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35 results on '"Brucker, Sara Y."'

1. Pembrolizumab in combination with nab-paclitaxel for the treatment of patients with early-stage triple-negative breast cancer – A single-arm phase II trial (NeoImmunoboost, AGO-B-041)

Author

Fasching, Peter A., primary, Hein, Alexander, additional, Kolberg, Hans-Christian, additional, Häberle, Lothar, additional, Uhrig, Sabrina, additional, Rübner, Matthias, additional, Belleville, Erik, additional, Hack, Carolin C., additional, Fehm, Tanja N., additional, Janni, Wolfang, additional, Hartmann, Arndt, additional, Erber, Ramona, additional, Theuser, Anna-Katharin, additional, Brucker, Sara Y., additional, Hartkopf, Andreas D., additional, and Untch, Michael, additional

Published
2023
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2. Machine Learning and Patient-reported Outcomes for Longitudinal Monitoring of Disease Progression in Metastatic Breast Cancer: A Multicenter, Retrospective Analysis

Author

Deutsch, Thomas M., primary, Pfob, André, additional, Brusniak, Katharina, additional, Riedel, Fabian, additional, Bauer, Armin, additional, Dijkstra, Tjeerd, additional, Engler, Tobias, additional, Brucker, Sara Y., additional, Hartkopf, Andreas D., additional, Schneeweiss, Andreas, additional, Sidey-Gibbons, Chris, additional, and Wallwiener, Markus, additional

Published
2023
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4. Functional characteristics of a broad spectrum of TBX6 variants in Mayer-Rokitansky-Küster-Hauser syndrome

Author

Ma, Congcong, primary, Chen, Na, additional, Jolly, Angad, additional, Zhao, Sen, additional, Coban-Akdemir, Zeynep, additional, Tian, Weijie, additional, Kang, Jia, additional, Ye, Yang, additional, Wang, Yuan, additional, Koch, André, additional, Zhang, Yuanqiang, additional, Qin, Chenglu, additional, Bonilla, Ximena, additional, Borel, Christelle, additional, Rall, Katharina, additional, Chen, Zefu, additional, Jhangiani, Shalini, additional, Niu, Yuchen, additional, Li, Xiaoxin, additional, Qiu, Guixing, additional, Zhang, Shuyang, additional, Luo, Guangnan, additional, Wu, Zhihong, additional, Bacopoulou, Flora, additional, Deligeoroglou, Efthymios, additional, Zhang, Terry Jianguo, additional, Rosenberg, Carla, additional, Gibbs, Richard A., additional, Dietrich, Jennifer E., additional, Dimas, Antigone S., additional, Liu, Pengfei, additional, Antonarakis, Stylianos E., additional, Brucker, Sara Y., additional, Posey, Jennifer E., additional, Lupski, James R., additional, Wu, Nan, additional, and Zhu, Lan, additional

Published
2022
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6. Occurrence and characteristics of patients with de novo advanced breast cancer according to patient and tumor characteristics – A retrospective analysis of a real world registry

Author

Müller, Volkmar, primary, Hein, Alexander, additional, Hartkopf, Andreas D., additional, Fasching, Peter A., additional, Kolberg, Hans-Christian, additional, Hadji, Peyman, additional, Tesch, Hans, additional, Häberle, Lothar, additional, Ettl, Johannes, additional, Lüftner, Diana, additional, Wallwiener, Markus, additional, Beckmann, Matthias W., additional, Schneeweiss, Andreas, additional, Belleville, Erik, additional, Uhrig, Sabrina, additional, Wimberger, Pauline, additional, Hielscher, Carsten, additional, Meyer, Julia, additional, Wurmthaler, Lena A., additional, Kurbacher, Christian M., additional, Wuerstlein, Rachel, additional, Untch, Michael, additional, Janni, Wolfgang, additional, Taran, Florin-Andrei, additional, Lux, Michael P., additional, Wallwiener, Diethelm, additional, Brucker, Sara Y., additional, Fehm, Tanja N., additional, and Michel, Laura L., additional

Published
2022
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7. Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis

Author

Hartkopf, Andreas D., primary, Brucker, Sara Y., additional, Taran, Florin-Andrei, additional, Harbeck, Nadia, additional, von Au, Alexandra, additional, Naume, Bjørn, additional, Pierga, Jean-Yves, additional, Hoffmann, Oliver, additional, Beckmann, Matthias W., additional, Rydén, Lisa, additional, Fehm, Tanja, additional, Aft, Rebecca, additional, Solà, Montserrat, additional, Walter, Vincent, additional, Rack, Brigitte, additional, Schuetz, Florian, additional, Borgen, Elin, additional, Ta, Minh-Hanh, additional, Bittner, Ann-Kathrin, additional, Fasching, Peter A., additional, Fernö, Mårten, additional, Krawczyk, Natalia, additional, Weilbaecher, Katherine, additional, Margelí, Mireia, additional, Hahn, Markus, additional, Jueckstock, Julia, additional, Domschke, Christoph, additional, Bidard, Francois-Clement, additional, Kasimir-Bauer, Sabine, additional, Schoenfisch, Birgitt, additional, Kurt, Ayse G., additional, Wallwiener, Markus, additional, Gebauer, Gerhard, additional, Klein, Christoph A., additional, Wallwiener, Diethelm, additional, Janni, Wolfgang, additional, and Pantel, Klaus, additional

Published
2021
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8. Prognostic effect of low-level HER2 expression in patients with clinically negative HER2 status

Author

Hein, Alexander, primary, Hartkopf, Andreas D., additional, Emons, Julius, additional, Lux, Michael P., additional, Volz, Bernhard, additional, Taran, Florin-Andrei, additional, Overkamp, Friedrich, additional, Hadji, Peyman, additional, Tesch, Hans, additional, Häberle, Lothar, additional, Ettl, Johannes, additional, Lüftner, Diana, additional, Wurmthaler, Lena A., additional, Wallwiener, Markus, additional, Müller, Volkmar, additional, Beckmann, Matthias W., additional, Belleville, Erik, additional, Wimberger, Pauline, additional, Hielscher, Carsten, additional, Kurbacher, Christian M., additional, Wuerstlein, Rachel, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Fehm, Tanja N., additional, Wallwiener, Diethelm, additional, Brucker, Sara Y., additional, Schneeweiss, Andreas, additional, and Kolberg, Hans-Christian, additional

