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395 results on '"An NV"'

3. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

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Vollset, SE, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, AHA, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Alrousan, SM, Philip, AK, Phillips, MR, Pigeolet, M, Piradov, MA, Pisoni, E, Plotnikov, E, Poddighe, D, Polibin, RV, Poluru, R, Ponkilainen, VT, Al-Sabah, SK, Popovic, DS, Postma, MJ, Pour-Rashidi, A, Prabhu, D, Prada, SI, Pradhan, J, Pradhan, PMS, Prashant, A, Prates, EJS, Priscilla, T, Alsabri, MA, Purnobasuki, H, Purohit, BM, Puvvula, J, Qasim, NH, Qattea, I, Qazi, AS, Qian, G, Rabiee Rad, M, Radhakrishnan, V, Raeisi Shahraki, H, Altaany, Z, Rafferty, Q, Raggi, A, Raggi, C, Raheem, N, Rahim, F, Rahim, MJ, Rahimibarghani, S, Rahman, MMMR, Rahman, M, Rahman, MA, Al-Tammemi, AB, Rahman, T, Rahmani, AM, Rahmanian, M, Rahmanian, N, Rahmati, R, Rahmawaty, S, Raimondo, D, Raja, A, Rajput, P, Ramadan, M, Al-Tawfiq, JA, Ramasamy, SK, Ramazanu, S, Ramteke, PW, Rana, K, Rana, RK, Ranabhat, CL, Rane, A, Rao, CR, Rao, M, Rasella, D, Altirkawi, KA, Rashedi, V, Rashid, AM, Rasouli-Saravani, A, Rastogi, P, Rasul, A, Rathish, D, Rathnaiah Babu, G, Rauniyar, SK, Ravangard, R, Rawaf, DL, Aluh, DO, Rawaf, S, Raza, RZ, Redwan, EMM, Reifels, L, Reitsma, MB, Remuzzi, G, Rengasamy, KRR, Reshmi, B, Resnikoff, S, Restaino, S, Alvis-Guzman, N, Reyes, LF, Rezaei, N, Rezaei, ZS, Rezaeian, M, Rhee, TG, Rickard, J, Robalik, T, Robinson-Oden, HE, Rocha, HAL, Al-Wardat, MS, Rodrigues, M, Rodriguez, JAB, Roever, L, Romadlon, DS, Ronfani, L, Rony, MKK, Roshandel, G, Rotimi, K, Rout, HS, Roy, B, Abd-Elsalam, S, Al-Worafi, YM, Rubagotti, E, Ruela, GDA, Rumisha, SF, Runghien, T, Russo, M, Saad, AMA, Saber, K, Saber-Ayad, MM, Sabet, CJ, Sabour, S, Aly, H, Sachdev, PS, Saddler, A, Sadee, BA, Sadeghi, M, Saeb, MR, Saeed, U, Safi, SZ, Sagar, R, Saghafi, A, Sagoe, D, Alyahya, MS, Sahebkar, A, Sahoo, PM, Sajid, MR, Salam, N, Salamati, P, Salami, AA, Saleh, MA, Salehi, L, Salem, MR, Salemcity, AJ, Alzoubi, KH, Salimi, S, Samadi Kafil, H, Samargandy, S, Samodra, YL, Samy, AM, Sanabria, J, Sanna, F, Santric-Milicevic, MM, Sao Jose, BP, Saraswathy, SYI, Al-Zyoud, W, Saravanan, A, Sarmiento-Suárez, R, Sarode, GS, Sarode, SC, Sartorius, B, Satpathy, M, Sayeed, A, Scarmeas, N, Schaarschmidt, BM, Schinckus, C, Amani, R, Schuermans, A, Schumacher, AE, Schutte, AE, Schwebel, DC, Schwendicke, F, Selvaraj, S, Semreen, MH, Senapati, S, Sengupta, P, Senthilkumaran, S, Ameyaw, EK, Serban, D, Sethi, Y, Seylani, A, Shafie, M, Shah, PA, Shahbandi, A, Shahid, S, Shahid, W, Shahsavari, HR, Shahwan, MJ, Amin, TT, Shaikh, MA, Shalash, AS, Shamekh, A, Shamim, MA, Shanawaz, M, Shankar, A, Shannawaz, M, Sharath, M, Sharfaei, S, Sharifan, A, Amindarolzarbi, A, Sharifi-Rad, J, Sharma, A, Sharma, M, Sharma, S, Sharma, V, Shastry, RP, Shayan, M, Shekhar, S, Shenoy, RR, Shetty, M, Amiri, S, Shetty, PH, Shetty, PK, Shi, P, Shiani, A, Shigematsu, M, Shimels, T, Shiri, R, Shittu, A, Shiue, I, Shivakumar, KM, Abdi, P, Amirzade-Iranaq, MH, Shool, S, Shorofi, SA, Shrestha, S, Shuval, K, Si, Y, Siddig, EE, Sidhu, JK, Silva, JP, Silva, LMLR, Silva, S, Amu, H, Silva, TPR, Simpson, CR, Simpson, KE, Singh, A, Singh, BB, Singh, B, Singh, H, Singh, J, Singh, P, Amugsi, DA, Skou, ST, Smith, G, Sobia, F, Socea, B, Solanki, S, Soleimani, H, Soliman, SSM, Song, Y, Soyiri, IN, Spartalis, M, Ancuceanu, R, Spearman, S, Sreeramareddy, CT, Stanaway, JD, Stanikzai, MH, Starodubova, AV, Stein, DJ, Steiner, C, Steiropoulos, P, Stockfelt, L, Stokes, MA, Anderlini, D, Straif, K, Subedi, N, Suliankatchi Abdulkader, R, Sultana, A, Sun, J, Sundström, J, Swain, CK, Szarpak, L, Szeto, MD, Tabaee Damavandi, P, Anderson, DB, Tabarés-Seisdedos, R, Tabatabaei Malazy, O, Tabatabaeizadeh, S-A, Tabatabai, S, Tabb, KM, Tabche, C, Tabish, M, Taheri Abkenar, Y, Taheri Soodejani, M, Taiba, J, Andrade, PP, Talaat, IM, Tamuzi, JL, Tan, K-K, Tang, H, Tat, NY, Tavakoli Oliaee, R, Tavangar, SM, Taveira, N, Tbakhi, A, Tehrani, H, Andrei, CL, Temsah, M-H, Teramoto, M, Tesfaye, BT, Teye-Kwadjo, E, Thangaraju, P, Thankappan, KR, Thapar, R, Thayakaran, R, Thirunavukkarasu, S, Thomas, N, Andrei, T, Thygesen, LC, Ticoalu, JHV, Timalsena, D, Tiruye, TY, Tiwari, K, Tomo, S, Tonelli, M, Topor-Madry, R, Touvier, M, Tovani-Palone, MR, Andrews, EA, Tran, AT, Tran, JT, Tran, NM, Tran, TH, Trico, D, Tromans, SJ, Truyen, TTTT, Tsatsakis, A, Tsermpini, EE, Tumurkhuu, M, Abdollahi, M, Anil, A, Turnock, ST, Udoh, A, Ullah, A, Ullah, S, Umakanthan, S, Umar, M, Umar, SS, Unim, B, Unnikrishnan, B, Anil, S, Upadhyay, E, Usman, JS, Vahdati, S, Vaithinathan, AG, Vakili, O, Valizadeh, R, Van den Eynde, J, Vart, P, Varthya, SB, Vasankari, TJ, Anoushiravani, A, Vasic, M, Venketasubramanian, N, Veroux, M, Verras, G-I, Vervoort, D, Vijayageetha, M, Villafañe, JH, Vinayak, M, Violante, FS, Vladimirov, SK, Antony, CM, Vlassov, V, Vo, B, Vohra, K, Vos, T, Wadood, AW, Waheed, Y, Wang, F, Wang, S, Wang, Y, Antriyandarti, E, Wang, Y-P, Wanjau, MN, Waqas, M, Ward, P, Waris, A, Wassie, EG, Watson, S, Weaver, MR, Weerakoon, KG, Anuoluwa, BS, Weintraub, RG, Weldetinsaa, HLL, Wells, KM, Wen, YF, Westerman, R, Wiangkham, T, Wickramasinghe, DP, Widowati, E, Wojewodzic, MW, Woldeyes, DH, Anvari, S, Wolf, AW, Wolfe, CDA, Wu, C, Wu, D, Wu, F, Wu, J, Wu, Z, Wulf Hanson, S, Xiao, H, Xu, S, Anyasodor, AE, Yadav, R, Yamagishi, K, Yang, D, Yano, Y, Yarahmadi, A, Yazdani