1. Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits
- Author
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Olivier Berdeaux, Elodie Masson, Stéphane Grégoire, Roman Walle, Véronique De Smedt-Peyrusse, Lucy Martine, Frank Aby, Clémentine Bosch-Bouju, Baptiste Caraballo, Suzanne van der Veldt, David W.L. Ma, Xavier Fioramonti, Jean-Christophe Helbling, Jing X. Kang, Sophie Layé, Gabriel Barreda-Gómez, Pierre Trifilieff, Sylvie Vancassel, Stéphanie Cabaret, Guillaume Ferreira, Marie-Lou Boyer, Tarson Tolentino-Cortez, Fabien Ducrocq, Asma Oummadi, Andrea Contini, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), IMG Pharma Biotech S.L., Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Massachusetts General Hospital, Harvard Medical School [Boston] (HMS), University of Guelph, Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Partenaires INRAE, Université de Bourgogne (UB), Massachusetts General Hospital [Boston], and Department of Human Health and Nutritional Sciences
- Subjects
Male ,0301 basic medicine ,N-3 PUFA ,Physiology ,[SDV]Life Sciences [q-bio] ,Dopamine ,Mice, Transgenic ,Nucleus accumbens ,Medium spiny neuron ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Dopamine receptor D2 ,Fatty Acids, Omega-3 ,medicine ,Animals ,Molecular Biology ,Pathological ,030304 developmental biology ,Neurons ,Medium spiny neurons ,chemistry.chemical_classification ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,0303 health sciences ,Motivation ,Receptors, Dopamine D2 ,business.industry ,[SCCO.NEUR]Cognitive science/Neuroscience ,Cell Biology ,Mice, Inbred C57BL ,Electrophysiology ,[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics ,030104 developmental biology ,chemistry ,Female ,Polyunsaturated fatty acids ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Causal link ,business ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug ,Polyunsaturated fatty acid - Abstract
International audience; Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational impairments. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) onto dopamine D1 receptor-expressing MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2-expressing neurons normalizes MSN collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate in the etiology of reward-related symptoms.
- Published
- 2020