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Your search keyword '"Almudena González-Álvarez"' showing total 2 results
Start Over Author "Almudena González-Álvarez" Publisher elsevier bv
2 results on '"Almudena González-Álvarez"'

1. An azamacrocyclic receptor as efficient polytopic chiral solvating agent for carboxylic acids

Author

Almudena González-Álvarez, Ignacio Alfonso, and Vicente Gotor

Subjects
Chemistry, Organic Chemistry, Drug Discovery, Diastereomer, Organic chemistry, Enantiomer, Enantiomeric excess, Receptor, Biochemistry
Abstract

The efficient use of a polyazamacrocycle as chiral solvating agent (CSA) for the determination of the enantiomeric excess of different carboxylic acids has been studied. All the data agree with the formation of multimolecular diastereomeric complexes in solution, which render good splitting of the NMR signals for the enantiomers of the acids (up to ΔΔ δ = 0.20 ppm) using a small amount (even 0.125 equiv) of the receptor.

Published
2006

2. Chemoenzymatic syntheses of new optically active C2-symmetrical macrocyclic polyazacyclophanes

Author

Ignacio Alfonso, Almudena González-Álvarez, Mercedes Rubio, and Vicente Gotor

Subjects
Inorganic Chemistry, Flexibility (anatomy), medicine.anatomical_structure, Enantiopure drug, Chemistry, Organic Chemistry, medicine, Physical and Theoretical Chemistry, Optically active, Combinatorial chemistry, Catalysis
Abstract

The syntheses of new C 2 -symmetrical optically active macrocyclic polyazacyclophanes have been achieved from a common synthetic precursor, which has been prepared in enantiopure form by means of a chemoenzymatic pathway. The effect of the aromatic spacer on the flexibility of the systems is also discussed.

Published
2005

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