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17 results on '"Bradshaw, Aaron"'

2. Morphometric and immunohistochemical analysis as a method to identify undifferentiated spermatogonial cells in adult subjects with Klinefelter syndrome: a cohort study

Author

Deebel, Nicholas A., primary, Soltanghoraee, Haleh, additional, Bradshaw, Aaron William, additional, Abdelaal, Omar, additional, Reynolds, Karl, additional, Howards, Stuart, additional, Kogan, Stanley, additional, Sadeghi, Mohammad Reza, additional, Atala, Anthony, additional, Stogner-Underwood, Kimberly, additional, and Sadri-Ardekani, Hooman, additional

Published
2022
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3. Impact of Metastasectomy on Cancer Specific and Overall Survival in Metastatic Renal Cell Carcinoma: Analysis of the REMARCC Registry

Author

Meagher, Margaret F., primary, Mir, Maria C, additional, Autorino, Riccardo, additional, Minervini, Andrea, additional, Kriegmair, Maximilian, additional, Maurer, Tobias, additional, Porpiglia, Francesco, additional, Van Bruwaene, Siska, additional, Linares, Estefania, additional, Hevia, Vital, additional, Musquera, Mireia, additional, Roussel, Eduard, additional, Pavan, Nicola, additional, Antonelli, Alessandro, additional, Zhang, Shudong, additional, Ghali, Fady, additional, Patel, Devin, additional, Javier-Desloges, Juan, additional, Bradshaw, Aaron, additional, Rubio, Jose, additional, Guruli, Georgi, additional, Tracey, Andrew, additional, Campi, Riccardo, additional, Albersen, Maarten, additional, Furlan, Maria, additional, McKay, Rana R., additional, and Derweesh, Ithaar H., additional

Published
2022
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4. Disparities in Cancer Specific and Overall Survival Outcomes in African Americans With Renal Cell Carcinoma: Analysis From the International Marker Consortium for Renal Cancer (INMARC)

Author

Meagher, Margaret F., primary, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Javier-Desloges, Juan F., additional, Bradshaw, Aaron W., additional, Patel, Sunil H., additional, Cotta, Brittney H., additional, Yasuda, Yosuke, additional, Eldefrawy, Ahmed, additional, Ghali, Fady, additional, Nasseri, Ryan, additional, Wan, Fang, additional, Fujii, Yasuhisa, additional, Master, Viraj, additional, and Derweesh, Ithaar H., additional

Published
2022
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5. Corrigendum to ‘Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)’ [European Urology Oncology 3 (2021) 256–263]

Author

Marchioni, Michele, primary, Kriegmair, Maximilian, additional, Heck, Mathias, additional, Amiel, Thomas, additional, Porpiglia, Francesco, additional, Checcucci, Enrico, additional, Campi, Riccardo, additional, Minervini, Andrea, additional, Mari, Andrea, additional, Van Bruwaene, Siska, additional, Linares, Estefania, additional, Hevia, Vital, additional, Musquera, Mireia, additional, D’Anna, Mauricio, additional, Derweesh, Ithaar, additional, Bradshaw, Aaron, additional, Autorino, Riccardo, additional, Guruli, Georgi, additional, Veccia, Alessandro, additional, Roussel, Eduard, additional, Albersen, Maarten, additional, Pavan, Nicola, additional, Claps, Francesco, additional, Antonelli, Alessandro, additional, Palumbo, Carlotta, additional, Klatte, Tobias, additional, Erdem, Selcuk, additional, and Carmen Mir, Maria, additional

Published
2021
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6. Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)

Author

Marchioni, Michele, primary, Kriegmair, Maximilian, additional, Heck, Mathias, additional, Amiel, Thomas, additional, Porpiglia, Francesco, additional, Ceccucci, Enrico, additional, Campi, Riccardo, additional, Minervini, Andrea, additional, Mari, Andrea, additional, Van Bruwaene, Siska, additional, Linares, Estefania, additional, Hevia, Vital, additional, Musquera, Mireia, additional, D’Anna, Mauricio, additional, Derweesh, Ithaar, additional, Bradshaw, Aaron, additional, Autorino, Riccardo, additional, Guruli, Georgi, additional, Veccia, Alessandro, additional, Roussel, Eduard, additional, Albersen, Maarten, additional, Pavan, Nicola, additional, Claps, Francesco, additional, Antonelli, Alessandro, additional, Palumbo, Carlotta, additional, Klatte, Tobias, additional, Erdem, Selcuk, additional, and Mir, Maria Carmen, additional