Nia, I, Ye, P, Yesodharan, R, Yesuf, SA, Yezli, S, Appiah, F, Yiğit, A, Yiğit, V, Yigzaw, ZA, Yin, D, Yip, P, Yonemoto, N, You, Y, Younis, MZ, Yu, C, Yu, EA, Aquilano, M, Yu, Y, Yuan, C-W, Yusuf, H, Zafar, U, Zafari, N, Zahid, MH, Zakham, F, Zaki, N, Zerfu, TA, Zhang, H, Abdoun, M, Arab, JP, Zhang, J, Zhang, L, Zhang, Y, Zhang, Z, Zhao, X-JG, Zhao, Y, Zhao, Z, Zhong, C, Zhou, B, Zhou, J, Arabloo, J, Zhou, S, Zhu, B, Zhumagaliuly, A, Zielińska, M, Zoghi, G, Zumla, A, Zyoud, SH, Smith, AE, Murray, CJL, Arafa, EA, Arafat, M, Aravkin, AY, Ardekani, A, Areda, D, Aregawi, BB, Aremu, A, Ariffin, H, Abdullahi, A, Arkew, M, Armani, K, Artamonov, AA, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Abebe, M, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, AW, Ayatollahi, H, Ayuso-Mateos, JL, Azadnajafabad, S, Azeez, FK, Azevedo, RMS, Badar, M, Abiodun, O, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, JL, Bako, AT, Balakrishnan, S, Balcha, WF, Baltatu, OC, Barchitta, M, Aboagye, RG, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barqawi, HJ, Barteit, S, Basiru, A, Basso, JD, Bastan, M-M, Basu, S, Bauckneht, M, Abolhassani, H, Baune, BT, Bayati, M, Bayileyegn, NS, Behnoush, AH, Behzadi, P, Beiranvand, M, Bello, OO, Belo, L, Beloukas, A, Bemanalizadeh, M, Abouzid, M, Bensenor, IM, Benzian, H, Beran, A, Berezvai, Z, Bernstein, RS, Bettencourt, PJG, Beyene, KA, Beyene, MG, Bhagat, DS, Bhagavathula, AS, Aboye, GB, Bhala, N, Bhandari, D, Bharadwaj, R, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhattacharjee, NV, Bhatti, GK, Abreu, LG, Bhatti, JS, Bhatti, MS, Bhuiyan, MA, Bisignano, C, Biswas, B, Bjørge, T, Bodolica, V, Bodunrin, AO, Bonakdar Hashemi, M, Bora Basara, B, Absalan, A, Borhany, H, Bosoka, SA, Botero Carvajal, A, Bouaoud, S, Boufous, S, Boxe, C, Boyko, EJ, Brady, OJ, Braithwaite, D, Brauer, M, Abualruz, H, Brazo-Sayavera, J, Brenner, H, Brown, CS, Browne, AJ, Brugha, T, Bryazka, D, Bulamu, NB, Buonsenso, D, Burkart, K, Burns, RA, Abubakar, B, Busse, R, Bustanji, Y, Butt, ZA, Caetano dos Santos, FL, Çakmak Barsbay, M, Calina, D, Campos, LA, Cao, S, Capodici, A, Cárdenas, R, Abukhadijah, HJJ, Carreras, G, Carugno, A, Carvalho, M, Castaldelli-Maia, JM, Castelpietra, G, Cattaruzza, MS, Caye, A, Cegolon, L, Cembranel, F, Cenko, E, Addolorato, G, Cerin, E, Chadban, SJ, Chadwick, J, Chakraborty, C, Chakraborty, S, Chalek, J, Chan, JSK, Chandika, RM, Chandy, S, Charan, J, Adekanmbi, V, Chaudhary, AA, Chaurasia, A, Chen, A-T, Chen, H, Chen, MX, Chen, S, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Adetunji, CO, Chimoriya, R, Ching, PR, Chirinos-Caceres, JL, Chitheer, A, Cho, DY, Cho, WCS, Choi, D-W, Chong, B, Chong, CL, Chopra, H, Adetunji, JB, Chu, D-T, Chung, E, Chutiyami, M, Clayton, JT, Cogen, RM, Cohen, AJ, Columbus, A, Comfort, H, Conde, J, Connolly, JT, Adeyeoluwa, TE, Cooper, EEK, Cortese, S, Cruz-Martins, N, da Silva, AG, Dadras, O, Dai, X, Dai, Z, Dalton, BE, Damiani, G, Dandona, L, Adha, R, Dandona, R, Das, JK, Das, S, Dash, NR, Davletov, K, De la Hoz, FP, De Leo, D, Debopadhaya, S, Delgado-Enciso, I, Adhikary, RK, Denova-Gutiérrez, E, Dervenis, N, Desai, HD, Devanbu, VGC, Dewan, SMR, Dhama, K, Dhane, AS, Dhingra, S, Dias da Silva, D, Diaz, D, Adnani, QES, Diaz, LA, Diaz, MJ, Dima, A, Ding, DD, Do, THP, do Prado, CB, Dodangeh, M, Doegah, PT, Dohare, S, Adzigbli, LA, Dong, W, D'Oria, M, Doshi, R, Dowou, RK, Dsouza, HL, Dsouza, V, Dube, J, Dumith, SC, Duncan, BB, Duraes, AR, Afrashteh, F, Duraisamy, S, Durojaiye, OC, Dushpanova, A, Dutta, S, Dzianach, PA, Dziedzic, AM, Eboreime, E, Ebrahimi, A, Ebrahimi Kalan, M, Edinur, HA, Afzal, MS, Efendi, F, Eikemo, TA, Eini, E, Ekundayo, TC, El Arab, RA, El Sayed, I, Elamin, O, Elemam, NM, ElGohary, GMT, Elhadi, M, Afzal, S, Elmeligy, OAA, Elmoselhi, AB, Elshaer, M, Elsohaby, I, Eltahir, ME, Emeto, TI, Eshrati, B, Eslami, M, Esmaeili, Z, Fabin, N, Agbozo, F, Fagbamigbe, AF, Fagbule, OF, Falzone, L, Fareed, M, Farinha, CSES, Faris, MEM, Faro, A, Fasihi, K, Fatehizadeh, A, Fauk, NK, Agodi, A, Fazylov, T, Feigin, VL, Fekadu, G, Feng, X, Fereshtehnejad, S-M, Ferrara, P, Ferreira, N, Firew, BS, Fischer, F, Fitriana, I, Agrawal, A, Flavel, J, Flor, LS, Folayan, MO, Foley, KM, Fonzo, M, Force, LM, Foschi, M, Freitas, A, Fridayani, NKY, Fukutaki, KG, Agyemang-Duah, W, Furtado, JM, Fux, B, Gaal, PA, Gadanya, MA, Gallus, S, Ganesan, B, Ganiyani, MA, Gautam, RK, Gebi, TG, Gebregergis, MW, Ahinkorah, BO, Gebrehiwot, M, Getacher, L, Getahun, GKA, Gething, PW, Ghadimi, DJ, Ghadirian, F, Ghafarian, S, Ghailan, KY, Ghasemi, M, Ghasempour Dabaghi, G, Ahlstrom, AJ, Ghazy, RM, Ghoba, S, Gholami, E, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Ghorbani Vajargah, P, Ghotbi, E, Gil, AU, Gill, TK, Ahmad, A, Girmay, A, Glasbey, JC, Glushkova, EV, Gnedovskaya, EV, Göbölös, L, Goldust, M, Goleij, P, Golinelli, D, Gopalani, SV, Goulart, AC, Ahmad, F, Gouravani, M, Goyal, A, Grivna, M, Grosso, G, Guarducci, G, Gubari, MIM, Guicciardi, S, Guimarães, RA, Gulati, S, Gulisashvili, D, Ahmad, MM, Gunawardane, DA, Guo, C, Gupta, AK, Gupta, R, Gupta, S, Gupta, VK, Haakenstad, A, Hadi, NR, Ahmad, S, Haep, N, Hafiz, A, Haghmorad, D, Haile, D, Hajj Ali, A, Haj-Mirzaian, A, Halboub, ES, Haller, S, Halwani, R, Hamagharib Abdullah, K, Hamdy, NM, Hamoudi, R, Hanifi, N, Hankey, GJ, Haq, ZA, Haque, MR, Harapan, H, Hargono, A, Haro, JM, Ahmed, A, Hasaballah, AI, Hasan, SMM, Hasanian, M, Hasnain, MS, Hassan, A, Haubold, J, Hay, SI, Hebert, JJ, Hegazi, OE, Heidari, M, Hemmati, M, Henson, CA, Herrera-Serna, BY, Herteliu, C, Heydari, M, Hezam, K, Hidayana, I, Hiraike, Y, Hoan, NQ, Holla, R, Ahmed, H, Hoogar, P, Horita, N, Hossain, MM, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hu, C, Huang, J, Hultström, M, Ahmed, S, Hundie, TG, Hunt, AJ, Hushmandi, K, Hussain, J, Hussain, MA, Hussein, NR, Huynh, H-H, Hwang, B-F, Ibitoye, SE, Iftikhar, PM, Ahmed, SA, Ikiroma, AI, Ikwegbue, PC, Ilic, IM, Ilic, MD, Immurana, M, Isa, MA, Islam, MR, Islam, SMS, Ismail, F, Ismail, NE, Akinosoglou, K, Isola, G, Iwagami, M, Iyamu, IO, Jacob, L, Jacobsen, KH, Jafarinia, M, Jahankhani, K, Jahanmehr, N, Jain, N, Jairoun, AA, Akkaif, MA, Jakhmola