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60 results on '"Bolund, Lars"'

1. Extrachromosomal Circular DNA Orchestrates Genome Heterogeneity In Urothelial Bladder Carcinoma

Author

Lv, Wei, primary, Pan, Xiaoguang, additional, Han, Peng, additional, Wu, Shuang, additional, Zeng, Yuchen, additional, Wang, Qingqing, additional, Guo, Lidong, additional, Xu, Mengyang, additional, Wang, Fei, additional, Qi, Yanwei, additional, Deng, Li, additional, Xu, Zhe, additional, Li, Yi, additional, Teng, Huajing, additional, Li, Conghui, additional, Gao, Shang, additional, Yu, Tianxi, additional, Cui, Xin, additional, Xiang, Chongjun, additional, Tan, Haotian, additional, Li, Yue, additional, Liang, Ning, additional, Tao, Huiying, additional, Yu, Guohua, additional, Mi, Jia, additional, Xu, Fuyi, additional, Gong, Benjiao, additional, Shi, Lei, additional, Wang, Tao, additional, Yang, Huanming, additional, Dong, Wei, additional, Liu, Siqi, additional, Wu, Kui, additional, Bolund, Lars, additional, Lin, Lin, additional, Wang, Wenting, additional, Li, Hanbo, additional, Huang, Jinrong, additional, Lin, Chunhua, additional, and Luo, Yonglun, additional

Published
2023
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2. A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency

Author

Andersen, Olav M., primary, Bøgh, Nikolaj, additional, Landau, Anne M., additional, Pløen, Gro G., additional, Jensen, Anne Mette G., additional, Monti, Giulia, additional, Ulhøi, Benedicte P., additional, Nyengaard, Jens R., additional, Jacobsen, Kirsten R., additional, Jørgensen, Margarita M., additional, Holm, Ida E., additional, Kristensen, Marianne L., additional, Alstrup, Aage Kristian O., additional, Hansen, Esben S.S., additional, Teunissen, Charlotte E., additional, Breidenbach, Laura, additional, Droescher, Mathias, additional, Liu, Ying, additional, Pedersen, Hanne S., additional, Callesen, Henrik, additional, Luo, Yonglun, additional, Bolund, Lars, additional, Brooks, David J., additional, Laustsen, Christoffer, additional, Small, Scott A., additional, Mikkelsen, Lars F., additional, and Sørensen, Charlotte B., additional

Published
2022
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3. Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer

Author

Banerjee, Santasree, primary, Zhang, Xianxiang, additional, Kuang, Shan, additional, Wang, Jigang, additional, Li, Lei, additional, Fan, Guangyi, additional, Luo, Yonglun, additional, Sun, Shuai, additional, Han, Peng, additional, Wu, Qingyao, additional, Yang, Shujian, additional, Ji, Xiaobin, additional, Li, Yong, additional, Deng, Li, additional, Tian, Xiaofen, additional, Wang, Zhiwei, additional, Zhang, Yue, additional, Wu, Kui, additional, Zhu, Shida, additional, Bolund, Lars, additional, Yang, Huanming, additional, Xu, Xun, additional, Liu, Junnian, additional, Lu, Yun, additional, and Liu, Xin, additional

Published
2021
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4. Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs

Author

Xiang, Xi, primary, Zhao, Xiaoying, additional, Pan, Xiaoguang, additional, Dong, Zhanying, additional, Yu, Jiaying, additional, Li, Siyuan, additional, Liang, Xue, additional, Han, Peng, additional, Qu, Kunli, additional, Jensen, Jonas Brorson, additional, Farup, Jean, additional, Wang, Fei, additional, Petersen, Trine Skov, additional, Bolund, Lars, additional, Teng, Huajing, additional, Lin, Lin, additional, and Luo, Yonglun, additional

Published
2021
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5. In vivo Evidence That SORL1, Encoding the Endosomal Recycling Receptor SORLA, Can Function as a Causal Gene in Alzheimer's Disease

