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46 results on '"Bhanderi, A."'

21. P-210: Oral ixazomib (Ixa), IV daratumumab (Dara), and dexamethasone (dex; IDd) in relapsed/refractory multiple myeloma (RRMM) patients (pts) with 1–3 prior therapies: phase 2 study interim analysis (IA)

Author

Orlowski, Robert, primary, Delimpasi, Sosana, additional, Straub, Jan, additional, Symeonidis, Argiris, additional, Pour, Luděk, additional, Hájek, Roman, additional, Touzeau, Cyrille, additional, Bhanderi, Viralkumar, additional, Pavlíček, Petr, additional, Robak, Pawel, additional, Berdeja, Jesus G., additional, Matous, Jeffrey V., additional, Karlin, Lionel, additional, Zweegman, Sonja, additional, Grosicki, Sebastian, additional, Pluta, Andrzej, additional, Kambhampati, Suman, additional, Suryanarayan, Kaveri, additional, Twumasi-Ankrah, Philip, additional, Dash, Ajeeta, additional, Labotka, Richard, additional, and Dimopoulos, Meletios-Athanasios, additional

Published
2021
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22. Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study

Author

T. Yang, T. Pitts-Tucker, Daron Smith, S. Suresh, A.A. Khetarpal, C. Brathwaite-Shirley, Justine Davies, Sayinthen Vivekanantham, A. A. Adebayo, T. Sorah, N. Yim, H.R. Jackson, Salim Tayeh, R.H. Bremner, A. Piquet, L. Higgs, R. Yuen, P. Fergurson, N.K. Sim, A. Hibberd, A. Mehdi, N. Moody, D. Maru, C. Joyner, I. Hindle Fisher, Vartan Balian, N. Wetherall, Siyin Liu, P.N. Phan, S. Mallick, C. Lek, B. Oremule, S. Nelaj, M. Williams, Maqsood Qamar, A. Menon, M. Mohamud, H. Cheema, C. Chan, H.M. Omer, S.J. Cole, E. Craig, K.E. Leslie, S.S. Talukdar, R.B.S. Holliday, J. Heskin, A. Cody, Syed Shumon, S. McAleer, S. Abburu, P. Deekonda, S.F. Ashraf, R. Bose, AE Cotton, C. McGowan, S. Rashid, K. Theodoropoulou, A. MacAskill, Vishal Narwani, R. Maamari, S. Stokes, L.N. Harris, Peng Yong Sim, Evie Gardner, Leo Ng, N. Chandan, J.W. Lockey, M. Acres, H. Jhala, M.L. Kwan, A. Abdulmajid, A.E. Cardwell, P. Buakuma, C.P. Keane, M. Ahmed, N.J. Chilvers, E. Semple, J. Meek, A.K. Clarke, K. Koysombat, A. Hague, E.J.H. Turner, N. Keelty, P. Karunakaran, K.D. Clement, Mansoor Khan, Y. Cao, O. Prys-Jones, S.L. Walsh, C.N. McKerr, Sanjay Shah, S. Peroos, A. Dhanji, Joseph M. Norris, Neil Smith, M. Lakhani, M. Wijesekera, M. Bhatti, Midhun Mohan, C.Y. Luk, M. Elkawafi, S. Wadanamby, Jameel Mushtaq, Jonathan C. M. Wan, A. Ghaffar, M. Siddiqui, S. Naqib, Michaeline Kelly, J.W. Duncumb, F. Hughes, H.E.M. Jordan, R. Callan, G. Hung, C.F. Brewer, E.M. Ruiz, A. Higgins, C. Horst, C. Roberts, S. Kanabar, C. Wall, A.M. Buchan, A. Luhishi, R.P. Watson, D. Xylas, A. McBride, A. Bell, G. Heppenstall-Harris, A. Pericleous, Akanksha Chhabra, N. Hitchen, P. Raut, Shahzada Ahmed, M. Mirza, C.H. Archer, G. Russell, C.T. Francescon, D.T. Robertson, N. Gardiner, K. Cheng, A. Mishra, E. Webb, L. Rothwell, Dee A. Carter, V. Gupta, M. Johnstone, M.E. Kelly, R.D.C. Moon, E. Woin, K. Nadanakumaran, U. White, J. Empey, F. Bulley, R. Morley, G. Charalambous, L. Turner, S. Angelov, D. Coffey, S. Hartley, S. Pronin, E. Seager, R.K. Varma, Sharifullah Khan, S.B. Husnoo, R.K. Sethi, H.M. Chang, A. Duffy, Hew D.T. Torrance, P. Cunha, L. Kimani, W. Din, E.G. Heywood, C. O'Connell, D. Wylam, L. Anderson, N. Ahern, A.J. Trist, D. Burke, A. He, M. Sundar-Singh, A. Odeleye, G. Kumaran, N.L. Salloum, T.M. Brooks, A.S. Lynch, R. Debenham, Howard Gardner, M. Nielsen, M. Das, G. Bingham, S. Qureshi, Aditya Borakati, J. Wylie, Z. Kazmi, J.H. Park, P. Gill, A.R. Craig, M. Chen, Jonathan Wild, S.J. Lim, K.P. Choo, G. Culleton, G. Deas, E.Y. Chua, D. Vanniasegaram, A.H. Amphlett, N. Rajan, J.H. Chen, M. Hameed, Paul Ziprin, C. Toale, D. Gold, N. Keane, Jacob H Matthews, E. Palkhi, Nick Watson, C.M. Hewitt, A. Yousif, Faheem Ahmed, D. Wilkinson, John Mason, C. Reeder, R. Sagar, Deirdre A. Collins, S. Sandhu, S. Singh, J. Herron, A.Y.L. Ng, K. Brennan, K.A. Hoban, V. Navayogaarajah, A.S. Jawad, J.Y.L. Low, Julian R. Johnston, J. Wye, Inge Bernstein, John Parkin, A.D. Henson, Y.H. Soo, C. Topham, M. Steel, Priyank Patel, C.M. Lankage, U. Ashfaq, E.J. Brown, N.L. Foster, C.W. Rookes, R.J. Greig, K.L. McKevitt, N. Jathanna, J.M. Geraghty, M. Karia, S. Cumming, H. Holyoak, S. Parthiban, R.B. Karsan, V.C. Wing, T.E. Glover, R.D. Adams, B.H. Miranda, S. Gaffney, S. Rogers, G.E. Torlot, J.J. Filby, S. Sii, N.M. Rafiq, M. Shoa, S. Singagireson, N. Ungcharoen, Jennie Parker, B.F. Chong, N.M. Shafiq, V. Wong, E. Shakweh, A. Al-Mousawi, J. Pearce, S. Botchey, L. Horne, L. Fletcher, B. Singh, E.A. Whatling, K. Duke, A. Mastan, A.L. Frank, S. Verma, Humaira Shaheen, W. Liew, J. Turner, R. Rampal, T. Filipescu, R.M. Markham, B.A. Patel, S. Lim, A. Atayi, S. Yoganathan, N. Ramsay, M. Khattak, O. Amin, E. McAleer, K. Gohil, H. Shufflebotham, George S Bethell, M. Dhar, J.E. Davies, A.F. Carroll, E. Cornish, S. Omara, J. Bartlett, D. Loughran, A. Iqbal, L.R. Springford, D.R. McCormack, S. Leong, R. Ingham, D. Tan, A. Khajuria, M. Tonkins, M. Petrarca, A.M. Bucko, L.L. McKelvey, C. Gill, C.E. Thakker, K. Mohan, J. Turnbull, G. Cuthbert, W. Dean, R.D.J. Whitham, D.M. Lees, N. Chan, D. Osei-Kuffour, A. Sahathevan, K. Ng, L.B. Anderson, J. Eraifej, A. O'Connor, O.J. Cundy, C. Kong, R.K. Hughes, Bryan Paul Traynor, P. Keane, C. Liu, E. Canning, E.D. Mills, C. Gouldthrope, S. Patel, M.J.V. Holmes, C. Cullen, Lisa McNamee, Alberto Pizzolato, P. Harries, M. Elseedawy, R. Varley, C. Whacha, S.G. Ratu, A. Wright, S. Parsons, Pishoy Gouda, A. Mian, R. Bhudia, R. Adams, N. Bell, Talisa Ross, R. Reid, J.P. Shah, Sarah Dean, C. Neophytou, Alex Ward, J.D. Thompson, M. Seedat, A. Ramnarine, R.T. Harris, A. Qureshi, C. Major, Y. Sinha, A.S. Rocke, C.S. Yong, P. Kwang, David Neil Cooper, L. Aildasani, R.W. Goh, A.R. Dyal, L. Braganza, L. Healy, N. Davies, T. Reakes, N. Patel, S. Sng, C. Brennan, Z.R. Bakewell, S.L. Jenkin, Ahmed Daoub, I.A. Rhema, R.A. Walford, O. Spence, L. Yow, E.J. Roberts, W. Cymes, Y. Liew, E. Segall, June A. Sullivan, K.K. Sandhu, L. Satterthwaite, G.X. Xu, R.M. Waldron, S. McGarvie, D. Brown, M. Alizadeh, J.A. Syeed, H.F. Roberts, P. Dawson, H.R. Abdikadir, S. O'Connor, Y. Maheswaran, B.A. Hughes, B.A. Atraszkiewicz, K. Singh, C. Mcgenity, A.D. Wood, Ewan D. Kennedy, S.X. Poo, S. Mitrasinovic, Max Marsden, A. Ibrahim, Daniel F. McAuley, M. Attalla, S. Govinden, Siti Asma' Hassan, T. Raghvani, T. Bloomfield, R. Heminway, M. Ali, K.L. Robertson, P. Lalor, T. Dogra, I. Antoniou, A. Tahmina, Markus L. Sagmeister, Ronan McMullan, J. Matthams, Richard J. Egan, Elspeth Cumber, M. Dolaghan, P. Sritharan, S. Sarwar, E.S.M. Tan, S.E. Murray, S. Morris, S. Mansoor, M. King, Randall V. Martin, P. Williams, G. Brent, N.B. Reid, S. Collinson, T. Sarvanandan, R. Ratnakumaran, R.E. Keeling, M.A. Sherif, D. Thomas, I.J. Clark, R. Coulson, T.P. Bemand, A. Abid, A.L. Martin, J.C.K. Ng, P. Avery, Y. Narang, R. Manson, H. Petra, J.E. Giles, A.E. Lim, N.A. Vithanage, S. Osman, D. Elf, Panagis M. Lykoudis, A. Ang, Debra Salmon, A. Croall, T. Sale, S. Bonsu, Y.P. Mogan, G.E. Cooper, J. Lamont, S.T. Marchal, P. Naran, A.N. Kumar, R. Owasil, F. Koumpa, J.Q. Ng, P.N. Nesargikar, J. Boyle, Ryan Preece, E. Sewart, S. Lee, S. Kosasih, N. Jamal, Stephen J Chapman, N.A. Redgrave, C. Holmes, A.E. Barthorpe, S. Mistry, J.A. Yates, Robin Wilson, E. Prakash, J.Y. Kee, S.M. Anderson, R.S. Suresh, N. Hussain, S. Gentry, S. Darr, H. Heneghan, H.D. McRobbie, S. Assadullah, Shivam Bhanderi, C. Weston, A. Delport, A. Winarski, M.M. Li, T. Tharmachandirar, N. Canning, P.R. Forrest, Adam J Boulton, A. Ponweera, G.E. Stewart, J.S. Ahn, J. Hartley, A. Isaac, J.L.Y. Allen, R. Carr, S. Gokani, J. Zhao, C. Player, D. Sim, W. English, R.J. McGalliard, S. Cullen, R. Thethi, A. Livesey, K.N. Lwin, M. K. Abd Ghaffar, C.L. Knight, P.C. Hurst, A.Y. Tay, Devender Mittapalli, F. Winslow, G. Bhaskaran, L. Gauntlett, W. Leung, D.M. Golding, A. Wali, D.C. Marshall, H. Ross, K.P. Raman, P.J. Teoh, C. Allan, I. Nehikhare, C.M. Ventre, M. Venn, J.A. Crewdson, A. Shukla, N. Ramjeeawon, S. Shahid, P. Mithrakumar, J. Fern, Y. Tan, H. Haq, S. Turaga, U. Hayat, C. Palmer, H. Goradia, T. Ramtoola, J. Bloomer, C. Chhina, Z. Momoh, W.M. Wynell-Mayow, N. Jayakody, M. Bravo, J. Gabriel, R. Khanijau, L. Esteve, A. Malik, R.D. Obute, S. Sheth, S. Lunawat, U. Qureshi, C. Rees, A. Kerai, M. Peters, A.Y. Tsui, K. Kow, M. Trail, A. Coates, F. Long, V. Paraoan, M.T. Stoddart, N. Li, M. Bright, W.W. Chaudhry, M.K. Malys, S. Owczarek, C.L. Jubainville, E. Brennan, M. Hanrahan, A. Wang, A. Burgess, S. Dutt, N. Varma, R.P. Williams, A. Ledsam, R.T. Buckle, W. Ho, U. Sajjad, B. Goh, M.R. Hardy, E. Lim, L.J. Burney, C.S.D. Roy, Thomas M Drake, Harry J. Gilbert, A. Yener, A. Trimble, Archana Shah, H. Ahmed, E.C. Barton, K. Eparh, C. McCrann, F. Harding, J. Mah, D. Kotecha, A. Al-Robeye, J. MacDonald, S. Kim, Andrew Logan, C. McLaughin, H. Collier, O. Brewster, J. Loveday, L. Tung, S. Dindyal, O. Al-Obaedi, A. Simpson, M. Sirakaya, F. Morgan, G.S. Ng, S. Mahboob, D. FitzPatrick, A. Jindal, O. O'Carroll, Y. Devabalan, T. Axelson, D. Rojoa, K. Sasapu, Kirsty Davies, J. Moradzadeh, Ewen M Harrison, K. Gandhi, S. Beecroft, G. McCabe, C.P. Chilima, T. Goldsmith, H.Z. Bazeer, N. Kalra, P. Morrison, T.C. Hoskins, J.J. Wiltshire, A. Narain, D. Joshi, D. Horth, H.C.P. Wilson, Y.F. Dennis, M. Mills, C. Diaper, J.A. Sanders, S.M. Chiu, J. Coffin, V. Elangovan, K.S. Dolbec, H.L. Warwick, R.H. Shuttleworth, T. Patel, R. Goodson, F.S. Brown, Jane Lim, O. Ziff, M. Rashid, V. Mirdavoudi, K.G. Reid, A. Broyd, E. Woon, M. Zuhair, A.D. Greenhalgh, L.R. Wingfield, S. Stevens, O. Hussain, G. Pandey, A. Bakhsh, I.B. Ptacek, J. Dobson, L. Bolton, A.L. Kerr, T.M.P. Fung, P. Narayan, T. Ward, Ruth Lyons, C. Robinson, Buket Gundogan, S. Akhtar, P. Vanmali, L. Austreng, N. Kelly, M. Kadicheeni, H Ali, P. Holton, H. Turley, C.J. Morrison, L. Hu, M. Sukkari, D.A. O'Sullivan, J. Brecher, C.J. White, M.A. Charalambos, William Bolton, M. Tahir, L. Grundy, T.P. Pezas, Ewan Brown, Nicholas Bullock, A.M.A. Shafi, A. Aslanyan, Michael F. Bath, H. Wilson, P.C. Copley, S.E. Scotcher, Heather Kennedy, N. Bassam, A. Omar, G.D. Stott, S. Ashraf, E. Galloway, R.D. Bartlett, H. Amin, Y.N. Neo, W.C. Soon, S. Rabinthiran, C. Phillips, L.A. Henderson, K. Whitehurst, A. Kahar, S. Sukumar, M.R. Williams, W.A. Gatfield, C. Ntala, K. Dear, A.R. Chitnis, M. Eragat, H.C. Huang, K. O'Sullivan, N. Yong, J. Robson, A. Valli, A. Mohite, G.J. Salam, F. Tongo, S. Lopes, R.A. O'Loughlin, S.L. Hickling, J. Fong, A. Chung, Kathy Nicholls, H. Abid, S. Balaji, J. Hardie, T. Reeves, H.R. Paine, M. Hayat, H. Nayee, Y.N. Suleman, S. Tan, M. Sharifpour, X. Chen, I. Barai, A. Yan, M.A. Gillies, T.W. Tilston, A. Kreibich, Y.H. Tan, A. Murtaza, Chris Dunn, P. Jull, J.W. Kim, A.D. Semana, N. Abuhussein, P. Shepherd, L. Derbyshire, P.M. McEnhill, J.B. Patel, C. Toh, T. Arif, B.W. Matthews, D. Shanahan, N. Seneviratne, L. Carr, A. Curran, A. Batho, L.D. O'Flynn, R. McAllister, A. Durr, Rahul Bhome, S. Mackin, K. Ahmad, R. Shaunak, S. Bassiony, H.A. Khokhar, R. Chin, R. Priestland, G.X.J. Sherliker, J.H. Entwisle, C. Anandarajah, H. Aziz, M. Chaudhary, A. Kishore, H. Adjei, M. Minhas, S.W. McLure, T. Kane, E. Ingram, T. Fautz, D. Chrastek, R. Singh, B.N. Shurovi, A. Asmadi, N. Ansari, J. Mahmood, K. Patel, A.N. Street, A. Thacoor, C. Girling, L. Cheskes, V. Shatkar, B. Ali, A. McGrath, Shaun Trecarten, J.D. Farmer, R. Dean, R.C. McLean, P.L.M. Harrison, S. Iqbal, S. Hirani, R. Fleck, S. Pope, C.Y. Kong, A.M. Demetri, H. Selvachandran, M. Malaj, H.K. Blege, B.D. Mistry, C.M. Grossart, R. Slade, S.A. Stanger, A.J. Dhutia, A. Amajuoyi, Ased Ali, M. Robinson, R. Punj, Jane Dickson, J. Lucas de Carvalho, Jessica Harvey, L.M. Bullman, D Nepogodiev, H.L. Joyce, Catrin Morgan, J. Paul, R. Vaughan, A. Prabhudesai, C. Egerton, A. Sheldon, C. Holloway, K. Brzyska, J. Ashwood, Christine McGarrigle, S. Pal, H. Rosen O'Sullivan, A. Rangedara, A. Hill, A. Szczap, S. Hudson-Phillips, J. Lavery, Harriet Mitchell, J.D.B. Hayes, M. Salem, F.A. Bamgbose, J. Bassett, V. Raghuvir, R. Dennis, S.E. Cox, C.J. Dewdney, N. Mitha, A.W. Roberts, Brij Patel, J. Wills, R. Goodier, R.M. Koshy, D. Weinberg, E.J. Griffin, Harriet L. Mills, A. Marsh, Z. Khonat, Kenneth A. McLean, E. Hester, T. Spencer, A.H.Y. Lee, J. Chong, L.R. Bookless, Michael J. Raphael, P. Sangal, M. McMenamin, H. Khalid, G.S. Harbhajan Singh, F.I. Chaudhry, N. Favero, J.E.F. Fitzgerald, Chetan Khatri, J. Remedios, A. Charania, Daniel J. George, S. Jackson, C. Murkin, R. Dawar, I. Kisyov, E. Wong, R.J. Pearse, A.N. Baker, L. Carthew, N. Warren, I. Adeleja, M. McCann, C. Drislane, R. Tan, S. Ho, K. Hulley, L. Doan, E.M. O'Neill, R. Gratton, M. Srikantharajah, C. Henderson, L. Puan, H. Whittingham, A. Johnston, E. Mckean, A.K. Tear, D. Varma, H. McFarlane, C.N. Lou, E.M. Cumber, Aneel Bhangu, Z.H. Siddiqui, J. Cleere, M. Chamberlain, James Glasbey, Sarah Ali, M. Masood, A. Linton, G. Chillarge, M. Davis-Hall, A. Anilkumar, U. Khan, A. Tai, R. Shepherd, Joshua Burke, W. Loke, M. Edison, A. Mortimer, N. Anim-Addo, R.S. Reehal, R. Blessed, Daniyal J. Jafree, M.S. Sait, H.C. Copley, N. Ward, M. Wells, K. Raji, J. Gulati, H. Keevil, C.A. Asbjoernsen, A. White, Nikita R. Bhatt, J. Barnes, S. Wang, F. Cheung, Clive Graham, K. Dynes, C. Dorman, E. Strange, A. Radotra, A. Reed, R. Nachiappan, I. Ibrahim, F. Acquaah, P. Jalota, S. Stezaker, J.E. Rogers, MI Perera, R. Kiff, T. Rangan, R. Weaver, E. Mazumdar, J. Beckett, Rowena McGregor, E.V. Wright, N. Punjabi, V. Charavanamuttu, Stephen O'Neill, S. Majid, Zulfiqarali G. Abbas, S.M. Lakhani, G. Rattan, J. Lua Boon Xuan, K. Joshi, HE Whewell, M. Patel, T.M. Schulz, O.K. Vernon, L.F. McClymont, N. Woodcock, L. Gray, Reena Shah, H. Thakur, F.S. Peck, P. Karia, L. Ashken, S. Rinkoff, M. McDowell, L. Chew, C.D. Blore, A.C.D. Smith, E. Auyoung, L.M. Sabine, O. Parker, S.M. Choi, V. Thirumal, J. Pickard, L. Murphy, C.J. Coffey, P. Dube, M.H. Abul, T. Khan, J. Campbell, M.T. Turner, Adam Gwozdz, K.K. Ong, B. Durrani, A. O'Kane, A.S. North, Najeeb Ahmed, C. Xiao, D. Maclennan, Nora Abdul Aziz, S.A. Semnani, L. Bell, Amy Ashton, L. Crozier, V. Teng, M. O'Bryan, K. Clesham, Vanisha Patel, L. Kretzmer, T. Lo, G.H. Stanley, M.D. Theodoreson, J.K. Mehta, F. Morris, L. Howells, R. Pinto, T. Bergara, J. Matheson, E. Devlin, E.T. Tan, E. Toner, L. Jacob, Sher Ahmad, J. Sellathurai, Catherine Doherty, J. Norton, C. Maxwell-Armstrong, S. Ng, T.R. Barrow, N. Boxall, A.A. Thevathasan, M. Ryan, E. Uppal, C. Jenvey, G.E. Aidoo-Micah, Karan Verma, U. Datta, F. Hirst, H. Woodward, J. Khangura, J. Chervenkoff, F. Edozie, E. Burke, M.G. Rasiah, A. Jaitley, Thomas L. Lewis, D. Lazenby, A. Lotfallah, A. Khan, E. McCance, Henry A. Claireaux, A.S. Fawaz, P.D. Jewell, R.G. Tharakan, R. Narramore, E. Heathcote, G. Nixon, H. Chin, E. Sun, L.S. Chew, K. Lim, G. Lakshmipathy, R. Telfer, B.A. Shuker, H. Kitt, O.D. Thompson, N. Behar, H. Naveed, R. Allot, E. Batt, E.J. Stone, J.M. Aithie, I. Henderson, Rakesh Heer, C. Deall, C.J. McIntyre, L. Dinsmore, S. Milne, Bhavik Anil Patel, N. Cody, A. Pandey, A. Kaushal, M.C. Sykes, N. Maple, R. Simpson, S. Lynne, S. Shahidi, M.I. Zegeye, B. Forte, P. Khonsari, G. Thomas, O. Sitta, V. Robertson, K. Mazan, J. Prest-Smith, D. O'Reilly, A. Sreh, A.E. Salih, Anna Craig-Mcquaide, Vandana Agarwal, E.G. Chisholm, Z. Afzal, G.L. de Bernier, P.W. Stather, Lucy Elliott, A. Collins, D. Lim, M. Abdelhadi, Q. Lu, and J. Stein

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Critical Care, medicine.medical_treatment, Patient Care Planning, Young Adult, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, 030202 anesthesiology, Laparotomy, Intensive care, medicine, Humans, Hospital Mortality, Prospective Studies, Prospective cohort study, Digestive System Surgical Procedures, Aged, Aged, 80 and over, Postoperative Care, business.industry, Patient Selection, Professional Practice, Odds ratio, Middle Aged, United Kingdom, Confidence interval, Anesthesiology and Pain Medicine, Cohort, Emergency medicine, Female, Observational study, Emergencies, business, Ireland, Abdominal surgery
Abstract

Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery.This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy.Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre. Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51-19.97) than planned admissions (OR: 2.32, 95% CI: 1.43-3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8-51.9%, P0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI.After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies.