Mani, DR, Jamil, S, Jamora, RDG, Jatau, AI, Javadov, S, Javaheri, T, Jayaram, S, Jee, SH, Jeganathan, J, Jiang, H, Akrami, AE, Jokar, M, Jonas, JB, Joseph, N, Joshua, CE, Jürisson, M, K, V, Kabir, A, Kabir, Z, Kadashetti, V, Kalankesh, LR, Akter, E, Kalra, S, Kamath, A, Kamath, R, Kamireddy, A, Kanaan, M, Kanchan, T, Kanmiki, EW, Kanmodi, KK, Kansal, SK, Karim, A, Al Awaidy, S, Karkhah, S, Kashoo, FZ, Kasraei, H, Kassel, MB, Katikireddi, SV, Kauppila, JH, Kaur, H, Kayode, GA, Kazemi, F, Kazemian, S, Al Hasan, SM, Kebede, F, Kendal, ES, Kesse-Guyot, E, Khademvatan, S, Khajuria, H, Khalaji, A, Khalid, A, Khalid, N, Khalilian, A, Khamesipour, F, Al Mosa, AS, Khan, F, Khan, MJ, Khan, MAB, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, MM, Khatib, MN, Khayat Kashani, HR, Kheirallah, KA, Al Ta'ani, O, Khokhar, M, Khormali, M, Khorrami, Z, Khosla, AA, Khosravi, M, Khosrowjerdi, M, Khubchandani, J, Kifle, ZD, Kim, G, Kim, JS, Al Zaabi, OAM, Kim, MS, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Knibbs, LD, Knudsen, AKS, Kochhar, S, Kolahi, A-A, Kompani, F, Alahdab, F, Koren, G, Korzh, O, Krishan, K, Krishna, V, Krishnamoorthy, V, Kucuk Bicer, B, Kuddus, MA, Kuddus, M, Kuitunen, I, Kujan, O, Alajlani, MM, Kulimbet, M, Kulkarni, V, Kumar, GA, Kumar, H, Kumar, N, Kumar, R, Kumar, V, Kundu, A, Kusuma, D, Kyei-Arthur, F, Al-Ajlouni, Y, Kytö, V, Kyu, HH, La Vecchia, C, Lacey, B, Ladan, MA, Laflamme, L, Lahariya, C, Lai, DTC, Lalloo, R, Lallukka, T, Alalalmeh, SO, Lám, J, Lan, Q, Lan, T, Landires, I, Lanfranchi, F, Langguth, B, Lansingh, VC, Laplante-Lévesque, A, Larijani, B, Larsson, AO, Al-Aly, Z, Lasrado, S, Lauriola, P, Lawlor, HR, Le, H-H, Le, LKD, Le, NHH, Le, TTT, Le, TDT, Leasher, JL, Lee, DW, Alam, K, Lee, M, Lee, PH, Lee, S-W, Lee, SW, Lee, SWH, Lee, YH, Leigh, J, Leong, E, Li, M-C, Libra, M, Alam, N, Ligade, VS, Lim, L-L, Lim, SS, Limenh, LW, Lindholm, D, Lindstedt, PA, Listl, S, Liu, G, Liu, S, Alam, T, Liu, X, Llanaj, E, López-Bueno, R, López-Gil, JF, Loreche, AM, Lotufo, PA, Lozano, R, Lubinda, J, Lucchetti, G, Alam, Z, Luo, L, Lusk, JB, Lv, L, M Amin, HI, Ma, ZF, Maass, KL, Machairas, N, Machoy, M, Madureira-Carvalho, ÁM, Magdy Abd El Razek, H, Al-amer, RM, Maghazachi, AA, Mahadeshwara Prasad, DR, Mahalleh, M, Mahasha, PW, Mahmoud, MA, Mahmoudi, E, Mahmoudvand, G, Makama, M, Malakan Rad, E, Malhotra, K, Alanezi, FM, Malik, AA, Malta, DC, Manla, Y, Mansour, A, Mansouri, MH, Mansouri, P, Mansouri, V, Mansourian, M, Mansournia, MA, Marasini, BP, Alanzi, TM, Marateb, HR, Maravilla, JC, Mardi, P, Marjani, A, Markazi Moghadam, H, Marrugo Arnedo, CA, Martinez, G, Martinez-Piedra, R, Martins-Melo, FR, Martorell, M, Albakri, A, Marx, W, Marzo, RR, Masoudi, S, Mathangasinghe, Y, Mathioudakis, AG, Mathur, M, Mathur, N, Matozinhos, FP, Mattumpuram, J, Aldhaleei, WA, Maude, RJ, Maugeri, A, Mayeli, M, Mazidi, M, Mazzotti, A, McGrath, JJ, McKee, M, McKowen, ALW, McPhail, MA, McPhail, SM, Aldridge, RW, Mehmood, A, Mehrabani-Zeinabad, K, Mehravar, S, Mekene Meto, T, Melese, EB, Mendez-Lopez, MAM, Mendoza, W, Menezes, RG, Mensah, GA, Mensah, LG, Alemohammad, SY, Mentis, A-FA, Meo, SA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mestrovic, T, Mettananda, KCD, Mettananda, S, Mhlanga, A, Mhlanga, L, Alemu, YM, Miazgowski, T, Michalek, IM, Micheletti Gomide Nogueira de Sá, AC, Miller, TR, Minh, LHN, Mirahmadi, A, Mirijello, A, Mirrakhimov, EM, Mirzaei, R, Mitchell, PB, Al-Gheethi, AAS, Mittal, C, Moberg, ME, Moghadam Fard, A, Mohajelin, S, Mohamadkhani, A, Mohamed, AI, Mohamed, J, Mohamed, MFH, Mohamed, NS, Mohammad, AM, Al-Hanawi, MK, Mohammadi, S, Mohammed, H, Mohammed, M, Mohammed, S, Mokdad, AH, Molokhia, M, Momani, SM, Momtazmanesh, S, Monasta, L, Mondello, S, Ali, A, Moni, MA, Montazeri, F, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moraga, P, Morawska, L, Moreira, RS, Morovatdar, N, Morrison, SD, Mosapour, A, Mosser, JF, Mossialos, E, Motappa, R, Mougin, V, Mousavi, P, Mrejen, M, Mubarik, S, Mueller, UO, Mulita, F, Ali, I, Munjal, K, Murillo-Zamora, E, Musallam, KM, Musina, A-M, Mustafa, G, Myung, W, Nafei, A, Nagarajan, AJ, Naghavi, P, Naik, GR, Ali, MU, Naik, G, Nainu, F, Najdaghi, S, Nakhostin Ansari, N, Nangia, V, Narasimha Swamy, S, Nargus, S, Narimani Davani, D, Nascimento, BR, Nascimento, GG, Ali, R, Naser, AY, Nashwan, AJ, Natto, ZS, Nauman, J, Navaratna, SNK, Naveed, M, Nawsherwan, Nayak, BP, Nayak, VC, Negash, H, Ali, 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Ikwegbue, PC, Ilic, IM, Ilic, MD, Immurana, M, Isa, MA, Islam, MR, Islam, SMS, Ismail, F, Ismail, NE, Akinosoglou, K, Isola, G, Iwagami, M, Iyamu, IO, Jacob, L, Jacobsen, KH, Jafarinia, M, Jahankhani, K, Jahanmehr, N, Jain, N, Jairoun, AA, Akkaif, MA, Jakhmola Mani, DR, Jamil, S, Jamora, RDG, Jatau, AI, Javadov, S, Javaheri, T, Jayaram, S, Jee, SH, Jeganathan, J, Jiang, H, Akrami, AE, Jokar, M, Jonas, JB, Joseph, N, Joshua, CE, Jürisson, M, K, V, Kabir, A, Kabir, Z, Kadashetti, V, Kalankesh, LR, Akter, E, Kalra, S, Kamath, A, Kamath, R, Kamireddy, A, Kanaan, M, Kanchan, T, Kanmiki, EW, Kanmodi, KK, Kansal, SK, Karim, A, Al Awaidy, S, Karkhah, S, Kashoo, FZ, Kasraei, H, Kassel, MB, Katikireddi, SV, Kauppila, JH, Kaur, H, Kayode, GA, Kazemi, F, Kazemian, S, Al