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2. A Systematic Review on the Impact of Quality Assurance Programs on Outcomes after Radical Prostatectomy

Author

van der Graaf, Sophia H., primary, Hagens, Marinus J., additional, Veerman, Hans, additional, Roeleveld, Ton A., additional, Nieuwenhuijzen, Jakko A., additional, Wit, Esther M.K., additional, W.J.M. Wouters, Michel, additional, van der Mierden, Stevie, additional, van Moorselaar, R. Jeroen A., additional, Beerlage, Harrie P., additional, Vis, André N., additional, van Leeuwen, Pim J., additional, and van der Poel, Henk G., additional

Published
2024
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3. Development and Internal Validation of a Novel Nomogram Predicting the Outcome of Salvage Radiation Therapy for Biochemical Recurrence after Radical Prostatectomy in Patients without Metastases on Restaging Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography

Author

Meijer, Dennie, primary, van Leeuwen, Pim J., additional, Eppinga, Wietse S.C., additional, Vanneste, Ben G.L., additional, Meijnen, Philip, additional, Daniels, Laurien A., additional, van den Bergh, Roderick C.N., additional, Lont, Anne P., additional, Bodar, Yves J.L., additional, Ettema, Rosemarijn H., additional, de Bie, Katelijne C.C., additional, Oudshoorn, Frederik H.K., additional, Nieuwenhuijzen, Jakko A., additional, van der Poel, Henk G., additional, Donswijk, Maarten L., additional, Heymans, Martijn W., additional, Oprea-Lager, Daniela E., additional, Schaake, Eva E., additional, and Vis, André N., additional

Published
2024
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4. Development and Internal Validation of a Novel Nomogram Predicting the Outcome of Salvage Radiation Therapy for Biochemical Recurrence after Radical Prostatectomy in Patients without Metastases on Restaging Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography

Author

MS Radiotherapie, Cancer, Meijer, Dennie, van Leeuwen, Pim J., Eppinga, Wietse S.C., Vanneste, Ben G.L., Meijnen, Philip, Daniels, Laurien A., van den Bergh, Roderick C.N., Lont, Anne P., Bodar, Yves J.L., Ettema, Rosemarijn H., de Bie, Katelijne C.C., Oudshoorn, Frederik H.K., Nieuwenhuijzen, Jakko A., van der Poel, Henk G., Donswijk, Maarten L., Heymans, Martijn W., Oprea-Lager, Daniela E., Schaake, Eva E., Vis, André N., MS Radiotherapie, Cancer, Meijer, Dennie, van Leeuwen, Pim J., Eppinga, Wietse S.C., Vanneste, Ben G.L., Meijnen, Philip, Daniels, Laurien A., van den Bergh, Roderick C.N., Lont, Anne P., Bodar, Yves J.L., Ettema, Rosemarijn H., de Bie, Katelijne C.C., Oudshoorn, Frederik H.K., Nieuwenhuijzen, Jakko A., van der Poel, Henk G., Donswijk, Maarten L., Heymans, Martijn W., Oprea-Lager, Daniela E., Schaake, Eva E., and Vis, André N.

Published
2024

5. The Probability of Metastases Within Different Prostate-specific Antigen Ranges Using Prostate-specific Membrane Antigen Positron Emission Tomography in Patients with Newly Diagnosed Prostate Cancer

Author

Luining, Wietske I., primary, Hagens, Marinus J., additional, Meijer, Dennie, additional, Ringia, Joanneke B., additional, de Weijer, Tessa, additional, Bektas, Huseyyin O., additional, Ettema, Rosemarijn H., additional, Knol, Remco J.J., additional, Roeleveld, Ton A., additional, Srbljin, Sandra, additional, Weltings, Saskia, additional, Koppes, Jose C.C., additional, van Moorselaar, Reindert J.A., additional, van Leeuwen, Pim J., additional, Oprea-Lager, Daniela E., additional, and Vis, André N., additional

Published
2024
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7. Added Clinical Value of 18F-FDG-PET/CT to Stage Patients With High-Risk Non-Muscle Invasive Bladder Cancer Before Radical Cystectomy

Author

Noor van Ginkel, Erik J. van Gennep, Liselot Oosterbaan, Joyce Greidanus, Thierry N. Boellaard, Maurits Wondergem, André N. Vis, Theo M. de Reijke, Bas W.G. van Rhijn, Laura S. Mertens, Urology, APH - Personalized Medicine, APH - Quality of Care, and CCA - Imaging and biomarkers

