeghi, and Viktor Reva

Subjects
medicine.medical_specialty, business.industry, Emergency medicine, medicine, Traumatic cardiac arrest, Surgery, In patient, Cardiology and Cardiovascular Medicine, business, medicine.disease, Outcome (game theory)
Published
2019

10. Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide

Author

Qiao-Xin Li, Aphrodite Caragounis, Katrina M. Laughton, Irene Volitakis, Kevin J. Barnham, Tai Du, Anthony R. White, Robert A. Cherny, Robyn A. Sharples, Paul S. Donnelly, Andrew F. Hill, and Colin L. Masters

Subjects
Thiosemicarbazones, Drug Evaluation, Preclinical, Biological Availability, Gene Expression, chemistry.chemical_element, Peptide, CHO Cells, Zinc, Biochemistry, Amyloid beta-Protein Precursor, Cricetulus, Alzheimer Disease, Cricetinae, mental disorders, Extracellular, Amyloid precursor protein, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Metalloproteinase, Dose-Response Relationship, Drug, biology, Chinese hamster ovary cell, Cell Biology, chemistry, biology.protein, PBT2, Oxidation-Reduction, Copper, Intracellular
Abstract

Copper and zinc play important roles in Alzheimer disease pathology with recent reports describing potential therapeutics based on modulation of metal bioavailability. We examined the ability of a range of metal bis(thiosemicarbazonato) complexes (MII(btsc), where M=CuII or ZnII) to increase intracellular metal levels in Chinese hamster ovary cells overexpressing amyloid precursor protein (APP-CHO) and the subsequent effect on extracellular levels of amyloid-beta peptide (Abeta). The CuII(btsc) complexes were engineered to be either stable to both a change in oxidation state and dissociation of metal or susceptible to intracellular reduction and dissociation of metal. Treatment of APP-CHO cells with stable complexes resulted in elevated levels of intracellular copper with no effect on the detected levels of Abeta. Treatment with complexes susceptible to intracellular reduction increased intracellular copper levels but also resulted in a dose-dependent reduction in the levels of monomeric Abeta. Treatment with less stable ZnII(btsc) complexes increased intracellular zinc levels with a subsequent dose-dependent depletion of monomeric Abeta levels. The increased levels of intracellular bioavailable copper and zinc initiated a signaling cascade involving activation of phosphoinositol 3-kinase and c-Jun N-terminal kinase. Inhibition of these enzymes prevented Abeta depletion induced by the MII(btsc) complexes. Inhibition of metalloproteases also partially restored Abeta levels, implicating metal-driven metalloprotease activation in the extracellular monomeric Abeta depletion. However, a role for alternative metal-induced Abeta metabolism has not been ruled out. These studies demonstrate that MII(btsc) complexes have potential for Alzheimer disease therapy.

Published
2008

13. Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide

Author

Donnelly, Paul S., primary, Caragounis, Aphrodite, additional, Du, Tai, additional, Laughton, Katrina M., additional, Volitakis, Irene, additional, Cherny, Robert A., additional, Sharples, Robyn A., additional, Hill, Andrew F., additional, Li, Qiao-Xin, additional, Masters, Colin L., additional, Barnham, Kevin J., additional, and White, Anthony R., additional

Published
2008
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14. Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

Author

Price, Katherine A., primary, Filiz, Gulay, additional, Caragounis, Aphrodite, additional, Du, Tai, additional, Laughton, Katrina M., additional, Masters, Colin L., additional, Sharples, Robyn A., additional, Hill, Andrew F., additional, Li, Qiao-Xin, additional, Donnelly, Paul S., additional, Barnham, Kevin J., additional, Crouch, Peter J., additional, and White, Anthony R., additional

Published
2008
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