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Background: Gestational diabetes (GD) and maternal excess weight are common pregnancy conditions that increase the risk of future complications for both the mother and her offspring. Their consequences on neurodevelopment are widely described in the literature, but less is known concerning the potential transgenerational influence on the brain structure. Methods: We used a combination of support vectors machine and hierarchical clustering to investigate the potential presence of anatomical brain differences in a sample of 109 children aged six years, born to mothers with overweight or obesity, or to mothers diagnosed with GD during pregnancy. Results: Significant effects are visible in the brain of children born to mothers with GD associated with pregestational excess weight, especially overweight instead of obesity. No differences in children's brain were observed when considering those born to normal-weight mothers. Conclusions: Our study highlights the need for clinical attention of pregnant women at risk to develop GD, and especially those with pregestational excess weight, since this status was found to be associated with detectable transgenerational brain changes. These effects may be due to the absence of specific and individualized intervention in these mothers during pregnancy., Spanish Ministry of Innovation and Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341), Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01), DynaHEALTH EU Project - HORIZON 2020 Research and Innovation Programme, Grant Agreement No 633595, Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396)

This study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund, the European Commission (No 667302) and the Alicia Koplowitz Foundation. This study was partially funded by the UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence; Scientific Unit of Excellence on Exercise and Health (UCEES) and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN IthornDthornI 2017-2021 (Spain). Additional funding was obtained from the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, project ref: B-CTS-355-UGR18). PS-U is supported by a grant from ANID/BECAS Chile/72180543. IE-C is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). JV-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). Funding for open access charge: Universidad de Granada/CBUA. We would like to thank all the families participating in the ActiveBrains. We are grateful to Ms. Ana Yara Postigo-Fuentes for her assistance with the English language. We also acknowledge everyone who helped with the data collection and all of the members involved in the fieldwork for their effort, enthusiasm, and support. This work is part of Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain., Background & aims: Exposure to a suboptimal environment during the fetal and early infancy period's results in long-term consequences for brain morphology and function. We investigated the associations of early life factors such as anthropometric neonatal data (i.e., birth length, birth weight and birth head circumference) and breastfeeding practices (i.e., exclusive and any breastfeeding) with white matter (WM) microstructure, and ii) we tested whether WM tracts related to early life factors are associated with academic performance in children with overweight/obesity. Methods: 96 overweight/obese children (10.03 +/- 1.16 years; 38.7% girls) were included from the ActiveBrains Project. WM microstructure indicators used were fractional anisotropy (FA) and mean diffusivity (MD), derived from Diffusion Tensor Imaging. Academic performance was evaluated with the Battery III Woodcock-Munoz Tests of Achievement. Regression models were used to examine the associations of the early life factors with tract-specific FA and MD, as well as its association with academic performance. Results: Head circumference at birth was positively associated with FA of the inferior fronto-occipital fasciculus tract (0.441; p = 0.005), as well as negatively associated with MD of the cingulate gyrus part of cingulum (-0.470; p = 0.006), corticospinal (-0.457; p = 0.005) and superior thalamic radiation tract (-0.476; p = 0.001). Association of birth weight, birth length and exclusive breastfeeding with WM microstructure did not remain significant after false discovery rate correction. None tract related to birth head circumference was associated with academic performance (all p > 0.05). Conclusions: Our results highlighted the importance of the perinatal growth in WM microstructure later in life, although its possible academic implications remain inconclusive., Spanish Government DEP2013-47540 DEP2016-79512-R DEP2017-91544-EXP, European Commission European Commission European Commission Joint Research Centre 667302, Alicia Koplowitz Foundation, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme, European Commission SOMM17/6107/UGR, SAMID III network, RETICS - PN I+D+I 2017-2021 (Spain), Andalusian Operational Programme - European Regional Development Funds B-CTS-355-UGR18, ANID/BECAS Chile 72180543, Spanish Government RTI2018-095284-J-100 FJCI-2017-33396 RYC2019-027287-I

Decision making in risky driving contexts is mainly guided by automatic processes. This requires the previous learning of cognitive rules and heuristics. The acquisition of safer cognitive heuristics depends on previous experience and adequate feedback to our responses. The first aim of this research was to analyze the effect of negative feedback on risk evaluation and decision processes in dangerous and harmless driving contexts. The second aim was to demonstrate the influence of prior experience upon the process of decision-making and feedback, comparing individuals with and without driving experience. One hundred and three participants (with and without driving license) were required to evaluate a set of 120 driving images with respect to the risk level of the situations and decide whether to brake or not. Half of the participants received negative feedback. The results showed that decisions were faster and more accurate than evaluations, and both were improved by the effect of feedback and previous experience in risk situations. However, the same feedback resulted in inaccurate risk evaluations and decisions in harmless situations. The cognitive processes underlying these effects point to a response bias rather than to discriminative factors. These results clarify the effect of negative feedback and previous experience on different phases of the decision-making process, showing the importance of these factors for the automatic processes and cognitive heuristics implied in driving. Our findings have potentially important applied value in the promotion of safe driving practices.