Subjects
Positron-emission tomography-computed tomography, Oncology, Treatment change, Urology, Diagnosis, Non-muscle invasive bladder cancer, Accuracy, Imaging
Abstract

Introduction and Objectives: 18F-fluorodeoxyglucose positron-emission tomography-computed tomography (FDG-PET/CT) is increasingly used in the preoperative staging of patients with muscle-invasive bladder cancer. The clinical added value of FDG-PET/CT in high-risk non-muscle invasive bladder cancer (NMIBC) is unknown. In this study, the value of FDG-PET/CT in addition to contrast enhanced (CE)-CT was evaluated in high-risk NMIBC before radical cystectomy (RC). Materials and Methods: This is a retrospective analysis of consecutive patients with high risk and very-high risk urothelial NMIBC scheduled for RC in a tertiary referral center between 2011 and 2020. Patients underwent staging with CE-CT (chest and abdomen/pelvis) and FDG-PET/CT. We assessed the clinical disease stage before and after FDG-PET/CT and the treatment recommendation based on the stage before and after FDG-PET/CT. The accuracy of CT and FDG-PET/CT for identifying metastatic disease was defined by the receiver-operating curve using a reference-standard including histopathology/cytology (if available), imaging and follow-up. Results: A total of 92 patients were identified (median age: 71 years). In 14/92 (15%) patients, FDG-PET/CT detected metastasis (12 suspicious lymph nodes and 4 distant metastases). The disease stage changed in 11/92 (12%) patients based on additional FDG-PET/CT findings. FDG-PET/CT led to a different treatment in 9/92 (10%) patients. According to the reference standard, 25/92 (27%) patients had metastases. The sensitivity, specificity and accuracy of FDG-PET/CT was 36%, 93% and 77% respectively, versus 12%, 97% and 74% of CE-CT only. The area under the ROC curve was 0.643 for FDG-PET/CT and 0.545 for CT, P = .036. Conclusion: The addition of FDG-PET/CT to CE-CT imaging changed the treatment in 10% of patients and proved to be a valuable diagnostic tool in a selected subgroup of NMIBC patients scheduled for RC.

Published
2023

10. Combining electrochemical, molecular simulation and operando techniques to investigate the stability of electrodes and organic electrolytes used in EDLCs

Author

Venâncio, Raissa, primary, Vicentini, Rafael, additional, Pinzón C．, Manuel J., additional, Corrêa, Débora A., additional, Miranda, André N., additional, Queiroz, Adriana C., additional, Degasperi, Francisco Tadeu, additional, Siqueira, Leonardo J.A., additional, Da Silva, Leonardo M., additional, and Zanin, Hudson, additional

Published
2023
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13. Combining in situ electrochemistry, operando FTIR and post-mortem analyses to understand Co-Mn-Al spinels on mitigating shuttle effect in lithium-sulfur battery

Author

Santos, Érick A., primary, Anchieta, Chayene G., additional, Fernandes, Rodolfo C., additional, Pinzón C, Manuel J., additional, Miranda, André N., additional, Galantini, Isabela, additional, Maia, Francisco C.B., additional, Doubek, Gustavo, additional, Rodella, C.B., additional, Da Silva, Leonardo M., additional, and Zanin, Hudson, additional

Published
2023
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14. Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study

Author

Aiken, Alexander M, primary, Rehman, Andrea M, additional, de Kraker, Marlieke E A, additional, Madrid, Lola, additional, Kebede, Meron, additional, Labi, Appiah-Korang, additional, Obeng-Nkrumah, Noah, additional, Nyamwaya, Brian, additional, Kagucia, Eunice, additional, Cocker, Derek, additional, Kawaza, Kondwani, additional, Lester, Rebecca, additional, Iregbu, Kenneth C, additional, Medugu, Nubwa, additional, Nwajiobi-Princewill, Philip I, additional, Dramowski, Angela, additional, Sonda, Tolbert, additional, Hemed, Asia, additional, Fwoloshi, Sombo, additional, Ojok, David, additional, Scott, J Anthony G, additional, Whitelaw, Andrew, additional, Aliye, Jabir, additional, Assefa, Nega, additional, Edessa, Dumessa, additional, Oundo, Joseph, additional, Berihun, Mulu, additional, Dankwah, Thomas, additional, Osei, Mary M, additional, Fandoh, Maud, additional, Gakpo, Margaret, additional, Mulunda, Caroline, additional, Mvera, Benedict, additional, Chimenya, Mabvuto, additional, Feasey, Nicholas, additional, Mallewa, Jane, additional, Abdulraheem, Khadija, additional, Akujobi, Tobechi A, additional, Okonkwo, Chinelo H, additional, Britz, Luzell, additional, Bulbula, André N H, additional, Fataar, Aaqilah, additional, Mmbaga, Blandina T, additional, Ng'unda, Neema, additional, Chirwa, Uchizi, additional, Kakula, Nyambe, additional, Mutemba, Charles, additional, and Nakazwe, Ruth, additional