Published
2019

25. P-210: Oral ixazomib (Ixa), IV daratumumab (Dara), and dexamethasone (dex; IDd) in relapsed/refractory multiple myeloma (RRMM) patients (pts) with 1–3 prior therapies: phase 2 study interim analysis (IA)

Author

Richard Labotka, Meletios-Athanasios Dimopoulos, Jeffrey Matous, Suman Kambhampati, Roman Hájek, Sosana Delimpasi, Lionel Karlin, Jesus G. Berdeja, Andrzej Pluta, Kaveri Suryanarayan, Petr Pavlicek, Ajeeta B Dash, Robert Z. Orlowski, Argiris Symeonidis, Sebastian Grosicki, Sonja Zweegman, Jan Straub, Pawel Robak, Cyrille Touzeau, Luděk Pour, Viralkumar Bhanderi, and Philip Twumasi-Ankrah

Subjects
Cancer Research, medicine.medical_specialty, Anemia, business.industry, Daratumumab, Phases of clinical research, Hematology, medicine.disease, Interim analysis, Sudden death, Gastroenterology, Ixazomib, Discontinuation, chemistry.chemical_compound, Regimen, Oncology, chemistry, Internal medicine, medicine, business
Abstract

Background: Proteasome inhibitors (PIs) & monoclonal antibodies are backbones of RRMM treatment;Ixa is approved with lenalidomide-dex for pts with ≥1 prior therapy, & Dara is approved in various regimens, including with bortezomib-dex (DVd). In CASTOR (DVd vs Vd), Vd was limited to 8 cycles;however, prolonged PI therapy is associated with improved outcomes. The IDd regimen with oral Ixa may enable longer-term PI therapy than with DVd. We evaluate IDd using a treat-to-progression approach. Methods: Ixa/Dara-naive RRMM pts receive Ixa 4 mg (days 1, 8, 15), Dara 16 mg/kg (days 1, 8, 15, 22, cycles 1–2;days 1, 15, cycles 3–6;day 1, cycles 7+), & dex 20 mg (days 1, 2, 8, 9, 15, 16, 22, 23) in 28-day cycles. The primary endpoint is ≥ very good partial response (VGPR) rate;secondary endpoints include overall response rate (ORR), progression-free survival (PFS), time to progression (TTP), overall survival (OS), & safety. We report data from the 2nd IA, conducted after ~50% of PFS events had occurred (data cutoff: 1/1/2021). Results: 61 pts were enrolled (median age 69 y, 19.7% aged ≥75 y;19.7% International Staging System stage III;26.2% high-risk cytogenetics [del(17p), t(4;14), t(14;16)], 42.6% expanded high-risk cytogenetics [high-risk &/or amp1q21]);59.0/26.2/14.8% of pts had received 1/2/3 prior lines. At data cutoff, pts had received a median of 16 IDd cycles;37.7% were ongoing. Relative dose intensity (RDI) of Ixa, Dara, & dex was 20%) TEAEs were diarrhea (39.3%), anemia (27.9%), thrombocytopenia (26.2%), & fatigue (21.3%);common (>5%) G≥3 TEAEs were pneumonia (11.5%), thrombocytopenia (11.5%), & anemia (8.2%). Infections & Infestations TEAEs were seen in 57.4% of pts (G≥3 24.6%) and were serious in 26.2%, including pneumonia (9.8%) and COVID-19/pneumonia (4.9%). Rate of peripheral neuropathy (PN) was 18.0% (1.6% G≥3). PN was 28.6% & 12.5%in pts with & without history of PN, respectively. Study drug dose modifications, reductions & discontinuations due to TEAEs were required in 57.4% (Ixa 36.1%, Dara 34.4%, dex 41.0%), 32.8%, & 9.8%of pts, respectively. Four pts died on study due to sudden death, COVID-19 pneumonia, septic shock, & COVID-19 (none were considered study drug-related). Conclusion: These IA data suggest IDd has a positive risk-benefit profile in RRMM pts, with a ≥VGPR rate of 30.5%, median PFS of 17.0 m, & a low rate of discontinuation due to TEAEs. The final analysis of this ongoing study is expected in 2022.

Published
2021

26. One-Pot Synthesis of High Density Aviation Fuel with Cyclohexanol

Author

Nil Patel, Akshat Khandelwal, Vaishali R. Umrigar, Jenish Bhanderi, Ajay Maiwala, and Darshak Panchani

Subjects
Materials science, business.industry, One-pot synthesis, Fossil fuel, Mixing (process engineering), Cyclohexanol, engineering.material, Jet fuel, Freezing point, Catalysis, chemistry.chemical_compound, Chemical engineering, chemistry, engineering, Aviation fuel, business
Abstract

Due to exhaustion of fossil fuels, there is a keen need for the alternative solution to fuel reliance. Globally, jet fuels account for 12% of current used liquid transportation fuels. Production of branched decalins, one of the most advanced jet fuel is in research with high density, low freezing point and high thermal stability. Decalins being most thermally stable component of jet fuels due to the unique bicyclic structure with hydrogen-detonating capability are in demand for synthesis. In the present study, the reaction is carried out in a single reactor using H2SO4 as catalyst with N2 as an inert. The experiment comprises of three steps in single reactor by managing addition and speed of mixing of reactant and catalyst. 1) Oligomerisation in N2 atmosphere 2) Neutralisation with NaOH 3) Separation and drying New and simple routes for branched decalins from cyclic alcohols and cyclic alkanes through alkylation and hydride transfer in a one-pot process have been presented. The reaction mass is analysed by GC and GCMS for quantification of the products. Further operating parameters such as temperature, concentration and feed addition time and stirring speed are studied in detailed.

Published
2020

27. Randomized Phase 2 Studies of Checkpoint Inhibitors Alone or in Combination With Pegilodecakin in Patients With Metastatic NSCLC (CYPRESS 1 and CYPRESS 2)

Author

Spigel, David, primary, Jotte, Robert, additional, Nemunaitis, John, additional, Shum, Merrill, additional, Schneider, Jeffrey, additional, Goldschmidt, Jerome, additional, Eisenstein, Jennifer, additional, Berz, David, additional, Seneviratne, Lasika, additional, Socoteanu, Matei, additional, Bhanderi, Viralkumar, additional, Konduri, Kartik, additional, Xia, Meng, additional, Wang, Hong, additional, Hozak, Rebecca R., additional, Gueorguieva, Ivelina, additional, Ferry, David, additional, Gandhi, Leena, additional, Chao, Bo H., additional, and Rybkin, Igor, additional

Published
2021
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28. Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study