Published
2021
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9. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Author

Baxter, Joseph S., primary, Johnson, Nichola, additional, Tomczyk, Katarzyna, additional, Gillespie, Andrea, additional, Maguire, Sarah, additional, Brough, Rachel, additional, Fachal, Laura, additional, Michailidou, Kyriaki, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Dennis, Joe, additional, Ahearn, Thomas U., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Arndt, Volker, additional, Aronson, Kristan J., additional, Augustinsson, Annelie, additional, Becher, Heiko, additional, Beckmann, Matthias W., additional, Behrens, Sabine, additional, Benitez, Javier, additional, Bermisheva, Marina, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Brenner, Hermann, additional, Brucker, Sara Y., additional, Cai, Qiuyin, additional, Campa, Daniele, additional, Canzian, Federico, additional, Castelao, Jose E., additional, Chan, Tsun L., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chenevix-Trench, Georgia, additional, Choi, Ji-Yeob, additional, Clarke, Christine L., additional, Colonna, Sarah, additional, Conroy, Don M., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Daly, Mary B., additional, Devilee, Peter, additional, Dörk, Thilo, additional, Dossus, Laure, additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Ekici, Arif B., additional, Eliassen, A. Heather, additional, Engel, Christoph, additional, Fasching, Peter A., additional, Figueroa, Jonine, additional, Flyger, Henrik, additional, Gago-Dominguez, Manuela, additional, Gao, Chi, additional, García-Closas, Montserrat, additional, García-Sáenz, José A., additional, Ghoussaini, Maya, additional, Giles, Graham G., additional, Goldberg, Mark S., additional, González-Neira, Anna, additional, Guénel, Pascal, additional, Gündert, Melanie, additional, Haeberle, Lothar, additional, Hahnen, Eric, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hamann, Ute, additional, Hartman, Mikael, additional, Hatse, Sigrid, additional, Hauke, Jan, additional, Hollestelle, Antoinette, additional, Hoppe, Reiner, additional, Hopper, John L., additional, Hou, Ming-Feng, additional, Ito, Hidemi, additional, Iwasaki, Motoki, additional, Jager, Agnes, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Joseph, Vijai, additional, Jung, Audrey, additional, Kaaks, Rudolf, additional, Kang, Daehee, additional, Keeman, Renske, additional, Khusnutdinova, Elza, additional, Kim, Sung-Won, additional, Kosma, Veli-Matti, additional, Kraft, Peter, additional, Kristensen, Vessela N., additional, Kubelka-Sabit, Katerina, additional, Kurian, Allison W., additional, Kwong, Ava, additional, Lacey, James V., additional, Lambrechts, Diether, additional, Larson, Nicole L., additional, Larsson, Susanna C., additional, Le Marchand, Loic, additional, Lejbkowicz, Flavio, additional, Li, Jingmei, additional, Long, Jirong, additional, Lophatananon, Artitaya, additional, Lubiński, Jan, additional, Mannermaa, Arto, additional, Manoochehri, Mehdi, additional, Manoukian, Siranoush, additional, Margolin, Sara, additional, Matsuo, Keitaro, additional, Mavroudis, Dimitrios, additional, Mayes, Rebecca, additional, Menon, Usha, additional, Milne, Roger L., additional, Mohd Taib, Nur Aishah, additional, Muir, Kenneth, additional, Muranen, Taru A., additional, Murphy, Rachel A., additional, Nevanlinna, Heli, additional, O’Brien, Katie M., additional, Offit, Kenneth, additional, Olson, Janet E., additional, Olsson, Håkan, additional, Park, Sue K., additional, Park-Simon, Tjoung-Won, additional, Patel, Alpa V., additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Plaseska-Karanfilska, Dijana, additional, Presneau, Nadege, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Rennert, Gad, additional, Romero, Atocha, additional, Ruebner, Matthias, additional, Rüdiger, Thomas, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schmidt, Marjanka K., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Shah, Mitul, additional, Shen, Chen-Yang, additional, Shu, Xiao-Ou, additional, Simard, Jacques, additional, Southey, Melissa C., additional, Stone, Jennifer, additional, Surowy, Harald, additional, Swerdlow, Anthony J., additional, Tamimi, Rulla M., additional, Tapper, William J., additional, Taylor, Jack A., additional, Teo, Soo Hwang, additional, Teras, Lauren R., additional, Terry, Mary Beth, additional, Toland, Amanda E., additional, Tomlinson, Ian, additional, Truong, Thérèse, additional, Tseng, Chiu-Chen, additional, Untch, Michael, additional, Vachon, Celine M., additional, van den Ouweland, Ans M.W., additional, Wang, Sophia S., additional, Weinberg, Clarice R., additional, Wendt, Camilla, additional, Winham, Stacey J., additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Wu, Anna H., additional, Yamaji, Taiki, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Pharoah, Paul D.P., additional, Dunning, Alison M., additional, Easton, Douglas F., additional, Pettitt, Stephen J., additional, Lord, Christopher J., additional, Haider, Syed, additional, Orr, Nick, additional, and Fletcher, Olivia, additional

Published
2021
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10. Perturbations of genes essential for Müllerian duct and Wölffian duct development in Mayer-Rokitansky-Küster-Hauser syndrome