Published
2021
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7. Oncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis

Author

Patel, Sunil H., primary, Uzzo, Robert G., additional, Larcher, Alessandro, additional, Peyronnet, Benoit, additional, Lane, Brian R., additional, Pruthi, Deepak, additional, Reddy, Madhumitha, additional, Capitanio, Umberto, additional, Joshi, Shreyas, additional, Noyes, Sabrina, additional, Eldefrawy, Ahmed, additional, Ghali, Fady, additional, Meagher, Margaret F., additional, Hamilton, Zachary A., additional, Yim, Kendrick, additional, Nasseri, Ryan, additional, Bradshaw, Aaron W., additional, Dey, Sumi, additional, Kirmiz, Samer, additional, Wan, Fang, additional, Liss, Michael A., additional, Bensalah, Karim, additional, Montorsi, Francesco, additional, and Derweesh, Ithaar H., additional

Published
2020
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9. Rates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma

Author

Roussel, Eduard, primary, Campi, Riccardo, additional, Larcher, Alessandro, additional, Verbiest, Annelies, additional, Antonelli, Alessandro, additional, Palumbo, Carlotta, additional, Derweesh, Ithaar, additional, Ghali, Fady, additional, Bradshaw, Aaron, additional, Meagher, Margaret F., additional, Heck, Matthias, additional, Amiel, Thomas, additional, Kriegmair, Maximilian C., additional, Rubio, Jose, additional, Musquera, Mireia, additional, D’Anna, Maurizio, additional, Autorino, Riccardo, additional, Guruli, Georgi, additional, Veccia, Alessandro, additional, Linares-Espinos, Estefania, additional, Van Bruwaene, Siska, additional, Hevia, Vital, additional, Porpiglia, Francesco, additional, Checcucci, Enrico, additional, Minervini, Andrea, additional, Mari, Andrea, additional, Pavan, Nicola, additional, Claps, Francesco, additional, Marchioni, Michele, additional, Capitanio, Umberto, additional, Beuselinck, Benoit, additional, Mir, Maria C., additional, and Albersen, Maarten, additional

Published
2020
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10. Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria

Author

Hamilton, Zachary A., primary, Capitanio, Umberto, additional, Pruthi, Deepak, additional, Ghali, Fady, additional, Larcher, Alessandro, additional, Patel, Devin N., additional, Eldefrawy, Ahmed, additional, Patel, Sunil, additional, Cotta, Brittney H., additional, Bradshaw, Aaron W., additional, Meagher, Margaret F., additional, Miller, Nathan S., additional, Carenzi, Cristina, additional, Wan, Fang, additional, Liss, Michael A., additional, McGregor, Thomas, additional, Montorsi, Francesco, additional, and Derweesh, Ithaar H., additional

Published
2020
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11. Upstaging to pT3a disease in patients undergoing robotic partial nephrectomy for cT1 kidney cancer: Outcomes and predictors from a multi-institutional dataset

Author

Veccia, Alessandro, primary, Antonelli, Alessandro, additional, Minervini, Andrea, additional, Mottrie, Alexandre, additional, Dell'Oglio, Paolo, additional, Ashrafi, Akbar N., additional, Larcher, Alessandro, additional, Eun, Daniel, additional, Bradshaw, Aaron, additional, Amparore, Daniele, additional, Brassetti, Aldo, additional, Hampton, Lance J., additional, Simeone, Claudio, additional, Mari, Andrea, additional, Carini, Marco, additional, De Naeyer, Geert, additional, Yang, Kevin, additional, Capitanio, Umberto, additional, Simone, Giuseppe, additional, Porpiglia, Francesco, additional, Derweesh, Ithaar, additional, Aron, Monish, additional, and Autorino, Riccardo, additional

Published
2020
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15. Using electrical, magnetic and acoustic sensors to detect damage in segmental concrete pipes subjected to permanent ground displacement