Published
2023
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16. Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study

Author

van Riel, Luigi A. M. J. G., van Kollenburg, Rob A. A., Vis, André N., van Leeuwen, Pim J., de Reijke, Theo M., de Bruin, Daniel M., Oddens, Jorg R., Urology, CCA - Cancer Treatment and quality of life, Graduate School, Other Research, APH - Personalized Medicine, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life, Biomedical Engineering and Physics, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Focal therapy, Urology, Prostatic neoplasm, Laser ablation, Minimally invasive therapy
Abstract

Background: Soractelite™ transperineal focal laser ablation (TPLA) for the treatment of localized prostate cancer (PCa) using the Echolaser® system is a novel minimally invasive technique that has the potential to induce tissue ablation, while reducing treatment-related morbidity, when compared with robot-assisted radical prostatectomy (RARP) and radiotherapy. Objective: To determine the short-term safety and feasibility of single or multifiber TPLA, its functional outcomes, and quality of life (QoL). Design, setting, and participants: TPLA was performed in 12 patients, consecutively assigned to four treatment regimens, with localized PCa who were scheduled for RARP (“ablate and resect design”). The treatment regimens were as follows: (1) a single fiber at 3 W, (2) two fibers at 5 mm distance at 3 W, (3) two fibers at 10 mm distance at 3 W, and (4) a single fiber at 5 W. TPLA was scheduled 4 wk prior to RARP. Intervention: TPLA using the Echolaser® system under local anesthesia at the outpatient clinic. Outcome measurements and statistical analysis: Safety and feasibility were determined by the assessment of device-related peri- and postoperative adverse events (AEs), and length of hospital stay. Functional outcomes and QoL were measured using validated questionnaires. Feasibility of RARP was assessed by a questionnaire for the urologist. Results and limitations: Patients were dismissed after a median (interquartile range) hospital admission of 3.25 (1.25) h. No device-related AEs occurred. AEs that occurred were mostly related to lower urinary tract symptoms and were mild (grade 1–2). Most AEs resolved within 1 wk. A QoL analysis showed no significant differences for all treatment regimens. Functional outcomes remained unchanged, except for erectile function after 1 wk, which returned to baseline after 4 wk. TPLA treatment did not compromise RARP, based on the questionnaires. Conclusions: TPLA for the treatment of PCa at the outpatient clinic appears to be safe and feasible with good short-term QoL and functional outcomes; oncological results are awaited. Patient summary: Focal treatment of localized prostate cancer can safely be performed in a daycare setting using a new technique, based on laser ablation, without compromising quality of life.

Published
2022

17. Development and External Validation of a Novel Nomogram to Predict the Probability of Pelvic Lymph-node Metastases in Prostate Cancer Patients Using Magnetic Resonance Imaging and Molecular Imaging with Prostate-specific Membrane Antigen Positron Emission Tomography

Author

Vis, André N., primary, Meijer, Dennie, additional, Roberts, Matthew J., additional, Siriwardana, Amila R., additional, Morton, Andrew, additional, Yaxley, John W., additional, Samaratunga, Hemamali, additional, Emmett, Louise, additional, van de Ven, Peter M., additional, Heymans, Martijn W., additional, Nieuwenhuijzen, Jakko A., additional, van der Poel, Henk G., additional, Donswijk, Maarten L., additional, Boellaard, Thierry N., additional, Schoots, Ivo G., additional, Stricker, Phillip, additional, Haynes, Anne-Maree, additional, Oprea-Lager, Daniela E., additional, Coughlin, Geoffrey D., additional, and van Leeuwen, Pim J., additional

Published
2023
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19. Genetic Aspects and Molecular Testing in Prostate Cancer: A Report from a Dutch Multidisciplinary Consensus Meeting