Author

Chen, Na, primary, Zhao, Sen, additional, Jolly, Angad, additional, Wang, Lianlei, additional, Pan, Hongxin, additional, Yuan, Jian, additional, Chen, Shaoke, additional, Koch, André, additional, Ma, Congcong, additional, Tian, Weijie, additional, Jia, Ziqi, additional, Kang, Jia, additional, Zhao, Lina, additional, Qin, Chenglu, additional, Fan, Xin, additional, Rall, Katharina, additional, Coban-Akdemir, Zeynep, additional, Chen, Zefu, additional, Jhangiani, Shalini, additional, Liang, Ze, additional, Niu, Yuchen, additional, Li, Xiaoxin, additional, Yan, Zihui, additional, Wu, Yong, additional, Dong, Shuangshuang, additional, Song, Chengcheng, additional, Qiu, Guixing, additional, Zhang, Shuyang, additional, Liu, Pengfei, additional, Posey, Jennifer E., additional, Zhang, Feng, additional, Luo, Guangnan, additional, Wu, Zhihong, additional, Su, Jianzhong, additional, Zhang, Jianguo, additional, Chen, Eugenia Y., additional, Rouskas, Konstantinos, additional, Glentis, Stavros, additional, Bacopoulou, Flora, additional, Deligeoroglou, Efthymios, additional, Chrousos, George, additional, Lyonnet, Stanislas, additional, Polak, Michel, additional, Rosenberg, Carla, additional, Dingeldein, Irene, additional, Bonilla, Ximena, additional, Borel, Christelle, additional, Gibbs, Richard A., additional, Dietrich, Jennifer E., additional, Dimas, Antigone S., additional, Antonarakis, Stylianos E., additional, Brucker, Sara Y., additional, Lupski, James R., additional, Wu, Nan, additional, Zhu, Lan, additional, Zhang, Terry Jianguo, additional, Wang, Shengru, additional, Liu, Jiaqi, additional, Liu, Sen, additional, Zuo, Yuzhi, additional, Liu, Gang, additional, Yu, Chenxi, additional, Liu, Lian, additional, Shao, Jiashen, additional, Zhao, Hengqiang, additional, Wang, Huizi, additional, Liu, Bowen, additional, Cheng, Xi, additional, Lin, Jiachen, additional, Du, Huakang, additional, Li, Yaqi, additional, Song, Shuang, additional, Xie, Zhixin, additional, Zhao, Zhengye, additional, Zhao, Zhi, additional, Zheng, Zhifa, additional, and Huang, Yingzhao, additional

Published
2021
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11. Corrigendum to “Initial experience with CDK4/6 inhibitor-based therapies compared to antihormone monotherapies in routine clinical use in patients with hormone receptor positive, HER2 negative breast cancer — Data from the PRAEGNANT research network for the first 2 years of drug availability in Germany”

Author

Schneeweiss, Andreas, primary, Ettl, Johannes, additional, Lüftner, Diana, additional, Beckmann, Matthias W., additional, Belleville, Erik, additional, Fasching, Peter A., additional, Fehm, Tanja N., additional, Geberth, Matthias, additional, Häberle, Lothar, additional, Hadji, Peyman, additional, Hartkopf, Andreas D., additional, Hielscher, Carsten, additional, Huober, Jens, additional, Ruckhäberle, Eugen, additional, Janni, Wolfgang, additional, Kolberg, Hans Christian, additional, Kurbacher, Christian M., additional, Klein, Evelyn, additional, Lux, Michael P., additional, Müller, Volkmar, additional, Nabieva, Naiba, additional, Overkamp, Friedrich, additional, Tesch, Hans, additional, Laakmann, Elena, additional, Taran, Florin-Andrei, additional, Seitz, Julia, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Wimberger, Pauline, additional, Wuerstlein, Rachel, additional, Volz, Bernhard, additional, Wallwiener, Diethelm, additional, Wallwiener, Markus, additional, and Brucker, Sara Y., additional

Published
2021
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12. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Author

Kramer, Iris, Hooning, Maartje J, Mavaddat, Nasim, Hauptmann, Michael, Keeman, Renske, Steyerberg, Ewout W, Giardiello, Daniele, Antoniou, Antonis C, Pharoah, Paul DP, Canisius, Sander, Abu-Ful, Zumuruda, Andrulis, Irene L, Anton-Culver, Hoda, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Brauch, Hiltrud, Bremer, Michael, Brucker, Sara Y, Burwinkel, Barbara, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, NBCS Collaborators, Collée, J Margriet, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hartman, Mikael, Heemskerk-Gerritsen, Bernadette AM, Hollestelle, Antoinette, Hopper, John L, Hou, Ming-Feng, Howell, Anthony, ABCTB Investigators, kConFab Investigators, Ito, Hidemi, Jakimovska, Milena, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kets, C Marleen, Khusnutdinova, Elza, Ko, Yon-Dschun, Kristensen, Vessela N, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Muranen, Taru A, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Park-Simon, Tjoung-Won, Peto, Julian, Petridis, Christos, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Pylkäs, Katri, Radice, Paolo, Rennert, Gad, Romero, Atocha, Roylance, Rebecca, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, See, Mee-Hoong, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Siesling, Sabine, Slager, Susan, Sohn, Christof, Southey, Melissa C, Spinelli, John J, Stone, Jennifer, Tapper, William J, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Tollenaar, Rob AEM, Tomlinson, Ian, Troester, Melissa A, Vachon, Celine M, van Ongeval, Chantal, van Veen, Elke M, Winqvist, Robert, Wolk, Alicja, Zheng, Wei, Ziogas, Argyrios, Easton, Douglas F, Hall, Per, Schmidt, Marjanka K, Mavaddat, Nasim [0000-0003-0307-055X], Antoniou, Antonis [0000-0001-9223-3116], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], Easton, Douglas [0000-0003-2444-3247], and Apollo - University of Cambridge Repository

Subjects
Adult, Multifactorial Inheritance, Receptor, ErbB-2, Gene Expression, Breast Neoplasms, Risk Assessment, White People, Cohort Studies, Asian People, parasitic diseases, Humans, Genetic Predisposition to Disease, Aged, Proportional Hazards Models, Genome, Human, Estrogen Receptor alpha, Neoplasms, Second Primary, Middle Aged, Prognosis, Neoadjuvant Therapy, polygenic risk score, contralateral breast cancer, epidemiology, Female, genetic, Receptors, Progesterone, Genome-Wide Association Study
Abstract

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies.