Author

Andersen, Olav, primary, Bøgh, Nikolaj, additional, Landau, Anne, additional, Pløen, Gro, additional, Jensen, Anne Mette, additional, Monti, Giulia, additional, Ulhøi, Benedicte, additional, Nyengaard, Jens, additional, Jacobsen, Kirsten, additional, Jørgensen, Margarita, additional, Holm, Ida, additional, Kristensen, Marianne, additional, Hansen, Esben, additional, Teunissen, Charlotte E., additional, Breidenbach, Laura, additional, Droescher, Mathias, additional, Liu, Ying, additional, Pedersen, Hanne Skovsgaard, additional, Callesen, Henrik, additional, Luo, Yonglun, additional, Bolund, Lars, additional, Brooks, David J., additional, Laustsen, Christoffer, additional, Small, Scott, additional, Mikkelsen, Lars, additional, and Sørensen, Charlotte, additional

Published
2021
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6. Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Author

Rohlenova, Katerina, primary, Goveia, Jermaine, additional, García-Caballero, Melissa, additional, Subramanian, Abhishek, additional, Kalucka, Joanna, additional, Treps, Lucas, additional, Falkenberg, Kim D., additional, de Rooij, Laura P.M.H., additional, Zheng, Yingfeng, additional, Lin, Lin, additional, Sokol, Liliana, additional, Teuwen, Laure-Anne, additional, Geldhof, Vincent, additional, Taverna, Federico, additional, Pircher, Andreas, additional, Conradi, Lena-Christin, additional, Khan, Shawez, additional, Stegen, Steve, additional, Panovska, Dena, additional, De Smet, Frederik, additional, Staal, Frank J.T., additional, Mclaughlin, Rene J., additional, Vinckier, Stefan, additional, Van Bergen, Tine, additional, Ectors, Nadine, additional, De Haes, Patrik, additional, Wang, Jian, additional, Bolund, Lars, additional, Schoonjans, Luc, additional, Karakach, Tobias K., additional, Yang, Huanming, additional, Carmeliet, Geert, additional, Liu, Yizhi, additional, Thienpont, Bernard, additional, Dewerchin, Mieke, additional, Eelen, Guy, additional, Li, Xuri, additional, Luo, Yonglun, additional, and Carmeliet, Peter, additional

Published
2020
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7. An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Author

Goveia, Jermaine, primary, Rohlenova, Katerina, additional, Taverna, Federico, additional, Treps, Lucas, additional, Conradi, Lena-Christin, additional, Pircher, Andreas, additional, Geldhof, Vincent, additional, de Rooij, Laura P.M.H., additional, Kalucka, Joanna, additional, Sokol, Liliana, additional, García-Caballero, Melissa, additional, Zheng, Yingfeng, additional, Qian, Junbin, additional, Teuwen, Laure-Anne, additional, Khan, Shawez, additional, Boeckx, Bram, additional, Wauters, Els, additional, Decaluwé, Herbert, additional, De Leyn, Paul, additional, Vansteenkiste, Johan, additional, Weynand, Birgit, additional, Sagaert, Xavier, additional, Verbeken, Erik, additional, Wolthuis, Albert, additional, Topal, Baki, additional, Everaerts, Wouter, additional, Bohnenberger, Hanibal, additional, Emmert, Alexander, additional, Panovska, Dena, additional, De Smet, Frederik, additional, Staal, Frank J.T., additional, Mclaughlin, Rene J., additional, Impens, Francis, additional, Lagani, Vincenzo, additional, Vinckier, Stefan, additional, Mazzone, Massimiliano, additional, Schoonjans, Luc, additional, Dewerchin, Mieke, additional, Eelen, Guy, additional, Karakach, Tobias K., additional, Yang, Huanming, additional, Wang, Jian, additional, Bolund, Lars, additional, Lin, Lin, additional, Thienpont, Bernard, additional, Li, Xuri, additional, Lambrechts, Diether, additional, Luo, Yonglun, additional, and Carmeliet, Peter, additional