Author

Nepogodiev, Dmitri, primary, Wilkin, Richard JW, additional, Bradshaw, Catherine J, additional, Skerritt, Clare, additional, Ball, Alasdair, additional, Moni-Nwinia, Waaka, additional, Blanco-Colino, Ruth, additional, Chauhan, Priyesh, additional, Drake, Thomas M, additional, Frasson, Matteo, additional, Gee, Oliver, additional, Glasbey, James C, additional, Matthews, Jacob H, additional, Morley, Gabriella L, additional, Naumann, David N, additional, Pata, Francesco, additional, Soares, Antonio S, additional, Bhangu, Aneel, additional, Abbas, SH, additional, Abdelgadir, AM, additional, Abdelrahman, A, additional, Abdelrahman, M, additional, Abdelwahed, A, additional, Abou El Ella, Y, additional, Abulafi, M, additional, Acharya, A, additional, Adam, ME, additional, Adams, RE, additional, Adegbola, SO, additional, Adimonye, A, additional, Adnan, M, additional, Afshar, S, additional, Ahad, A, additional, Ahel, J, additional, Ahern, DP, additional, Ahmad Asmadi, A, additional, Ahmed, B, additional, Ahmed, G, additional, Ahmed, OS, additional, Ahmed, S, additional, Akbari, K, additional, Akinsola, O, additional, Al-Khyatt, W, additional, Al-Sarireh, B, additional, Al-Sheikh, M, additional, Alani, M, additional, Alexander, R, additional, Alhammali, T, additional, Ali, M, additional, Aljorfi, A, additional, Allen, M, additional, Allington, J, additional, Alshafei, A, additional, Amarasinghe, R, additional, Amayo, A, additional, Amin, V, additional, Amuthalingam, Thuva, additional, Anandan, L, additional, Anderson, O, additional, Andreani, SM, additional, Andrews, B, additional, Ang, A, additional, Aravind, B, additional, Archer, JE, additional, Aremu, MA, additional, Arunachalam, S, additional, Aruparayil, N, additional, Ashmore, DL, additional, Ashour, O, additional, Ashraf, N, additional, Assaf, N, additional, Avalapati, H, additional, Awokoya, OO, additional, Ayube-Brown, J, additional, Badenoch, T, additional, Bagga, R, additional, Baginski, A, additional, Bailey, S, additional, Bailey, STR, additional, Baird, C, additional, Baker, B, additional, Balai, EJ, additional, Balasubramaniam, A, additional, Bandyopadhyay, SK, additional, Banks, A, additional, Bansal, H, additional, Barnieh, W, additional, Barrie, A, additional, Barter, CA, additional, Bastianpillai, J, additional, Beasley, WD, additional, Bell, CR, additional, Bell, J, additional, Beral, D, additional, Berry, BJM, additional, Bevan, KE, additional, Bevan, V, additional, Bhanderi, Shiv, additional, Bhargava, A, additional, Bilku, D, additional, Birindelli, A, additional, Blackford, OD, additional, Blackwell, JEM, additional, Blake, L, additional, Blencowe, Natalie S, additional, Boam, TD, additional, Boereboom, C, additional, Bogdan, M, additional, Bohra, P, additional, Bolger, JC, additional, Bolton, W, additional, Bond, S, additional, Borg, CM, additional, Borghol, K, additional, Boshier, PR, additional, Bouhadiba, N, additional, Bowen, J, additional, Bowerman, H, additional, Bowman, CR, additional, Boyd-Carson, H, additional, Bradshaw, CJ, additional, Branagan, G, additional, Brennan, P, additional, Brett, M, additional, Brewer, HK, additional, Brewer, H, additional, Bronder, C, additional, Brown, A, additional, Brown, AG, additional, Brown, CE, additional, Brown, M, additional, Brown, R, additional, Buckley-Jones, S, additional, Budzanowski, A, additional, Bukhari, W, additional, Bull, C, additional, Bullivant, JK, additional, Burns, KM, additional, Burnside, D, additional, Busuttil, A, additional, Byrne, BE, additional, Byrnes, CK, additional, Caldwell, M, additional, Callan, R, additional, Cameron, FC, additional, Campbell, U, additional, Campbell, UM, additional, Campbell, W, additional, Carden, CA, additional, Carder, CFW, additional, Carney, K, additional, Cartwright, H, additional, Cay, P, additional, Chalk, A, additional, Chambers, B, additional, Champsi, A, additional, Chan, D, additional, Chan, TCW, additional, Chandler, SB, additional, Chapman, J, additional, Charalabopoulos, A, additional, Chasty, B, additional, Chatzikonstantinou, M, additional, Cheah, WL, additional, Chean, CS, additional, Cheng, S, additional, Cheng, SA, additional, Cheruvu, M, additional, Chin, MY, additional, Chishti, IA, additional, Choi, S, additional, Chok, SM, additional, Chong, B, additional, Choong, JH, additional, Chowdhary, M, additional, Chowdhury, F, additional, Choy, CH, additional, Christian, L, additional, Christopoulos, P, additional, Chui, K, additional, Cipparrone, M, additional, Clark, GL, additional, Clarke, SA, additional, Cleeve, SJ, additional, Clement, KD, additional, Clements, B, additional, Clements, C, additional, Clements, JD, additional, Clements, JM, additional, Clements, JS, additional, Clements, JA, additional, Clingan, R, additional, Cloney, L, additional, Clough, ECS, additional, Coe, PO, additional, Collier-Wakefield, O, additional, Colliver, DW, additional, Colvin, DA, additional, Connelly, TM, additional, Connor, MJ, additional, Cook, V, additional, Cooke, F, additional, Cooper, F, additional, Cotton, AE, additional, Couch, DG, additional, Cousins, L, additional, Coyle, D, additional, Creasy, W, additional, Cresner, RL, additional, Crone, A, additional, Cross, K, additional, Crozier, J, additional, Cunha, P, additional, Curtis, NJ, additional, D'Souza, N, additional, Dagash, H, additional, Dalmia, S, additional, Daniels, I, additional, Danquah-Boateng, D, additional, Dar, FA, additional, Dart, K, additional, Das, A, additional, Daureeawoo, R, additional, Davidson, S, additional, Davidson, JR, additional, Davies, PL, additional, Davis, S, additional, Daya Shetty, V, additional, De-Manzoni-Garberini, A, additional, De-Marchi, JA, additional, Dean, EA, additional, Dean, S, additional, Delimpalta, C, additional, Denley, S, additional, Dennison, G, additional, Devine, AA, additional, Dharamavaram, S, additional, Dhari, AA, additional, Di Franco, F, additional, Di Saverio, S, additional, Dobson, C, additional, Docherty, JA, additional, Doherty, C, additional, Donaldson, G, additional, Donohoe, NO, additional, Donohoe, O, additional, Douka, E, additional, Doulias, T, additional, Downey, M, additional, Doyle, C, additional, Drye, N, additional, Du, DT, additional, Dudek, JG, additional, Dunning, PG, additional, Dyal, ARS, additional, Eardley, NJ, additional, Earnshaw, L, additional, Easdon, S, additional, Edwards, SE, additional, Egan, RJ, additional, El-Masry, S, additional, El-Tayar, O, additional, Elbourne, CR, additional, Elgaddal, S, additional, Elseedawy, M, additional, Elshaer, M, additional, Elsharnoby, OH, additional, Elzeneini, WMA, additional, Emslie, KM, additional, Engall, NFT, additional, Ertansel, B, additional, Esmail, HD, additional, Ettles, C, additional, Evans, J, additional, Evans, JD, additional, Everden, A, additional, Fadel, M, additional, Fahmy, SE, additional, Fairfield, CJ, additional, Fanibi, BF, additional, Farina, Valeria, additional, Farrell, SM, additional, Farrow, EZ, additional, Fasuyi, JA, additional, Faulkner, G, additional, Fawkner-Corbett, D, additional, Fawzi, F, additional, Fehervari, M, additional, Ferguson, N, additional, Finch, JG, additional, Finlayson, H, additional, Flack, T, additional, Foers, W, additional, Foley, NM, additional, Ford, K, additional, Forgie, A, additional, Foster, A, additional, Foster, JD, additional, Fox, AMW, additional, Francis, N, additional, Franklin, D, additional, Froud, H, additional, Fuller, HL, additional, Gaines, E, additional, Galea, J, additional, Gammeri, E, additional, Garnham, J, additional, Garvin, J, additional, Gates, Z, additional, Gentry, R, additional, Ghaffari, I, additional, Ghatorae, S, additional, Gidwani, AL, additional, Gilbert, TG, additional, Gilbert, TM, additional, Gill, S, additional, Gillespie, M, additional, Gillick, J, additional, Giorga, A, additional, Gopalakrishnan, K, additional, Gopalswamy, S, additional, Gopinath, S, additional, Gormely, R, additional, Govind, G, additional, Grant, C, additional, Graveston, J, additional, Gray, J, additional, Gray, RT, additional, Griffith, D, additional, Griffith, JP, additional, Griffiths, Ewen A, additional, Griffiths, SN, additional, Griggs, EJ, additional, Grosvenor, S, additional, Grove, T, additional, Gulamhussein, M, additional, Guliani, J, additional, Gummaraju, A, additional, Gunning, S, additional, Gurjar, SV, additional, Guru-Naidu, S, additional, Gurung, S, additional, Habib, H, additional, Hackney, L, additional, Haddow, James B, additional, Hajibandeh, S, additional, Halkias, C, additional, Hall, NJ, additional, Hamelmann, RN, additional, Haneef, M, additional, Haneef, MS, additional, Hanif, Z, additional, Hanley, C, additional, Hann, AJ, additional, Hanna, T, additional, Hardy, E, additional, Harlinska, A, additional, Harper, F, additional, Harries, RL, additional, Harris, A, additional, Harris, Grant, additional, Harris, MP, additional, Hasan, R, additional, Hassane, A, additional, Hatt, JR, additional, Haveliwala, Z, additional, Hawkins, W, additional, Hayat, Z, additional, Hayes, C, additional, Hebbar, KRM, additional, Henderson, L, additional, Henderson, LT, additional, Herrod, PJJ, additional, Hever, P, additional, Hickey, LM, additional, Hicks, G, additional, Hodgson, JM, additional, Hoff, M, additional, Hollingsworth, A, additional, Hook, A, additional, Hornby, ST, additional, Horsfield, E, additional, Howie, EE, additional, Huang, L, additional, Hudson-Peacock, NJ, additional, Hughes, DL, additional, Hureibi, KA, additional, Hussain, A, additional, Hussain, N, additional, Hussaini, SA, additional, Hussein, A, additional, Hutchinson, B, additional, Ibrahim, YMS, additional, Ikram, S, additional, Ilozue, T, additional, Iosif, E, additional, Iqbal, MR, additional, Irukulla, S, additional, Irwin, R, additional, Islam, N, additional, Ivey, P, additional, Jackson, CR, additional, Jackson, A, additional, Jah, SMH, additional, Jain, A, additional, Jain, S, additional, Jain, Sarus, additional, Jama, GM, additional, Jamieson, NB, additional, Janardanan, S, additional, Jasinski, B, additional, Jenner, D, additional, Jerome, E, additional, Johnson, B, additional, Johnstone, A, additional, Jokhan, S, additional, Jones, A, additional, Jones, CE, additional, Jones, CS, additional, Jones, E, additional, Jones, L, additional, Kabir, U, additional, Kabwama, S, additional, Kamal, M, additional, Kamande, IW, additional, Kanakala, V, additional, Kannegieser-Bailey, M, additional, Kaptanis, S, additional, Karim, MJ, additional, Karwal, RS, additional, Kaur, G, additional, Keegan, R, additional, Kelay, A, additional, Kennedy, ND, additional, Kent, DA, additional, Khair, A, additional, Khan, K, additional, Khan, S, additional, Khasria, A, additional, Kho, H, additional, Kilkenny, J, additional, King, R, additional, Kinross, J, additional, Kirkham, EN, additional, Knight, B, additional, Kochupapy, R, additional, Koh, C, additional, Kouli, O, additional, Krishnamoorthy, A, additional, Krivan, S, additional, Kumar, K, additional, Kumar, S, additional, Kung, VWS, additional, Kuo, R, additional, Lafaurie, G, additional, Lai, CW, additional, Lal, N, additional, Lawday, S, additional, Layman, S, additional, Layton, GR, additional, Lazzaro, A, additional, Lecky-Thompson, L, additional, Lee, KA, additional, Lee, KJ, additional, Lee, M, additional, Lee, SL, additional, Leighton, PA, additional, Leitch, RP, additional, Lennox-Warburton, HC, additional, Leung, EL, additional, Li, CH, additional, Lim, JM, additional, Limb, C, additional, Ljungqvist, G, additional, Lloyd, G, additional, Lodhia, S, additional, Logan, PC, additional, Long, M, additional, Long, P, additional, Long, RH, additional, Longshaw, A, additional, Louw, C, additional, Lund, JN, additional, Ly, C, additional, Lynch Wong, MJ, additional, Ma, JKY, additional, Macdonald, A, additional, Macinnes, EGE, additional, Magro, T, additional, Mahapatra, R, additional, Mahendran, B, additional, Mahmood, F, additional, Mahmoud, A, additional, Mahon, D, additional, Mai, D, additional, Maina, A, additional, Major, CP, additional, Makhija, R, additional, Malam, Y, additional, Malik, A, additional, Malik, K, additional, Malik, SN, additional, Manda, VM, additional, Manektella, KM, additional, Mann, C, additional, Manoharan, P, additional, Manson, R, additional, Mansoor, S, additional, Mansour, MM, additional, Mansour, S, additional, Maqboul, F, additional, Maragouthakis, D, additional, Marangoni, G, additional, Mardhiah, S, additional, Maripi, H, additional, Marriott, P, additional, Marsh, L, additional, Marshall, G, additional, Martin, A, additional, Martin, LM, additional, Martinou, E, additional, Mashar, R, additional, Mason, John, additional, Masood, M, additional, Mathew, G, additional, Maude, K, additional, Mazumdar, E, additional, Mc-Dermott, A, additional, Mcarthur, D, additional, Mccain, RS, additional, McCain, S, additional, Mccann, C, additional, Mccaughey, P, additional, Mccluney, SJ, additional, Mccullough, J, additional, Mcdonnell, D, additional, Mcdowall, NA, additional, McEntee, JE, additional, McGlynn, K, additional, Mcgrath, D, additional, Mcgucken, O, additional, Mcilwaine, S, additional, Mcilwrath, AC, additional, Mckay, SC, additional, McKelvie, MA, additional, Mckenna, M, additional, Mckeon, J, additional, Mckevitt, KL, additional, Mckinley, NC, additional, McLaughlin, D, additional, McMahon, SV, additional, Mcmorran, D, additional, McNally, L, additional, Mcquaid, M, additional, Mcwhirter, DM, additional, Mealy, K, additional, Mears, A, additional, Menzies, D, additional, Merai, H, additional, Mersh, RJ, additional, Miguras, M, additional, Milgrom, D, additional, Miller, K, additional, Milward, J, additional, Mirza, S, additional, Misky, AT, additional, Mistry, D, additional, Mitchard, MJ, additional, Mitru, RM, additional, Mohamed, IM, additional, Mohamed, Imran, additional, Mohamed, TM, additional, Mohamed, WO, additional, Mohd, N, additional, Moore, C, additional, Moradzadeh, J, additional, Morrison, TEM, additional, Morrison-Jones, V, additional, Morton, Dion G, additional, Mothe, BS, additional, Motiwala, Fh, additional, Motter, D, additional, Mowbray, NG, additional, Mughal, Z, additional, Mulsow, J, additional, Mundkur, N, additional, Muntean, A, additional, Murphy, C, additional, Murphy, R, additional, Murray, MP, additional, Muzaffar, M, additional, Myatt, A, additional, Nadeem, A, additional, Nagarajan, D, additional, Nagendram, S, additional, Nair, A, additional, Nair, MK, additional, Nair, MS, additional, Naismith, KN, additional, Nambiar, K, additional, Nana, GR, additional, Nash, Z, additional, Nastro, P, additional, Nazarian, S, additional, Neagle, G, additional, Neale, A, additional, Neary, PM, additional, Newton, RC, additional, Ng, M, additional, Ng, S, additional, Niaz, O, additional, Nickson, S, additional, Nicol, D, additional, Nimako, E, additional, Noor Mohamed, MS, additional, Nyeko-Lacek, M, additional, O'Connor, BR, additional, O'Neill, E, additional, O'Neill, N, additional, O'Sullivan, D, additional, O'Brien, J, additional, Oakey, M, additional, Obeid, N, additional, Odeh, A, additional, Ogboru, S, additional, Ogbuokiri, C, additional, Okekunle, B, additional, Okorocha, E, additional, Olagbaiye, O, additional, Olivier, JB, additional, Ooi, R, additional, Orawiec, P, additional, Orizu, M, additional, Orme, N, additional, Ormiston, R, additional, Paget, C, additional, Pal, A, additional, Palani-Velu, LK, additional, Pan, Y, additional, Panda, N, additional, Pandey, V, additional, Pandya, R, additional, Pandya, D, additional, Paramasevon, KR, additional, Pardy, C, additional, Parkola, MJ, additional, Pasquali, Sandro, additional, Patel, AS, additional, Patel, BY, additional, Patel, C, additional, Patel, H, additional, Patel, N, additional, Patel, RT, additional, Patel, S, additional, Patel, Y, additional, Patel, MM, additional, Patil, SD, additional, Payne, CJ, additional, Payne, RE, additional, Pearce, JCH, additional, Pearce, L, additional, Pedder, A, additional, Peirce, CB, additional, Peiris, GB, additional, Peleki, A, additional, Pellino, Gianluca, additional, Pento, V, additional, Peprah, D, additional, Perera, HS, additional, Perera, MI, additional, Phelan, L, additional, Photiou, D, additional, Pierre, R, additional, Pilkington, JP, additional, Pinkney, Thomas D, additional, Pisavadia, B, additional, Poacher, A, additional, Podda, M, additional, Pollard, H, additional, Popova, D, additional, Poudevigne, M, additional, Prideaux, A, additional, Pullabatla Venkata, UP, additional, Quddus, A, additional, Quill, S, additional, Rabie, M, additional, Rabie, MR, additional, Radwan, RW, additional, Rae, JF, additional, Rahim, A, additional, Rahmani, LS, additional, Rajagopal, S, additional, Rajaram, R, additional, Rajaretnam, N, additional, Rajjoub, Y, additional, Rallage, H, additional, Ramcharan, S, additional, Ranathunga, S, additional, Rao, M, additional, Rao, VSR, additional, Raofi, A, additional, Rashid, M, additional, Rate, A, additional, Ravindran, R, additional, Raymond, M, additional, Raza, SS, additional, Reddy, A, additional, Redman, EP, additional, Redmond, AE, additional, Rekhraj, S, additional, Renshaw, S, additional, Rex, D, additional, Rezacova, M, additional, Rezvani, S, additional, Ribeiro, B, additional, Rich, JE, additional, Richardson, TD, additional, Rigby, S, additional, Rigney, B, additional, Rinkoff, S, additional, Robb, HD, additional, Robertson, C, additional, Robinson, D, additional, Robinson, A, additional, Rodger, V, additional, Rolph, R, additional, Roomi, S, additional, Roth, NPG, additional, Rothnie, K, additional, Roy, C, additional, Rupani, S, additional, Rutherford, DG, additional, Sacks, R, additional, Saghir, N, additional, Saha, A, additional, Sahay, SJ, additional, Sahnan, K, additional, Salama, Y, additional, Salim, S, additional, Samuel, M, additional, Sana, S, additional, Sandu, L, additional, Sarmah, P, additional, Sarveswaran, J, additional, Saunders, SMF, additional, Savill, A, additional, Savioli, F, additional, Schuster Bruce, JR, additional, Sebastian, JF, additional, Seddon, TC, additional, Seneviratne, N, additional, Seth, M, additional, Setshwaelo, T, additional, Sezen, E, additional, Sgardelis, P, additional, Sgrò, A, additional, Shah, C, additional, Shah, J, additional, Shah, K, additional, Shah, SM, additional, Shakoor, Z, additional, Shalaby, MS, additional, Shanmuganathan, V, additional, Shanmugarajah, K, additional, Sharma, A, additional, Sharma, P, additional, Sharp, OL, additional, Shepherd, JA, additional, Sherif, MA, additional, Shet, S, additional, Shingler, G, additional, Shiwani, MH, additional, Shreshta, D, additional, Sian, T, additional, Siddiqui, MN, additional, Siddiqui, ZA, additional, Siggens, KL, additional, Sihra, N, additional, Silva, I, additional, Simioni, A, additional, Simmonds, LFC, additional, Simpson, DJ, additional, Singh, A, additional, Singh, S, additional, Singhal, T, additional, Sivaloganathan, P, additional, Sloan, K, additional, Smallcombe, N, additional, Smart, CJ, additional, Smart, Neil J, additional, Smith, R, additional, Smoker, H, additional, Solinas, L, additional, Souter, JEH, additional, Springate, EL, additional, Stephens, GF, additional, Stevenson, R, additional, Stewart, DJ, additional, Stoica, I, additional, Strachan, E, additional, Stubbs, BM, additional, Stupalkowska, W, additional, Suliman, A, additional, Sultana, A, additional, Sunter, H, additional, Suriyakumar, S, additional, Symons, NRA, additional, Szentpali, K, additional, Szucs, A, additional, Tabain, V, additional, Tague, LE, additional, Tailor, K, additional, Tan, CY, additional, Tan, S, additional, Tang, AM, additional, Tarazi, M, additional, Tay, YH, additional, Tayeh, S, additional, Taylor, M, additional, Taylor, NS, additional, Taze, D, additional, Teasdale, E, additional, Thakral, N, additional, Thava, B, additional, Thavanesan, N, additional, Thaventhiran, AJ, additional, Theodoropoulou, K, additional, Thomas, AT, additional, Thomas, L, additional, Thompson, DB, additional, Thompson, R, additional, Thoukididou, SN, additional, Tiboni, SG, additional, Tiedt, LA, additional, Ting, N, additional, Tinsley, BJ, additional, Tognarelli, JM, additional, Torkington, J, additional, Torrance, A, additional, Townsend, DC, additional, Tozer, PJ, additional, Trail, M, additional, Trew, F, additional, Tudyka, V, additional, Tullie, L, additional, Turnbull, A, additional, Turner, EJ, additional, Twum-Barima, CS, additional, Tyler, Robert, additional, Vakis, S, additional, Valle, A La, additional, Van Boxel, GI, additional, Vance-Daniel, J, additional, Varcada, M, additional, Varma, N, additional, Vaughan, EM, additional, Velchuru, VR, additional, Velho, R, additional, Venkatasubramaniam, AK, additional, Venn, ML, additional, Vijay, V, additional, Vinnicombe, Z, additional, Vitish-Sharma, P, additional, Wagener, S, additional, Waite, K, additional, Walters, KJ, additional, Walters, U, additional, Wardle, BG, additional, Wardle, SD, additional, Warusavitarne, J, additional, Watfah, J, additional, Watson, N, additional, Wauchope, J, additional, Weatherburn, LW, additional, Weegenaar, CR, additional, Welsh, S, additional, Wheatstone, S, additional, Whewell, HE, additional, Whitehouse, P, additional, Whiteman, E, additional, Whittaker, L, additional, Wijesundera, K, additional, Wilkinson, D, additional, Williams, GL, additional, Williams, M, additional, Williams, R, additional, Williams, S, additional, Wilson, EJ, additional, Wilson, MSJ, additional, Winter, DC, additional, Winter, G, additional, Wolff, J, additional, Wong, A, additional, Wong, CLL, additional, Wong, SY, additional, Wood, CS, additional, Woodrow, C, additional, Woodward, A, additional, Woodward, B, additional, Wright, E, additional, Wright, HL, additional, Wu, F, additional, Yalamarthi, S, additional, Yang, P, additional, Yardimci, E, additional, Yasin, T, additional, Yen, SK, additional, Yoganathan, S, additional, Yoong, S, additional, Youssef, H, additional, Yow, LPS, additional, Zaborowski, A, additional, Zadi, AZ, additional, Zarka, ZA, additional, Zarog, MA, additional, and Zhang, AY, additional

