Search

Pure diasteriomers, obtained simply and directly by reaction of hypophosphorous acid salts of (R)(+) or (S)(−) - N-α-methylbenzylamine with aldehydes, can be simultaneously deprotected and oxidised in one step to provide a highly convenient synthesis of α - aminophosphonic acids in high optical purity.

Serine phosphonate isosteres (7), suitably protected for direct use in peptide synthesis, have been prepared from vinylphosphonate diesters in three steps and high overall yield.

A 3-step synthesis to the title compounds has been developed which provides them differentially protected at nitrogen. These could then be selectively deprotected using hydrazine hydrate or hydrogenolysis over Pd/C.

A statistical mechanical analysis of an isotropic, spatially frustrated Ising model is presented. Information from Monte Carlo simulation, low-temperature series and the ϵ-expansion is used to construct the global phase diagram of the model. Whilst this combination of statistical mechanical techniques has been helpful, we also stress the limitations in studies of this type. We discuss the techniques of parallelization and vectorization as applied to simulations of lattice spin models. Where possible, we have made suggestions which may be of help in further elucidating the properties of the lattice model of microemulsions.