Author

Pour-Ghaz, Mohammad, primary, Kim, Junhee, additional, Nadukuru, Srinivasa S., additional, O’Connor, Sean M., additional, Michalowski, Radoslaw L., additional, Bradshaw, Aaron S., additional, Green, Russell A., additional, Lynch, Jerome P., additional, Poursaee, Amir, additional, and Jason Weiss, W., additional

Published
2011
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16. Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)

Author

Michele Marchioni, Francesco Claps, Andrea Minervini, Andrea Mari, Nicola Pavan, Mathias Heck, C. Palumbo, Maarten Albersen, Tobias Klatte, Eduard Roussel, Mireia Musquera, Georgi Guruli, Mauricio D'Anna, Estefania Linares, Alessandro Antonelli, Selcuk Erdem, Ithaar Derweesh, Enrico Ceccucci, Thomas Amiel, Vital Hevia, Alessandro Veccia, Francesco Porpiglia, Riccardo Campi, Aaron Bradshaw, Maria Carmen Mir, Siska Van Bruwaene, Maximilian C. Kriegmair, Riccardo Autorino, Marchioni, Michele, Kriegmair, Maximilian, Heck, Mathia, Amiel, Thoma, Porpiglia, Francesco, Ceccucci, Enrico, Campi, Riccardo, Minervini, Andrea, Mari, Andrea, Van Bruwaene, Siska, Linares, Estefania, Hevia, Vital, Musquera, Mireia, D'Anna, Mauricio, Derweesh, Ithaar, Bradshaw, Aaron, Autorino, Riccardo, Guruli, Georgi, Veccia, Alessandro, Roussel, Eduard, Albersen, Maarten, Pavan, Nicola, Claps, Francesco, Antonelli, Alessandro, Palumbo, Carlotta, Klatte, Tobia, Erdem, Selcuk, and Mir, Maria Carmen

Subjects
Oncology, Metastasis, Prognostic score, Renal neoplasm, Total nephrectomy, medicine.medical_specialty, Scoring system, Urology, 030232 urology & nephrology, Disease, Metastasi, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Interquartile range, Renal cell carcinoma, Internal medicine, Mean Survival Time, medicine, Humans, Radiology, Nuclear Medicine and imaging, Registries, Cytoreductive nephrectomy, Carcinoma, Renal Cell, Retrospective Studies, Framingham Risk Score, business.industry, Cytoreduction Surgical Procedures, medicine.disease, Kidney Neoplasms, 030220 oncology & carcinogenesis, Surgery, business
Abstract

BACKGROUND: Selection of patients for upfront cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) has to be improved. OBJECTIVE: To evaluate a new scoring system for the prediction of overall mortality (OM) in mRCC patients undergoing CN. DESIGN, SETTING, AND PARTICIPANTS: We identified a total of 519 patients with synchronous mRCC undergoing CN between 2005 and 2019 from a multi-institutional registry (Registry for Metastatic RCC [REMARCC]). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Cox proportional hazard regression was used to test the main predictors of OM. Restricted mean survival time was estimated as a measure of the average overall survival time up to 36 mo of follow-up. The concordance index (C-index) was used to determine the model's discrimination. Decision curve analyses were used to compare the net benefit from the REMARCC model with International mRCC Database Consortium (IMDC) or Memorial Sloan Kettering Cancer Center (MSKCC) risk scores. RESULTS AND LIMITATIONS: The median follow-up period was 18 mo (interquartile range: 5.9-39.7). Our models showed lower mortality rates in obese patients (p = 0.007). Higher OM rates were recorded in those with bone (p = 0.010), liver (p = 0.002), and lung metastases (p < 0.001). Those with poor performance status (