Published
2020
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31. Evaluation of the impact of surfactants on miscibility of griseofulvin in spray dried amorphous solid dispersions

Author

Hisham Al-Obaidi, Amit Bhanderi, and Fiza Bari

Subjects
Recrystallization (geology), Materials science, Antifungal drug, Pharmaceutical Science, 02 engineering and technology, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, Miscibility, Amorphous solid, Solvent, 03 medical and health sciences, 0302 clinical medicine, Chemical engineering, Spray drying, Solubility, 0210 nano-technology, Glass transition
Abstract

The aim of this contribution is to examine the impact of incorporating surfactants into amorphous solid dispersions on solid state miscibility and aqueous solubility of the antifungal drug griseofulvin. Spray dried amorphous solid dispersions of griseofulvin (GF) and hypromellose acetate succinate (HPMCAS) were prepared by spray drying. Three different surfactants of varying ratios between 1 to 5% were used namely the anionic sodium dodecyl sulfate (SDS), the cationic dodecyletrimethylammonium bromide (DTAB) and the non-ionic pluronic (F127). Flory-Huggins model combined with calculations based on Hoffman's equation were used to calculate miscibility and predicted solubility of the amorphous form. The results showed that the prepared solid dispersions exhibited enhanced drug-polymer miscibility reflected by improved thermodynamics of mixing. The highest miscibility was achieved when DTAB was incorporated by which the drug-polymer miscibility was enhanced by approximately 1.5 times. The tendency to recrystallize was calculated using reduced recrystallization parameter and correlated with the measured saturation solubility showing distinct properties which were dependent on the type of surfactant. Saturated solubility of the solid dispersions was compared with micellar solubility and was found to be significantly affected by the presence of the polymer. The glass transition temperature (Tg) decreased significantly upon the addition of surfactants. However, gravimetric analysis showed that solvent content did not exceed 1% which suggests that the shifted Tg was not related to plasticizing effect of residual solvent. Overall, these results suggest potential role for the surfactants in enhancing solid state miscibility when incorporated into the solid dispersions.