Author

Mehra, Niven, primary, Kloots, Iris, additional, Vlaming, Michiel, additional, Aluwini, Shafak, additional, Dewulf, Els, additional, Oprea-Lager, Daniela E., additional, van der Poel, Henk, additional, Stoevelaar, Herman, additional, Yakar, Derya, additional, Bangma, Chris H., additional, Bekers, Elise, additional, van den Bergh, Roderick, additional, Bergman, Andries M., additional, van den Berkmortel, Franchette, additional, Boudewijns, Steve, additional, Dinjens, Winand N.M., additional, Fütterer, Jurgen, additional, van der Hulle, Tom, additional, Jenster, Guido, additional, Kroeze, Leonie I., additional, van Kruchten, Michel, additional, van Leenders, Geert, additional, van Leeuwen, Pim J., additional, de Leng, Wendy W.J., additional, van Moorselaar, R. Jeroen A., additional, Noordzij, Walter, additional, Oldenburg, Rogier A., additional, van Oort, Inge M., additional, Oving, Irma, additional, Schalken, Jack A., additional, Schoots, Ivo G., additional, Schuuring, Ed, additional, Smeenk, Robert J., additional, Vanneste, Ben G.L., additional, Vegt, Erik, additional, Vis, André N., additional, de Vries, Kim, additional, Willemse, Peter-Paul M., additional, Wondergem, Maurits, additional, and Ausems, Margreet, additional

Published
2023
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20. Added Clinical Value of 18F-FDG-PET/CT to Stage Patients With High-Risk Non-Muscle Invasive Bladder Cancer Before Radical Cystectomy

Author

van Ginkel, Noor, primary, van Gennep, Erik J., additional, Oosterbaan, Liselot, additional, Greidanus, Joyce, additional, Boellaard, Thierry N., additional, Wondergem, Maurits, additional, Vis, André N., additional, de Reijke, Theo M., additional, van Rhijn, Bas W.G., additional, and Mertens, Laura S., additional

Published
2023
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21. Genetic Aspects and Molecular Testing in Prostate Cancer: A Report from a Dutch Multidisciplinary Consensus Meeting

Author

Genetica Sectie Oncogenetica, Cancer, MS Urologische Oncologie, Researchgr. Nucleaire Geneeskunde, Pathologie Pathologen staf, Genetica Klinische Genetica, Mehra, Niven, Kloots, Iris, Vlaming, Michiel, Aluwini, Shafak, Dewulf, Els, Oprea-Lager, Daniela E, van der Poel, Henk, Stoevelaar, Herman, Yakar, Derya, Bangma, Chris H, Bekers, Elise, van den Bergh, Roderick, Bergman, Andries M, van den Berkmortel, Franchette, Boudewijns, Steve, Dinjens, Winand N M, Fütterer, Jurgen, van der Hulle, Tom, Jenster, Guido, Kroeze, Leonie I, van Kruchten, Michel, van Leenders, Geert, van Leeuwen, Pim J, de Leng, Wendy W J, van Moorselaar, R Jeroen A, Noordzij, Walter, Oldenburg, Rogier A, van Oort, Inge M, Oving, Irma, Schalken, Jack A, Schoots, Ivo G, Schuuring, Ed, Smeenk, Robert J, Vanneste, Ben G L, Vegt, Erik, Vis, André N, de Vries, Kim, Willemse, Peter-Paul M, Wondergem, Maurits, Ausems, Margreet, Genetica Sectie Oncogenetica, Cancer, MS Urologische Oncologie, Researchgr. Nucleaire Geneeskunde, Pathologie Pathologen staf, Genetica Klinische Genetica, Mehra, Niven, Kloots, Iris, Vlaming, Michiel, Aluwini, Shafak, Dewulf, Els, Oprea-Lager, Daniela E, van der Poel, Henk, Stoevelaar, Herman, Yakar, Derya, Bangma, Chris H, Bekers, Elise, van den Bergh, Roderick, Bergman, Andries M, van den Berkmortel, Franchette, Boudewijns, Steve, Dinjens, Winand N M, Fütterer, Jurgen, van der Hulle, Tom, Jenster, Guido, Kroeze, Leonie I, van Kruchten, Michel, van Leenders, Geert, van Leeuwen, Pim J, de Leng, Wendy W J, van Moorselaar, R Jeroen A, Noordzij, Walter, Oldenburg, Rogier A, van Oort, Inge M, Oving, Irma, Schalken, Jack A, Schoots, Ivo G, Schuuring, Ed, Smeenk, Robert J, Vanneste, Ben G L, Vegt, Erik, Vis, André N, de Vries, Kim, Willemse, Peter-Paul M, Wondergem, Maurits, and Ausems, Margreet

Published
2023

22. Development and External Validation of a Novel Nomogram to Predict the Probability of Pelvic Lymph-node Metastases in Prostate Cancer Patients Using Magnetic Resonance Imaging and Molecular Imaging with Prostate-specific Membrane Antigen Positron Emission Tomography

