1. Control-IQ technology enhanced by educative path in diabetes children
- Author
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Claudio Cavalli, Ivana Rabbone, and Andrea Scaramuzza
- Subjects
Technology ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Control (management) ,General Medicine ,medicine.disease ,Article ,Diabetes Mellitus, Type 1 ,Endocrinology ,Physical medicine and rehabilitation ,Diabetes mellitus ,Path (graph theory) ,Internal Medicine ,Educational Status ,Humans ,Medicine ,Child ,business - Abstract
BACKGROUND: A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes. METHODS: In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, in a 3:1 ratio, children 6 to 13 years of age who had type 1 diabetes to receive treatment with the use of either a closed-loop system of insulin delivery (closed-loop group) or a sensor-augmented insulin pump (control group). The primary outcome was the percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter, as measured by continuous glucose monitoring. RESULTS: A total of 101 children underwent randomization (78 to the closed-loop group and 23 to the control group); the glycated hemoglobin levels at baseline ranged from 5.7 to 10.1%. The mean (±SD) percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter increased from 53±17% at baseline to 67±10% (the mean over 16 weeks of treatment) in the closed-loop group and from 51±16% to 55±13% in the control group (mean adjusted difference, 11 percentage points [equivalent to 2.6 hours per day]; 95% confidence interval, 7 to 14; P
- Published
- 2020