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As previously reported, intention-to-treat findings from our phase III randomized clinical trial found that a supplement of 600 mg docosahexaenoic acid (DHA)/day during the last half of pregnancy reduced the incidence of early preterm birth (ePTB

OBJECTIVES: Caffeine is associated with brain health, and it is suggested to lower the risk of neurological diseases. This cross-sectional study aimed to investigate the association between caffeine intake and concentration of brain metabolites in healthy older adults. METHODS: Caffeine intake was determined in 60 cognitively normal, healthy older adults aged between 60–85 years (61.9% women) using a 7-day food record (7D) that was collected seven days prior to their Magnetic Resonance scan. The 7D was entered in the Nutrition Data System for Research (NDS-R version 2012) for nutrient analysis. Brain metabolites [N-acetylaspartate, creatine, total choline, glutamate + glutamine, and myo-inositol (mI)] were measured using a 1H magnetic resonance spectroscopic imaging method at 3T. All metabolites were quantified using LCModel analysis software and concentrations are shown as a ratio to creatine. Measurements were presented as mean ± standard deviation and n(%). We assessed the relationship between caffeine intake and brain metabolite concentrations by multiple linear regression, adjusting for age and sex. Statistical analyses were performed using SPSS (v25, IBM) with significance of P ≤ 0.05. RESULTS: Participants had a mean age of 69.3 ± 7.3 years. Mean caffeine intake among the participants was 152.17 ± 133.79mg/d (range: 0–635.98mg/d). There was a significant correlation between caffeine and mI (β = 0.443; P = 0.001). The remaining metabolites were not correlated with caffeine intake. CONCLUSIONS: Higher caffeine intake in older adults was associated with higher brain mI concentrations. The metabolic link between brain mI concentrations and neurological diseases is still unclear, thus, future studies are necessary regarding the mechanism for the impact of caffeine on brain metabolism. FUNDING SOURCES: This study is supported by funding from National Dairy Council (IYC). The Hoglund Brain Imaging Center is supported by grants from the NIH (C76 HF00201, P30 HD002528, S10 RR29577, UL1 TR000001, and P30AG035982) and the Hoglund Family Foundation.

To investigate the mechanisms involved in graft survival, a rat cell line (PC12) that differentiates into sympathetic-like neurons by exposure to trophic factors has been grafted into rat striatum and hippocampus, two structures which differ in their amounts of trophic factors. Our results show that grafted PC12 cells behave differently depending on the area of implantation; they display a differentiated morphology in the hippocampus and proliferate as a tumor in the striatum. A qualitatively similar immunological reaction occurs in both structures, characterized by the invasion of T and B lymphocytes, macrophage-like cells and by the expression of major histocompatibility complex class I and II antigens around the graft.

Primary lymphoma of central nervous system: preliminary results of the POF LCP 88 Trial. This trial is based on 3 curses of chemotherapy following by an in toto cerebral irradiation. Our preliminary results on 29 patients HIV-are hopeful with 20 complete remissions and 2 relapses at 5 and 16 months. Toxicity was acceptable.