Author

André N. Vis, Dennie Meijer, Matthew J. Roberts, Amila R. Siriwardana, Andrew Morton, John W. Yaxley, Hemamali Samaratunga, Louise Emmett, Peter M. van de Ven, Martijn W. Heymans, Jakko A. Nieuwenhuijzen, Henk G. van der Poel, Maarten L. Donswijk, Thierry N. Boellaard, Ivo G. Schoots, Phillip Stricker, Anne-Maree Haynes, Daniela E. Oprea-Lager, Geoffrey D. Coughlin, and Pim J. van Leeuwen

Subjects
Oncology, Urology, Radiology, Nuclear Medicine and imaging, Surgery
Published
2023

23. Reply to Xiangyang Yao, Chen Duan, Bo Li, Xiaoliang Wu and Hua Xu’s Letter to the Editor Re: Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, et al. Robot-assisted Prostate-specific Membrane Antigen–radioguided Salvage Surgery in Recurrent Prostate Cancer Using a DROP-IN Gamma Probe: The First Prospective Feasibility Study. Eur Urol 2022;82:97–105

Author

de Barros, Hilda A., primary, van Oosterom, Matthias N., additional, Donswijk, Maarten L., additional, Hendrikx, Jeroen J.M.A., additional, Vis, André N., additional, Maurer, Tobias, additional, van Leeuwen, Fijs W.B., additional, van der Poel, Henk G., additional, and van Leeuwen, Pim J., additional

Published
2023
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26. LatHyS global hybrid simulation of the BepiColombo second Venus flyby

Author

Aizawa, S., primary, Persson, M., additional, Menez, T., additional, André, N., additional, Modolo, R., additional, Génot, V., additional, Sanchez-Cano, B., additional, Volwerk, M., additional, Chaufray, J.-Y., additional, Baskevitch, C., additional, Heyner, D., additional, Saito, Y., additional, Harada, Y., additional, Leblanc, F., additional, Barthe, A., additional, Penou, E., additional, Fedorov, A., additional, Sauvaud, J.-A., additional, Yokota, S., additional, Auster, U., additional, Richter, I., additional, Mieth, J., additional, Horbury, T.S., additional, Louarn, P., additional, Owen, C.J., additional, and Murakami, G., additional

Published
2022
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27. A Prospective Multicenter Comparison Study of Risk-adapted Ultrasound-directed and Magnetic Resonance Imaging–directed Diagnostic Pathways for Suspected Prostate Cancer in Biopsy-naïve Men

Author

Wagensveld, Ivo M., primary, Osses, Daniel F., additional, Groenendijk, Pieter M., additional, Zijta, Frank M., additional, Busstra, Martijn B., additional, Rociu, Elena, additional, Barentsz, Jelle O., additional, Michiel Sedelaar, J.P., additional, Arbeel, Berber, additional, Roeleveld, Ton, additional, Geenen, Remy, additional, Koeter, Ingrid, additional, van der Meer, Saskia A., additional, Cappendijk, Vincent, additional, Somford, Rik, additional, Klaver, Sjoerd, additional, Van der Lely, Hans, additional, Wolters, Tineke, additional, Hellings, Willem, additional, Leter, Maicle R., additional, Van der Poel, Henk G., additional, Heijmink, Stijn W.T.P.J., additional, Debruyne, Frans, additional, Immerzeel, Jos, additional, Leijte, Joost, additional, van Roermund, Joep, additional, Miclea, Razvan, additional, Planken, Erik, additional, Vis, André N., additional, Jan de Jong, Igle, additional, Tijsterman, Jasper, additional, Wolterbeek, Derk, additional, Claessen, Anoesjka, additional, Vrijhof, Eric, additional, Nederend, Joost, additional, Van Leenders, Geert J.L.H., additional, Bangma, Chris H., additional, Krestin, Gabriel P., additional, Remmers, Sebastiaan, additional, and Schoots, Ivo G., additional

Published
2022
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29. Surgical and Functional Outcomes of Bladder Neck Incision for Primary Vesico-Urethral Anastomosis Stricture after Robot-assisted Radical Prostatectomy are Influenced by the Presence of Pre- or Postoperative Radiotherapy

Author

Veerman, Hans, primary, Vis, André N., additional, Hagens, Marinus J., additional, Tillier, Corinne T., additional, Roeleveld, Ton A., additional, Wit, Esther, additional, van der Sluis, Tim M., additional, van Leeuwen, Pim J., additional, Pigot, Garry L.S., additional, Nieuwenhuijzen, Jakko A., additional, and van der Poel, Henk G., additional

