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20 results on '"Bottlaender M"'

14. Identification et quantification d’une neurodégénérescence précoce au cours de la sclérose en plaques avec la tomographie à émission de positons au [11C]-Flumazenil

Author

Stankoff, B., primary, Bosqué-Freeman, L., additional, Leroy, C., additional, Galanaud, D., additional, Sureau, F., additional, Assouad, R., additional, Tourbah, A., additional, Papeix, C., additional, Comtat, C., additional, Trebossen, R., additional, Lubetzki, C., additional, Delforge, J., additional, and Bottlaender, M., additional

Published
2010
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16. Improved synthesis of the peripheral benzodiazepine receptor ligand [11C]DPA-713 using [11C]methyl triflate

Author

Thominiaux, C., primary, Dollé, F., additional, James, M.L., additional, Bramoullé, Y., additional, Boutin, H., additional, Besret, L., additional, Grégoire, M.-C., additional, Valette, H., additional, Bottlaender, M., additional, Tavitian, B., additional, Hantraye, Ph., additional, Selleri, S., additional, and Kassiou, M., additional

Published
2006
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18. A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: Pharmacological evaluation and pet experiments

Author

Helfenbein, J., primary, Loc'h, C., additional, Bottlaender, M., additional, Emond, P., additional, Coulon, C., additional, Ottaviani, M, additional, Fuseau, C., additional, Chalon, S., additional, Guenther, I., additional, Besnard, J-C., additional, Frangin, Y., additional, Guilloteau, D., additional, and Maziere, B., additional

Published
1999
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20. Preparation of [76Br]FLB 457 and [76Br]FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET

Author

Lars Farde, Mariannick Mazière, Christian Loc'h, Christer Halldin, R. M. Moresco, Bernard Maziere, Carl-Gunnar Swahn, Michel Bottlaender, Loc'H, C, Halldin, C, Bottlaender, M, Swahn, C, Moresco, R, Mazière, M, Farde, L, and Mazière, B

Subjects
Male, Cancer Research, Pyrrolidines, Striatum, Electrophilic substitution, chemistry.chemical_compound, Dopamine, Salicylamides, Radioligand, medicine, Animals, Radiology, Nuclear Medicine and imaging, Receptor, Chemical purity, Benzamide, Receptors, Dopamine D2, Chemistry, Corpus Striatum, High uptake, Dopamine Antagonists, Molecular Medicine, Chromatography, Thin Layer, Bromine Radioisotopes, Bromine-76, Substituted benzamide, Dopamine D-2 receptor antagonist, Extrastriatal binding, Positron emission tomography, Papio, Tomography, Emission-Computed, Nuclear chemistry, medicine.drug
Abstract

Both FLB 457 and FLB 463, two substituted benzamides with high affinity for the dopamine D-2 receptors, were labeled with bromine-76 for PET investigations. [76Br]FLB 457 was prepared by electrophilic substitution of the tributyltin precursor. The radiochemical yield was 80%. [76Br]FLB 463 was prepared by a direct electrophilic substitution enhanced by the hydroxyl group of the debromo analogue, with a total radiochemical yield of 50%. Radiochemical and chemical purity values of the radioligands as analyzed by radio-TLC and HPLC were > 99%, and the specific radioactivity was -40 GBq/mumol. During PET examinations of [76Br]FLB 457 and [76Br]FLB 463 binding in baboons there was a rapid and high uptake in the striatum. The striatal radioactivity concentration reached a plateau 1 h postinjection (p.i.). The striatum-to-cerebellum radioactivity concentration ratio increased from 11 at 1 h p.i., to 28 at 4 h p.i. for [76Br]FLB 457, owing to a continuous wash-out from the cerebellum. For [76Br]FLB 463 the corresponding value increased from 10 to 19.5. [76Br]FLB 457 has in contrast to [76Br]FLB 463 a high uptake in thalamic structures and has therefore an additional potential as a radioligand for PET examination of extrastriatal dopamine D-2 receptors in the living human brain.

Published
1996

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