Published
2021

17. Rates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma

Author

Francesco Porpiglia, Mireia Musquera, Georgi Guruli, Maurizio D'Anna, Maarten Albersen, Alessandro Antonelli, Estefanía Linares-Espinós, Andrea Minervini, Riccardo Campi, Carlotta Palumbo, Aaron Bradshaw, Alessandro Larcher, Thomas Amiel, Maria Carmen Mir, Siska Van Bruwaene, Enrico Checcucci, Annelies Verbiest, Eduard Roussel, Nicola Pavan, Vital Hevia, Alessandro Veccia, Andrea Mari, J. Rubio, Benoit Beuselinck, Umberto Capitanio, Michele Marchioni, Francesco Claps, Matthias Heck, Margaret Meagher, Ithaar Derweesh, Maximilian C. Kriegmair, Riccardo Autorino, Fady Ghali, Roussel, Eduard, Campi, Riccardo, Larcher, Alessandro, Verbiest, Annelie, Antonelli, Alessandro, Palumbo, Carlotta, Derweesh, Ithaar, Ghali, Fady, Bradshaw, Aaron, Meagher, Margaret F, Heck, Matthia, Amiel, Thoma, Kriegmair, Maximilian C, Rubio, Jose, Musquera, Mireia, D'Anna, Maurizio, Autorino, Riccardo, Guruli, Georgi, Veccia, Alessandro, Linares-Espinos, Estefania, Van Bruwaene, Siska, Hevia, Vital, Porpiglia, Francesco, Checcucci, Enrico, Minervini, Andrea, Mari, Andrea, Pavan, Nicola, Claps, Francesco, Marchioni, Michele, Capitanio, Umberto, Beuselinck, Benoit, Mir, Maria C, and Albersen, Maarten

Subjects
Male, medicine.medical_specialty, Complications, Urology, medicine.medical_treatment, Metastatic renal cell carcinoma, 030232 urology & nephrology, Logistic regression, Nephrectomy, Targeted therapy, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Cytoreductive nephrectomy, Renal cell carcinoma, medicine, Humans, Radiology, Nuclear Medicine and imaging, Registries, Mortality, Adverse effect, Carcinoma, Renal Cell, Aged, Retrospective Studies, business.industry, Cytoreduction Surgical Procedures, Perioperative, Odds ratio, Middle Aged, Morbidity, Surgery, Prognosis, medicine.disease, Kidney Neoplasms, Confidence interval, Oncology, 030220 oncology & carcinogenesis, Female, business, Complication
Abstract

Background Cytoreductive nephrectomy (CN) plays an important role in the treatment of a subgroup of metastatic renal cell carcinoma (mRCC) patients. Objective We aimed to evaluate morbidity associated with this procedure and identify potential predictors thereof to aid patient selection for this procedure and potentially improve patient outcomes. Design, setting, and participants Data from 736 mRCC patients undergoing CN at 14 institutions were retrospectively recorded in the Registry for Metastatic RCC (REMARCC). Outcome measurements and statistical analysis Logistic regression analysis was used to identify predictors for intraoperative, any-grade (AGCs), low-grade, and high-grade (HGCs) postoperative complications (according to the Clavien-Dindo classification) as well as 30-d readmission rates. Results and limitations Intraoperative complications were observed in 69 patients (10.9%). Thrombectomy (odds ratio [OR] 1.38, 95% confidence interval [CI] 1.08–1.75, p = 0.009) and adjacent organ removal (OR 2.7, 95% CI 1.38–5.30) were significant predictors of intraoperative complications at multivariable analysis. Two hundred seventeen patients (29.5%) encountered AGCs, while 45 (6.1%) encountered an HGC, of whom 10 (1.4%) died. Twenty-four (3.3%) patients had multiple postoperative complications. Estimated blood loss (EBL; OR 1.49, 95% CI 1.08–2.05, p = 0.01) was a significant predictor of AGCs at multivariable analysis. CN case load (OR 0.13, 95% CI 0.03–0.59, p = 0.009) and EBL (OR 2.93, 95% CI 1.20–7.15, p = 0.02) were significant predictors solely for HGCs at multivariable analysis. Forty-one patients (11.5%) were readmitted within 30 d of surgery. No significant predictors were identified. Results were confirmed in a subanalysis focusing solely on patients treated in the contemporary targeted therapy era. Conclusions Morbidity associated with CN is not negligible. Predictors of high-grade postoperative morbidity are predominantly indicators of complex surgery. EBL is a strong predictor of postoperative complications. CN case load correlates with lower high-grade morbidity and highlights the benefit of centralization of complex surgery. However, risks and benefits should be balanced when considering CN in mRCC patients. Patient summary We studied patients with metastatic renal cancer to evaluate the outcomes associated with the surgical removal of the primary kidney tumor. We found that this procedure is often complex and adverse events are not uncommon. High intraoperative blood loss and a small number of cases performed at the treating center are associated with a higher rate of postoperative complications.

Published
2020

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