Published
2022
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30. Prospective analysis of prostate cancer local staging with [18F]PSMA PET/MRI combined with multiparametric MRI – A comparison to histopathology in the radical prostatectomy specimen. – ProStaPET –

Author

K. De Bie, André N. Vis, D. Meijer, B.H.E. Jansen, A.D. Windhorst, Y.J.L. Bodar, D.E. Oprea-Lager, S.Q. Kol, N.H. Hendrikse, G.J.C. Zwezerijnen, M. Yaqub, R.S. Smit, and J.P. Van Der Voorn

Subjects
medicine.medical_specialty, Prostatectomy, business.industry, Urology, medicine.medical_treatment, Multiparametric MRI, medicine.disease, Prostate cancer, Prospective analysis, Psma pet, medicine, Histopathology, Radiology, business
Published
2021

31. Robot-assisted Prostate-specific Membrane Antigen–radioguided Salvage Surgery in Recurrent Prostate Cancer Using a DROP-IN Gamma Probe: The First Prospective Feasibility Study

Author

de Barros, Hilda A., primary, van Oosterom, Matthias N., additional, Donswijk, Maarten L., additional, Hendrikx, Jeroen J.M.A., additional, Vis, André N., additional, Maurer, Tobias, additional, van Leeuwen, Fijs W.B., additional, van der Poel, Henk G., additional, and van Leeuwen, Pim J., additional

Published
2022
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33. Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

Author

Michels, Charlotte T.J., primary, Wijburg, Carl J., additional, Hannink, Gerjon, additional, Witjes, J. Alfred, additional, Rovers, Maroeska M., additional, Grutters, Janneke P.C., additional, Helder, Sip, additional, Venderbosch, Guus, additional, Calsbeek, Hilly, additional, Onna, Ilze E.W.van, additional, Barten, Evert J., additional, Koldewijn, Evert L., additional, Boormans, Joost L., additional, Wijsman, Bart P., additional, Nooter, Ronald I., additional, Zwaan, Peter J., additional, Slaa, Ed te, additional, Meer, Saskia van der, additional, Klaver, Sjoerd O., additional, Fossion, Laurent M.C.L., additional, Bos, Siebe D., additional, Melick, Harm H.E.van, additional, Leliveld, Anna M., additional, Meijer, Richard P., additional, Vis, André N., additional, Molijn, Gerard J., additional, Berendsen, Chris L., additional, and Oddens, Jorg R., additional

Published
2022
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35. Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Is Associated with Improved Oncological Outcome in Men Treated with Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer

Author

MS Radiotherapie, Cancer, Meijer, Dennie, Eppinga, Wietse S.C., Mohede, Roos M., Vanneste, Ben G.L., Meijnen, Philip, Meijer, Otto W.M., Daniels, Laurien A., van den Bergh, Roderick C.N., Lont, Anne P., Ettema, Rosemarijn H., Oudshoorn, Frederik H.K., van Leeuwen, Pim J., van der Poel, Henk G., Donswijk, Maarten L., Oprea-Lager, Daniela E., Schaake, Eva E., Vis, André N., MS Radiotherapie, Cancer, Meijer, Dennie, Eppinga, Wietse S.C., Mohede, Roos M., Vanneste, Ben G.L., Meijnen, Philip, Meijer, Otto W.M., Daniels, Laurien A., van den Bergh, Roderick C.N., Lont, Anne P., Ettema, Rosemarijn H., Oudshoorn, Frederik H.K., van Leeuwen, Pim J., van der Poel, Henk G., Donswijk, Maarten L., Oprea-Lager, Daniela E., Schaake, Eva E., and Vis, André N.

Published
2022

36. Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

Author

MS Urologische Oncologie, Cancer, Michels, Charlotte T.J., Wijburg, Carl J., Hannink, Gerjon, Witjes, J. Alfred, Rovers, Maroeska M., Grutters, Janneke P.C., Helder, Sip, Venderbosch, Guus, Calsbeek, Hilly, Onna, Ilze E.W.van, Barten, Evert J., Koldewijn, Evert L., Boormans, Joost L., Wijsman, Bart P., Nooter, Ronald I., Zwaan, Peter J., Slaa, Ed te, Meer, Saskia van der, Klaver, Sjoerd O., Fossion, Laurent M.C.L., Bos, Siebe D., Melick, Harm H.E.van, Leliveld, Anna M., Meijer, Richard P., Vis, André N., Molijn, Gerard J., Berendsen, Chris L., Oddens, Jorg R., MS Urologische Oncologie, Cancer, Michels, Charlotte T.J., Wijburg, Carl J., Hannink, Gerjon, Witjes, J. Alfred, Rovers, Maroeska M., Grutters, Janneke P.C., Helder, Sip, Venderbosch, Guus, Calsbeek, Hilly, Onna, Ilze E.W.van, Barten, Evert J., Koldewijn, Evert L., Boormans, Joost L., Wijsman, Bart P., Nooter, Ronald I., Zwaan, Peter J., Slaa, Ed te, Meer, Saskia van der, Klaver, Sjoerd O., Fossion, Laurent M.C.L., Bos, Siebe D., Melick, Harm H.E.van, Leliveld, Anna M., Meijer, Richard P., Vis, André N., Molijn, Gerard J., Berendsen, Chris L., and Oddens, Jorg R.