Published
2021

32. Exploring the cost implications of increased renewable energy for the U.S. power system

Author

Trieu Mai, KAUSHAL BHANDERI, Nathaniel Gates, and Wesley Cole

Subjects
business.industry, Natural resource economics, 020209 energy, Electricity system, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Renewable energy, Electric power system, Electricity generation, Management of Technology and Innovation, 0202 electrical engineering, electronic engineering, information engineering, Renewable generation, Environmental science, Electricity, Business and International Management, business, Renewable energy penetration, Cost implications, 0105 earth and related environmental sciences, Energy (miscellaneous)
Abstract

Over the last decade, the fraction of annual U.S. electricity generation for renewable energy has doubled from 10 % to 20 %. This growth has been driven by several factors, including technology cost reductions and policy support. The share of renewable generation is projected to increase over time. Reference case scenarios from four different organizations show least-cost U.S. electricity buildouts with renewable energy generation fractions of 31–36 % by 2030 and 40–65 % by 2050. Using a capacity expansion modeling tool, we investigate how changing the amount of renewable energy from the least-cost solution impacts the cost of building and operating the electricity system. The relationship between system cost and renewable energy generation fraction is non-linear. Small deviations near the least-cost solution have minimal cost impacts (changing the renewable energy penetration by +/- 5% results in system cost changes of less than 1%), while similar deviations that are farther from the least-cost solution can result in large cost changes. Increased levels of RE lead to lower absolute emissions, and we evaluate the trade-offs between emissions savings and system costs for higher and lower levels of RE penetration.