Hasan, SM, Kebede, F, Kendal, ES, Kesse-Guyot, E, Khademvatan, S, Khajuria, H, Khalaji, A, Khalid, A, Khalid, N, Khalilian, A, Khamesipour, F, Al Mosa, AS, Khan, F, Khan, MJ, Khan, MAB, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, MM, Khatib, MN, Khayat Kashani, HR, Kheirallah, KA, Al Ta'ani, O, Khokhar, M, Khormali, M, Khorrami, Z, Khosla, AA, Khosravi, M, Khosrowjerdi, M, Khubchandani, J, Kifle, ZD, Kim, G, Kim, JS, Al Zaabi, OAM, Kim, MS, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Knibbs, LD, Knudsen, AKS, Kochhar, S, Kolahi, A-A, Kompani, F, Alahdab, F, Koren, G, Korzh, O, Krishan, K, Krishna, V, Krishnamoorthy, V, Kucuk Bicer, B, Kuddus, MA, Kuddus, M, Kuitunen, I, Kujan, O, Alajlani, MM, Kulimbet, M, Kulkarni, V, Kumar, GA, Kumar, H, Kumar, N, Kumar, R, Kumar, V, Kundu, A, Kusuma, D, Kyei-Arthur, F, Al-Ajlouni, Y, Kytö, V, Kyu, HH, La Vecchia, C, Lacey, B, Ladan, MA, Laflamme, L, Lahariya, C, Lai, DTC, Lalloo, R, Lallukka, T, Alalalmeh, SO, Lám, J, Lan, Q, Lan, T, Landires, I, Lanfranchi, F, Langguth, B, Lansingh, VC, Laplante-Lévesque, A, Larijani, B, Larsson, AO, Al-Aly, Z, Lasrado, S, Lauriola, P, Lawlor, HR, Le, H-H, Le, LKD, Le, NHH, Le, TTT, Le, TDT, Leasher, JL, Lee, DW, Alam, K, Lee, M, Lee, PH, Lee, S-W, Lee, SW, Lee, SWH, Lee, YH, Leigh, J, Leong, E, Li, M-C, Libra, M, Alam, N, Ligade, VS, Lim, L-L, Lim, SS, Limenh, LW, Lindholm, D, Lindstedt, PA, Listl, S, Liu, G, Liu, S, Alam, T, Liu, X, Llanaj, E, López-Bueno, R, López-Gil, JF, Loreche, AM, Lotufo, PA, Lozano, R, Lubinda, J, Lucchetti, G, Alam, Z, Luo, L, Lusk, JB, Lv, L, M Amin, HI, Ma, ZF, Maass, KL, Machairas, N, Machoy, M, Madureira-Carvalho, ÁM, Magdy Abd El Razek, H, Al-amer, RM, Maghazachi, AA, Mahadeshwara Prasad, DR, Mahalleh, M, Mahasha, PW, Mahmoud, MA, Mahmoudi, E, Mahmoudvand, G, Makama, M, Malakan Rad, E, Malhotra, K, Alanezi, FM, Malik, AA, Malta, DC, Manla, Y, Mansour, A, Mansouri, MH, Mansouri, P, Mansouri, V, Mansourian, M, Mansournia, MA, Marasini, BP, Alanzi, TM, Marateb, HR, Maravilla, JC, Mardi, P, Marjani, A, Markazi Moghadam, H, Marrugo Arnedo, CA, Martinez, G, Martinez-Piedra, R, Martins-Melo, FR, Martorell, M, Albakri, A, Marx, W, Marzo, RR, Masoudi, S, Mathangasinghe, Y, Mathioudakis, AG, Mathur, M, Mathur, N, Matozinhos, FP, Mattumpuram, J, Aldhaleei, WA, Maude, RJ, Maugeri, A, Mayeli, M, Mazidi, M, Mazzotti, A, McGrath, JJ, McKee, M, McKowen, ALW, McPhail, MA, McPhail, SM, Aldridge, RW, Mehmood, A, Mehrabani-Zeinabad, K, Mehravar, S, Mekene Meto, T, Melese, EB, Mendez-Lopez, MAM, Mendoza, W, Menezes, RG, Mensah, GA, Mensah, LG, Alemohammad, SY, Mentis, A-FA, Meo, SA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mestrovic, T, Mettananda, KCD, Mettananda, S, Mhlanga, A, Mhlanga, L, Alemu, YM, Miazgowski, T, Michalek, IM, Micheletti Gomide Nogueira de Sá, AC, Miller, TR, Minh, LHN, Mirahmadi, A, Mirijello, A, Mirrakhimov, EM, Mirzaei, R, Mitchell, PB, Al-Gheethi, AAS, Mittal, C, Moberg, ME, Moghadam Fard, A, Mohajelin, S, Mohamadkhani, A, Mohamed, AI, Mohamed, J, Mohamed, MFH, Mohamed, NS, Mohammad, AM, Al-Hanawi, MK, Mohammadi, S, Mohammed, H, Mohammed, M, Mohammed, S, Mokdad, AH, Molokhia, M, Momani, SM, Momtazmanesh, S, Monasta, L, Mondello, S, Ali, A, Moni, MA, Montazeri, F, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moraga, P, Morawska, L, Moreira, RS, Morovatdar, N, Morrison, SD, Mosapour, A, Mosser, JF, Mossialos, E, Motappa, R, Mougin, V, Mousavi, P, Mrejen, M, Mubarik, S, Mueller, UO, Mulita, F, Ali, I, Munjal, K, Murillo-Zamora, E, Musallam, KM, Musina, A-M, Mustafa, G, Myung, W, Nafei, A, Nagarajan, AJ, Naghavi, P, Naik, GR, Ali, MU, Naik, G, Nainu, F, Najdaghi, S, Nakhostin Ansari, N, Nangia, V, Narasimha Swamy, S, Nargus, S, Narimani Davani, D, Nascimento, BR, Nascimento, GG, Ali, R, Naser, AY, Nashwan, AJ, Natto, ZS, Nauman, J, Navaratna, SNK, Naveed, M, Nawsherwan, Nayak, BP, Nayak, VC, Negash, H, Ali, SSS, Negoi, I, Negoi, RI, Nejadghaderi, SA, Nejjari, C, Nematollahi, S, Netsere, HB, Ng, M, Nguefack-Tsague, G, Ngunjiri, JW, Nguyen, AH, Ali, VE, Nguyen, DH, Nguyen, HTH, Nguyen, N, Nguyen, NNY, Nguyen, PT, Nguyen, QP, Nguyen, VT, Nguyen Tran Minh, D, Niazi, RK, Ali, W, Nigatu, YT, Niknam, M, Nikoobar, A, Nikpoor, AR, Nikravangolsefid, N, Noman, EA, Nomura, S, Noor, STA, Noroozi, N, Nouri, M, Al-Ibraheem, A, Nozari, M, Nri-Ezedi, CA, Ntaios, G, Nunemo, MH, Nurrika, D, Nutor, JJ, Nzoputam, CI, Nzoputam, OJ, Oancea, B, Obamiro, KO, Alicandro, G, Odetokun, IA, Oduro, MS, Ogundijo, OA, Ogunfowokan, AA, Ogunkoya, A, Oguntade, AS, Oh, I-H, Ojo-Akosile, TR, Okati-Aliabad, H, Okekunle, AP, Alif, SM, Okonji, OC, Olagunju, AT, Olatubi, MI, Oliveira, GMM, Olusanya, BO, Olusanya, JO, Oluwafemi, YD, Omar, HA, Omer, GL, Ong, S, Aljunid, SM, Onie, S, Onwujekwe, OE, Opejin, AO, Ordak, M, Orish, VN, Ortiz, A, Ortiz-Prado, E, Osman, WMS, Ostojic, SM, Ostroff, SM, Alla, F, Osuagwu, UL, Otoiu, A, Otstavnov, SS, Ouyahia, A, Owolabi, MO, Oyeyemi, OT, Ozair, A, P A, MP, Padron-Monedero, A, Padubidri, JR, Almazan, JU, Pal, PK, Palicz, T, Pan, F, Pan, H-F, Panda-Jonas, S, Pandey, A, Pando-Robles, V, Pangaribuan, HU, Panos, GD, Panos, LD, Al-Mekhlafi, HM, Pantazopoulos, I, Pantea Stoian, AM, Parikh, RR, Park, E-K, Park, S, Parsons, N, Parthasarathi, A, Pasovic, M, Passera, R, Alqutaibi, AY, Patel, J, Pathan, AR, Patil, S, Patoulias, D, Pawar, S, Pazoki Toroudi, H, Pease, SA, Peden, AE, Pedersini, P, Pensato, U, Alrawashdeh, A, Pepito, VCF, Peprah, P, Pereira, M, Pereira, MO, Perianayagam, A, Perico, N, Perna, S, Pesudovs, K, Petermann-Rocha, FE, and Pham, HT

