Search

Your search keyword '"Balkaya, Mustafa"' showing total 14 results
Start Over Author "Balkaya, Mustafa" Publisher elsevier bv
14 results on '"Balkaya, Mustafa"'

1. 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience

Author

Kumar, Amit, primary, Karuppagounder, Saravanan S., additional, Chen, Yingxin, additional, Corona, Carlo, additional, Kawaguchi, Riki, additional, Cheng, Yuyan, additional, Balkaya, Mustafa, additional, Sagdullaev, Botir T., additional, Wen, Zhexing, additional, Stuart, Charles, additional, Cho, Sunghee, additional, Ming, Guo-li, additional, Tuvikene, Jürgen, additional, Timmusk, Tõnis, additional, Geschwind, Daniel H., additional, and Ratan, Rajiv R., additional

Published
2023
Full Text
View/download PDF

4. Conditional Deletion of LRRC8A in the Brain Protects Against Stroke Damage Independently of Effect on Swelling-Activated Glutamate Release

Author

Fidaleo, Antonio M., Mongin, Alexander A., Balkaya, Mustafa Gokalp, Sah, Rajan, Schober, Alexandra L., Chen, Sophie, Nalwalk, Julia W., and Dohare, Preeti

Subjects
Neuroscience and Neurobiology, Medicine and Health Sciences, Life Sciences, Diseases, Nervous System Diseases
Abstract

The ubiquitous volume-regulated anion channels (VRACs), which are composed of LRRC8 proteins, facilitate cell volume homeostasis, and contribute to many other physiological processes. Prior studies demonstrated that treatment with non-specific VRAC blockers, or brain-specific deletion of the essential VRAC subunit LRRC8A, are highly protective in rodent stroke. In this work, we tested the widely accepted idea that harmful effects of VRACs in the brain are mediated by pathological release of the excitatory transmitter glutamate. We used two molecular genetic strategies to ablate LRRC8A expression in either brain astrocytes only (inducible deletion ofLrrc8aflox/floxwithAldh1l1CreERT2) or the majority of brain cells (neurons, astrocytes, and oligodendrocytes withNestinCre). To produce stroke, genetically modified mice were subjected to a 40-minute occlusion of the middle cerebral artery. The inducible deletion of astrocytic LRRC8A yielded no histological or behavioral protection. In contrast, the brain-wide LRRC8A knockout reduced ischemic infarction by ~50% in both heterozygotes (Het) and the fullLrrc8aknockout (KO) as compared to the controlLrrc8aflox/+genotype. However, despite identical brain damage, Het and KO mice dramatically differed in their VRAC activities. Het mice had full swelling-activated glutamate release, while KO animals showed its virtual absence. These new findings refute the notion that VRAC-mediated glutamate release plays significant role in ischemic brain injury.

Published
2023

6. An Intermittent Fasting Mimetic Drives Plasticity Via an Adaptive ER Stress-ATF4 Pathwayand Elicits Stroke Recovery and Alzheimer's Resilience

Author

Kumar, Amit, primary, Karuppagounder, Saravanan S., additional, Chen, Yingxin, additional, Corona, Carlo, additional, Kawaguchi, Riki, additional, Cheng, Yuyan, additional, Balkaya, Mustafa, additional, Sagdullaev, Botir T., additional, Wen, Zhexing, additional, Stuart, Charles, additional, Cho, Sunghee, additional, Ming, Guo-li, additional, Tuvikene, Jürgen, additional, Timmusk, Tõnis, additional, Geschwind, Daniel H., additional, and Ratan, Rajiv R., additional

Published
2022
Full Text
View/download PDF

11. Exofocal Dopaminergic Degeneration as Antidepressant Target in Mouse Model of Poststroke Depression

Author

Kronenberg, Golo, primary, Balkaya, Mustafa, additional, Prinz, Vincent, additional, Gertz, Karen, additional, Ji, Shengbo, additional, Kirste, Imke, additional, Heuser, Isabella, additional, Kampmann, Björn, additional, Hellmann-Regen, Julian, additional, Gass, Peter, additional, Sohr, Reinhard, additional, Hellweg, Rainer, additional, Waeber, Christian, additional, Juckel, Georg, additional, Hörtnagl, Heide, additional, Stumm, Ralf, additional, and Endres, Matthias, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results