Published
2021

33. Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study

Author

McLean, K.A., primary, Glasbey, J.C., additional, Borakati, A., additional, Brooks, T.M., additional, Chang, H.M., additional, Choi, S.M., additional, Goodson, R., additional, Nielsen, M., additional, Pronin, S., additional, Salloum, N.L., additional, Sewart, E., additional, Vanniasegaram, D., additional, Drake, T.M., additional, Gillies, M.A., additional, Harrison, E.M., additional, Chapman, S.J., additional, Khatri, C., additional, Kong, C.Y., additional, Claireaux, H.A., additional, Bath, M.F., additional, Mohan, M., additional, McNamee, L., additional, Kelly, M., additional, Mitchell, H., additional, Fitzgerald, J.E., additional, Bhangu, A., additional, Nepogodiev, D., additional, Antoniou, I., additional, Dean, R., additional, Davies, N., additional, Trecarten, S., additional, Henderson, I., additional, Holmes, C., additional, Wylie, J., additional, Shuttleworth, R.H., additional, Jindal, A., additional, Hughes, F., additional, Gouda, P., additional, Fleck, R., additional, Hanrahan, M., additional, Karunakaran, P., additional, Chen, J.H., additional, Sykes, M.C., additional, Sethi, R.K., additional, Suresh, S., additional, Patel, P., additional, Patel, M., additional, Varma, R.K., additional, Mushtaq, J., additional, Gundogan, B., additional, Bolton, W., additional, Khan, T., additional, Burke, J., additional, Morley, R., additional, Favero, N., additional, Adams, R., additional, Thirumal, V., additional, Kennedy, E.D., additional, Ong, K.K., additional, Tan, Y.H., additional, Gabriel, J., additional, Bakhsh, A., additional, Low, J.Y.L., additional, Yener, A., additional, Paraoan, V., additional, Preece, R., additional, Tilston, T.W., additional, Cumber, E., additional, Dean, S., additional, Ross, T., additional, McCance, E., additional, Amin, H., additional, Satterthwaite, L., additional, Clement, K.D., additional, Gratton, R., additional, Mills, E.D., additional, Chiu, S.M., additional, Hung, G., additional, Rafiq, N.M., additional, Hayes, J.D.B., additional, Robertson, K.L., additional, Dynes, K., additional, Huang, H.C., additional, Assadullah, S., additional, Duncumb, J.W., additional, Moon, R.D.C., additional, Poo, S.X., additional, Mehta, J.K., additional, Joshi, K.R., additional, Callan, R., additional, Norris, J.M., additional, Chilvers, N.J., additional, Keevil, H., additional, Jull, P., additional, Mallick, S., additional, Elf, D., additional, Carr, L., additional, Player, C., additional, Barton, E.C., additional, Martin, A.L., additional, Ratu, S.G., additional, Roberts, E.J., additional, Phan, P.N., additional, Dyal, A.R., additional, Rogers, J.E., additional, Henson, A.D., additional, Reid, N.B., additional, Burke, D., additional, Culleton, G., additional, Lynne, S., additional, Mansoor, S., additional, Brennan, C., additional, Blessed, R., additional, Holloway, C., additional, Hill, A., additional, Goldsmith, T., additional, Mackin, S., additional, Kim, S., additional, Woin, E., additional, Brent, G., additional, Coffin, J., additional, Ziff, O., additional, Momoh, Z., additional, Debenham, R., additional, Ahmed, M., additional, Yong, C.S., additional, Wan, J.C., additional, Copley, H.C., additional, Raut, P., additional, Chaudhry, F.I., additional, Nixon, G., additional, Dorman, C., additional, Tan, R., additional, Kanabar, S., additional, Canning, N., additional, Dolaghan, M., additional, Bell, N., additional, McMenamin, M., additional, Chhabra, A., additional, Duke, K., additional, Turner, L., additional, Patel, T., additional, Chew, L.S., additional, Mirza, M., additional, Lunawat, S., additional, Oremule, B., additional, Ward, N., additional, Khan, M., additional, Tan, E.T., additional, Maclennan, D., additional, McGregor, R.J., additional, Chisholm, E.G., additional, Griffin, E.J., additional, Bell, L., additional, Hughes, B.A., additional, Davies, J., additional, Haq, H., additional, Ahmed, H., additional, Ungcharoen, N., additional, Whacha, C., additional, Thethi, R., additional, Markham, R.M., additional, Lee, A.H.Y., additional, Batt, E., additional, Bullock, N.P., additional, Francescon, C.T., additional, Davies, J.E., additional, Shafiq, N.M., additional, Zhao, J., additional, Vivekanantham, S., additional, Barai, I., additional, Allen, J.L.Y., additional, Marshall, D.C., additional, McIntyre, C.J., additional, Wilson, H.C.P., additional, Ashton, A.J., additional, Lek, C., additional, Behar, N., additional, Davis-Hall, M., additional, Seneviratne, N., additional, Esteve, L., additional, Sirakaya, M., additional, Ali, S., additional, Pope, S., additional, Ahn, J.S., additional, Craig-McQuaide, A., additional, Gatfield, W.A., additional, Leong, S., additional, Demetri, A.M., additional, Kerr, A.L., additional, Rees, C., additional, Loveday, J., additional, Liu, S., additional, Wijesekera, M., additional, Maru, D., additional, Attalla, M., additional, Smith, N., additional, Brown, D., additional, Sritharan, P., additional, Shah, A., additional, Charavanamuttu, V., additional, Heppenstall-Harris, G., additional, Ng, K., additional, Raghvani, T., additional, Rajan, N., additional, Hulley, K., additional, Moody, N., additional, Williams, M., additional, Cotton, A., additional, Sharifpour, M., additional, Lwin, K.N., additional, Bright, M., additional, Chitnis, A.R., additional, Abdelhadi, M., additional, Semana, A.D., additional, Morgan, F., additional, Reid, R., additional, Dickson, J., additional, Anderson, L., additional, McMullan, R., additional, Ahern, N., additional, Asmadi, A., additional, Anderson, L.B., additional, Boon Xuan, J. Lua, additional, Crozier, L., additional, McAleer, S., additional, Lees, D.M., additional, Adebayo, A.A., additional, Das, M., additional, Amphlett, A.H., additional, Al-Robeye, A., additional, Valli, A., additional, Khangura, J., additional, Winarski, A., additional, Ali, A., additional, Woodward, H., additional, Gouldthrope, C., additional, Turner, M., additional, Sasapu, K., additional, Tonkins, M., additional, Wild, J.R.L., additional, Robinson, M., additional, Hardie, J., additional, Heminway, R., additional, Narramore, R., additional, Ramjeeawon, N., additional, Hibberd, A., additional, Winslow, F., additional, Ho, W., additional, Chong, B.F., additional, Lim, K., additional, Ho, S., additional, Crewdson, J.A., additional, Singagireson, S., additional, Kalra, N., additional, Koumpa, F., additional, Jhala, H., additional, Soon, W.C., additional, Karia, M., additional, Rasiah, M.G., additional, Xylas, D., additional, Gilbert, H., additional, Sundar-Singh, M., additional, Wills, J., additional, Akhtar, S., additional, Patel, S., additional, Hu, L., additional, Brathwaite-Shirley, C., additional, Nayee, H., additional, Amin, O., additional, Rangan, T., additional, Turner, E.J.H., additional, McCrann, C., additional, Shepherd, R., additional, Patel, N., additional, Prest-Smith, J., additional, Auyoung, E., additional, Murtaza, A., additional, Coates, A., additional, Prys-Jones, O., additional, King, M., additional, Gaffney, S., additional, Dewdney, C.J., additional, Nehikhare, I., additional, Lavery, J., additional, Bassett, J., additional, Davies, K., additional, Ahmad, K., additional, Collins, A., additional, Acres, M., additional, Egerton, C., additional, Cheng, K., additional, Chen, X., additional, Chan, N., additional, Sheldon, A., additional, Khan, S., additional, Empey, J., additional, Ingram, E., additional, Malik, A., additional, Johnstone, M., additional, Goodier, R., additional, Shah, J.P., additional, Giles, J.E., additional, Sanders, J.A., additional, McLure, S.W., additional, Pal, S., additional, Rangedara, A., additional, Baker, A.N., additional, Asbjoernsen, C.A., additional, Girling, C., additional, Gray, L., additional, Gauntlett, L., additional, Joyner, C., additional, Qureshi, S., additional, Mogan, Y.P., additional, Ng, J.C.K., additional, Kumar, A.N., additional, Park, J.H., additional, Tan, D., additional, Choo, K.P., additional, Raman, K.P., additional, Buakuma, P., additional, Xiao, C., additional, Govinden, S., additional, Thompson, O.D., additional, Charalambos, M.A., additional, Brown, E., additional, Karsan, R.B., additional, Dogra, T., additional, Bullman, L.M., additional, Dawson, P.M., additional, Frank, A.L., additional, Abid, H., additional, Tung, L., additional, Qureshi, U., additional, Tahmina, A., additional, Matthews, B.W., additional, Harris, R.T., additional, O'Connor, A., additional, Mazan, K., additional, Iqbal, S., additional, Stanger, S.A., additional, Thompson, J.D., additional, Sullivan, J.A.L., additional, Uppal, E., additional, MacAskill, A., additional, Bamgbose, F.A., additional, Neophytou, C., additional, Carroll, A.F., additional, Rookes, C.W., additional, Datta, U., additional, Dhutia, A.J., additional, Rashid, S., additional, Ahmed, N., additional, Lo, T., additional, Bhanderi, S., additional, Blore, C.D., additional, Ahmed, S., additional, Shaheen, H., additional, Abburu, S., additional, Majid, S., additional, Abbas, Z., additional, Talukdar, S.S., additional, Burney, L.J., additional, Patel, J.B., additional, Al-Obaedi, O., additional, Roberts, A.W., additional, Mahboob, S., additional, Singh, B., additional, Sheth, S., additional, Karia, P., additional, Prabhudesai, A., additional, Kow, K., additional, Koysombat, K., additional, Wang, S., additional, Morrison, P., additional, Maheswaran, Y., additional, Keane, P., additional, Copley, P.C., additional, Brewster, O., additional, Xu, G.X., additional, Harries, P., additional, Wall, C., additional, Al-Mousawi, A., additional, Bonsu, S., additional, Cunha, P., additional, Ward, T., additional, Paul, J., additional, Nadanakumaran, K., additional, Tayeh, S., additional, Holyoak, H., additional, Remedios, J., additional, Theodoropoulou, K., additional, Luhishi, A., additional, Jacob, L., additional, Long, F., additional, Atayi, A., additional, Sarwar, S., additional, Parker, O., additional, Harvey, J., additional, Ross, H., additional, Rampal, R., additional, Thomas, G., additional, Vanmali, P., additional, McGowan, C., additional, Stein, J., additional, Robertson, V., additional, Carthew, L., additional, Teng, V., additional, Fong, J., additional, Street, A.N., additional, Thakker, C.E., additional, O'Reilly, D., additional, Bravo, M., additional, Pizzolato, A., additional, Khokhar, H.A., additional, Ryan, M., additional, Cheskes, L., additional, Carr, R., additional, Salih, A.E., additional, Bassiony, S., additional, Yuen, R., additional, Chrastek, D., additional, Rosen O'Sullivan, H., additional, Amajuoyi, A., additional, Wang, A., additional, Sitta, O., additional, Wye, J., additional, Qamar, M.A., additional, Major, C., additional, Kaushal, A., additional, Morgan, C., additional, Petrarca, M., additional, Allot, R., additional, Verma, K., additional, Dutt, S., additional, Chilima, C.P., additional, Peroos, S., additional, Kosasih, S.R., additional, Chin, H., additional, Ashken, L., additional, Pearse, R.J., additional, O'Loughlin, R.A., additional, Menon, A., additional, Singh, K., additional, Norton, J., additional, Sagar, R., additional, Jathanna, N., additional, Rothwell, L., additional, Watson, N., additional, Harding, F., additional, Dube, P., additional, Khalid, H., additional, Punjabi, N., additional, Sagmeister, M., additional, Gill, P., additional, Shahid, S., additional, Hudson-Phillips, S., additional, George, D., additional, Ashwood, J., additional, Lewis, T., additional, Dhar, M., additional, Sangal, P., additional, Rhema, I.A., additional, Kotecha, D., additional, Afzal, Z., additional, Syeed, J.A., additional, Prakash, E., additional, Jalota, P., additional, Herron, J., additional, Kimani, L., additional, Delport, A., additional, Shukla, A., additional, Agarwal, V., additional, Parthiban, S., additional, Thakur, H., additional, Cymes, W., additional, Rinkoff, S., additional, Turnbull, J.A., additional, Hayat, M., additional, Darr, S., additional, Khan, U., additional, Lim, J., additional, Higgins, A., additional, Lakshmipathy, G., additional, Forte, B., additional, Canning, E., additional, Jaitley, A., additional, Lamont, J., additional, Toner, E., additional, Ghaffar, A., additional, McDowell, M., additional, Salmon, D., additional, O'Carroll, O., additional, Khan, A., additional, Kelly, M.E., additional, Clesham, K., additional, Palmer, C., additional, Lyons, R., additional, Bell, A., additional, Chin, R., additional, Waldron, R.M., additional, Trimble, A., additional, Cox, S.E., additional, Ashfaq, U., additional, Campbell, J., additional, Holliday, R.B.S., additional, McCabe, G., additional, Morris, F., additional, Priestland, R., additional, Vernon, O.K., additional, Ledsam, A., additional, Vaughan, R., additional, Lim, D., additional, Bakewell, Z.R., additional, Hughes, R.K., additional, Koshy, R.M., additional, Jackson, H.R., additional, Narayan, P., additional, Cardwell, A.E., additional, Jubainville, C.L., additional, Arif, T., additional, Elliott, L.E., additional, Gupta, V., additional, Bhaskaran, G., additional, Odeleye, A., additional, Ahmed, F., additional, Shah, R., additional, Pickard, J., additional, Suleman, Y.N., additional, North, A.S., additional, McClymont, L.F., additional, Hussain, N., additional, Ibrahim, I., additional, Ng, G.S., additional, Wong, V., additional, Lim, A.E., additional, Harris, L.N., additional, Tharmachandirar, T., additional, Mittapalli, D., additional, Patel, V., additional, Lakhani, M., additional, Bazeer, H.Z., additional, Narwani, V., additional, Sandhu, K.K., additional, Wingfield, L.R., additional, Gentry, S., additional, Adjei, H., additional, Bhatti, M., additional, Braganza, L., additional, Barnes, J., additional, Mistry, S., additional, Chillarge, G., additional, Stokes, S., additional, Cleere, J., additional, Wadanamby, S., additional, Bucko, A.M., additional, Meek, J., additional, Boxall, N., additional, Heywood, E.G., additional, Wiltshire, J.J., additional, Toh, C., additional, Ward, A.E., additional, Shurovi, B.N., additional, Horth, D., additional, Patel, B.Y., additional, Ali, B., additional, Spencer, T., additional, Axelson, T., additional, Kretzmer, L., additional, Chhina, C., additional, Anandarajah, C., additional, Fautz, T., additional, Horst, C., additional, Thevathasan, A.A., additional, Ng, J.Q., additional, Hirst, F., additional, Brewer, C.F., additional, Logan, A.E., additional, Lockey, J.W., additional, Forrest, P.R., additional, Keelty, N., additional, Wood, A.D., additional, Springford, L.R., additional, Avery, P., additional, Schulz, T.M., additional, Bemand, T.P., additional, Howells, L., additional, Collier, H., additional, Khajuria, A., additional, Tharakan, R.G., additional, Parsons, S., additional, Buchan, A.M., additional, McGalliard, R.J., additional, Mason, J.D., additional, Cundy, O.J., additional, Li, N., additional, Redgrave, N.A., additional, Watson, R.P., additional, Pezas, T.P., additional, Dennis, Y.F., additional, Segall, E., additional, Hameed, M., additional, Lynch, A.S., additional, Chamberlain, M., additional, Peck, F.S., additional, Neo, Y.N., additional, Russell, G., additional, Elseedawy, M., additional, Lee, S., additional, Foster, N.L., additional, Soo, Y.H., additional, Puan, L., additional, Dennis, R., additional, Goradia, H., additional, Qureshi, A., additional, Osman, S., additional, Reeves, T., additional, Dinsmore, L., additional, Marsden, M., additional, Lu, Q., additional, Pitts-Tucker, T., additional, Dunn, C.E., additional, Walford, R.A., additional, Heathcote, E., additional, Martin, R., additional, Pericleous, A., additional, Brzyska, K., additional, Reid, K.G., additional, Williams, M.R., additional, Wetherall, N., additional, McAleer, E., additional, Thomas, D., additional, Kiff, R., additional, Milne, S., additional, Holmes, M.J.V., additional, Bartlett, J., additional, Lucas