Published
2020

13. Initial experience with CDK4/6 inhibitor-based therapies compared to antihormone monotherapies in routine clinical use in patients with hormone receptor positive, HER2 negative breast cancer — Data from the PRAEGNANT research network for the first 2 years of drug availability in Germany

Author

Schneeweiss, Andreas, primary, Ettl, Johannes, additional, Lüftner, Diana, additional, Beckmann, Matthias W., additional, Belleville, Erik, additional, Fasching, Peter A., additional, Fehm, Tanja N., additional, Geberth, Matthias, additional, Häberle, Lothar, additional, Hadji, Peyman, additional, Hartkopf, Andreas D., additional, Hielscher, Carsten, additional, Huober, Jens, additional, Ruckhäberle, Eugen, additional, Janni, Wolfgang, additional, Kolberg, Hans Christian, additional, Kurbacher, Christian M., additional, Klein, Evelyn, additional, Lux, Michael P., additional, Müller, Volkmar, additional, Nabieva, Naiba, additional, Overkamp, Friedrich, additional, Tesch, Hans, additional, Laakmann, Elena, additional, Taran, Florin-Andrei, additional, Seitz, Julia, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Wimberger, Pauline, additional, Wuerstlein, Rachel, additional, Volz, Bernhard, additional, Wallwiener, Diethelm, additional, Wallwiener, Markus, additional, and Brucker, Sara Y., additional

Published
2020
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14. Mismatch repair deficiency as a predictive marker for response to adjuvant radiotherapy in endometrial cancer

Author

Reijnen, Casper, primary, Küsters-Vandevelde, Heidi V.N., additional, Prinsen, Clemens F., additional, Massuger, Leon F.A.G., additional, Snijders, Marc P.M.L., additional, Kommoss, Stefan, additional, Brucker, Sara Y., additional, Kwon, Janice S., additional, McAlpine, Jessica N., additional, and Pijnenborg, Johanna M.A., additional

Published
2019
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15. Correction: TERT promoter mutation in adult granulosa cell tumor of the ovary

Author

Pilsworth, Jessica A., primary, Cochrane, Dawn R., additional, Xia, Zhouchunyang, additional, Aubert, Geraldine, additional, Färkkilä, Anniina E.M., additional, Horlings, Hugo M., additional, Yanagida, Satoshi, additional, Yang, Winnie, additional, Lim, Jamie L.P., additional, Wang, Yi Kan, additional, Bashashati, Ali, additional, Keul, Jacqueline, additional, Wong, Adele, additional, Norris, Kevin, additional, Brucker, Sara Y., additional, Taran, Florin-Andrei, additional, Krämer, Bernhard, additional, Staebler, Annette, additional, van Meurs, Hannah, additional, Oliva, Esther, additional, Shah, Sohrab P., additional, Kommoss, Stefan, additional, Kommoss, Friedrich, additional, Gilks, C.Blake, additional, Baird, Duncan M., additional, and Huntsman, David G., additional

Published
2019
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16. Quality of life measurement in breast cancer patients: Reliability of an ePRO tool using EORTC QLQ-C30

Author

Keilmann, Lucia, primary, Matthies, Lina, additional, Simoes, Elisabeth, additional, Hartkopf, Andreas D., additional, Sokolov, Alexander N., additional, Walter, Christina B., additional, Sickenberger, Nina, additional, Wallwiener, Stephanie, additional, Feisst, Manuel, additional, Gass, Paul, additional, Fasching, Peter A., additional, Lux, Michael P., additional, Wallwiener, Diethelm, additional, Taran, Florin-Andrei, additional, Rom, Joachim, additional, Schneeweiss, Andreas, additional, Brucker, Sara Y., additional, Graf, Joachim, additional, and Wallwiener, Markus, additional

Published
2019
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17. Screening and evaluation of potential recipients and donors for living donor uterus transplantation: results from a single-center observational study

Author

Taran, Florin-Andrei, primary, Schöller, Dorit, additional, Rall, Katharina, additional, Nadalin, Silvio, additional, Königsrainer, Alfred, additional, Henes, Melanie, additional, Bösmüller, Hans, additional, Fend, Falko, additional, Nikolaou, Konstantin, additional, Notohamiprodjo, Mike, additional, Grasshoff, Christian, additional, Heim, Eckhard, additional, Zipfel, Stephan, additional, Schäffeler, Norbert, additional, Bakchoul, Tamam, additional, Heyne, Nils, additional, Guthoff, Martina, additional, Krämer, Bernhard, additional, Reisenauer, Christl, additional, Hoopmann, Markus, additional, Kagan, Karl-Oliver, additional, Brännström, Mats, additional, Wallwiener, Diethelm, additional, and Brucker, Sara Y., additional

Published
2019
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18. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Author

