1. A digital health platform for assisting the diagnosis and monitoring of COVID-19 progression: An adjuvant approach for augmenting the antiviral response and mitigating the immune-mediated target organ damage
- Author
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Assaf Potruch, Marc D. Berg, Samuel Agus, Yuval Ishay, Khurram Jamil, Yaron Ilan, and Asaf Schwartz
- Subjects
ARDS ,medicine.medical_treatment ,CoV, coronavirus ,IFNR, type I IFN receptor ,RIG-I, retinoic acid-inducible gene I ,PRM, patterns recognition molecules ,Disease ,Antiviral therapy ,Severity of Illness Index ,RT-PCR, reverse transcriptase polymerase chain reaction ,NK cells, natural killer cells ,Pandemic ,TLR, toll-like receptors ,MT, microtubules ,SK1, sphingokinase 1 ,Th cells, T helper cells ,NLR, neutrophil-lymphocyte ratio ,COVID-19, coronavirus disease 2019 ,TNF, tumor necrosis factor ,Immunity, Cellular ,Disease Management ,SphK, sphingosine kinase ,General Medicine ,ICU, intensive care unit ,S-1P, sphingosine-1-phosphate ,Chemotherapy, Adjuvant ,Antiviral response ,Tregs, regulatory T cells ,Disease Progression ,Digital health ,Adjuvant ,Algorithms ,NF-κB, nuclear factor kappa-light-chain ,medicine.medical_specialty ,Myocarditis ,JAK-STAT, Janus kinase signal transducer and activation of transcription ,CD, cluster of differentiation ,HLH, hemophagocytic lymphohistiocytosis ,IG, immunoglobulin ,IFNβ, interferon-beta ,IP-10, IFN gamma-induced protein 10 ,RM1-950 ,HRV, heart rate variability ,Antiviral Agents ,Article ,Immune system ,Severity of illness ,medicine ,Humans ,IFN, interferon ,APC, antigen-presenting cells ,NKT, NK T cells ,HBC, hyperimmune bovine colostrum ,SARS, severe acute respiratory syndrome ,Intensive care medicine ,ARDS, acute respiratory distress syndrome ,Pharmacology ,Hepatitis ,business.industry ,MERS, Middle East respiratory syndrome ,COVID-19 ,CTL, cytotoxic T cells ,MCP, monocyte chemoattractant protein ,medicine.disease ,IL, interleukin ,Immunity, Humoral ,COVID-19 Drug Treatment ,Gastrointestinal Tract ,Coronavirus ,GC, glucosylceramide ,RNA, ribonucleic acid ,dsRNA, double-stranded RNA ,Therapeutics. Pharmacology ,HCC, hepatocellular carcinoma ,business ,Medical Informatics ,IRF, interferon regulatory factor - Abstract
Coronavirus disease 2019 (COVID-19), which is a respiratory illness associated with high mortality, has been classified as a pandemic. The major obstacles for the clinicians to contain the disease are limited information availability, difficulty in disease diagnosis, predicting disease prognosis, and lack of disease monitoring tools. Additionally, the lack of valid therapies has further contributed to the difficulties in containing the pandemic. Recent studies have reported that the dysregulation of the immune system leads to an ineffective antiviral response and promotes pathological immune response, which manifests as ARDS, myocarditis, and hepatitis. In this study, a novel platform has been described for disseminating information to physicians for the diagnosis and monitoring of patients with COVID-19. An adjuvant approach using compounds that can potentiate antiviral immune response and mitigate COVID-19-induced immune-mediated target organ damage has been presented. A prolonged beneficial effect is achieved by implementing algorithm-based individualized variability measures in the treatment regimen.
- Published
- 2021
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