de Carvalho, J., additional, Bloomfield, T., additional, Tongo, F., additional, Bremner, R.H., additional, Yong, N., additional, Atraszkiewicz, B.A., additional, Mehdi, A., additional, Tahir, M., additional, Sherliker, G.X.J., additional, Tear, A.K., additional, Pandey, A., additional, Broyd, A., additional, Omer, H.M., additional, Raphael, M., additional, Chaudhry, W.W., additional, Shahidi, S., additional, Jawad, A.S., additional, Gill, C.K., additional, Fisher, I. Hindle, additional, Adeleja, I., additional, Clark, I.J., additional, Aidoo-Micah, G.E., additional, Stather, P.W., additional, Salam, G.J., additional, Glover, T.E., additional, Deas, G., additional, Sim, N.K., additional, Obute, R.D., additional, Wynell-Mayow, W.M., additional, Sait, M.S., additional, Mitha, N., additional, de Bernier, G.L., additional, Siddiqui, M., additional, Shaunak, R., additional, Wali, A., additional, Cuthbert, G., additional, Bhudia, R., additional, Webb, E., additional, Shah, S., additional, Ansari, N., additional, Perera, M., additional, Kelly, N., additional, McAllister, R., additional, Stanley, G.H., additional, Keane, C.P., additional, Shatkar, V., additional, Maxwell-Armstrong, C., additional, Henderson, L.A., additional, Maple, N., additional, Manson, R., additional, Adams, R.D., additional, Semple, E., additional, Mills, M., additional, Daoub, A., additional, Marsh, A., additional, Ramnarine, A., additional, Hartley, J., additional, Malaj, M., additional, Jewell, P.D., additional, Whatling, E.A., additional, Hitchen, N., additional, Chen, M., additional, Goh, B., additional, Fern, J., additional, Rogers, S., additional, Derbyshire, L., additional, Robertson, D.T., additional, Abuhussein, N., additional, Deekonda, P., additional, Abid, A., additional, Harrison, P.L.M., additional, Aildasani, L., additional, Turley, H., additional, Sherif, M.A., additional, Pandey, G., additional, Filby, J.J., additional, Johnston, A., additional, Burke, E., additional, Mohamud, M., additional, Gohil, K., additional, Tsui, A.Y., additional, Singh, R., additional, Lim, S.J., additional, O'Sullivan, K., additional, McKelvey, L.L., additional, O'Neill, S., additional, Roberts, H.F., additional, Brown, F.S., additional, Cao, Y., additional, Buckle, R.T., additional, Liew, Y., additional, Sii, S., additional, Ventre, C.M., additional, Graham, C.J., additional, Filipescu, T., additional, Yousif, A., additional, Dawar, R., additional, Wright, A., additional, Peters, M., additional, Varley, R., additional, Owczarek, S., additional, Hartley, S., additional, Khattak, M., additional, Iqbal, A., additional, Ali, M., additional, Durrani, B., additional, Narang, Y., additional, Bethell, G.S., additional, Horne, L., additional, Pinto, R., additional, Nicholls, K., additional, Kisyov, I., additional, Torrance, H.D., additional, English, W., additional, Lakhani, S.M., additional, Ashraf, S.F., additional, Venn, M., additional, Elangovan, V., additional, Kazmi, Z., additional, Brecher, J., additional, Sukumar, S., additional, Mastan, A., additional, Mortimer, A., additional, Parker, J., additional, Boyle, J., additional, Elkawafi, M., additional, Beckett, J., additional, Mohite, A., additional, Narain, A., additional, Mazumdar, E., additional, Sreh, A., additional, Hague, A., additional, Weinberg, D., additional, Fletcher, L., additional, Steel, M., additional, Shufflebotham, H., additional, Masood, M., additional, Sinha, Y., additional, Jenvey, C., additional, Kitt, H., additional, Slade, R., additional, Craig, A.R., additional, Deall, C., additional, Reakes, T., additional, Chervenkoff, J., additional, Strange, E., additional, O'Bryan, M., additional, Murkin, C., additional, Joshi, D., additional, Bergara, T., additional, Naqib, S., additional, Wylam, D., additional, Scotcher, S.E., additional, Hewitt, C.M., additional, Stoddart, M.T., additional, Kerai, A., additional, Trist, A.J., additional, Cole, S.J., additional, Knight, C.L., additional, Stevens, S., additional, Cooper, G.E., additional, Ingham, R., additional, Dobson, J., additional, O'Kane, A., additional, Moradzadeh, J., additional, Duffy, A., additional, Henderson, C., additional, Ashraf, S., additional, McLaughin, C., additional, Hoskins, T.C., additional, Reehal, R.S., additional, Bookless, L.R., additional, McLean, R.C., additional, Stone, E.J., additional, Wright, E.V., additional, Abdikadir, H.R., additional, Roberts, C., additional, Spence, O., additional, Srikantharajah, M., additional, Ruiz, E.M., additional, Matthews, J.H., additional, Gardner, E., additional, Hester, E., additional, Naran, P., additional, Simpson, R., additional, Minhas, M., additional, Cornish, E., additional, Semnani, S.A., additional, Rojoa, D., additional, Radotra, A., additional, Eraifej, J., additional, Eparh, K., additional, Smith, D.N.E., additional, Mistry, B.D., additional, Hickling, S.L., additional, Din, W., additional, Liu, C., additional, Mithrakumar, P., additional, Mirdavoudi, V., additional, Rashid, M., additional, Mcgenity, C., additional, Hussain, O., additional, Kadicheeni, M., additional, Gardner, H., additional, Anim-Addo, N., additional, Pearce, J., additional, Aslanyan, A., additional, Ntala, C., additional, Sorah, T., additional, Parkin, J., additional, Alizadeh, M., additional, White, A., additional, Edozie, F., additional, Johnston, J., additional, Kahar, A., additional, Navayogaarajah, V., additional, Patel, B., additional, Carter, D., additional, Khonsari, P., additional, Burgess, A., additional, Kong, C., additional, Ponweera, A., additional, Cody, A., additional, Tan, Y., additional, Ng, A.Y.L., additional, Croall, A., additional, Allan, C., additional, Ng, S., additional, Raghuvir, V., additional, Telfer, R., additional, Greenhalgh, A.D., additional, McKerr, C.N., additional, Edison, M.A., additional, Patel, B.A., additional, Dear, K., additional, Hardy, M.R., additional, Williams, P., additional, Hassan, S., additional, Sajjad, U., additional, O'Neill, E.M., additional, Lopes, S., additional, Healy, L., additional, Jamal, N., additional, Tan, S., additional, Lazenby, D., additional, Husnoo, S.B., additional, Beecroft, S., additional, Sarvanandan, T., additional, Weston, C., additional, Bassam, N., additional, Rabinthiran, S., additional, Hayat, U., additional, Ng, L., additional, Varma, D., additional, Sukkari, M., additional, Mian, A., additional, Omar, A., additional, Kim, J.W., additional, Sellathurai, J., additional, Mahmood, J., additional, O'Connell, C., additional, Bose, R., additional, Heneghan, H., additional, Lalor, P., additional, Matheson, J., additional, Doherty, C., additional, Cullen, C., additional, Cooper, D., additional, Angelov, S., additional, Drislane, C., additional, Smith, A.C.D., additional, Kreibich, A., additional, Palkhi, E., additional, Durr, A., additional, Lotfallah, A., additional, Gold, D., additional, Mckean, E., additional, Dhanji, A., additional, Anilkumar, A., additional, Thacoor, A., additional, Siddiqui, Z.H., additional, Lim, S., additional, Piquet, A., additional, Anderson, S.M., additional, McCormack, D.R., additional, Gulati, J., additional, Ibrahim, A., additional, Murray, S.E., additional, Walsh, S.L., additional, McGrath, A., additional, Ziprin, P., additional, Chua, E.Y., additional, Lou, C.N., additional, Bloomer, J., additional, Paine, H.R., additional, Osei-Kuffour, D., additional, White, C.J., additional, Szczap, A., additional, Gokani, S., additional, Patel, K., additional, Malys, M.K., additional, Reed, A., additional, Torlot, G.E., additional, Cumber, E.M., additional, Charania, A., additional, Ahmad, S., additional, Varma, N., additional, Cheema, H., additional, Austreng, L., additional, Petra, H., additional, Chaudhary, M., additional, Zegeye, M.I., additional, Cheung, F., additional, Coffey, D., additional, Heer, R.S., additional, Singh, S., additional, Seager, E., additional, Cumming, S., additional, Suresh, R.S., additional, Verma, S., additional, Ptacek, I.B., additional, Gwozdz, A.M., additional, Yang, T., additional, Khetarpal, A.A., additional, Shumon, S., additional, Fung, T.M.P., additional, Leung, W., additional, Kwang, P., additional, Chew, L., additional, Loke, W., additional, Curran, A., additional, Chan, C., additional, McGarrigle, C., additional, Mohan, K., additional, Cullen, S., additional, Wong, E., additional, Toale, C., additional, Collins, D., additional, Keane, N., additional, Traynor, B.P., additional, Shanahan, D., additional, Yan, A., additional, Jafree, D.J., additional, Topham, C., additional, Mitrasinovic, S., additional, Omara, S., additional, Bingham, G., additional, Lykoudis, P.M., additional, Miranda, B.H., additional, Whitehurst, K., additional, Kumaran, G., additional, Devabalan, Y., additional, Aziz, H., additional, Shoa, M., additional, Dindyal, S., additional, Yates, J.A., additional, Bernstein, I., additional, Rattan, G., additional, Coulson, R., additional, Stezaker, S., additional, Isaac, A., additional, Salem, M., additional, McBride, A., additional, McFarlane, H., additional, Yow, L., additional, MacDonald, J., additional, Bartlett, R.D., additional, Turaga, S., additional, White, U., additional, Liew, W., additional, Yim, N., additional, Ang, A., additional, Simpson, A., additional, McAuley, D., additional, Craig, E., additional, Murphy, L., additional, Shepherd, P., additional, Kee, J.Y., additional, Abdulmajid, A., additional, Chung, A., additional, Warwick, H.L., additional, Livesey, A., additional, Holton, P., additional, Theodoreson, M.D., additional, Jenkin, S.L., additional, Turner, J., additional, Entwisle, J.H., additional, Marchal, S.T., additional, O'Connor, S., additional, Blege, H.K., additional, Aithie, J.M., additional, Sabine, L.M., additional, Stewart, G.E., additional, Jackson, S., additional, Kishore, A., additional, Lankage, C.M., additional, Acquaah, F., additional, Joyce, H.L., additional, McKevitt, K.L., additional, Coffey, C.J., additional, Fawaz, A.S., additional, Dolbec, K.S., additional, O'Sullivan, D.A., additional, Geraghty, J.M., additional, Lim, E., additional, Bolton, L., additional, FitzPatrick, D., additional, Robinson, C., additional, Ramtoola, T., additional, Collinson, S., additional, Grundy, L., additional, McEnhill, P.M., additional, Harbhajan Singh, G.S., additional, Loughran, D., additional, Golding, D.M., additional, Keeling, R.E., additional, Williams, R.P., additional, Whitham, R.D.J., additional, Yoganathan, S., additional, Nachiappan, R., additional, Egan, R.J., additional, Owasil, R., additional, Kwan, M.L., additional, He, A., additional, Goh, R.W., additional, Bhome, R., additional, Wilson, H., additional, Teoh, P.J., additional, Raji, K., additional, Jayakody, N., additional, Matthams, J., additional, Chong, J., additional, Luk, C.Y., additional, Greig, R.J., additional, Trail, M., additional, Charalambous, G., additional, Rocke, A.S., additional, Gardiner, N., additional, Bulley, F., additional, Warren, N., additional, Brennan, E., additional, Fergurson, P., additional, Wilson, R., additional, Whittingham, H., additional, Brown, E.J., additional, Khanijau, R., additional, Gandhi, K., additional, Morris, S., additional, Boulton, A.J., additional, Chandan, N., additional, Barthorpe, A.E., additional, Maamari, R., additional, Sandhu, S., additional, McCann, M., additional, Higgs, L., additional, Balian, V., additional, Reeder, C., additional, Diaper, C., additional, Sale, T., additional, Ali, H., additional, Archer, C.H., additional, Clarke, A.K., additional, Heskin, J., additional, Hurst, P.C., additional, Farmer, J.D., additional, O'Flynn, L.D., additional, Doan, L., additional, Shuker, B.A., additional, Stott, G.D., additional, Vithanage, N.A., additional, Hoban, K.A., additional, Nesargikar, P.N., additional, Kennedy, H.R., additional, Grossart, C.M., additional, Tan, E.S.M., additional, Roy, C.S.D., additional, Sim, P., additional, Leslie, K.E., additional, Sim, D., additional, Abul, M.H., additional, Cody, N., additional, Tay, A.Y., additional, Woon, E., additional, Sng, S., additional, Mah, J., additional, Robson, J., additional, Shakweh, E., additional, Wing, V.C., additional, Mills, H., additional, Li, M.M., additional, Barrow, T.R., additional, Balaji, S., additional, Jordan, H.E.M., additional, Phillips, C., additional, Naveed, H., additional, Hirani, S., additional, Tai, A., additional, Ratnakumaran, R., additional, Sahathevan, A., additional, Shafi, A.M.A., additional, Seedat, M., additional, Weaver, R., additional, Batho, A., additional, Punj, R., additional, Selvachandran, H., additional, Bhatt, N., additional, Botchey, S., additional, Khonat, Z., additional, Brennan, K., additional, Morrison, C.J., additional, Devlin, E., additional, Linton, A., additional, Galloway, E., additional, McGarvie, S., additional, Ramsay, N., additional, McRobbie, H.D., additional, Whewell, H., additional, Dean, W., additional, Nelaj, S., additional, Eragat, M., additional, Mishra, A., additional, Kane, T., additional, Zuhair, M., additional, Wells, M., additional, Wilkinson, D., additional, Woodcock, N., additional, Sun, E., additional, Aziz, N., additional, and Ghaffar, M. K. Abd, additional