Mavaddat, Nasim, primary, Michailidou, Kyriaki, additional, Dennis, Joe, additional, Lush, Michael, additional, Fachal, Laura, additional, Lee, Andrew, additional, Tyrer, Jonathan P., additional, Chen, Ting-Huei, additional, Wang, Qin, additional, Bolla, Manjeet K., additional, Yang, Xin, additional, Adank, Muriel A., additional, Ahearn, Thomas, additional, Aittomäki, Kristiina, additional, Allen, Jamie, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Arndt, Volker, additional, Aronson, Kristan J., additional, Auer, Paul L., additional, Auvinen, Päivi, additional, Barrdahl, Myrto, additional, Beane Freeman, Laura E., additional, Beckmann, Matthias W., additional, Behrens, Sabine, additional, Benitez, Javier, additional, Bermisheva, Marina, additional, Bernstein, Leslie, additional, Blomqvist, Carl, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bonanni, Bernardo, additional, Børresen-Dale, Anne-Lise, additional, Brauch, Hiltrud, additional, Bremer, Michael, additional, Brenner, Hermann, additional, Brentnall, Adam, additional, Brock, Ian W., additional, Brooks-Wilson, Angela, additional, Brucker, Sara Y., additional, Brüning, Thomas, additional, Burwinkel, Barbara, additional, Campa, Daniele, additional, Carter, Brian D., additional, Castelao, Jose E., additional, Chanock, Stephen J., additional, Chlebowski, Rowan, additional, Christiansen, Hans, additional, Clarke, Christine L., additional, Collée, J. Margriet, additional, Cordina-Duverger, Emilie, additional, Cornelissen, Sten, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Daly, Mary B., additional, Devilee, Peter, additional, Dörk, Thilo, additional, dos-Santos-Silva, Isabel, additional, Dumont, Martine, additional, Durcan, Lorraine, additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Ekici, Arif B., additional, Eliassen, A. Heather, additional, Ellberg, Carolina, additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Figueroa, Jonine, additional, Fletcher, Olivia, additional, Flyger, Henrik, additional, Försti, Asta, additional, Fritschi, Lin, additional, Gabrielson, Marike, additional, Gago-Dominguez, Manuela, additional, Gapstur, Susan M., additional, García-Sáenz, José A., additional, Gaudet, Mia M., additional, Georgoulias, Vassilios, additional, Giles, Graham G., additional, Gilyazova, Irina R., additional, Glendon, Gord, additional, Goldberg, Mark S., additional, Goldgar, David E., additional, González-Neira, Anna, additional, Grenaker Alnæs, Grethe I., additional, Grip, Mervi, additional, Gronwald, Jacek, additional, Grundy, Anne, additional, Guénel, Pascal, additional, Haeberle, Lothar, additional, Hahnen, Eric, additional, Haiman, Christopher A., additional, Håkansson, Niclas, additional, Hamann, Ute, additional, Hankinson, Susan E., additional, Harkness, Elaine F., additional, Hart, Steven N., additional, He, Wei, additional, Hein, Alexander, additional, Heyworth, Jane, additional, Hillemanns, Peter, additional, Hollestelle, Antoinette, additional, Hooning, Maartje J., additional, Hoover, Robert N., additional, Hopper, John L., additional, Howell, Anthony, additional, Huang, Guanmengqian, additional, Humphreys, Keith, additional, Hunter, David J., additional, Jakimovska, Milena, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Johnson, Nichola, additional, Jones, Michael E., additional, Jukkola-Vuorinen, Arja, additional, Jung, Audrey, additional, Kaaks, Rudolf, additional, Kaczmarek, Katarzyna, additional, Kataja, Vesa, additional, Keeman, Renske, additional, Kerin, Michael J., additional, Khusnutdinova, Elza, additional, Kiiski, Johanna I., additional, Knight, Julia A., additional, Ko, Yon-Dschun, additional, Kosma, Veli-Matti, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Krüger, Ute, additional, Kühl, Tabea, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lilyquist, Jenna, additional, Lindblom, Annika, additional, Lindström, Sara, additional, Lissowska, Jolanta, additional, Lo, Wing-Yee, additional, Loibl, Sibylle, additional, Long, Jirong, additional, Lubiński, Jan, additional, Lux, Michael P., additional, MacInnis, Robert J., additional, Maishman, Tom, additional, Makalic, Enes, additional, Maleva Kostovska, Ivana, additional, Mannermaa, Arto, additional, Manoukian, Siranoush, additional, Margolin, Sara, additional, Martens, John W.M., additional, Martinez, Maria Elena, additional, Mavroudis, Dimitrios, additional, McLean, Catriona, additional, Meindl, Alfons, additional, Menon, Usha, additional, Middha, Pooja, additional, Miller, Nicola, additional, Moreno, Fernando, additional, Mulligan, Anna Marie, additional, Mulot, Claire, additional, Muñoz-Garzon, Victor M., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Neven, Patrick, additional, Newman, William G., additional, Nielsen, Sune F., additional, Nordestgaard, Børge G., additional, Norman, Aaron, additional, Offit, Kenneth, additional, Olson, Janet E., additional, Olsson, Håkan, additional, Orr, Nick, additional, Pankratz, V. Shane, additional, Park-Simon, Tjoung-Won, additional, Perez, Jose I.A., additional, Pérez-Barrios, Clara, additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Pinchev, Mila, additional, Plaseska-Karanfilska, Dijana, additional, Polley, Eric C., additional, Prentice, Ross, additional, Presneau, Nadege, additional, Prokofyeva, Darya, additional, Purrington, Kristen, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Radice, Paolo, additional, Rau-Murthy, Rohini, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, Rhenius, Valerie, additional, Robson, Mark, additional, Romero, Atocha, additional, Ruddy, Kathryn J., additional, Ruebner, Matthias, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schmidt, Daniel F., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Schumacher, Fredrick, additional, Schürmann, Peter, additional, Schwentner, Lukas, additional, Scott, Christopher, additional, Scott, Rodney J., additional, Seynaeve, Caroline, additional, Shah, Mitul, additional, Sherman, Mark E., additional, Shrubsole, Martha J., additional, Shu, Xiao-Ou, additional, Slager, Susan, additional, Smeets, Ann, additional, Sohn, Christof, additional, Soucy, Penny, additional, Southey, Melissa C., additional, Spinelli, John J., additional, Stegmaier, Christa, additional, Stone, Jennifer, additional, Swerdlow, Anthony J., additional, Tamimi, Rulla M., additional, Tapper, William J., additional, Taylor, Jack A., additional, Terry, Mary Beth, additional, Thöne, Kathrin, additional, Tollenaar, Rob A.E.M., additional, Tomlinson, Ian, additional, Truong, Thérèse, additional, Tzardi, Maria, additional, Ulmer, Hans-Ulrich, additional, Untch, Michael, additional, Vachon, Celine M., additional, van Veen, Elke M., additional, Vijai, Joseph, additional, Weinberg, Clarice R., additional, Wendt, Camilla, additional, Whittemore, Alice S., additional, Wildiers, Hans, additional, Willett, Walter, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Yang, Xiaohong R., additional, Yannoukakos, Drakoulis, additional, Zhang, Yan, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Dunning, Alison M., additional, Thompson, Deborah J., additional, Chenevix-Trench, Georgia, additional, Chang-Claude, Jenny, additional, Schmidt, Marjanka K., additional, Hall, Per, additional, Milne, Roger L., additional, Pharoah, Paul D.P., additional, Antoniou, Antonis C., additional, Chatterjee, Nilanjan, additional, Kraft, Peter, additional, García-Closas, Montserrat, additional, Simard, Jacques, additional, and Easton, Douglas F., additional