Published
2022

37. OC-0103 Comparative study of brachytherapy vs. radical cystectomy for cT1-2 muscle-invasive bladder cancer

Author

Luc M.F. Moonen, Bradley R. Pieters, Axel Bex, M. Burger, Kees Hendricksen, H.G. van der Poel, André N. Vis, Floris J. Pos, Judith Bosschieter, B.W.G. Van Rhijn, E. van Werkhoven, Charlotte S. Voskuilen, S. Horenblas, and Jakko A. Nieuwenhuijzen

Subjects
medicine.medical_specialty, Bladder cancer, business.industry, medicine.medical_treatment, Brachytherapy, Muscle invasive, Urology, Hematology, medicine.disease, Cystectomy, Oncology, medicine, Radiology, Nuclear Medicine and imaging, business
Published
2021

38. Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Is Associated with Improved Oncological Outcome in Men Treated with Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer

Author

Meijer, Dennie, primary, Eppinga, Wietse S.C., additional, Mohede, Roos M., additional, Vanneste, Ben G.L., additional, Meijnen, Philip, additional, Meijer, Otto W.M., additional, Daniels, Laurien A., additional, van den Bergh, Roderick C.N., additional, Lont, Anne P., additional, Ettema, Rosemarijn H., additional, Oudshoorn, Frederik H.K., additional, van Leeuwen, Pim J., additional, van der Poel, Henk G., additional, Donswijk, Maarten L., additional, Oprea-Lager, Daniela E., additional, Schaake, Eva E., additional, and Vis, André N., additional

Published
2022
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43. Detection of Recurrent Prostate Cancer Using Prostate-specific Membrane Antigen Positron Emission Tomography in Patients not Meeting the Phoenix Criteria for Biochemical Recurrence After Curative Radiotherapy

Author

Jansen, Bernard H.E., primary, van Leeuwen, Pim J., additional, Wondergem, Maurits, additional, van der Sluis, Tim M., additional, Nieuwenhuijzen, Jakko A., additional, Knol, Remco J.J., additional, van Moorselaar, Reindert J.A., additional, van der Poel, Henk G., additional, Oprea-Lager, Daniela E., additional, and Vis, André N., additional

Published
2021
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45. External Validation and Addition of Prostate-specific Membrane Antigen Positron Emission Tomography to the Most Frequently Used Nomograms for the Prediction of Pelvic Lymph-node Metastases: an International Multicenter Study

Author

Meijer, Dennie, primary, van Leeuwen, Pim J., additional, Roberts, Matthew J., additional, Siriwardana, Amila R., additional, Morton, Andrew, additional, Yaxley, John W., additional, Samaratunga, Hemamali, additional, Emmett, Louise, additional, van de Ven, Peter M., additional, van der Poel, Henk G., additional, Donswijk, Maarten L., additional, Boellaard, Thierry N., additional, Schoots, Ivo G., additional, Oprea-Lager, Daniela E., additional, Coughlin, Geoffrey D., additional, and Vis, André N., additional

Published
2021
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47. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial

Author

André N. Vis, Maarten C.C.M. Hulshof, Wim P.J. Witjes, R. Jeroen A. van Moorselaar, Aeilko H. Zwinderman, Paul C.M.S. Verhagen, Karl P.J. Delaere, Liselotte M. S. Boevé, George van Andel, Jos W. R. Twisk, Urology, CCA - Cancer Treatment and quality of life, APH - Methodology, APH - Health Behaviors & Chronic Diseases, Epidemiology and Data Science, ACS - Atherosclerosis & ischemic syndromes, CCA - Cancer Treatment and Quality of Life, and Radiotherapy