Published
2019
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34. Effects of feeding nutritionally balanced rations on animal productivity, feed conversion efficiency, feed nitrogen use efficiency, rumen microbial protein supply, parasitic load, immunity and enteric methane emissions of milking animals under field conditions

Author

B. T. Phondba, M. R. Garg, Harinder P. S. Makkar, S K Shelke, B. M. Bhanderi, and P. L. Sherasia

Subjects
business.industry, Phosphorus, food and beverages, chemistry.chemical_element, Biology, Feed conversion ratio, Milking, Biotechnology, Excretion, Rumen, Nutrient, Animal science, Productivity (ecology), chemistry, Animal Science and Zoology, Dry matter, business
Abstract

Milking animals produce milk commensurate with their genetic potential only when they are fed a nutritionally balanced ration in an amount that provides nutrients to express their genetic potential. As animals kept by smallholder farmers are rarely fed a balanced ration, a programme to feed balanced rations to animals of such farmers was launched in India. Based on their milk yield, the animals were categorized as: low ( 12 kg/d) yielders. Milk yield, milk fat and net daily income to milk producers were recorded before and after feeding a balanced ration. Nutritional status of animals showed that, for 71% of animals’, crude protein (CP) and metabolizable energy intakes were higher and, for 65% of animals’, calcium and phosphorus intakes were lower than requirements. Ration balancing improved milk yield by 2–14% and its milk fat proportion by 0.2–15%. Feed conversion efficiency, as kg of fat corrected milk (FCM)/kg of dry matter intake of buffaloes ( n = 1131) before and after feeding balanced rations was 0.6 and 0.7, respectively, and in cows ( n = 540) the values were 0.6 and 0.8. Dietary N secreted into milk increased from 0.16 to 0.25 and 0.16 to 0.19 in low and medium yielding cows and buffaloes, respectively. Rumen microbial CP synthesis also increased (P 4 emissions (g/kg milk yield) was reduced by 15–20% (P 4 emissions and N excretion from lactating cows and buffaloes. While implementation of a ration balancing programme under small holding systems is challenging, large scale use of this programme in tropical countries can help improve productivity of milking animals with available feed resources in an environmentally sustainable manner.

Published
2013

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