Published
2024

7. Stimulation of ATP Hydrolysis by ssDNA Provides the Necessary Mechanochemical Energy for G4 Unfolding

Author

Dai, Yang-Xue, primary, Duan, Xiao-Lei, additional, Fu, Wen-Tong, additional, Wang, Shan, additional, Liu, Na-Nv, additional, Li, Hai-Hong, additional, Ai, Xia, additional, Guo, Hai-Lei, additional, Navés, Cel Areny, additional, Bugnard, Elisabeth, additional, Auguin, Daniel, additional, Hou, Xi-Miao, additional, Rety, Stephane, additional, and Xi, Xu-Guang, additional

Published
2024
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16. PSEUDOPLAQUETOPENIA: IMPORTÂNCIA DA IMPLEMENTAÇÃO DA REVISÃO DE LÂMINAS HEMATOLÓGICAS POR MICROSCOPIA PARA CORREÇÃO DA CONTAGEM DE PLAQUETAS E NO CONTROLE INTERNO DA QUALIDADE FRENTE ÀS MODERNAS TECNOLOGIAS DOS CONTADORES AUTOMATIZADAS EM UM PRONTO SOCORRO UNIVERSITÁRIO DE PERNAMBUCO

Author

Barros, AEL, primary, Gandra, BBC, additional, Rodrigues, NV, additional, Domingos, IF, additional, Junior, JGMM, additional, Furtado, VC, additional, and Ramos, TMB, additional

Published
2023
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19. Pyroptotic MAITs link microbial translocation with severity of alcohol-related liver disease

Author

Zhang, Li-Ping, primary, Wang, Hui-Fang, additional, Zhai, Xing-Ran, additional, Zhou, Chun-Bao, additional, Yuan, Jin-Hong, additional, Ma, Ye-Nv, additional, Yao, Zeng-Tao, additional, Huang, Shuo, additional, Li, Wei-Zhe, additional, Jiao, Yan-Mei, additional, Wang, Fu-Sheng, additional, Zou, Zhengsheng, additional, Zhang, Ji-Yuan, additional, and Zeng, Qing-Lei, additional

Published
2023
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27. The epidemiology of sepsis in paediatric intensive care units in Brazil (the Sepsis PREvalence Assessment Database in Pediatric population, SPREAD PED): an observational study

Author

Daniela Carla de Souza, Joelma Gonçalves Martin, Vanessa Soares Lanziotti, Cláudio Flauzino de Oliveira, Cristian Tonial, Werther Brunow de Carvalho, José Roberto Fioretto, Jefferson Pedro Piva, Eduardo Juan Troster, Aline Siqueira Bossa, Flávia Gregorini, Josiane Ferreira, Juliana Lubarino, Alexandre Biasi Cavalcanti, Flávia Ribeiro Machado, SC Silva, J Giacomazzi, Domingos A. Boldrini, FH Gilli, LC de Castro, ML de Albuquerque, VCTG Osorio, MLC Elias, AA da Câmara, M Maia, PB de Carvalho, FM Augusto, RCCM de Figueiredo, EL Ikino, FAS Nogueres, RJ de Almeida, L Torreão, J Ramalho, MMS Camões, CS de Oliveira, VIIS Serafim, J Colleti Junior, CG de Almeida, MHM da Costa, JF Valerio, ME Navajas, PM Riveiro, A Lubiana, ACLC Brito, V Moretto, LMMD Rachid, M Valle, PP de Souza, RPL Victor, NR Castro, T Sakomura, M Molon, AR Ferreira, JG da Fonseca, VCA Cunali, VCA Chagas, G Belek, TS da Rocha, LCFF de Mello, LM Machado, NV Moliterno, C Duran, CLEB Sanos, GT Ribeiro, PSL da Silva, R Lipinski, A Soledade, KC Branco, ACO Teles, GF da Cruz, MR de Mendonça, E Malheiros, J Vicari, PNT Izidro, NMP Campos, TC Pontes, CRF Carneiro, AH Imamura, FM Yoshioka, MCMB Duarte, T Menezes, C Falconiere, F Matos, RS Zeitel, CC Nogueras, ML da Silva, M Aprille, TYM Pires, AF Portella, PVG Flores, PP Alfradique, RC Nascimento, MO Saldanha, AT Alves, WJ de Almeida, M Rodrigues, E Lopes Júnior, MRP Komka, MAR Nascimento, CRC Lopes, TMC Bernardi, RV Falcão, AR Fraga, AA Machado, JEF Godoy, J Barcellos, RLS Queiroz, VVS de Almeida, JZG Lira, M Alvo, TCP Peçanha, AM de Sousa, CS Sanches, AR Wendhausen, SR Pinheiro, MA Orione, AM Minossi, NL Bresolin, CDF Martins, VF Cury, RPB Quinet, AL Netto, R Limonge, SST Tamari, SER de Souza, R Veiga, NGCB Couto, MFP Ribeiro, AK de Aguiar, M Evangelista, JR Krauzer, H Muller, DHS Genu, PA Alvares, KL Maciel, FT Valente, M Centeville, GJ Espinheira, A da Silva, PL Vasconcelos, AZ Hädrich, ALDGC Sousa, GA Gandra, ACA Souto, L Sabatini, PRD João, ABMP Machado, FR Fonseca, APA Resende, RV da Silva, TP da Silva, LLT Barros, CSV de Souza, KO Harada, D Calçado, LSB Pinheiro, MCM Frota, LB Pulcheri, LM e Silva, KJ dos Santos, FH de Nuncio, IO Gomes Júnior, ACC Gomes, MA Klitzke, FR de Souza, FSC Carvalho, FP de Lima, LR Braun Filho, MAG de Oliveira, T Castilho, IP Pistelli, JD Paccez, C Cendon, R Sapolnick, D Fronza, C Toscan, RM Pinelli, JV Alencar, HL di Pace, AD Ramos, AC Molinari, JF Assis, APCR Chavarri, RC Pereira, CL Freitas, ICDM Salmen, RCM Guerini, J Asakura, ACR Pires, G Benvenuti, LM Fernandes, NF Oliveira, HJB Barros, LCE Nascimento, MB Machado, AOR dos Santos, AC da Silva, ACE de Oliveira, SKY Reinheimer, PCS Mello, IO Araújo, KLC Rodrigues, MN Amari, M Andersson, LMCM Petrini, AKSF Luz, ESS Serafim, RF Barbosa, D Souza, AF Delgado, ALP Guerra, JY Afiune, J Huber, S Casonato, DCB da Silva, OR de Araujo, FMD Fialho, LFR Soares, AA de Queiroz Júnior, A Sartorelli, ACP Zuccoli, M Castelani, LAA da Silva, SRA Lima, MJSL de Araújo, ACS da Cruz, PM Sillero, G Sgorlon, TRS Alves, MMB Muniz, RHP Pereira, NR Gonçalves, RPV Teixeira, IA Vasconcelos, CT Rossetti, RG Cesar, MAJ Alves, MK Martins, JAR Rocha, L Arruda, ALY Grillo, and G Barros

Subjects
Male, medicine.medical_specialty, Adolescent, Databases, Factual, Prevalence, Intensive Care Units, Pediatric, Sepsis, symbols.namesake, Epidemiology, Developmental and Educational Psychology, medicine, Humans, Hospital Mortality, Poisson regression, Child, business.industry, Septic shock, Mortality rate, Infant, Newborn, Infant, medicine.disease, Hospitalization, Child, Preschool, Relative risk, Pediatrics, Perinatology and Child Health, Emergency medicine, symbols, Female, Observational study, business, Brazil
Abstract

Data on the prevalence and mortality of paediatric sepsis in resource-poor settings are scarce. We aimed to assess the prevalence and in-hospital mortality of severe sepsis and septic shock treated in paediatric intensive care units (PICUs) in Brazil, and risk factors for mortality.We performed a nationwide, 1-day, prospective point prevalence study with follow-up of patients with severe sepsis and septic shock, using a stratified random sample of all PICUs in Brazil. Patients were enrolled at each participating PICU on a single day between March 25 and 29, 2019. All patients occupying a bed at the PICU on the study day (either admitted previously or on that day) were included if they were aged 28 days to 18 years and met the criteria for severe sepsis or septic shock at any time during hospitalisation. Patients were followed up until hospital discharge or death, censored at 60 days. Risk factors for mortality were assessed using a Poisson regression model. We used prevalence to generate national estimates.Of 241 PICUs invited to participate, 144 PICUs (capacity of 1242 beds) included patients in the study. On the day of the study, 1122 children were admitted to the participating PICUs, of whom 280 met the criteria for severe sepsis or septic shock during hospitalisation, resulting in a prevalence of 25·0% (95% CI 21·6-28·8), with a mortality rate of 19·8% (15·4-25·2; 50 of 252 patients with complete clinical data). Increased risk of mortality was associated with higher Pediatric Sequential Organ Failure Assessment score (relative risk per point increase 1·21, 95% CI 1·14-1·29, p0·0001), unknown vaccination status (2·57, 1·26-5·24; p=0·011), incomplete vaccination status (2·16, 1·19-3·92; p=0·012), health care-associated infection (2·12, 1·23-3·64, p=0·0073), and compliance with antibiotics (2·38, 1·46-3·86, p=0·0007). The estimated incidence of PICU-treated sepsis was 74·6 cases per 100 000 paediatric population (95% CI 61·5-90·5), which translates to 42 374 cases per year (34 940-51 443) in Brazil, with an estimated mortality of 8305 (6848-10 083).In this representative sample of PICUs in a middle-income country, the prevalences of severe sepsis or septic shock and in-hospital mortality were high. Modifiable factors, such as incomplete vaccination and health care-associated infections, were associated with greater risk of in-hospital mortality.Fundação de Amparo à Pesquisa do Estado de São Paulo and Conselho Nacional de Desenvolvimento Científico e Tecnológico.For the Portuguese translation of the abstract see Supplementary Materials section.

