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6. Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

Author

Nath, Artika P., primary, Ritchie, Scott C., additional, Grinberg, Nastasiya F., additional, Tang, Howard Ho-Fung, additional, Huang, Qin Qin, additional, Teo, Shu Mei, additional, Ahola-Olli, Ari V., additional, Würtz, Peter, additional, Havulinna, Aki S., additional, Santalahti, Kristiina, additional, Pitkänen, Niina, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Lyytikäinen, Leo-Pekka, additional, Raitoharju, Emma, additional, Seppälä, Ilkka, additional, Sarin, Antti-Pekka, additional, Ripatti, Samuli, additional, Palotie, Aarno, additional, Perola, Markus, additional, Viikari, Jorma S., additional, Jalkanen, Sirpa, additional, Maksimow, Mikael, additional, Salmi, Marko, additional, Wallace, Chris, additional, Raitakari, Olli T., additional, Salomaa, Veikko, additional, Abraham, Gad, additional, Kettunen, Johannes, additional, and Inouye, Michael, additional

Published
2019
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7. Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

Author

Ahola-Olli, Ari V., primary, Würtz, Peter, additional, Havulinna, Aki S., additional, Aalto, Kristiina, additional, Pitkänen, Niina, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Lyytikäinen, Leo-Pekka, additional, Raitoharju, Emma, additional, Seppälä, Ilkka, additional, Sarin, Antti-Pekka, additional, Ripatti, Samuli, additional, Palotie, Aarne, additional, Perola, Markus, additional, Viikari, Jorma S., additional, Jalkanen, Sirpa, additional, Maksimow, Mikael, additional, Salomaa, Veikko, additional, Salmi, Marko, additional, Kettunen, Johannes, additional, and Raitakari, Olli T., additional

Published
2017
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8. Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children,,,

Author

Ahola-Olli, Ari V, primary, Pitkänen, Niina, additional, Kettunen, Johannes, additional, Oikonen, Mervi K, additional, Mikkilä, Vera, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Pahkala, Katja, additional, Niinikoski, Harri, additional, Kangas, Antti J, additional, Soininen, Pasi, additional, Ala-Korpela, Mika, additional, Viikari, Jorma S, additional, Rönnemaa, Tapani, additional, Simell, Olli, additional, and Raitakari, Olli T, additional

Published
2014
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10. Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

Author

Nath, Artika P, Ritchie, Scott C, Grinberg, Nastasiya F, Tang, Howard Ho-Fung, Huang, Qin Qin, Teo, Shu Mei, Ahola-Olli, Ari V, Würtz, Peter, Havulinna, Aki S, Santalahti, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarno, Perola, Markus, Viikari, Jorma S, Jalkanen, Sirpa, Maksimow, Mikael, Salmi, Marko, Wallace, Chris, Raitakari, Olli T, Salomaa, Veikko, Abraham, Gad, Kettunen, Johannes, and Inouye, Michael

Subjects
Adult, Male, Adolescent, Quantitative Trait Loci, Polymorphism, Single Nucleotide, protein QTLs, colocalisation analysis, Young Adult, GWAS, Humans, Gene Regulatory Networks, Genetic Predisposition to Disease, Longitudinal Studies, Prospective Studies, Child, metabolites, Aged, Genome, Human, eQTLs, 1. No poverty, Genetic Pleiotropy, Blood Proteins, Middle Aged, Prognosis, cytokines, 3. Good health, blood cell traits, multivariate analysis, Cardiovascular Diseases, Female, cardiometabolic diseases, Biomarkers, Follow-Up Studies, Genome-Wide Association Study
Abstract

Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pleiotropic effects on cytokines. Using three population-based cohorts (n = 9,263), we performed multivariate genome-wide association studies (GWAS) for a correlation network of 11 circulating cytokines, then combined our results in meta-analysis. We identified a total of eight loci significantly associated with the cytokine network, of which two (PDGFRB and ABO) had not been detected previously. In addition, conditional analyses revealed a further four secondary signals at three known cytokine loci. Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the cytokine network associations revealed shared causal variants between the eight cytokine loci and other traits; in particular, cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.

11. Second law analysis of water flow through smooth microtubes under adiabatic conditions

Author

Hasan Fehmi Küçük, Tahsin Engin, Vedat Ari, Mesut Gur, Nezaket Parlak, Parlak, N, Gur, M, Ari, V, Kucuk, H, Engin, T, Sakarya Üniversitesi/Mühendislik Fakültesi/Makine Mühendisliği Bölümü, Parlak, Nezaket, Arı, Vedat, Küçük, Hasan, Engin, Tahsin, and Gür, Mesut

Subjects
Fluid Flow and Transfer Processes, Materials science, Water flow, Mechanical Engineering, General Chemical Engineering, media_common.quotation_subject, Aerospace Engineering, Thermodynamics, Second law of thermodynamics, Laminar flow, Dissipation, Volumetric flow rate, Physics::Fluid Dynamics, Nuclear Energy and Engineering, Heat transfer, Adiabatic process, Entropy (arrow of time), media_common
Abstract

In the study, a second law analysis for a steady-laminar flow of water in adiabatic microtubes has been conducted. Smooth microtubes with the diameters between 50 and 150 mu m made of fused silica were used in the experiments. Considerable temperature rises due to viscous dissipation and relatively high pressure losses of flow were observed in experiments. To identify irreversibility of flow, rate of entropy generation from the experiments have been determined in the laminar flow range of Re = 20-2200. The second law of thermodynamics was applied to predict the entropy generation. The results of model taken from the literature, proposed to predict the temperature rise caused by viscous heating, correspond well with the experimental data. The second law analysis results showed that the flow characteristics in the smooth microtubes distinguish substantially from the conventional theory for flow in the larger tubes with respect to viscous heating/dissipation (temperature rise of flow) total entropy generation rate and lost work. (C) 2010 Elsevier Inc. All rights reserved.

Published
2011

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