1. Tuberculous and brucellosis meningitis differential diagnosis
- Author
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Sibel Bolukcu, Asli Haykir-Solay, Fatma Sirmatel, Melanie Catroux, Secil Deniz, Recep Tekin, Huseyin Turgut, Nefise Oztoprak, Hakan Erdem, Saygin Nayman-Alpat, Levent Gorenek, Selçuk Kaya, Serap Gencer, Meltem Avci, Mahmut Sunnetcioglu, Mustafa Namiduru, Mehmet Ulug, Kadriye Kart Yaşar, Gokhan Karaahmetoglu, Yves Hansmann, Tumer Guven, Rok Čivljak, Tuna Demirdal, Celal Ayaz, Mustafa Kemal Çelen, Isik Somuncu Johansen, Ayse Batirel, Ayten Kadanali, Oğuz Reşat Sipahi, Gonul Sengoz, Emel Yilmaz, Rodrigo Hasbun, Selma Ates-Guler, Ali İrfan Baran, Yasemin Cag, Hasan Karsen, Affan Denk, Emine Parlak, Ayşe Seza Inal, Filiz Pehlivanoglu, Hanefi Cem Gul, Ayhan Akbulut, Elif Sahin-Horasan, Soline Simeon, Seniha Senbayrak, Esmeray Mutlu-Yilmaz, Sukran Kose, Selma Tosun, Abdullah Umut Pekok, Mustafa Kasim Karahocagil, and Çukurova Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Tuberculosis ,Scoring system ,Turkey ,retrospective study ,urologic and male genital diseases ,Article ,Brucellosis ,Tuberculous meningitis ,Meningitis, Bacterial ,Diagnosis, Differential ,Young Adult ,Internal medicine ,differential diagnosis ,middle aged ,Diagnosis ,medicine ,Humans ,agglutination test ,controlled study ,Meningitis ,human ,Retrospective Studies ,business.industry ,Public Health, Environmental and Occupational Health ,meningoencephalitis ,scoring system ,Meningoencephalitis ,medicine.disease ,major clinical study ,Surgery ,female ,Infectious Diseases ,priority journal ,tuberculous meningitis ,Tuberculosis, Meningeal ,Etiology ,Differential diagnosis ,business ,cerebrospinal fluid culture - Abstract
PubMedID: 25801665 SummaryBackground The Thwaites and Lancet scoring systems have been used in the rapid diagnosis of tuberculous meningitis (TBM). However, brucellar meningoencephalitis (BME) has similar characteristics with TBM. The ultimate aim of this study is to infer data to see if BME should be included in the differential diagnosis of TBM when these two systems suggest the presence of TBM. Method BME and TBM patients from 35 tertiary hospitals were included in this study. Overall 294 adult patients with BME and 190 patients with TBM were enrolled. All patients involved in the study had microbiological confirmation for either TBM or BME. Finally, the Thwaites and Lancet scoring systems were assessed in both groups. Results The Thwaites scoring system more frequently predicted BME cases (n = 292, 99.3%) compared to the TBM group (n = 182, 95.8%) (P = 0.017). According to the Lancet scoring system, the mean scores for BME and TBM were 9.43 ± 1.71 and 11.45 ± 3.01, respectively (P < 0.001). In addition, TBM cases were classified into "probable" category more significantly compared to BME cases, and BME cases were categorized into the "possible" category more frequently. Conclusions When the Thwaites or Lancet scoring systems indicate TBM, brucellar etiology should also be taken into consideration particularly in endemic countries. © 2015 Elsevier Ltd. All rights reserved.
- Published
- 2015
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