Published
2020
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8. Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

Author

Zhang, Yu, Schmid, Benjamin, Qas Younan, Nanett Kvist, Rasmussen, Mikkel A., Garcia, Blanca Irene Aldana, Agger, Mikkel, Callø, Kirstine, Stummann, Tina C., Larsen, Hjalte M., Nielsen, Troels T., Huang, Jinrong, Xu, Fengping, Liu, Xin, Bolund, Lars, Meyer, Morten, Bak, Lasse Kristoffer, Waagepetersen, Helle S., Luo, Yonglun, Nielsen, Jørgen Erik, Consortium, The FReJA, Holst, Bjørn, Clausen, Christian, Hyttel, Poul, and Freude, Kristine

Subjects
0301 basic medicine, Mitochondrion, Biochemistry, 0302 clinical medicine, disease modeling, oxidative stress, Induced pluripotent stem cell, lcsh:QH301-705.5, Neurons, Genetics, lcsh:R5-920, Neurodegeneration, CHMP2B, neurodegeneration, Cell Differentiation, Cellular Reprogramming, 3. Good health, Cell biology, mitochondria, Frontotemporal Dementia, lcsh:Medicine (General), Frontotemporal dementia, Endosome, Iron, Induced Pluripotent Stem Cells, Endosomes, Biology, Article, ESCRT, 03 medical and health sciences, medicine, Journal Article, Humans, iPSC-derived neuron, endosome, Endosomal Sorting Complexes Required for Transport, Gene Expression Profiling, Cell Biology, Charged multivesicular body protein 2B, frontotemporal dementia linked to chromosome 3 (FTD3), Fibroblasts, medicine.disease, 030104 developmental biology, lcsh:Biology (General), Mutation, iron homeostasis, Transcriptome, Cristae formation, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Summary The truncated mutant form of the charged multivesicular body protein 2B (CHMP2B) is causative for frontotemporal dementia linked to chromosome 3 (FTD3). CHMP2B is a constituent of the endosomal sorting complex required for transport (ESCRT) and, when mutated, disrupts endosome-to-lysosome trafficking and substrate degradation. To understand the underlying molecular pathology, FTD3 patient induced pluripotent stem cells (iPSCs) were differentiated into forebrain-type cortical neurons. FTD3 neurons exhibited abnormal endosomes, as previously shown in patients. Moreover, mitochondria of FTD3 neurons displayed defective cristae formation, accompanied by deficiencies in mitochondrial respiration and increased levels of reactive oxygen. In addition, we provide evidence for perturbed iron homeostasis, presenting an in vitro patient-specific model to study the effects of iron accumulation in neurodegenerative diseases. All phenotypes observed in FTD3 neurons were rescued in CRISPR/Cas9-edited isogenic controls. These findings illustrate the relevance of our patient-specific in vitro models and open up possibilities for drug target development., Graphical Abstract, Highlights • FTD3 neurons show abnormalities in endosomes and mitochondria • Parkinson's and Alzheimer's disease core genes are altered in FTD3 neurons • Iron homeostasis is perturbed in FTD3 neurons • Impairments in FTD3 neurons are rescued in CRISPR/Cas9-edited isogenic controls, In this article, Freude, Zhang, and colleagues describe a patient iPSC-derived neuronal model for FTD3. This cellular model shows endosome abnormalities previously reported in patients. Furthermore, it provides insights into the role of impaired mitochondria function and imbalanced iron homeostasis in FTD3 pathology. All observed phenotypes were rescued in CRISPR/Cas9-edited isogenic controls.