Published
2021

33. Nonstructural N- and C-tails of Dbp2 confer the protein full helicase activities

Author

Qin-Xia Song, Na-Nv Liu, Zhao-Xia Liu, Ying-Zi Zhang, Stephane Rety, Xi-Miao Hou, Xu-Guang Xi, Northwest A and F University, Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biotechnologie et Pharmacogénétique Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), and National Natural Science Foundation of China (32071291,32201042, 32071225, and 31870788)CNRS LIA ('Helicase-mediated G-quadruplex DNA unwinding and genome stability').

Subjects
disordered protein regions, RNA-protein interaction, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], RNA helicase Dbp2, FRET, Cell Biology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], RNA helicase Dbp2 disordered protein regions RNA-protein interaction X-ray crystallography FRET, Molecular Biology, Biochemistry, X-ray crystallography
Abstract

International audience; Human DDX5 and its yeast ortholog Dbp2 are ATP-dependent RNA helicases that play a keyrole in normal cell processes, cancer development and viral infection. The crystal structure ofthe RecA1-like domain of DDX5 is available, but the global structure of DDX5/Dbp2subfamily proteins remains to be elucidated. Here, we report the first X-ray crystal structuresof the Dbp2 helicase core alone and in complex with adenosine diphosphate nucleotide (ADP)at 3.22 Å and 3.05 Å resolutions, respectively. The structures of the ADP-bound post-hydrolysisstate and apo-state demonstrate the conformational changes that occur when the nucleotides arereleased. Our results showed that the helicase core of Dbp2 shifted between open and closedconformation in solution, but the unwinding activity was hindered when the helicase core wasrestricted to a single conformation. A small-angle X-ray scattering (SAXS) experiment showedthat the disordered amino- (N-) and carboxy- (C-) tails are flexible in solution. Truncationmutations confirmed that the N- and C-tails were critical for the nucleic acid binding, ATPase,and unwinding activities, with the C-tail being exclusively responsible for the annealing activity.Furthermore, we labeled the terminal tails to observe the conformational changes between thedisordered tails and the helicase core upon binding nucleic acid substrates. Specifically, wefound that the nonstructural N- and C-tails bind to RNA substrates and tether them to thehelicase core domain, thereby conferring full helicase activities to the Dbp2 protein. Thisdistinct structural characteristic provides new insight into the mechanism of DEAD-box RNAhelicases.

Published
2023

34. Strengths-building through life purpose, self-care goal setting and social support: Study protocol for Caregiver Support.

Author

Abshire Saylor, M, Pavlovic, NV, DeGroot, L, Jajodia, A, Hladek, MD, Perrin, N, Wolff, J, Davidson, PM, Szanton, S, Abshire Saylor, M, Pavlovic, NV, DeGroot, L, Jajodia, A, Hladek, MD, Perrin, N, Wolff, J, Davidson, PM, and Szanton, S

Abstract

BACKGROUND: For caregivers of people with heart failure, addressing a range of care recipient needs at home can potentially be burdensome, but caregivers may also gain meaning from caregiving. The Caregiver Support Program, a multicomponent strengths-based intervention, is designed to improve outcomes of heart failure caregivers. OBJECTIVES: 1) Test the feasibility and gauge an initial effect size of the Caregiver Support Program to improve caregiver quality of life (primary outcome), and fatigue and burden (secondary outcomes) from baseline to 16 weeks, 2) test whether fatigue and caregiver burden are associated with objective measures of resilience (sweat inflammatory cytokines (Il-6 and IL-10) and self-reported resilience, 3) evaluate changes in heart rate variability, IL-6 and IL-10, pre- and post-intervention. METHODS: This is a single-blind, two group, waitlist control trial. Eligible caregivers are 1) ≥ 18 years, 2) English speaking, 3) live with the person with heart failure or visit them at least 3 days per week to provide care, 4) provide support for at least 1 instrumental activity of daily living (IADL), 5) live within a 1 h driving radius of the Johns Hopkins Hospital, and 6) the care-recipient has been hospitalized within the last 6 months. Trial participants are randomized into the immediate intervention (n = 24) or waitlist control group (n = 24). Data collection is at baseline, 16 weeks, and 32 weeks. CONCLUSION: The Caregiver Support program has the potential to increase quality of life and decrease fatigue and caregiver burden for caregivers of people with heart failure and multiple co-morbidities.

Published
2022

37. Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial

Author

Chen, Gui-Ling, primary, Li, Xiao-Feng, additional, Dai, Xia-Hong, additional, Li, Nan, additional, Cheng, Meng-Li, additional, Huang, Zhen, additional, Shen, Jian, additional, Ge, Yu-Hua, additional, Shen, Zhen-Wei, additional, Deng, Yong-Qiang, additional, Yang, Shu-Yuan, additional, Zhao, Hui, additional, Zhang, Na-Na, additional, Zhang, Yi-Fei, additional, Wei, Ling, additional, Wu, Kai-Qi, additional, Zhu, Meng-Fei, additional, Peng, Cong-Gao, additional, Jiang, Qi, additional, Cao, Shou-Chun, additional, Li, Yu-Hua, additional, Zhao, Dan-Hua, additional, Wu, Xiao-Hong, additional, Ni, Ling, additional, Shen, Hua-Hao, additional, Dong, Chen, additional, Ying, Bo, additional, Sheng, Guo-Ping, additional, Qin, Cheng-Feng, additional, Gao, Hai-Nv, additional, and Li, Lan-Juan, additional

Published
2022
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38. The effect of greenness on allergic rhinitis outcomes in children and adolescents: A systematic review and meta-analysis

Author

Nv-Wei, Cao, Hao-Yue, Zhou, Yu-Jie, Du, Xian-Bao, Li, Xiu-Jie, Chu, and Bao-Zhu, Li

Subjects
Schools, Asia, Environmental Engineering, Adolescent, Housing, Humans, Environmental Chemistry, Prospective Studies, Child, Rhinitis, Allergic, Pollution, Waste Management and Disposal
Abstract

The relationship between greenness and health emerges as new public health concern. More published studies from multiple areas have explored the relationship between greenness and allergic rhinitis (AR) in children and adolescents. This study aims to determine the association between greenness and allergic rhinitis by systematic review and meta-analysis, in order to provide a more comprehensive assessment of the impact of greenness on AR in children and adolescents.The relative literature was systematically searched in PubMed, Embase, and Web of science lastly on September 25, 2022. Terms related to greenness and allergic rhinitis were used for searching. Summary effect estimates of greenness on AR in children and adolescents were calculated for per 10 % increase of greenness exposure with different buffer sizes by random-effects model.A total of 579 studies were screened, and fourteen studies from Europe, Asia and North America were finally included. Most greenness exposure were measured by normalized difference vegetation index (NDVI). Enhanced vegetation index, outdoor-green environmental score and existed to measuring different greenness types. Greenness surrounding residences and schools were assessed. The overall effect of greenness on primary outcome was 1.00 (95%CI = 0.99-1.00). Most effect estimates of greenness were included in the NDVI-500 m group, and the pooled OR was 0.99 (95%CI = 0.97-1.01). No significant pooled estimates were found in analyses with study locations.This study indicates no significant association between greenness exposure and AR in children and adolescents. Various exposure measures and conversion of data may affect the results of this meta-analysis. More precise assessment of personal greenness exposure in well-designed prospective studies are vital for drawing a definite association in future. Furthermore, greenness exposure surrounding schools should be paid considerable attention for its effect on AR in school-aged children and adolescents.