INTRODUCTION: Chronic inflammation plays an important role on the pathogenesis of several cardiovascular and metabolic diseases, as well as on brain function and behaviour. The aim of the present study was to examine the associations between inflammatory biomarkers and a wide range of brain health indicators (i.e., academic performance, executive function, behavioural and emotional functioning, and brain volume) in children with overweight/obesity. METHODS: A total of 107 children (10.0 ± 1.1 years, 41% girls) from the ActiveBrains project were included in the analysis. Five inflammatory biomarkers were analysed in plasma: white blood cell (WBC) count, interleukin-6 (IL-6), interleukin-1beta, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). Academic performance was assessed by Woodcock-Munoz Tests of Achievement. Executive function was assessed through the Design Fluency Test for cognitive flexibility, the Stroop test for cognitive inhibition, and the Delayed Non-Match-to-Sample task for working memory. Behavioural and emotional functioning was evaluated through the Behavior Assessment System for Children (BASC) questionnaire. Total and regional brain volume was assessed by magnetic resonance imaging. RESULTS: IL-6 was inversely associated with adaptive skills (beta = -0.228; p = 0.030), while TNF-alpha was related to mathematics (beta = -0.198; p = 0.034). In addition, CRP was positively associated with externalizing (beta = 0.246; p = 0.046) and internalizing problems (beta = 0.234; p = 0.039), as well as the behavioural symptoms index (beta = 0.236; p = 0.047). However, these significant associations disappeared after multiple comparisons correction. Inflammatory biomarkers were not associated with executive function and total brain volumes. Regarding regional brain analyses, WBC was positively associated with gray matter volume in the left middle temporal gyrus (beta = 0.387; p

This study aimed to test the effects of the preexposure schedule and certain kinds of verbal instructions for pre-exposure in perceptual learning and attention to the distinctive features of the stimuli. For this, in two experiments adult human participants received concurrent or blocked pre-exposure to two stimuli, and were then required to judge them as same or different in a target identification task. During pre-exposure, participants could receive unspecific instructions to look only at the stimuli (Experiments 1 and 2), asking for “same/different” judgments (Experiments 1 and 2), or only for “different” or “same” judgments (Experiment 2), whilst the dwell time on the distinctive and common features of the stimuli was also recorded. Regardless of the instructions, Experiment 1 found a clear benefit of the concurrent schedule relative to the blocked schedule in the ability to differentiate the stimuli, accompanied by a preference to look at the distinctive features of the stimuli. In the concurrent preexposure condition, the instructions asking for same/different judgments boosted stimulus differentiation in general, along with an attentional shift, while a clear effect of instructions was not found for the blocked preexposure conditions. Experiment 2 further found that whilst such effects of the instructions for the concurrent schedule might appear when the participants were asked uniquely whether the stimuli were the same, these were stronger when the instructions asked explicitly whether the stimuli were different. According to these novel findings, the benefit of the concurrent preexposure schedule for human perceptual learning might arise from an attentional shift toward the distinctive elements; the instructions encouraging the search for stimulus differences are not needed for either stimulus differentiation or an attentional shift during concurrent preexposure, even though such instructions might enhance both effects. Several valuable implications of these findings for human and non-human perceptual learning are discussed.

Measures of drinking and eating behaviors may be assessed both explicitly (e.g., sensory and quality judgments) and implicitly (e.g., Electroencephalography, EEG), although the relationship between the results of both approaches remains unclear and each might be differentially affected by acquired knowledge. The main aim of the present study was to determine the strength of the relationship between these measures in sensory and hedonic processing of beers depending on the degree of tasting expertise. Beer experts, experts in non-beer beverages or edibles, and non-expert consumers took part in a sensory analysis procedure where they rated beers in terms of their sensory attributes and general quality-visual, olfactory, and gustatory phases-as well as their global hedonic value while their brain activity was recorded. The results suggest that participants evaluated the sensory properties of the beers in a rather similar manner. However, during the gustatory phase, experts and general tasters differed in terms of the activation of brain areas related to memory processes, while general tasters and consumers differed in brain activation related to hedonic processing. The relationship between self-reported quality judgments and EEG activity - particularly in relation to recognition and working memory components - appeared to be stronger in experts in comparison with the other groups (lowest |r| = 0.67, p .01). Although lower in number, significant relationships were also found in general tasters and consumers, primarily involving hedonic processing (lowest |r| = 0.58, p .01) and recognition memory (lowest |r| = 0.57, p .01) components. Moreover, those relationships differed significantly, mostly between experts and consumers (lowest |z| = 2.68, p .01), in terms of the involvement of working memory components. Taken together, the results of this study suggest that beer experts have a more efficient pattern of gustatory processing and show a better fit between explicit (judgments) and implicit (EEG) measures of sensory and hedonic quality of beers.