Subjects
Male, Oncology, medicine.medical_specialty, Time Factors, Urology, medicine.medical_treatment, 030232 urology & nephrology, Bone Neoplasms, Androgen deprivation therapy, 03 medical and health sciences, Prostate cancer, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Median follow-up, Prostate, Internal medicine, Clinical endpoint, Humans, Medicine, Prospective Studies, Aged, Netherlands, business.industry, Standard treatment, Prostatic Neoplasms, Androgen Antagonists, Chemoradiotherapy, Middle Aged, Prostate-Specific Antigen, medicine.disease, Progression-Free Survival, Radiation therapy, medicine.anatomical_structure, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], 030220 oncology & carcinogenesis, Disease Progression, Hormonal therapy, Kallikreins, Dose Fractionation, Radiation, business
Abstract

Background: The cornerstone of standard treatment for patients with primary bone metastatic prostate cancer (mPCa) is androgen deprivation therapy (ADT). Retrospective studies suggest a survival benefit for treatment of the primary prostatic tumour in mPCa, but to date, no randomised-controlled-trials (RCTs) have been published addressing this issue. Objective: To determine whether overall survival is prolonged by adding local treatment of the primary prostatic tumour with external beam radiation therapy (EBRT) to ADT. Design, setting, and participants: The HORRAD trial is a multicentre RCT recruiting 432 patients with prostate-specific antigen (PSA) >20 ng/ml and primary bone mPCa on bone scan between 2004 and 2014. Intervention: Patients were randomised to either ADT with EBRT (radiotherapy group) or ADT alone (control group). Outcome measurements and statistical analysis: Primary endpoint was overall survival. Secondary endpoint was time to PSA progression. Crude and adjusted analyses were applied to evaluate treatment effect. Results and limitations: Median PSA level was 142 ng/ml and 67% of patients had more than five osseous metastases. Median follow up was 47 mo. Median overall survival was 45 mo (95% confidence interval [CI], 40.4–49.6) in the radiotherapy group and 43 mo (95% CI: 32.6–53.4) in the control group (p = 0.4). No significant difference was found in overall survival (hazard ratio [HR]: 0.90; 95% CI: 0.70–1.14; p = 0.4). Median time to PSA progression in the radiotherapy group was 15 mo (95% CI: 11.8–18.2), compared with 12 mo (95% CI: 10.6–13.4) in the control group. The crude HR (0.78; 95% CI: 0.63–0.97) was statistically significant (p = 0.02). Conclusions: The current RCT comparing ADT to ADT with EBRT to the prostate in patients with primary bone mPCa did not show a significant difference in overall survival, although the CI cannot exclude a substantial survival benefit. Further research is needed to confirm our findings. Patient summary: This study investigated the effect of adding radiation therapy to the prostate to hormonal therapy in prostate cancer patients with metastasis to the bone at diagnosis. In our patient group, additional radiotherapy did not improve overall survival. Further research is needed to confirm our findings. Twitter summary: Adding radiotherapy to the prostate in patients with bone metastatic prostate cancer does not improve overall survival. In the current randomised controlled trial, there is no improvement in overall survival when comparing androgen deprivation therapy alone to androgen deprivation therapy with concurrent radiotherapy to the prostate in patients with primary bone metastatic prostate cancer.

Published
2019

49. Patient-specific magnetic resonance imaging-based 3D models may lower the positive surgical margin rate at robot-assisted radical prostatectomy

Author

André N. Vis, H. Veerman, H.G. Van Der Poel, Thierry N. Boellaard, and P.J. Van Leeuwen

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Prostatectomy, Urology, medicine.medical_treatment, Magnetic resonance imaging, 3d model, Patient specific, medicine, Robot, Radiology, Positive Surgical Margin, business
Published
2021

50. Automated Multi-Dataset Analysis (AMDA): An on-line database and analysis tool for heliospheric and planetary plasma data

Author

Génot, V., primary, Budnik, E., additional, Jacquey, C., additional, Bouchemit, M., additional, Renard, B., additional, Dufourg, N., additional, André, N., additional, Cecconi, B., additional, Pitout, F., additional, Lavraud, B., additional, Fedorov, A., additional, Ganfloff, M., additional, Plotnikov, I., additional, Modolo, R., additional, Lormant, N., additional, Mohand, H. Si Hadj, additional, Tao, C., additional, Besson, B., additional, Heulet, D., additional, Boucon, D., additional, Durand, J., additional, Bourrel, N., additional, Brzustowski, Q., additional, Jourdane, N., additional, Hitier, R., additional, Garnier, P., additional, Grison, B., additional, Aunai, N., additional, Jeandet, A., additional, and Cabrolie, F., additional

Published
2021
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