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Stroke in air travelers is being increasingly recognized. We report on stroke among passengers arriving at or transiting through a busy air travel hub.The stroke database of the sole tertiary care center for stroke in a large busy international hub was interrogated. Demographic data of transit passengers, their stroke risk factors, stroke severity, National Institutes of Health Stroke Scale (NIHSS), acute stroke interventions, discharge status and outcome utilizing the Modified Raking scale (mRS) were retrieved and compared between passengers and non-passenger controls.Forty-three flight-related stroke patients were compared to 2564 non-passenger stroke patients. The mean age in the flight-related stroke group was 59.53±10.83 years, 30/43 (69.8%) were males. The stroke subtypes were ischemic in 30 (69.8%) patients, hemorrhagic in 9 (20.9%), and transient ischemic attack in 3 (7.0%), with one cerebral sinus venous thrombosis (2.3%). The mean NIHSS score was 7.79±6.44 in passengers, demonstrating moderate severity. Ten patients (23.3%) received thrombolysis, one (2.3%) received thrombectomy, and one (2.3%) received both thrombolysis and thrombectomy. Outcomes, 54.8% had a good outcome (mRS 0-2), and 45.2% had dependence/death (mRS 3-6).Air passengers with stroke were found to be older with more severe strokes and a higher probability of receiving acute stroke treatment compared to non-passengers. Increased awareness with appropriate and timely recognition and triaging of transit passengers with stroke is warranted.

Introduction: Neurotuberculosis comprises around 6% of systemic tuberculosis. It targets a younger population, and it often leads to severe neurological complications or death. Case report: We report a young gentleman with a clinically defined tuberculous meningitis (TBM) and multiple neurological complication associated with TBM occurring simultaneously. This includes hydrocephalus requiring a ventriculoperitoneal shunt, vasculitic infarcts, cranial nerve palsies, TB granuloma and cerebral venous thrombosis. The cerebrospinal fluid polymerase chain reaction for tuberculosis as well as cultures remained negative repeatedly. The patient was treated with anti-tuberculous medication in addition to steroids based on validated scoring systems suggestive of TBM and made a good recovery. Conclusion: This report highlights the different complication seen with TBM and the importance of using clinical criteria to guide management plan particularly when cultures are negative.

Background: Both neurodevelopmental and neurodegenerative processes have been proposed to contribute to the development of schizophrenia. However, there is no validated surrogate marker of neuronal pathology for schizophrenia. To quantify neuronal pathology in subjects with schizophrenia using corneal confocal microscopy (CCM) and brain volumetric MRI. Methods: In this cross-sectional study, subjects with DSM-5 based criteria for schizophrenia enrolled from the Psychiatry Hospital in Qatar and healthy controls were recruited between August 26, 2019 and March 11, 2020. Subjects with schizophrenia were assessed for positive and negative symptoms, and with controls underwent assessment of cognitive function, CCM and brain volumetric MRI. Neuronal pathology was assessed by quantifying corneal nerve fibre density (CNFD), length (CNFL), branch density (CNBD) and CNBD:CNFD ratio, and MRI volume of whole brain, cortical gray matter, ventricle, cingulate gyrus, hippocampus, amygdala, thalamus and entorhinal cortex. Findings: Subjects with schizophrenia (n=36) and controls (n=26) with a comparable age and gender were studied. After adjusting for confounders, subjects with schizophrenia had lower cognitive function (P≤0.01), CNFD, CNFL, CNBD and CNBD:CNFD ratio (P