The cross-ethnic effect (in the literature, usually termed the cross-race effect) is defined as the greater difficulty in recognizing faces of other ethnicities compared with faces of one’s own. The aims of the present research were: 1) to test the hypothesis that the cross-ethnic effect is due to lack of contact with the other ethnicity. 2) to study possible differences in the perceptual mechanisms employed in face recognition as a function of the contact degree between ethnicities, which may be the basis of the cross-ethnic effect. We compared two ethnic groups with a high degree of contact, but different identities and cultural values: Andalusian Gypsies and Andalusian Caucasians. Both groups had to recognize a set of East Asian, Caucasian, and Gypsy faces while eye movements were monitored. In accordance with the contact hypothesis, our results revealed no differences between Gypsies and Caucasians observers in face recognition success. However, East Asian faces were more poorly recognized than Gypsies and Caucasian faces by both observer groups. With respect to the perceptual strategies, despite achieving similar face recognition performance, Caucasian and Gypsy observers employed different visual exploration strategies. Gypsies focused their attention on the eyes, while Caucasians fixated more on the nose than Gypsies. Our results support the contact hypothesis as an explanation for the cross-ethnic effect, and show how cultural factors imply differences in perceptual strategies even between close ethnic groups.

Driver fatigue can impair performance as much as alcohol does. It is the most important road safety concern, causing thousands of accidents and fatalities every year. Thanks to technological developments, wearable, single-channel EEG devices are now getting considerable attention as fatigue monitors, as they could help drivers to assess their own levels of fatigue and, therefore, prevent the deterioration of performance. However, the few studies that have used single-channel EEG devices to investigate the physiological effects of driver fatigue have had inconsistent results, and the question of whether we can monitor driver fatigue reliably with these EEG devices remains open. Here, we assessed the validity of a single-channel EEG device (TGAM-based chip) to monitor changes in mental state (from alertness to fatigue). Fifteen drivers performed a 2-h simulated driving task while we recorded, simultaneously, their prefrontal brain activity and saccadic velocity. We used saccadic velocity as the reference index of fatigue. We also collected subjective ratings of alertness and fatigue, as well as driving performance. We found that the power spectra of the delta EEG band showed an inverted U-shaped quadratic trend (EEG power spectra increased for the first hour and half, and decreased during the last thirty minutes), while the power spectra of the beta band linearly increased as the driving session progressed. Coherently, saccadic velocity linearly decreased and speeding time increased, suggesting a clear effect of fatigue. Subjective data corroborated these conclusions. Overall, our results suggest that the TGAM-based chip EEG device is able to detect changes in mental state while performing a complex and dynamic everyday task as driving.

Summary Background Using their voices in inappropriate working conditions causes teachers to misuse their voices, because in order to be heard they need to force their voices. Objective This preliminary study examines the effects of a short-term voice training program aimed at teachers. Methods The pre- and posttraining evaluations consisted of acoustic, perceptual (GRBAS [grade, roughness, breathiness, asthenia, and strain]), aerodynamic, and subjective measurements (VHI-10). Results The results indicate that the voice performance of teachers improves after 25 hours of training. Specifically, significant changes are observed at the acoustic level, in fundamental frequency (F0) and in frequency perturbation measures (Jitter, PPQ [pitch perturbation quotient]), as well as in subjective voice assessment using the Voice Handicap Index (VHI-10), in both the physical subscale (VHI-P) and the total score (VHI-T). Conclusions This study confirms the effectiveness of the training program and discusses the most sensitive measures for evaluating the short-term effect of the change.