Published
2017
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9. Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Author

Kalucka, Joanna, primary, de Rooij, Laura P.M.H., additional, Goveia, Jermaine, additional, Rohlenova, Katerina, additional, Dumas, Sébastien J., additional, Meta, Elda, additional, Conchinha, Nadine V., additional, Taverna, Federico, additional, Teuwen, Laure-Anne, additional, Veys, Koen, additional, García-Caballero, Melissa, additional, Khan, Shawez, additional, Geldhof, Vincent, additional, Sokol, Liliana, additional, Chen, Rongyuan, additional, Treps, Lucas, additional, Borri, Mila, additional, de Zeeuw, Pauline, additional, Dubois, Charlotte, additional, Karakach, Tobias K., additional, Falkenberg, Kim D., additional, Parys, Magdalena, additional, Yin, Xiangke, additional, Vinckier, Stefan, additional, Du, Yuxiang, additional, Fenton, Robert A., additional, Schoonjans, Luc, additional, Dewerchin, Mieke, additional, Eelen, Guy, additional, Thienpont, Bernard, additional, Lin, Lin, additional, Bolund, Lars, additional, Li, Xuri, additional, Luo, Yonglun, additional, and Carmeliet, Peter, additional

Published
2020
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10. Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

Author

Leng, Lizhi, primary, Sun, Jiya, additional, Huang, Jinrong, additional, Gong, Fei, additional, Yang, Ling, additional, Zhang, Shuoping, additional, Yuan, Xuye, additional, Fang, Fang, additional, Xu, Xun, additional, Luo, Yonglun, additional, Bolund, Lars, additional, Peters, Brock A., additional, Lu, Guangxiu, additional, Jiang, Taijiao, additional, Xu, Fengping, additional, and Lin, Ge, additional

Published
2019
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11. Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Author

Shim, Jeong, primary, Poulsen, Christian Bo, additional, Hagensen, Mette K., additional, Larsen, Torben, additional, Heegaard, Peter M.H., additional, Christoffersen, Christina, additional, Bolund, Lars, additional, Schmidt, Mette, additional, Liu, Ying, additional, Li, Juan, additional, Li, Rong, additional, Callesen, Henrik, additional, Bentzon, Jacob F., additional, and Sørensen, Charlotte B., additional

Published
2017
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15. Array Comparative Genomic Hybridization of Keratoacanthomas and Squamous Cell Carcinomas: Different Patterns of Genetic Aberrations Suggest Two Distinct Entities

Author

Li, Jian, primary, Wang, Kai, additional, Gao, Fei, additional, Jensen, Thomas D., additional, Li, Shengting T., additional, DeAngelis, Paula M., additional, Kølvraa, Steen, additional, Proby, Charlotte, additional, Forslund, Ola, additional, Bolund, Lars, additional, and Clausen, Ole Petter F., additional

Published
2012
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16. Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm

Author

Hou, Yong, primary, Song, Luting, additional, Zhu, Ping, additional, Zhang, Bo, additional, Tao, Ye, additional, Xu, Xun, additional, Li, Fuqiang, additional, Wu, Kui, additional, Liang, Jie, additional, Shao, Di, additional, Wu, Hanjie, additional, Ye, Xiaofei, additional, Ye, Chen, additional, Wu, Renhua, additional, Jian, Min, additional, Chen, Yan, additional, Xie, Wei, additional, Zhang, Ruren, additional, Chen, Lei, additional, Liu, Xin, additional, Yao, Xiaotian, additional, Zheng, Hancheng, additional, Yu, Chang, additional, Li, Qibin, additional, Gong, Zhuolin, additional, Mao, Mao, additional, Yang, Xu, additional, Yang, Lin, additional, Li, Jingxiang, additional, Wang, Wen, additional, Lu, Zuhong, additional, Gu, Ning, additional, Laurie, Goodman, additional, Bolund, Lars, additional, Kristiansen, Karsten, additional, Wang, Jian, additional, Yang, Huanming, additional, Li, Yingrui, additional, Zhang, Xiuqing, additional, and Wang, Jun, additional

Published
2012
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17. Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor

Author

Xu, Xun, primary, Hou, Yong, additional, Yin, Xuyang, additional, Bao, Li, additional, Tang, Aifa, additional, Song, Luting, additional, Li, Fuqiang, additional, Tsang, Shirley, additional, Wu, Kui, additional, Wu, Hanjie, additional, He, Weiming, additional, Zeng, Liang, additional, Xing, Manjie, additional, Wu, Renhua, additional, Jiang, Hui, additional, Liu, Xiao, additional, Cao, Dandan, additional, Guo, Guangwu, additional, Hu, Xueda, additional, Gui, Yaoting, additional, Li, Zesong, additional, Xie, Wenyue, additional, Sun, Xiaojuan, additional, Shi, Min, additional, Cai, Zhiming, additional, Wang, Bin, additional, Zhong, Meiming, additional, Li, Jingxiang, additional, Lu, Zuhong, additional, Gu, Ning, additional, Zhang, Xiuqing, additional, Goodman, Laurie, additional, Bolund, Lars, additional, Wang, Jian, additional, Yang, Huanming, additional, Kristiansen, Karsten, additional, Dean, Michael, additional, Li, Yingrui, additional, and Wang, Jun, additional

Published
2012
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24. Are Keratoacanthomas Variants of Squamous Cell Carcinomas? A Comparison of Chromosomal Aberrations by Comparative Genomic Hybridization

Author

Clausen, Ole Petter F., primary, Aass, Hans Christian D., additional, Beigi, Marzieh, additional, Purdie, Karin J., additional, Proby, Charlotte M., additional, Brown, Victoria L., additional, Mattingsdal, Morten, additional, Micci, Francesca, additional, Kølvraa, Steen, additional, Bolund, Lars, additional, and DeAngelis, Paula M., additional

Published
2006
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29. Expression and Localization of Peroxisome Proliferator-Activated Receptors and Nuclear Factor κB in Normal and Lesional Psoriatic Skin

Author

Westergaard, Majken, primary, Henningsen, Jeanette, additional, Rasmussen, Sofie, additional, Kristiansen, Karsten, additional, Johansen, Claus, additional, Svendsen, Morten Lyhne, additional, Jensen, Uffe Birk, additional, Schrøder, Henrik Daa, additional, Staels, Bart, additional, Iversen, Lars, additional, Bolund, Lars, additional, and Kragballe, Knud, additional

Published
2003
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30. Integrating Proteomic and Functional Genomic Technologies in Discovery-driven Translational Breast Cancer Research

Author

Celis, Julio E., primary, Gromov, Pavel, additional, Gromova, Irina, additional, Moreira, José M.A., additional, Cabezón, Teresa, additional, Ambartsumian, Noona, additional, Grigorian, Mariam, additional, Lukanidin, Eugene, additional, thor Straten, Per, additional, Guldberg, Per, additional, Bartkova, Jirina, additional, Bartek, Jiri, additional, Lukas, Jiri, additional, Lukas, Claudia, additional, Lykkesfeldt, Anne, additional, Jäättelä, Marja, additional, Roepstorff, Peter, additional, Bolund, Lars, additional, Ørntoft, Torben, additional, Brünner, Nils, additional, Overgaard, Jens, additional, Sandelin, Kerstin, additional, Blichert-Toft, Mogens, additional, Mouridsen, Henning, additional, and Rank, Fritz E., additional

Published
2003
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34. Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene

Author

Zhang, Xiuqing, primary, Yang, Huanming, additional, Yu, Jun, additional, Chen, Cong, additional, Zhang, Guangyu, additional, Bao, Jingyue, additional, Du, Yutao, additional, Kibukawa, Miho, additional, Li, Zhijie, additional, Wang, Jun, additional, Hu, Songnian, additional, Dong, Wei, additional, Wang, Jian, additional, Gregersen, Niels, additional, Niebuhr, Erik, additional, and Bolund, Lars, additional

