1. Desmettianosides A and B, bisdesmosidic furostanol saponins with molluscicidal activity from Yucca desmettiana
- Author
-
Efstathia Ioannou, Yasser Diab, Ahmed M. Emam, Constantinos Vagias, and Vassilios Roussis
- Subjects
Pharmacology ,Furostanol glycosides ,Chromatography ,Biomphalaria ,Molluscacides ,biology ,Chemistry ,Stereochemistry ,Methanol ,Organic Chemistry ,Clinical Biochemistry ,Yucca ,Water ,Saponins ,Biomphalaria alexandrina ,biology.organism_classification ,Biochemistry ,Plant Leaves ,Endocrinology ,Animals ,Water chemistry ,Sugar ,Molecular Biology - Abstract
Bioactivity-guided separation of the aqueous methanolic extract of Yucca desmettiana leaves, which in a preliminary screening exhibited significant molluscicidal activity, led to the isolation and structure elucidation of two new steroidal saponins (1 and 2). The structures of desmettianosides A and B, identified as bisdesmosidic furostanol glycosides with six and five sugar units, respectively, were established by detailed spectroscopic analyses of their NMR and MS data. Compounds 1 and 2 exhibited high molluscicidal activity against Biomphalaria alexandrina snails with LC100 values of 6 and 11 mg/L, respectively.
- Published
- 2012
- Full Text
- View/download PDF