Published
2019
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19. TERT promoter mutation in adult granulosa cell tumor of the ovary

Author

Pilsworth, Jessica A., primary, Cochrane, Dawn R., additional, Xia, Zhouchunyang, additional, Aubert, Geraldine, additional, Färkkilä, Anniina E.M., additional, Horlings, Hugo M., additional, Yanagida, Satoshi, additional, Yang, Winnie, additional, Lim, Jamie L.P., additional, Wang, Yi Kan, additional, Bashashati, Ali, additional, Keul, Jacqueline, additional, Wong, Adele, additional, Norris, Kevin, additional, Brucker, Sara Y., additional, Taran, Florin-Andrei, additional, Krämer, Bernhard, additional, Staebler, Annette, additional, van Meurs, Hannah, additional, Oliva, Esther, additional, Shah, Sohrab P., additional, Kommoss, Stefan, additional, Kommoss, Friedrich, additional, Gilks, C. Blake, additional, Baird, Duncan M., additional, and Huntsman, David G., additional

Published
2018
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21. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Author

Block, Matthew S., primary, Vierkant, Robert A., additional, Rambau, Peter F., additional, Winham, Stacey J., additional, Wagner, Philipp, additional, Traficante, Nadia, additional, Tołoczko, Aleksandra, additional, Tiezzi, Daniel G., additional, Taran, Florin Andrei, additional, Sinn, Peter, additional, Sieh, Weiva, additional, Sharma, Raghwa, additional, Rothstein, Joseph H., additional, Ramón y Cajal, Teresa, additional, Paz-Ares, Luis, additional, Oszurek, Oleg, additional, Orsulic, Sandra, additional, Ness, Roberta B., additional, Nelson, Gregg, additional, Modugno, Francesmary, additional, Menkiszak, Janusz, additional, McGuire, Valerie, additional, McCauley, Bryan M., additional, Mack, Marie, additional, Lubiński, Jan, additional, Longacre, Teri A., additional, Li, Zheng, additional, Lester, Jenny, additional, Kennedy, Catherine J., additional, Kalli, Kimberly R., additional, Jung, Audrey Y., additional, Johnatty, Sharon E., additional, Jimenez-Linan, Mercedes, additional, Jensen, Allan, additional, Intermaggio, Maria P., additional, Hung, Jillian, additional, Herpel, Esther, additional, Hernandez, Brenda Y., additional, Hartkopf, Andreas D., additional, Harnett, Paul R., additional, Ghatage, Prafull, additional, García-Bueno, José M., additional, Gao, Bo, additional, Fereday, Sian, additional, Eilber, Ursula, additional, Edwards, Robert P., additional, de Sousa, Christiani B., additional, de Andrade, Jurandyr M., additional, Chudecka-Głaz, Anita, additional, Chenevix-Trench, Georgia, additional, Cazorla, Alicia, additional, Brucker, Sara Y., additional, Alsop, Jennifer, additional, Whittemore, Alice S., additional, Steed, Helen, additional, Staebler, Annette, additional, Moysich, Kirsten B., additional, Menon, Usha, additional, Koziak, Jennifer M., additional, Kommoss, Stefan, additional, Kjaer, Susanne K., additional, Kelemen, Linda E., additional, Karlan, Beth Y., additional, Huntsman, David G., additional, Høgdall, Estrid, additional, Gronwald, Jacek, additional, Goodman, Marc T., additional, Gilks, Blake, additional, García, María José, additional, Fasching, Peter A., additional, de Fazio, Anna, additional, Deen, Suha, additional, Chang-Claude, Jenny, additional, Candido dos Reis, Francisco J., additional, Campbell, Ian G., additional, Brenton, James D., additional, Bowtell, David D., additional, Benítez, Javier, additional, Pharoah, Paul D.P., additional, Köbel, Martin, additional, Ramus, Susan J., additional, Goode, Ellen L., additional, Bowtell, D., additional, Chenevix-Trench, G., additional, Green, A., additional, Webb, P., additional, DeFazio, A., additional, Gertig, D., additional, Traficante, N., additional, Fereday, S., additional, Moore, S., additional, Hung, J., additional, Harrap, K., additional, Sadkowsky, T., additional, Pandeya, N., additional, Malt, M., additional, Mellon, A., additional, Robertson, R., additional, Vanden Bergh, T., additional, Jones, M., additional, Mackenzie, P., additional, Maidens, J., additional, Nattress, K., additional, Chiew, Y.E., additional, Stenlake, A., additional, Sullivan, H., additional, Alexander, B., additional, Ashover, P., additional, Brown, S., additional, Corrish, T., additional, Green, L., additional, Jackman, L., additional, Ferguson, K., additional, Martin, K., additional, Martyn, A., additional, Ranieri, B., additional, White, J., additional, Jayde, V., additional, Mamers, P., additional, Bowes, L., additional, Galletta, L., additional, Giles, D., additional, Hendley, J., additional, Alsop, K., additional, Schmidt, T., additional, Shirley, H., additional, Ball, C., additional, Young, C., additional, Viduka, S., additional, Tran, Hoa, additional, Bilic, Sanela, additional, Glavinas, Lydia, additional, Brooks, Julia, additional, Stuart-Harris, R., additional, Kirsten, F., additional, Rutovitz, J., additional, Clingan, P., additional, Glasgow, A., additional, Proietto, A., additional, Braye, S., additional, Otton, G., additional, Shannon, J., additional, Bonaventura, T., additional, Stewart, J., additional, Begbie, S., additional, Friedlander, M., additional, Bell, D., additional, Baron-Hay, S., additional, Ferrier, A., additional, Gard, G., additional, Nevell, D., additional, Pavlakis, N., additional, Valmadre, S., additional, Young, B., additional, Camaris, C., additional, Crouch, R., additional, Edwards, L., additional, Hacker, N., additional, Marsden, D., additional, Robertson, G., additional, Beale, P., additional, Beith, J., additional, Carter, J., additional, Dalrymple, C., additional, Houghton, R., additional, Russell, P., additional, Links, M., additional, Grygiel, J., additional, Hill, J., additional, Brand, A., additional, Byth, K., additional, Jaworski, R., additional, Harnett, P., additional, Sharma, R., additional, Wain, G., additional, Ward, B., additional, Papadimos, D., additional, Crandon, A., additional, Cummings, M., additional, Horwood, K., additional, Obermair, A., additional, Perrin, L., additional, Wyld, D., additional, Nicklin, J., additional, Davy, M., additional, Oehler, M.K., additional, Hall, C., additional, Dodd, T., additional, Healy, T., additional, Pittman, K., additional, Henderson, D., additional, Miller, J., additional, Pierdes, J., additional, Blomfield, P., additional, Challis, D., additional, McIntosh, R., additional, Parker, A., additional, Brown, B., additional, Rome, R., additional, Allen, D., additional, Grant, P., additional, Hyde, S., additional, Laurie, R., additional, Robbie, M., additional, Healy, D., additional, Jobling, T., additional, Manolitsas, T., additional, McNealage, J., additional, Rogers, P., additional, Susil, B., additional, Sumithran, E., additional, Simpson, I., additional, Phillips, K., additional, Rischin, D., additional, Fox, S., additional, Johnson, D., additional, Lade, S., additional, Loughrey, M., additional, O'Callaghan, N., additional, Murray, W., additional, Waring, P., additional, Billson, V., additional, Pyman, J., additional, Neesham, D., additional, Quinn, M., additional, Underhill, C., additional, Bell, R., additional, Ng, L.F., additional, Blum, R., additional, Ganju, V., additional, Hammond, I., additional, Leung, Y., additional, McCartney, A., additional, Buck, M., additional, Haviv, I., additional, Purdie, D., additional, Whiteman, D., additional, and Zeps, N., additional

