Search

Polymorphisms in the cytokine genes have been associated with immunological variations that lead to susceptibility to HPV infection and the development of cervical cancer. This study aims to evaluate the influence of TNF-α -308G>A and IL-10 -819C>T polymorphisms on cervical cancer susceptibility through a case-control study, meta-analysis and Trial Sequential Analysis (TSA). A case–control study including 45 cervical cancer patients and 179 healthy controls was conducted. TNF-α -308G>A and IL-10 -819C>T polymorphisms were analysed using real-time polymerase chain reaction (PCR real-time). For the meta-analysis, published articles were electronically searched through the databases PubMed, Science Direct, Scopus and Web of science. In the case-control study, the IL-10 -819T carriers were associated with an increased risk of cervical cancer. While the TNF-α -308G>A polymorphism was not associated with cervical cancer, but sample power was less than 80% (70%). The meta-analysis and TSA showed that both TNF-α -308A (Overall, Asian, Caucasian and African analysis) and IL-10 -819T (Overall and Asian analysis) carriers were associated with an increased risk of cervical cancer. In conclusion, the IL-10 -819C>T and TNF-α -308G>A polymorphisms may be an important genetic biomarker for identifying the risk of developing cervical cancer.

ResumoAtipias de células glandulares em esfregaços cervicovaginais é um achado citológico na rotina de rastreamento do câncer cervical, que aumentou nas últimas décadas. Sua constatação é importante clinicamente, pois é alta a percentagem de casos associados com doença cervical e endometrial de alto grau e câncer. Este trabalho avaliou, por meio de uma revisão sistemática, estudos que investigaram o perfil das lesões de colo uterino em avaliações histológicas de seguimento de pacientes já diagnosticadas com células glandulares atípicas. Foram excluídos os estudos cuja investigação diagnóstica não incluísse o diagnóstico histopatológico. Realizou-se uma busca abrangente de publicações no período de 1966 a 2009, nas bases do LILACS, SciELO, PubMed/Medline e Old Medline. Os artigos omitidos na busca eletrônica também foram incluídos. Estavam de acordo com os critérios de inclusão 19 artigos, que foram selecionados. Este estudo tem como objetivo avaliar se a atipia celular glandular observada inicialmente na citologia relacionava-se histologicamente com a presença de lesões benignas, pré-neoplásicas ou neoplásicas. Dos 19 estudos selecionados, 11 mostraram maior correlação entre atipia glandular com patologias benignas e seis com lesões escamosas pré-malignas.SummaryAtypical glandular cells are a common finding in cervical cytology in cervical cancer screening and its occurrence has increased in the last decades. The identification of these cells is clinically very important due to its association with cervical and endometrial dysplasic lesions and cancer. Using a systematic approach, this article reviewed studies investigating cervical lesions that are characteristic in patients previously diagnosed as having atypical glandular cells. Studies in which diagnostic investigation did not include histopathological diagnosis were excluded. A comprehensive search for available material in LILACS, SciELO, PubMed/ Medline and Old Medline databases, dated between 1966 and 2009 was performed. Articles omitted by the electronic database search were also included. Nineteen articles met the inclusion criteria and were selected. This report aims at evaluating whether atypical glandular cells, initially found in cervical cytology and subsequently identified at the histological analysis, are related to the presence of benign, pre-malignant and malignant lesions. Eleven out of 19 selected articles showed the highest correlation between atypical glandular cells with benign diseases and six with squamous pre-malignant lesions.