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53 results on '"Bao, Nan"'

6. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity

Author

Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, and Hongzhen Hu

Subjects
General Neuroscience
Abstract

Inflammatory and functional gastrointestinal disorders such as irritable bowel syndrome (IBS) and obstructive bowel disorder (OBD) underlie the most prevalent forms of visceral pain. Although visceral pain can be generally provoked by mechanical distension/stretch, the mechanisms that underlie visceral mechanosensitivity in colon-innervating visceral afferents remain elusive. Here, we show that virally mediated ablation of colon-innervating TRPV1-expressing nociceptors markedly reduces colorectal distention (CRD)-evoked visceromotor response (VMR) in mice. Selective ablation of the stretch-activated Piezo2 channels from TRPV1 lineage neurons substantially reduces mechanically evoked visceral afferent action potential firing and CRD-induced VMR under physiological conditions, as well as in mouse models of zymosan-induced IBS and partial colon obstruction (PCO). Collectively, our results demonstrate that mechanosensitive Piezo2 channels expressed by TRPV1-lineage nociceptors powerfully contribute to visceral mechanosensitivity and nociception under physiological conditions and visceral hypersensitivity under pathological conditions in mice, uncovering potential therapeutic targets for the treatment of visceral pain.

Published
2023

13. High-performance room temperature NO2 gas sensor based on visible light irradiated In2O3 nanowires

Author

Yi Ni, Bo Zhang, Lanlan Guo, Tao Wang, Yi Xia, Bao Nan, Pingping Yu, Yin Xu, Yue Dong, Qufu Wei, and Jing Wang

Subjects
Materials science, Mechanical Engineering, Metals and Alloys, Analytical chemistry, Nanowire, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Crystallinity, Light intensity, X-ray photoelectron spectroscopy, Mechanics of Materials, Transmission electron microscopy, Desorption, Materials Chemistry, 0210 nano-technology, Powder diffraction, Visible spectrum
Abstract

A batch of In2O3 nanowires (NWs) samples were prepared through a simple electrospinning method and the following sintering procedure. The X-ray powder diffraction (XRD) analysis identified their high purity and crystallinity. Furthermore, the field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) revealed the high quality of the synthesized products. The nanowires were homogeneous and of uniform diameter. The X-ray photoelectron spectroscopy (XPS) data showed that the oxygen vacancies and surface chemisorbed oxygen species occupied a large proportion in the total oxygen content. O2-temperature-programmed desorption (TPD) experiments identified the affinity of oxygen to In2O3 nanowires´ surface at room temperature and concrete adsorbed oxygen species. The above results were positive signals of their gas-sensing performance. In the subsequent gas-sensing test, we found that the sensor based on In2O3 NWs exhibited a high selectivity toward NO2 under room temperature. What's more, the response of the sensor toward 5 ppm NO2 at 25 ℃ in dark could reach as high as 740 and its detection limit was as low as 10 ppb. However, like most reported literatures on low-temperature gas sensors, the In2O3 NWs sensor likewise had a significant defect of long recovery process. Fortunately, we successfully solved this defect through the introduction of visible light irradiation during the recovery process. We detailedly explored the relationship between the light intensity and wavelength and the recovery properties of the sensor. Based on an in-depth analysis on the above two parameters and O2-TPD data, we proposed two different action mechanisms of photons according to their energy difference when accelerating the recovery of the sensor.

Published
2021

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