Obesity, as compared to normal weight, is associated with detectable structural differences in the brain. To the best of our knowledge, no previous study has examined the association of physical fitness with gray matter volume in overweight/obese children using whole brain analyses. Thus, the aim of this study was to examine the association between the key components of physical fitness (i.e. cardiorespiratory fitness, speed-agility and muscular fitness) and brain structural volume, and to assess whether fitness-related changes in brain volumes are related to academic performance in overweight/obese children. A total of 101 overweight/obese children aged 8-11 years were recruited from Granada, Spain. The physical fitness components were assessed following the ALPHA health-related fitness test battery. T1-weighted images were acquired with a 3.0 T S Magnetom Tim Trio system. Gray matter tissue was calculated using Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra (DARTEL). Academic performance was assessed by the Batería III Woodcock-Muñoz Tests of Achievement. All analyses were controlled for sex, peak high velocity offset, parent education, body mass index and total brain volume. The statistical threshold was calculated with AlphaSim and further Hayasaka adjusted to account for the non-isotropic smoothness of structural images. The main results showed that higher cardiorespiratory fitness was related to greater gray matter volumes (P 0.001, k = 64) in 7 clusters with β ranging from 0.493 to 0.575; specifically in frontal regions (i.e. premotor cortex and supplementary motor cortex), subcortical regions (i.e. hippocampus and caudate), temporal regions (i.e. inferior temporal gyrus and parahippocampal gyrus) and calcarine cortex. Three of these regions (i.e. premotor cortex, supplementary motor cortex and hippocampus) were related to better academic performance (β ranging from 0.211 to 0.352; all P 0.05). Higher speed-agility was associated with greater gray matter volumes (P 0.001, k = 57) in 2 clusters (i.e. the inferior frontal gyrus and the superior temporal gyrus) with β ranging from 0.564 to 0.611. Both clusters were related to better academic performance (β ranging from 0.217 to 0.296; both P 0.05). Muscular fitness was not independently associated with greater gray matter volume in any brain region. Furthermore, there were no statistically significant negative association between any component of physical fitness and gray matter volume in any region of the brain. In conclusion, cardiorespiratory fitness and speed-agility, but not muscular fitness, may independently be associated with greater volume of numerous cortical and subcortical brain structures; besides, some of these brain structures may be related to better academic performance. Importantly, the identified associations of fitness and gray matter volume were different for each fitness component. These findings suggest that increases in cardiorespiratory fitness and speed-agility may positively influence the development of distinctive brain regions and academic indicators, and thus counteract the harmful effect of overweight and obesity on brain structure during childhood.

The main aim of this study was to look into the effect of feedback contingency on decision making in complex risky situations, using a driving context. Participants had to decide braking or not in a set of risky traffic situations. After the response, a negative non-contingent or contingent feedback was used. The results highlight the importance of feedback contingency upon safer decision making in risky contexts, as they showed how a contingent feedback led to faster and safer responses than a control group without any feedback; whereas a non-contingent one gives rise to slower responses and, more importantly, an enhanced risk-taking behavior that could be the cause of undesirable effects on road safety. The feedback effect was even more evident in the appearance of an opposite response bias as a function of contingency and enhanced by learning. These results accord with the theoretical accounts based upon the feedback influence on the threshold level of decision making. Moreover, the effects of feedback may be explained by new proposals focusing on the importance of attentional factors as well as of the mental models people build to react in complex risky scenarios, as a product of feedback and learning. Finally, this research may increase our understanding of the role of feedback in the process of learning safer behavior in complex risky situations.

Objective Regular cardiovascular risk screening can prevent cardiovascular disease through timely implementation of lifestyle changes or medication. However, few studies have investigated what factors promote regular screening for risk factors like hypertension and high blood cholesterol. The aim of this study was to investigate the relationship between social support and adherence to cardiovascular risk screening. Methods We analyzed data from the Spanish National Health Survey—a cross-sectional representative survey conducted by the Spanish Ministry of Health in 2012 (N = 21,007). Participants reported whether they had their blood pressure and cholesterol levels measured by a health professional in the previous 12 months. Social support (i.e., the perception that emotional and practical support was available when needed) was measured with a validated scale. Multiple logistic regressions were conducted adjusted for demographic and health-related factors. Results Compared to individuals who reported a lack of social support, individuals who perceived sufficient social support were on average twice more likely to report participation in blood pressure screening, OR = 2.06, 95% CI [1.60, 2.66] and cholesterol screening, OR = 2.85, 95% CI [1.99, 4.09]. These effects were uniform across different demographics and were replicated in a previous wave of the survey. Factors associated with worse screening adherence were low social class, being single or widowed, smoking, alcohol consumption, and no history of cardiovascular risk. Discussion Perceptions of social support are positively related to cardiovascular risk screening adherence. Future research should investigate what type of social support most effectively increases screening participation among high risk populations.

Background Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors with crucial functions in lipid homeostasis, glucose metabolism, anti-inflammatory processes, placental development, and are involved in cognitive functions and neurodegenerative diseases. Polymorphisms in PPAR genes are shown to influence the activity of these receptors. Aims 1) To examine the association of PPARG Pro12Ala polymorphism in pregnant women and their offspring on infant's neurodevelopmental outcomes during the first 18months of life; 2) to determine the influence of Pro12Ala polymorphism on fatty acid concentrations in plasma phospholipids and placental tissue. Study design 138 mother–infant pairs from the PREOBE observational study were genotyped for PPARG Pro12Ala. Plasma phospholipids and placental fatty acid concentrations were measured at delivery. Infants' neuropsychological assessment at 6 and 18months of age was performed using Bayley III. Results The effect of Pro12Ala on infant's neurodevelopmental outcomes was detected at 18months, but not at 6months of age. 18months old infants born to mothers with wild-type Pro12 genotype had better cognitive (OR=5.11, 95% CI: 1.379–18.96, p=0.015), language (OR=3.41, 95% CI: 1.35–11.24, p=0.044), and motor development scores (OR=4.77, 95% CI: 1.243–18.33, p=0.023) than the Ala allele carriers. Pro12Ala variants did not seem to affect fatty acids concentrations in blood nor in placenta at delivery. Conclusions Infants born to mothers with Pro12 genotype have better neurodevelopmental outcomes at 18months of age than Ala allele carriers, indicating a long-term transplacental action of PPARγ variants on foetal brain development.

