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Your search keyword '"Akbarpour, M"' showing total 12 results
Start Over Author "Akbarpour, M" Publisher elsevier bv
12 results on '"Akbarpour, M"'

2. Differential Transcriptome Response to Proton (PT) Versus X-ray Radiation Identify PPARgamma as a Candidate Target for Combinatorial PT Therapy in Lymphoma

Author

Sertorio, M.G.B., primary, Nowrouzi, A., additional, Akbarpour, M., additional, Chetal, K., additional, Salomonis, N., additional, Brons, S., additional, Mascia, A.E., additional, McCauley, S., additional, Köthe, A., additional, Debus, J., additional, Perentesis, J.P., additional, Abdollahi, A., additional, Zheng, Y., additional, and Wells, S.I., additional

Published
2020
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3. Late Intervention with Radiation-Induced Lung Fibrosis - Comparing Pamrevlumab Anti-CTGF Therapy vs. Pirfenidone vs. Nintedanib as Mono-, Dual- and Triple-therapy Combinations

Author

Moustafa, M., primary, Lipson, K.E., additional, Akbarpour, M., additional, Fouse, S., additional, Kriegsmann, M., additional, Zhou, C., additional, Kriegsmann, K., additional, Weichert, W., additional, Seeley, T.W., additional, Kouchakji, E., additional, Debus, J., additional, and Abdollahi, A., additional

Published
2020
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4. 700 Targeting SIRT/CD38/NAD+ homeostasis to mitigate fibrosis in scleroderma

Author

Shi, B., primary, Wang, W., additional, Wei, J., additional, Bhattacharyya, S., additional, Korman, B., additional, Marangoni, R., additional, Xu, D., additional, Miller, S., additional, Akbarpour, M., additional, Bharat, A., additional, Kamp, D., additional, Cheresh, P., additional, Procissi, D., additional, de Olivera, G., additional, Chini, E., additional, and Varga, J., additional

Published
2019
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5. Radiobiological Effects of Photon, Proton and Carbon Ion Irradiation on Human Pluripotent-Stem-Cell-Derived Gastrointestinal Organoids

Author

Nowrouzi, A., primary, Sertorio, M.G., additional, Akbarpour, M., additional, Kuhar, M., additional, Golestaneh, A. Fahim, additional, Schwager, C., additional, Perentesis, J.P., additional, Zheng, Y., additional, Debus, J., additional, Wells, S.I., additional, Wells, J.M., additional, Abdollahi, A., additional, and Knoll, M., additional

Published
2017
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12. Immune responses in liver-directed lentiviral gene therapy

Author

Andrea Annoni, Luigi Naldini, Maria Grazia Roncarolo, Mahzad Akbarpour, Kevin Goudy, Annoni, A, Goudy, K, Akbarpour, M, Naldini, Luigi, and Roncarolo, MARIA GRAZIA

Subjects
Genetic enhancement, Transgene, Biology, Viral vector, 03 medical and health sciences, Transduction (genetics), 0302 clinical medicine, Immune system, Physiology (medical), Immune Tolerance, Animals, Humans, Transgenes, Antigen-presenting cell, 030304 developmental biology, 0303 health sciences, Toll-like receptor, Lentivirus, Biochemistry (medical), Immunity, Public Health, Environmental and Occupational Health, FOXP3, Genetic Therapy, General Medicine, 3. Good health, Liver, 030220 oncology & carcinogenesis, Immunology, Cancer research
Abstract

The use of lentiviral vectors (LV)s for in vivo gene therapy is an ideal platform for treating many types of disease. Since LVs can transduce a wide array of cells, support long-term gene expression, and be modified to enhance cell targeting, LVs are a powerful modality to deliver life-long therapeutic proteins. A major limitation facing the use of LVs for in vivo gene therapy is the induction of immune responses, which can reduce the transduction efficiency of LV, eliminate the transduced cells, and inhibit the effect of the therapeutic protein. LV strategies designed to restrict transgene expression to the liver to exploit its naturally tolerogenic properties have proven to significantly reduce the induction of pathogenic immune responses and increase therapeutic efficacy. In this review, we outline the immunological hurdles facing in vivo LV gene therapy and highlight the advantages and limitations of using liver-directed LV gene therapy.

Published
2013

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