Published
2002
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35. Modulation of Keratinocyte Gene Expression and Differentiation by PPAR-Selective Ligands and Tetradecylthioacetic Acid

Author

Westergaard, Majken, primary, Henningsen, Jeanette, additional, Kratchmarova, Irina, additional, Kristiansen, Karsten, additional, Svendsen, Morten Lyne, additional, Johansen, Claus, additional, Jensen, Uffe Birk, additional, Schrøder, Henrik Daa, additional, Berge, Rolf Kristian, additional, Iversen, Lars, additional, Bolund, Lars, additional, and Kragballe, Knud, additional

Published
2001
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39. Identification of Novel and Known Mutations in the Genes for Keratin 5 and 14 in Danish Patients with Epidermolysis Bullosa Simplex: Correlation Between Genotype and Phenotype

Author

Sørensen, Charlotte B., primary, Ladekjær-Mikkelsen, Anne-Sofie, additional, Andresen, Brage S., additional, Brandrup, Flemming, additional, Veien, Niels K., additional, Buus, Sanne K., additional, Anton-Lamprecht, Ingrun, additional, Kruse, Torben A., additional, Jensen, Peter K.A., additional, Eiberg, Hans, additional, Bolund, Lars, additional, and Gregersen, Niels, additional

Published
1999
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40. Clear Correlation of Genotype with Disease Phenotype in Very–Long-Chain Acyl-CoA Dehydrogenase Deficiency

Author

Andresen, Brage Storstein, primary, Olpin, Simon, additional, Poorthuis, Ben J.H.M., additional, Scholte, Hans R., additional, Vianey-Saban, Christine, additional, Wanders, Ronald, additional, Ijlst, Lodewijk, additional, Morris, Andrew, additional, Pourfarzam, Morteza, additional, Bartlett, Kim, additional, Baumgartner, E. Regula, additional, deKlerk, Johannis B.C., additional, Schroeder, Lisbeth Dahl, additional, Corydon, Thomas J., additional, Lund, Hans, additional, Winter, Vibeke, additional, Bross, Peter, additional, Bolund, Lars, additional, and Gregersen, Niels, additional

Published
1999
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42. Influence of Lewis α1-3/4-L-Fucosyltransferase (FUT3) Gene Mutations on Enzyme Activity, Erythrocyte Phenotyping, and Circulating Tumor Marker Sialyl-Lewis a Levels

Author

Ørntoft, Torben F., primary, Vestergaard, Else Marie, additional, Holmes, Eric, additional, Jakobsen, Jørn Sinkbæk, additional, Grunnet, Niels, additional, Mortensen, Mette, additional, Johnson, Philip, additional, Bross, Peter, additional, Gregersen, Niels, additional, Skorstengaard, Karna, additional, Jensen, Uffe Birk, additional, Bolund, Lars, additional, and Wolf, Hans, additional

Published
1996
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43. Effects of Two Mutations Detected in Medium Chain Acyl-CoA Dehydrogenase (MCAD)-deficient Patients on Folding, Oligomer Assembly, and Stability of MCAD Enzyme

Author

Bross, Peter, primary, Jespersen, Charlotte, additional, Jensen, Thomas G., additional, Andresen, Brage S., additional, Kristensen, Morten Juhl, additional, Winter, Vibeke, additional, Nandy, Andreas, additional, Kräutle, Franz, additional, Ghisla, Sandro, additional, Bolund, Lars, additional, Kim, Jung-Ja P., additional, and Gregersen, Niels, additional

Published
1995
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46. Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation

Author

Bross, Peter, primary, Andersen, Brage A., additional, Winter, Vibeke, additional, Kräutle, Franz, additional, Jensen, Thomas G., additional, Nandy, Andreas, additional, Kølvraa, Steen, additional, Ghisla, Sandro, additional, Bolund, Lars, additional, and Gregersen, Niels, additional

Published
1993
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