1. Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk
- Author
-
Samer Kibbani, Krista J. Stewart, Bouchra Douaihy, Danielle A. Badro, Michella Ghassibe-Sabbagh, Dominique Gauguier, Jorg Hager, Aline Milane, Sonia Youhanna, Rita Nemr, Angelique K. Salloum, Marc Haber, Raed Othman, Jean-Baptiste Cazier, Hamid el Bayeh, Daniel E. Platt, Nabil Shasha, Pierre Zalloua, Antoine Abchee, Elie Chammas, and Yoichiro Kamatani
- Subjects
Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Hyperhomocysteinemia ,Candidate gene ,Homocysteine ,Population ,Organic Anion Transporters ,Constriction, Pathologic ,Coronary Artery Disease ,Coronary artery disease ,chemistry.chemical_compound ,Risk Factors ,Internal medicine ,medicine ,Humans ,Lebanon ,Diuretics ,education ,Methylenetetrahydrofolate Reductase (NADPH2) ,Aged ,education.field_of_study ,Polymorphism, Genetic ,biology ,Liver-Specific Organic Anion Transporter 1 ,business.industry ,nutritional and metabolic diseases ,Middle Aged ,medicine.disease ,Stenosis ,Logistic Models ,chemistry ,Methylenetetrahydrofolate reductase ,Hypertension ,cardiovascular system ,Cardiology ,biology.protein ,Female ,Gene-Environment Interaction ,Cardiology and Cardiovascular Medicine ,business ,SLCO1B1 - Abstract
Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction. © 2012 Elsevier Ireland Ltd.
- Published
- 2012
- Full Text
- View/download PDF