1. Bin/Amphiphysin/Rvs (BAR) Family Members Bend Membranes in Cells
- Author
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Allison Suarez, Takanari Inoue, J. Michael McCaffery, Tasuku Ueno, and Robert Huebner
- Subjects
Multidisciplinary ,COS cells ,Bar (music) ,Cell Membrane ,Biophysics ,Nerve Tissue Proteins ,Biology ,Article ,Bin ,Cell Line ,Cell biology ,Cell membrane ,Structure-Activity Relationship ,Membrane ,medicine.anatomical_structure ,Membrane curvature ,COS Cells ,Chlorocebus aethiops ,Organelle ,Amphiphysin ,medicine ,Animals ,lipids (amino acids, peptides, and proteins) - Abstract
We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.
- Published
- 2015
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