1. Semi-automatic magnetic resonance imaging based orbital fat volumetry: reliability and correlation with computed tomography
- Author
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B. Degrieck, Robin Willaert, Kaan Orhan, Constantinus Politis, E. Shaheen, Reinhilde Jacobs, and Julie T. Deferm
- Subjects
Accuracy and precision ,computer-assisted image processing ,Intraclass correlation ,Computed tomography ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Orbital fat ,medicine ,Humans ,magnetic resonance imaging ,orbit ,Reliability (statistics) ,Observer Variation ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,computed tomography ,Magnetic resonance imaging ,030206 dentistry ,Magnetic Resonance Imaging ,Confidence interval ,Graves’ Orbitopathy ,Graves Ophthalmopathy ,Cross-Sectional Studies ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Surgery ,Oral Surgery ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,Orbit - Abstract
Post-processing analysis can provide valuable information for diagnosis and planning of orbital disorders. This cross-sectional study aims to evaluate the reliability of semi-automatic, orbital fat volumetry using magnetic resonance imaging (MRI). Two observers assessed the orbital fat volume using a standard MRI protocol (3T, T1w sequence) in 12 orbits diagnosed with Graves' orbitopathy (GO) and 10 healthy control orbits. MRI and computed tomography (CT) based analysis were compared. Intra-observer variability was good (intraclass correlation coefficient (ICC) 0.88; 95% confidence interval (CI) [0.70, 0.95]) and interobserver agreement was moderate (ICC 0.55; 95% CI [-0.09, 0.81]), which corresponds to a mean percentage difference of 1.3% and 17.9% of the total orbital fat volume. Mean differences between MRI and CT measurements were, respectively, 1.1 cm3 (P= 0.064, 95% CI [-0.20, 2.43]) and 1.4 cm3 (P=0.016, 95% CI [0.21, 2.56]) for the control and the GO group. MRI volumetry was strongly correlated with CT (Pearson's r= 0.7, P
- Published
- 2021
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