Background Sleep complaints are one of the most frequent and relevant symptoms that characterize fibromyalgia syndrome (FMS). However, objective sleep disturbances have not been consistently described across FMS studies. It is therefore commonly accepted that FMS patients experience sleep misperception, even though no studies have investigated the contribution of polysomnographic parameters to determine subjective sleep quality in FMS. We aimed to compare sleep variables (polysomnographic parameters and subjective sleep quality) between FMS patients and healthy controls. Furthermore, we also aimed to define the predictors of subjective sleep quality in FMS. Methods We performed in-home polysomnography to 99 women (53 FMS patients and 36 healthy controls). We also collected subjective ratings of sleep quality, daytime sleepiness, pain, depression, and anxiety. Results Multivariate analysis showed that groups differed in polysomnographic parameters ( p = 0.015) – after accounting for age, body mass index, and antidepressant consumption. Specifically, FMS patients exhibited lower sleep efficiency, greater percentage of stage N1 and wakefulness, and more frequent awakenings than controls ( p -values p 0.001). Percentage of time awake (as obtained by polysomnography), depression levels, and antidepressant consumption predicted self-reported sleep quality in FMS patients (adjusted R 2 = 0.33, p 0.001). Conclusions One night of in-home polysomnography supports the hypothesis that women with FMS show polysomnographic alterations compared to age-matched controls. In addition, the time spent awake is the best predictor of subjective sleep quality, although greater levels of depression and antidepressant consumption might result in exaggerated complaints. These findings contribute to our understanding of FMS symptoms and its management.

Although sleep complaints are often reported in patients with fibromyalgia syndrome (FMS), there is no conclusive evidence that these complaints represent symptomatic disorders of sleep physiology. Thus, the question of the role of sleep disturbances as an etiological or maintenance factor in FMS remains open. This study identifies the subjective and objective characteristics of sleep disturbances in adult women diagnosed with FMS. We carried out a systematic review of publications since 1990, the publication year of the American College of Rheumatology criteria of FMS. We selected empirical studies comparing sleep characteristics of adult women with FMS and healthy women or women with rheumatic diseases. We identified 42 articles. Patients with FMS were more likely to exhibit sleep complaints and also a less efficient, lighter and fragmented sleep. The evidence of a FMS signature on objective measures of sleep is inconsistent, however, as the majority of studies lacks statistical power. Current evidence cannot confirm the role played by sleep physiology in the pathogenesis or maintenance of FMS symptoms; nonetheless, it is clear that sleep disturbances are present in this syndrome.

Background and objectives Whilst traditional studies have shown that obese individuals are at a higher risk of cardiovascular events compared to lean subjects, recent studies in patients with acute myocardial infarction (AMI) have suggested that obesity may exert protective effects (the “obesity paradox”). We sought to assess the relationship between body mass index (BMI) and the BARI score (BARIsc), a validated tool used to assess myocardium at risk, in patients with acute coronary syndrome.

This study focused on the effects of emotion-laden stimuli (emotional roadside advertisements) on driver decision making. A common dilemma in driving is whether to speed up or brake when the lights turn yellow at an intersection. This study focused on this aspect of driver decision making. We compared the influence of emotion-laden roadside advertisements (positive, negative, and neutral solutions) either on the evaluation of possible risk (i.e., evaluative behavior) or the decision to stop/speed up (i.e., urgent behavior). We showed that drivers brake more often after negative advertisements than after positive and neutral ones; at the same time, the response latency was shorter when they decided to speed up. We also demonstrated that urgent behavior responses were faster than evaluative ones, independent of the emotional content. Thus, we conclude that urgent behavior may be more automatic than evaluative behavior according to the dual system models of risk perception and decision-making. Overall, our results suggest that emotional factors play a decisive role in making driving decisions, particularly in risky driving situations. These findings provide important information for the development of new and advanced driver emotional support systems and, in general, for the specification of future transportation police design guidelines.