Published
2023

39. Antibiotic use and associated factors in a large sample of hospitalised older people

Author

Ardoino, I, Mannucci, Pm, Nobili, A, Franchi, C, Tettamanti, M, Pasina, L, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Perticone, F, Licata, G, Violi, F, Corazza, Gr, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Caterina, C, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, Ea, Bernardi, M, Bassi, Sl, Santi, L, Zaccherini, G, Lupattelli, G, Mannarino, E, Bianconi, V, Paciullo, F, Alcidi, R, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Natoli, G, Mularo, S, Raspanti, M, Cavallaro, F, Zoli, M, Lazzari, I, Brunori, M, Fabbri, E, Magalotti, D, Arn?, R, Pasini, Fl, Capecchi, Pl, Palasciano, G, Modeo, Me, Di Gennaro, C, Cappellini, Md, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, De Amicis, Mm, De Luca, G, Scaramellini, N, Rossi, Pd, Damanti, S, Clerici, M, Conti, F, Bonini, G, Ottolini, Bb, Di Sabatino, A, Miceli, E, Lenti, Mv, Pisati, M, Dominioni, Cc, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Beccati, V, Nobili, G, Secchi, Mb, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, Mt, Valeriani, E, Rossi, I, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Pes, C, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccal?, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Manzoni, F, Volpini, A, Picardi, A, Gentilucci, Uv, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Tassone, B, Sesti, G, Serra, Mg, Bleve, Ma, Gasbarrone, L, Sajeva, Mr, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, Mv, Cosi, E, Scarinzi, P, Amabile, A, Omenetto, E, Prandini, T, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, De Giorgio, R, Paolisso, G, Rizzo, Mr, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Sabb?, C, Vella, Fs, Suppressa, P, Agosti, P, Schilardi, A, Loparco, F, De Vincenzo, Gm, Comitangelo, A, Amoruso, E, Fenoglio, L, Falcetta, A, Bracco, C, Fracanzani, Al, Fargion, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, Nl, Tognin, T, Bianchi, Gb, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Peasso, P, Favale, E, Poletto, C, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, Mv, Dondi, G, Pellegrini, E, Carulli, L, Galassi, M, Grassi, Y, Perticone, M, Battaglia, R, Filice, M, Maio, R, Stanghellini, V, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Capeci, W, Gabrielli, A, Mattioli, M, Martino, Gp, Biondi, L, Pettinari, P, Ghio, R, Dal Col, A, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, Me, Castellino, P, Zanoli, L, Pignataro, S, Gennaro, A, Blanco, J, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Marra, Am, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, Mc, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffr?, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Ceda, Gp, Maggio, Mg, Morganti, S, Artoni, A, Del Giacco, S, Firinu, D, Losa, F, Paoletti, G, Costanzo, G, Montalto, G, Licata, A, Malerba, V, Montalto, Fa, Lasco, A, Basile, G, Catalano, A, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, Gp, Sola, D, Porta, M, Riva, P, Quadri, R, Larovere, E, Novelli, M, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Nieves, Rd, Alberto, Mm, Pedro, Ar, Vanessa, Lp, Lara, T, Xavier, Cv, Francesc, F, Jesus, Dm, Esperanza, Bt, Esther, Dcb, Maria, Sp, Romero, M, Blanca, Pl, Cristina, Lgc, Victoria, Vgm, Saez, L, Bosco, J, Susana, Sb, Marta, Ag, Concepcion, Gb, Antonio, Fm, Hernandez, Mg, Borrego, Mp, Raquel, Pc, Florencia, Pr, Beatriz, Go, Sara, Cg, Alfonso, Gcc, Marta, Pm, Alberto, Rc, Antonio, Aa, Montserrat, Gg, Angel, Brm, Manuel, Mj, Ignacio, Nv, Lucia, As, Alfonso, L, David, Rb, Iniguez, Vi, Monica, Rp, Ardoino I., Mannucci P.M., Nobili A., Franchi C., Tettamanti M., Pasina L., Corrao S., Marengoni A., Salerno F., Cesari M., Perticone F., Licata G., Violi F., Corazza G.R., Ardoino, I, Mannucci, P M, Nobili, A, Franchi, C, and Rinaldi, Luca

Subjects
Registrie, Male, 0301 basic medicine, Antibiotics, Logistic regression, 0302 clinical medicine, Drug Prescription, 80 and over, Prevalence, Immunology and Allergy, LS4_4, Hospital Mortality, Registries, 030212 general & internal medicine, Multivariate Analysi, Respiratory Tract Infections, Aged, 80 and over, Anti-Bacterial Agents, Hospitalization, Italy, Antibiotic use, Female, Human, Microbiology (medical), medicine.medical_specialty, Logistic Model, Internal medicine ward, medicine.drug_class, 030106 microbiology, Immunology, Socio-culturale, Drug Prescriptions, Microbiology, Odds, 03 medical and health sciences, Antibiotic resistance, Anti-Bacterial Agent, medicine, Older people, Aged, Geriatric Assessment, Humans, Logistic Models, Multivariate Analysis, Medical prescription, business.industry, Confidence interval, Antibiotic use, Internal medicine ward, Older people, Emergency medicine, business
Abstract

Objectives: The aims of this study were to assess (i) the prevalence of antibiotic use, (ii) factors associated with their use and (iii) the association with in-hospital mortality in a large sample of hospitalised older people in Italy.Methods: Data were obtained from the 2010-2017 REPOSI register held in more than 100 internal medicine and geriatric wards in Italy. Patients aged >= 65 years with at least one antibiotic prescription during their hospitalisation were selected. Multivariable logistic regression models were used to determine factors associated with antibiotic use.Results: A total of 5442 older patients were included in the analysis, of whom 2786 (51.2%) were prescribed antibiotics during their hospitalisation. The most frequently prescribed antibiotic class was beta-lactams, accounting for 50% of the total prescriptions. Poor physical independence, corticosteroid use and being hospitalised in Northern Italy were factors associated with a higher likelihood of being prescribed antibiotics. Antibiotic use was associated with an increased risk of in-hospital mortality (odds ratio = 2.52, 95% confidence interval 1.82-3.48) also when accounting for factors associated with their use.Conclusion: Hospitalised older people are often prescribed antibiotics. Factors related to poor physical independence and corticosteroid use are associated with increased antibiotic use. Being prescribed antibiotics is also associated with an increased risk of in-hospital death. These results demand the implementation of specific stewardship programmes to improve the correct use of antibiotics in hospital settings and to reduce the risk of antimicrobial resistance. (C) 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.

Published
2019

41. The epidemiology of sepsis in paediatric intensive care units in Brazil (the Sepsis PREvalence Assessment Database in Pediatric population, SPREAD PED): an observational study

Author

de Souza, Daniela Carla, primary, Gonçalves Martin, Joelma, additional, Soares Lanziotti, Vanessa, additional, de Oliveira, Cláudio Flauzino, additional, Tonial, Cristian, additional, de Carvalho, Werther Brunow, additional, Roberto Fioretto, José, additional, Pedro Piva, Jefferson, additional, Juan Troster, Eduardo, additional, Siqueira Bossa, Aline, additional, Gregorini, Flávia, additional, Ferreira, Josiane, additional, Lubarino, Juliana, additional, Biasi Cavalcanti, Alexandre, additional, Ribeiro Machado, Flávia, additional, Silva, SC, additional, Giacomazzi, J, additional, Boldrini, Domingos A., additional, Gilli, FH, additional, Castro, LC de, additional, Albuquerque, ML de, additional, Osorio, VCTG, additional, Elias, MLC, additional, Câmara, AA da, additional, Maia, M, additional, Carvalho, PB de, additional, Augusto, FM, additional, Figueiredo, RCCM de, additional, Ikino, EL, additional, Nogueres, FAS, additional, Almeida, RJ de, additional, Torreão, L, additional, Ramalho, J, additional, Camões, MMS, additional, Oliveira, CS de, additional, Serafim, VIIS, additional, Junior, J Colleti, additional, Almeida, CG de, additional, Costa, MHM da, additional, Valerio, JF, additional, Navajas, ME, additional, Riveiro, PM, additional, Lubiana, A, additional, Brito, ACLC, additional, Moretto, V, additional, Rachid, LMMD, additional, Valle, M, additional, Souza, PP de, additional, Victor, RPL, additional, Castro, NR, additional, Sakomura, T, additional, Molon, M, additional, Ferreira, AR, additional, Fonseca, JG da, additional, Cunali, VCA, additional, Chagas, VCA, additional, Belek, G, additional, Rocha, TS da, additional, Mello, LCFF de, additional, Machado, LM, additional, Moliterno, NV, additional, Duran, C, additional, Sanos, CLEB, additional, Ribeiro, GT, additional, Silva, PSL da, additional, Lipinski, R, additional, Soledade, A, additional, Branco, KC, additional, Teles, ACO, additional, Cruz, GF da, additional, Mendonça, MR de, additional, Malheiros, E, additional, Vicari, J, additional, Izidro, PNT, additional, Campos, NMP, additional, Pontes, TC, additional, Carneiro, CRF, additional, Imamura, AH, additional, Yoshioka, FM, additional, Duarte, MCMB, additional, Menezes, T, additional, Falconiere, C, additional, Matos, F, additional, Zeitel, RS, additional, Nogueras, CC, additional, Silva, ML da, additional, Aprille, M, additional, Pires, TYM, additional, Portella, AF, additional, Flores, PVG, additional, Alfradique, PP, additional, Nascimento, RC, additional, Saldanha, MO, additional, Alves, AT, additional, Almeida, WJ de, additional, Rodrigues, M, additional, Lopes Júnior, E, additional, Komka, MRP, additional, Nascimento, MAR, additional, Lopes, CRC, additional, Bernardi, TMC, additional, Falcão, RV, additional, Fraga, AR, additional, Machado, AA, additional, Godoy, JEF, additional, Barcellos, J, additional, Queiroz, RLS, additional, Almeida, VVS de, additional, Lira, JZG, additional, Alvo, M, additional, Peçanha, TCP, additional, Sousa, AM de, additional, Sanches, CS, additional, Wendhausen, AR, additional, Pinheiro, SR, additional, Orione, MA, additional, Minossi, AM, additional, Bresolin, NL, additional, Martins, CDF, additional, Cury, VF, additional, Quinet, RPB, additional, Netto, AL, additional, Limonge, R, additional, Tamari, SST, additional, Souza, SER de, additional, Veiga, R, additional, Couto, NGCB, additional, Ribeiro, MFP, additional, Aguiar, AK de, additional, Evangelista, M, additional, Krauzer, JR, additional, Muller, H, additional, Genu, DHS, additional, Alvares, PA, additional, Maciel, KL, additional, Valente, FT, additional, Centeville, M, additional, Espinheira, GJ, additional, Silva, A da, additional, Vasconcelos, PL, additional, Hädrich, AZ, additional, Sousa, ALDGC, additional, Gandra, GA, additional, Souto, ACA, additional, Sabatini, L, additional, João, PRD, additional, Machado, ABMP, additional, Fonseca, FR, additional, Resende, APA, additional, Silva, RV da, additional, Silva, TP da, additional, Barros, LLT, additional, Souza, CSV de, additional, Harada, KO, additional, Calçado, D, additional, Pinheiro, LSB, additional, Frota, MCM, additional, Pulcheri, LB, additional, Silva, LM e, additional, Santos, KJ dos, additional, Nuncio, FH de, additional, Gomes Júnior, IO, additional, Gomes, ACC, additional, Klitzke, MA, additional, Souza, FR de, additional, Carvalho, FSC, additional, Lima, FP de, additional, Braun Filho, LR, additional, Oliveira, MAG de, additional, Castilho, T, additional, Pistelli, IP, additional, Paccez, JD, additional, Cendon, C, additional, Sapolnick, R, additional, Fronza, D, additional, Toscan, C, additional, Pinelli, RM, additional, Alencar, JV, additional, Pace, HL di, additional, Ramos, AD, additional, Molinari, AC, additional, Assis, JF, additional, Chavarri, APCR, additional, Pereira, RC, additional, Freitas, CL, additional, Salmen, ICDM, additional, Guerini, RCM, additional, Asakura, J, additional, Pires, ACR, additional, Benvenuti, G, additional, Fernandes, LM, additional, Oliveira, NF, additional, Barros, HJB, additional, Nascimento, LCE, additional, Machado, MB, additional, Santos, AOR dos, additional, Silva, AC da, additional, Oliveira, ACE de, additional, Reinheimer, SKY, additional, Mello, PCS, additional, Araújo, IO, additional, Rodrigues, KLC, additional, Amari, MN, additional, Andersson, M, additional, Petrini, LMCM, additional, Luz, AKSF, additional, Serafim, ESS, additional, Barbosa, RF, additional, Souza, D, additional, Delgado, AF, additional, Guerra, ALP, additional, Afiune, JY, additional, Huber, J, additional, Casonato, S, additional, Silva, DCB da, additional, Araujo, OR de, additional, Fialho, FMD, additional, Soares, LFR, additional, Queiroz Júnior, AA de, additional, Sartorelli, A, additional, Zuccoli, ACP, additional, Castelani, M, additional, Silva, LAA da, additional, Lima, SRA, additional, Araújo, MJSL de, additional, Cruz, ACS da, additional, Sillero, PM, additional, Sgorlon, G, additional, Alves, TRS, additional, Muniz, MMB, additional, Pereira, RHP, additional, Gonçalves, NR, additional, Teixeira, RPV, additional, Vasconcelos, IA, additional, Rossetti, CT, additional, Cesar, RG, additional, Alves, MAJ, additional, Martins, MK, additional, Rocha, JAR, additional, Arruda, L, additional, Grillo, ALY, additional, and Barros, G, additional