Published
2018
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22. Treatment landscape of advanced breast cancer patients with hormone receptor positive HER2 negative tumors – Data from the German PRAEGNANT breast cancer registry

Author

Hartkopf, Andreas D., primary, Huober, Jens, additional, Volz, Bernhard, additional, Nabieva, Naiba, additional, Taran, Florin-Andrei, additional, Schwitulla, Judith, additional, Overkamp, Friedrich, additional, Kolberg, Hans-Christian, additional, Hadji, Peyman, additional, Tesch, Hans, additional, Häberle, Lothar, additional, Ettl, Johannes, additional, Lux, Michael P., additional, Lüftner, Diana, additional, Wallwiener, Markus, additional, Müller, Volkmar, additional, Beckmann, Matthias W., additional, Belleville, Erik, additional, Wimberger, Pauline, additional, Hielscher, Carsten, additional, Geberth, Matthias, additional, Fersis, Nikos, additional, Abenhardt, Wolfgang, additional, Kurbacher, Christian, additional, Wuerstlein, Rachel, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Fehm, Tanja N., additional, Wallwiener, Diethelm, additional, Brucker, Sara Y., additional, and Schneeweiss, Andreas, additional

Published
2018
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23. Impact of disease progression on health-related quality of life in patients with metastatic breast cancer in the PRAEGNANT breast cancer registry

Author

Müller, Volkmar, primary, Nabieva, Naiba, additional, Häberle, Lothar, additional, Taran, Florin-Andrei, additional, Hartkopf, Andreas D., additional, Volz, Bernhard, additional, Overkamp, Friedrich, additional, Brandl, Anna Lisa, additional, Kolberg, Hans-Christian, additional, Hadji, Peyman, additional, Tesch, Hans, additional, Ettl, Johannes, additional, Lux, Michael P., additional, Lüftner, Diana, additional, Belleville, Erik, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Beckmann, Matthias W., additional, Wimberger, Pauline, additional, Hielscher, Carsten, additional, Fehm, Tanja N., additional, Brucker, Sara Y., additional, Wallwiener, Diethelm, additional, Schneeweiss, Andreas, additional, and Wallwiener, Markus, additional

Published
2018
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33. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Author

Block, Matthew S, Vierkant, Robert A, Rambau, Peter F, Winham, Stacey J, Wagner, Philipp, Traficante, Nadia, Tołoczko, Aleksandra, Tiezzi, Daniel G, Taran, Florin Andrei, Sinn, Peter, Sieh, Weiva, Sharma, Raghwa, Rothstein, Joseph H, Ramón Y Cajal, Teresa, Paz-Ares, Luis, Oszurek, Oleg, Orsulic, Sandra, Ness, Roberta B, Nelson, Gregg, Modugno, Francesmary, Menkiszak, Janusz, McGuire, Valerie, McCauley, Bryan M, Mack, Marie, Lubiński, Jan, Longacre, Teri A, Li, Zheng, Lester, Jenny, Kennedy, Catherine J, Kalli, Kimberly R, Jung, Audrey Y, Johnatty, Sharon E, Jimenez-Linan, Mercedes, Jensen, Allan, Intermaggio, Maria P, Hung, Jillian, Herpel, Esther, Hernandez, Brenda Y, Hartkopf, Andreas D, Harnett, Paul R, Ghatage, Prafull, García-Bueno, José M, Gao, Bo, Fereday, Sian, Eilber, Ursula, Edwards, Robert P, De Sousa, Christiani B, De Andrade, Jurandyr M, Chudecka-Głaz, Anita, Chenevix-Trench, Georgia, Cazorla, Alicia, Brucker, Sara Y, Australian Ovarian Cancer Study Group, Alsop, Jennifer, Whittemore, Alice S, Steed, Helen, Staebler, Annette, Moysich, Kirsten B, Menon, Usha, Koziak, Jennifer M, Kommoss, Stefan, Kjaer, Susanne K, Kelemen, Linda E, Karlan, Beth Y, Huntsman, David G, Høgdall, Estrid, Gronwald, Jacek, Goodman, Marc T, Gilks, Blake, García, María José, Fasching, Peter A, De Fazio, Anna, Deen, Suha, Chang-Claude, Jenny, Candido Dos Reis, Francisco J, Campbell, Ian G, Brenton, James D, Bowtell, David D, Benítez, Javier, Pharoah, Paul DP, Köbel, Martin, Ramus, Susan J, and Goode, Ellen L