Early life factors may influence brain and academic outcomes later in life, especially during childhood. Here we investigate the associations of early life factors (i.e., birth weight, birth length, and breastfeeding) with gray matter volume, adjusted for body mass index and cardiorespiratory fitness, and ii) we test whether early-life factor-related differences in gray matter volume are associated with academic performance in overweight/obese children. 96 children with overweight/obesity aged 8-11 years participated. Birth weight, birth length and gestational age were collected from birth records, and breastfeeding practices were asked to parents. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Academic performance was assessed with the Bateria III Woodcock-Muñoz Tests of Achievement. Whole-brain voxel-wise multiple regressions were used to test the associations of each early life factor with gray matter volume. Higher birth weight and birth length were associated with greater gray matter volume in 9 brain regions including the middle frontal gyrus, rectal gyrus, thalamus, putamen, middle temporal gyrus, lingual gyrus, middle occipital gyrus, calcarine cortex and cerebellum bilaterally (β ranging from 0.361 to 0.539, t ranging from 3.46 to 5.62 and cluster size from 82 to 4478 voxels; p 0.001); and greater duration of any breastfeeding was associated with greater gray matter volume in 3 regions including the bilateral inferior frontal gyrus and rolandic operculum (β ranging from 0.359 to 0.408, t ranging from 4.01 to 4.32 and cluster size from 64 to 171 voxels; p 0.001). No associations were found for duration of exclusive breastfeeding. Additionally, none of the gray matter regions that were associated with the early life factors were associated with academic performance (all p 0.05). Our results demonstrate that birth weight, birth length, and breastfeeding are predictive of gray matter volume of numerous brain structures that are involved in higher order cognition and emotion regulation, but how these results relate to measures of academic achievement remain a matter of speculation.

Background Impulsivity is thought to play a key role in cocaine addiction onset and progression; therefore, we hypothesized that different facets of impulsive personality may be significantly associated with brain structural abnormalities in cocaine-dependent individuals. Methods Thirty-eight cocaine-dependent individuals and 38 non-drug using controls completed the UPPS-P scale (measuring five different facets of impulsivity: sensation seeking, lack of premeditation, lack of perseverance, and positive and negative urgency) and were scanned on a 3T MRI scanner. We used whole-brain voxel-based morphometry analyses (VBM) to detect differences in gray matter (GM) and white matter (WM) volumes between cocaine users and controls, and to measure differences in the way that impulsivity relates to GM and WM volumes in cocaine users vs. controls. Results Cocaine-dependent individuals had lower GM volumes in a number of sections of the orbitofrontal cortex, right inferior frontal gyrus, right insula, left amygdala and parahippocampal gyrus, temporal gyrus, and bilateral caudate. They also had lower WM volumes in the left inferior and medial frontal gyrus, superior temporal gyrus, right anterior cingulate cortex, insula and caudate. There was a positive correlation between trait impulsivity and GM volume in the left inferior/middle frontal gyrus of cocaine-dependent individuals, a pattern directly opposed to the association in controls. Conversely, in cocaine users lack of premeditation was negatively correlated with GM volume in the insula and the putamen. Conclusions Trait impulsivity may influence cocaine dependence by impacting its neurobiological underpinnings in frontostriatal systems.

Resumen Objetivo: Existe un amplio consenso sobre la existencia de una mayor incidencia de accidentes de trafico en personas con sindrome de apneas-hipopneas del sueno (SAHS). Sin embargo, algunos aspectos de esta relacion estan aun por dilucidar. No se ha podido demostrar cual es la causa probable de esta mayor accidentalidad, existen posibles factores de confusion no controlados y algunos instrumentos de evaluacion utilizados poseen una baja validez ecologica. El objetivo del estudio fue analizar la conducta de riesgo en conduccion de pacientes con SAHS en un entorno vial virtual realista y con trafico simulado. Material y metodos: Se evaluo la conducta de riesgo en la conduccion mediante el simulador Honda Riding Trainer, en 12 pacientes diagnosticados de SAHS, tratados con presion positiva continua (CPAP), y 12 controles emparejados. Tambien se evaluaron, a traves de cuestionarios, la somnolencia diurna en los dos grupos y la fatiga mental y los niveles de activacion durante la prueba. Resultados: Aunque los pacientes con SAHS mostraban una mayor somnolencia diurna, no se han mostrado mas arriesgados que los controles durante la conduccion. No hubo diferencias en fatiga mental o niveles de activacion durante la simulacion. Conclusiones: A diferencia de los resultados encontrados en los estudios clasicos, cuando la evaluacion se realiza con herramientas mas ecologicas y la duracion de las pruebas es mas breve, la ejecucion de los pacientes con SAHS tratados con CPAP no difiere de la de los controles. Estos hallazgos apoyan el uso de la CPAP y respaldan la inclusion de pruebas de simulacion virtuales para obtener o prorrogar el permiso o licencia de conducir, sobre todo, en poblaciones de riesgo.