Published
2021
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45. MACROGLOBULINEMIA DE WALDENSTROM: UM RELATO DE CASO

Author

Lopes, GO, primary, Nunes, EA, additional, Silveira, GM, additional, Troncoso, G, additional, Scheer, IO, additional, Inácio, JO, additional, Gonçalves, LF, additional, Amaral, MVFD, additional, Del-Fiaco, NV, additional, and Araújo, GMB, additional

Published
2021
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47. Isolation and Growth Characteristics of SARS-CoV-2 in Vero Cell

Author

Hui Wang, Lei Chen, Jiancai Chen, Pingping Yao, Juncheng Ruan, Fu Zhenfang, Biao Niu, Dehui Wang, Yisheng Sun, Bo Su, An Qi, Chen Chen, Jianmin Jiang, Zhi-yong Zhu, Yue Guo, Hanping Zhu, Lixia Xie, Zhang-Nv Yang, Fang Xu, Hang-Jing Lu, Dayong Tian, Yajing Zhang, Gu Yulin, Yachun Zhang, and Yuying Zhao

Subjects
0301 basic medicine, medicine.medical_specialty, Letter, viruses, 030106 microbiology, Immunology, virus diseases, Biology, biology.organism_classification, medicine.disease, medicine.disease_cause, Virology, Virus, In vitro, 03 medical and health sciences, 030104 developmental biology, Medical microbiology, Pandemic, Vero cell, medicine, Molecular Medicine, Pneumonia (non-human), Betacoronavirus, Coronavirus
Abstract

The coronavirus disease 2019 (COVID-19) broke out in early December 2019 in Wuhan, China and escalated into a global pandemic. There is an urgent need to understand the biology of SARS-CoV-2. In this letter, we report the isolation and characterization of seven isolates of SARS-CoV-2. Results show that our viruses have 99% sequence identity with published virus sequences. In addition, all viruses grew well in Vero cells, and one of the viruses had a deletion mutation after short passage. These results shall facilitate the understanding of the characteristics of SARS-CoV-2 in vitro.

Published
2020

48. Correlation of Oxford MEST-C Scores With Clinical Variables for IgA Nephropathy in South India

Author

Yashita Gupta, Anila Abraham Kurien, Kiran K. Gowda, K S Jansi Prema, NV Seethalekshmy, Jyotsna Yesodharan, Swarnalata Gowrishankar, and Mahesha Vankalakunti

Subjects
Correlation, medicine.medical_specialty, Clinical variables, Text mining, Nephrology, business.industry, Internal medicine, Research Letter, MEDLINE, Medicine, business, medicine.disease, Nephropathy
Published
2019

49. Analysis on meso-damage processes in concrete by X-ray computed tomographic scanning techniques based on divisional zones

Author

Nv Han and Wei Tian

Subjects
Coalescence (physics), Materials science, medicine.diagnostic_test, Applied Mathematics, 020208 electrical & electronic engineering, 010401 analytical chemistry, Uniaxial compression, Computed tomography, 02 engineering and technology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, X ray computed, Ct number, 0202 electrical engineering, electronic engineering, information engineering, medicine, Electrical and Electronic Engineering, Ct imaging, Composite material, Instrumentation
Abstract

Concrete damage characteristics were investigated by X-ray computed tomography (CT) under uniaxial compression. CT imaging was performed to study concrete crack generation, propagation, coalescence, and failure under uniaxial compression. A damage-fracture divisional zone theory was proposed to quantitatively analyze the damage evolution of concrete by CT. The criteria of the divisional zones based on CT images were determined to define the safety, damage, and damage-fracture zones of a concrete specimen. The different region damage evolutions were revealed and analyzed, which lead to descriptions of concrete deterioration mechanisms.

Published
2019

50. A scale for prediction of response to AEDs in patients with MRI-negative epilepsy

Author

Ting Zhao, Ming-min Li, Xiong Han, Pan Zhao, Shijun Yang, Huan Ma, Yanan Chen, Gui-nv He, Bing-qian Ma, Na Wang, Xue-rui Zhu, and Yi Chen

Subjects
Adult, Male, Drug Resistant Epilepsy, medicine.medical_specialty, Adolescent, Logistic regression, Sensitivity and Specificity, Likelihood ratios in diagnostic testing, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, Epilepsy, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Child, Retrospective Studies, Univariate analysis, Framingham Risk Score, medicine.diagnostic_test, business.industry, Area under the curve, Electroencephalography, Magnetic resonance imaging, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, Logistic Models, Neurology, Anticonvulsants, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objectives Antiepileptic drugs (AEDs) are the first choice in magnetic resonance imaging (MRI)-negative patients with epilepsy, although the responses to AEDs are diverse. Preoperative evaluation and postoperative prognosis in MRI-negative epilepsy have been reported. However, there are few tools for predicting the response to AEDs. Herein, we developed an AED response scale based on clinical factors and video-electroencephalography (VEEG) in MRI-negative patients with epilepsy. Methods A total of 132 consecutive patients with MRI-negative epilepsy at the Epilepsy Center of Henan Provincial People's Hospital between August 2016 and August 2018 were included. Patients were further divided into drug-responsive epilepsy ([DSE-MRI (−)]; n = 101) and drug-resistant epilepsy ([DRE-MRI (−)]; n = 31) groups. The clinical and VEEG factors were evaluated in univariate analyses and multivariate logistic regression analyses. A scale was derived and the scores categorized into 3 risk levels of DRE-MRI (−). Results A scale was established based on 4 independent risk factors for DRE-MRI (−). The scale had a sensitivity of 83.87%, specificity of 80.20%, positive likelihood ratio of 4.24, negative likelihood ratio of 0.20, and showed good discrimination with the area under the curve (AUC) of 0.886 (0.826–0.946). The categorization of the risk score based on this scale was: low risk (0–3 points), medium risk (3–5 points), and high risk (> 5 points). Conclusion We established a DRE-MRI (−) scale with a good sensitivity and specificity, which may be useful for clinicians when making medical decisions in patients with MRI-negative epilepsy.

Published
2019

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