Subjects
Adult, Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Middle Aged, Immunohistochemistry, Survival Analysis, 3. Good health, Toll-Like Receptor 4, Tissue Array Analysis, Myeloid Differentiation Factor 88, Biomarkers, Tumor, Humans, Female, Aged
Abstract

OBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). RESULTS: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P

34. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Author

Baxter, Joseph S, Johnson, Nichola, Tomczyk, Katarzyna, Gillespie, Andrea, Maguire, Sarah, Brough, Rachel, Fachal, Laura, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Brucker, Sara Y, Cai, Qiuyin, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, NBCS Collaborators, Colonna, Sarah, Conroy, Don M, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Chi, García-Closas, Montserrat, García-Sáenz, José A, Ghoussaini, Maya, Giles, Graham G, Goldberg, Mark S, González-Neira, Anna, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hartman, Mikael, Hatse, Sigrid, Hauke, Jan, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Hou, Ming-Feng, KConFab Investigators, ABCTB Investigators, Ito, Hidemi, Iwasaki, Motoki, Jager, Agnes, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Joseph, Vijai, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Keeman, Renske, Khusnutdinova, Elza, Kim, Sung-Won, Kosma, Veli-Matti, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, Lacey, James V, Lambrechts, Diether, Larson, Nicole L, Larsson, Susanna C, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Jingmei, Long, Jirong, Lophatananon, Artitaya, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Mayes, Rebecca, Menon, Usha, Milne, Roger L, Mohd Taib, Nur Aishah, Muir, Kenneth, Muranen, Taru A, Murphy, Rachel A, Nevanlinna, Heli, O'Brien, Katie M, Offit, Kenneth, Olson, Janet E, Olsson, Håkan, Park, Sue K, Park-Simon, Tjoung-Won, Patel, Alpa V, Peterlongo, Paolo, Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Pylkäs, Katri, Rack, Brigitte, Rennert, Gad, Romero, Atocha, Ruebner, Matthias, Rüdiger, Thomas, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Schneeweiss, Andreas, Schoemaker, Minouk J, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C, Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Tapper, William J, Taylor, Jack A, Teo, Soo Hwang, Teras, Lauren R, Terry, Mary Beth, Toland, Amanda E, Tomlinson, Ian, Truong, Thérèse, Tseng, Chiu-Chen, Untch, Michael, Vachon, Celine M, Van Den Ouweland, Ans MW, Wang, Sophia S, Weinberg, Clarice R, Wendt, Camilla, Winham, Stacey J, Winqvist, Robert, Wolk, Alicja, Wu, Anna H, Yamaji, Taiki, Zheng, Wei, Ziogas, Argyrios, Pharoah, Paul DP, Dunning, Alison M, Easton, Douglas F, Pettitt, Stephen J, Lord, Christopher J, Haider, Syed, Orr, Nick, and Fletcher, Olivia

Subjects
Chromosome Mapping, Genetic Variation, Breast Neoplasms, Molecular Sequence Annotation, functional annotation, 3. Good health, Cell Line, breast cancer risk, risk locus, Risk Factors, Chromosomes, Human, Pair 2, Humans, Female, CRISPR-Cas Systems, Insulin-Like Growth Factor Binding Protein 5, Promoter Regions, Genetic, Genetic Association Studies, Sequence Deletion
Abstract

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74-0.81, p = 3.1 × 10-31).

35. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Author

Kramer, Iris, Hooning, Maartje J, Mavaddat, Nasim, Hauptmann, Michael, Keeman, Renske, Steyerberg, Ewout W, Giardiello, Daniele, Antoniou, Antonis C, Pharoah, Paul DP, Canisius, Sander, Abu-Ful, Zumuruda, Andrulis, Irene L, Anton-Culver, Hoda, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Brauch, Hiltrud, Bremer, Michael, Brucker, Sara Y, Burwinkel, Barbara, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, NBCS Collaborators, Collée, J Margriet, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hartman, Mikael, Heemskerk-Gerritsen, Bernadette AM, Hollestelle, Antoinette, Hopper, John L, Hou, Ming-Feng, Howell, Anthony, ABCTB Investigators, KConFab Investigators, Ito, Hidemi, Jakimovska, Milena, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kets, C Marleen, Khusnutdinova, Elza, Ko, Yon-Dschun, Kristensen, Vessela N, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Muranen, Taru A, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Park-Simon, Tjoung-Won, Peto, Julian, Petridis, Christos, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Pylkäs, Katri, Radice, Paolo, Rennert, Gad, Romero, Atocha, Roylance, Rebecca, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, See, Mee-Hoong, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Siesling, Sabine, Slager, Susan, Sohn, Christof, Southey, Melissa C, Spinelli, John J, Stone, Jennifer, Tapper, William J, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Tollenaar, Rob AEM, Tomlinson, Ian, Troester, Melissa A, Vachon, Celine M, Van Ongeval, Chantal, Van Veen, Elke M, Winqvist, Robert, Wolk, Alicja, Zheng, Wei, Ziogas, Argyrios, Easton, Douglas F, Hall, Per, and Schmidt, Marjanka K

Subjects
Adult, Multifactorial Inheritance, Receptor, ErbB-2, Gene Expression, Breast Neoplasms, Risk Assessment, White People, Cohort Studies, Asian People, parasitic diseases, Humans, Genetic Predisposition to Disease, Aged, Proportional Hazards Models, Genome, Human, Estrogen Receptor alpha, Neoplasms, Second Primary, Middle Aged, Prognosis, Neoadjuvant Therapy, 3. Good health, polygenic risk score, contralateral breast cancer, epidemiology, Female, genetic, Receptors, Progesterone, Genome-Wide Association Study
Abstract

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies.

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