In the last five decades, cognitive scientists and the psychologists of reasoning have dedicated a lot of effort designing usable traffic signs. This study investigated the interference effect produced by the position of the sign elements in traffic signage on response accuracy and reaction time. Sixteen drivers performed a flanker interference reaction time task. Incongruent graphical/space solutions, actually used for the airport stack-type sign, lead to increased reaction time and a reduction in the proportion of correct answers. These results suggest that incongruent visual information should be avoided, as this might impair drivers' performance. These findings provide important information for the specification of future signage design guidelines and for improving road safety.

Developing a valid measurement of mental fatigue remains a big challenge and would be beneficial for various application areas, such as the improvement of road traffic safety. In the present study we examined influences of mental fatigue on the dynamics of saccadic eye movements. Based on previous findings, we propose that among amplitude and duration of saccades, the peak velocity of saccadic eye movements is particularly sensitive to changes in mental fatigue. Ten participants completed a fixation task before and after 2 h of driving in a virtual simulation environment as well as after a rest break of fifteen minutes. Driving and rest break were assumed to directly influence the level of mental fatigue and were evaluated using subjective ratings and eye movement indices. According to the subjective ratings, mental fatigue was highest after driving but decreased after the rest break. The peak velocity of saccadic eye movements decreased after driving while the duration of saccades increased, but no effects of the rest break were observed in the saccade parameters. We conclude that saccadic eye movement parameters—particularly the peak velocity—are sensitive indicators for mental fatigue. According to these findings, the peak velocity analysis represents a valid on-line measure for the detection of mental fatigue, providing the basis for the development of new vigilance screening tools to prevent accidents in several application domains.

In road safety literature the effects of emotional content and salience of advertising billboards have been scarcely investigated. The main aim of this work was to uncover how affect-laden roadside advertisements can affect attention – eye-movements – and subsequent risky decisions – braking – on the Honda Riding Trainer motorcycle simulator. Results indicated that the number of fixations and total fixation time elicited by the negative and positive emotional advertisements were larger than the neutral ones. At the same time, negative pictures got later gaze disengagement than positive and neutral ones. This attentional capture results in less eye fixation times on the road relevant region, where the important driving events happen. Finally, the negative emotional valence advertisements sped up braking on subsequent risky situations. Overall results demonstrated how advertisements with emotional content modulate attention allocation and driving decisions in risky situations and might be helpful for designing roadside advertisements regulations and risk prevention programs.

Motorcyclist deaths and injuries follow the trend in sales rather than in growth in the number of motorcycles, suggesting that fatalities are related to the lack of driver experience with recently purchased motorcycles. The aim of the present investigation was to assess the effects of experience and training in hazard perception. We compared first-time riders (people who are not yet riders/drivers) before and after training in six different riding scenarios to expert motorcycle riders. Thirty-three participants took part in the experiment. Volunteers rode a moped in a fixed-base virtual environment and were presented with a number of preset risky events. We used a multidimensional methodology, including behavioral, subjective and eye-movements data. The results revealed differences between experts and first-time riders, as well as the effect of training on the novice group. As expected, training led to an improvement in the riding skills of first-time riders, reducing the number of accidents, improving their capacity to adapt their speed to the situation, reducing trajectory-corrective movements, and changing their pattern of gaze exploration. We identified several behavioral and eye-related measures that are sensitive to both long-term experience and training in motorcycle riders. These findings will be useful for the design of on-line monitoring systems to evaluate changes in risk behavior and of programs for preventing and controlling risk behavior and improving situation awareness for novice riders, with the ultimate aim of reducing road-user mortality.

Recent development of systems for assisted driving has raised questions about what features of the stimuli perceived by a driver may improve driving behaviour and road safety. The present study aimed to uncover whether emotional auditory stimuli can affect risky behaviour in hazardous situations. Forty-nine volunteers rode a motorcycle in a virtual environment and went through a number of preset risky scenarios, some of which were cued by a sound (a beep, a positive emotional sound or a negative sound). Results showed that hearing the beep reduced the frequency of accidents in the upcoming risky situation, while the emotional cues did not. Likewise, the beep induced the drivers to decrease their speed and focus their gaze on relevant areas of the visual field, while the emotional sounds did not. These results suggest that auditory warning systems for vehicles should avoid using emotion-laden sounds, as their affective content might diminish their utility to increase driving alertness. These findings could provide important information for the development of new advanced driver assistance systems and in general for the specification of future Human-Machine-Interaction design guidelines.

We present data from an ongoing research project on the cognitive, emotional and neuropsychological basis of risk behaviour. The main aim of the project is to build a model of risk behaviour so that if we know certain cognitive, behavioural and emotional variables, we will be able to predict decisions made in the face of uncertainty and risk, with the final goal of designing programs for evaluating, preventing and controlling risk behaviour. The objective of the present study was to look for individual differences in hazard perception during a static riding simulation and their relationship with mental workload. We used a multidimensional methodology, including behavioural, subjective and physiological data. The behavioural measures were obtained in a static riding simulation during eight hazard situations. We evaluated whether eye activity measures correlated with cognitive workload and different types of risky behaviours. Eye movement parameters were measured using a video-based eye tracking system. We found that risk-prone individuals showed specific patterns of risky behaviours and that peak of saccadic velocity and subjective mental workload indexes were both reliable indicators of risk proneness. Mental workload was higher for participants showing attitudes to risk behaviours probably because of a lack of conscious awareness of specific cues indicating dangerous scenarios.

In two experiments, we investigated the relative impact of causal beliefs and empirical evidence on both decision making and causal judgments, and whether this relative impact could be altered by previous experience. Participants had to decide which of two alternatives would attain a higher outcome on the basis of four cues. After completing the decision task, they were asked to estimate to what extent each cue was a reliable cause of the outcome. Participants were provided with instructions that causally related two of the cues to the outcome, whereas they received neutral information about the other two cues. Two of the four cues—a causal and a neutral cue—had high validity and were both generative. The remaining two cues had low validity, and were generative in Experiment 1, but almost not related to the outcome in Experiment 2. Selected groups of participants in both experiments received pre-training with either causal or neutral cues, or no pre-training was provided. Results revealed that the impact of causal beliefs and empirical evidence depends on both the experienced pre-training and cue validity. When all cues were generative and participants received pre-training with causal cues, they mostly relied on their causal beliefs, whereas they relied on empirical evidence when they received pre-training with neutral cues. In contrast, when some of the cues were almost not related to the outcome, participants’ responses were primarily influenced by validity and—to a lesser extent—by causal beliefs. In either case, however, the influence of causal beliefs was higher in causal judgments than in decision making. While current theoretical approaches in causal learning focus either on the effect of causal beliefs or empirical evidence, the present research shows that both factors are required to explain the flexibility involved in human inferences.

The present study is aimed at identifying how prior causal beliefs and covariation information contribute to belief updating when evidence, either compatible or contradictory with those beliefs, is provided. Participants were presented with a cover story with which it was intended to activate or generate a causal belief. Variables related to the prior belief (the type of information, the strength of the cause–effect causal link, and how confident the participant was that the link existed) were assessed. Subsequently, participants were presented with covariational information and were asked to update their beliefs in light of the new evidence. Information reliability, prior belief’s causal influence magnitude, and the cause–effect level of contingency portrayed by the new information – but not the type of the prior belief – are shown to directly determine belief updating.

A classical definition of automaticity establishes that automatic processing occurs without attention or consciousness, and cannot be controlled. Previous studies have demonstrated that semantic priming can be reduced if attention is directed to a low-level of analysis. This finding suggests that semantic processing is not automatic since it can be controlled. In this paper, we present two experiments that demonstrate that semantic processing may occur in the absence of attention and consciousness. A negative semantic priming effect was found when a low-level prime-task was required and when a masked lexical decision prime-task was performed (Experiment 1). This paper also discusses the limitations of the inhibitory mechanism involved in negative semantic priming effect.

Semantic (positive) priming refers to the facilitated processing of a probe word when preceded by a related prime word, and is a widely used technique for investigating semantic activation. However, the effect is interrupted or eliminated when attention is directed to low-level features of the prime word, such as its letters, a result which has been used to question the automaticity of semantic processing. We investigated this issue using both behavioural [reaction time (RT)] and electrophysiological measures [event-related potentials (ERPs)]. Subjects performed semantic categorization (living vs. nonliving) and letter search ("A" or "E") tasks on prime words followed by lexical decision on the probe. RT results showed the expected elimination of semantic priming following letter search. However, both prime tasks were affected by the semantic category of the prime, indicating that the meaning was processed. The ERP results supported this conclusion: an early component previously associated with automatic semantic processing [the Recognition Potential (RP)] was sensitive to the category of the prime word irrespective of the prime task. However, a later component (N400) was significantly affected by the task, in both the prime (categorization task) and probe words (semantic priming). The results dissociate rapid, automatic semantic processing from semantic priming. We suggest that a later inhibitory control mechanism suppresses this semantic activation when it is not relevant to the task, and that this produces the loss of semantic priming.

This work aimed at demonstrating, first, that naive reasoners are able to infer the existence of a relationship between two events that have never been presented together and, second, the sensitivity of such inference to the causal structure of the task. In all experiments, naive participants judged the strength of the causal link between a cue A and an outcome O in a first phase and between a second cue B and the same outcome O in a second phase. In the final test, participants estimated the degree of correlation between the two cues, A and B. Participants perceived the two cues as significantly more highly correlated when they were effects of a common potential cause (Experiment 1a and 2) than when they were potential causes of a common effect (Experiment 1b and 2). This effect of causal directionality on inferred correlation points out the influence of mental models on human causal detection and learning, as proposed by recent theoretical models.